| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,153,496 | 1,135,406 | -18,090 | 3.90 | 3.65 | -0.25 | sell |
| JENNISON ASSOCIATES LLC | 640,611 | 960,619 | +320,008 | 0.05 | 0.09 | +0.03 | buy |
| BlackRock, Inc. | 686,853 | 918,357 | +231,504 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 882,400 | 882,400 | 0 | 2.83 | 2.94 | +0.11 | hold |
| First Light Asset Management, LLC | 980,758 | 771,901 | -208,857 | 10.96 | 7.17 | -3.79 | sell |
| BVF INC/IL | 960,989 | 672,789 | -288,200 | 3.82 | 2.63 | -1.19 | sell |
| STATE STREET CORP | 458,999 | 653,172 | +194,173 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 402,564 | 638,868 | +236,304 | 0.01 | 0.01 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 374,035 | 478,833 | +104,798 | 0.48 | 0.68 | +0.20 | buy |
| FEDERATED HERMES, INC. | 433,015 | 433,015 | 0 | 0.09 | 0.10 | +0.01 | hold |
| Woodline Partners LP | 317,517 | 317,517 | 0 | 0.15 | 0.15 | +0.00 | hold |
| ORBIMED ADVISORS LLC | 134,600 | 292,360 | +157,760 | 0.37 | 0.85 | +0.48 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 205,609 | 276,164 | +70,555 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 257,485 | 257,485 | 0 | 0.89 | 0.80 | -0.09 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 195,030 | 256,182 | +61,152 | 0.02 | 0.02 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 262,835 | 253,168 | -9,667 | 0.01 | 0.01 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 233,248 | 231,484 | -1,764 | 0.48 | 0.47 | -0.01 | sell |
| EMERALD ADVISERS, LLC | 161,500 | 229,486 | +67,986 | 0.64 | 0.83 | +0.19 | buy |
| FMR LLC | 215,808 | 214,841 | -967 | 0.00 | 0.00 | +0.00 | sell |
| MPM BioImpact LLC | 206,404 | 204,027 | -2,377 | 1.99 | 1.90 | -0.09 | sell |
| GOLDMAN SACHS GROUP INC | 194,179 | 201,514 | +7,335 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 127,987 | 181,428 | +53,441 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 148,093 | 156,450 | +8,357 | 2.06 | 2.56 | +0.50 | buy |
| Bellevue Group AG | 0 | 155,000 | +155,000 | 0.00 | 0.50 | +0.50 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 105,820 | 129,847 | +24,027 | 0.64 | 0.70 | +0.06 | buy |
| Aberdeen Group plc | 81,081 | 120,238 | +39,157 | 0.02 | 0.03 | +0.01 | buy |
| NORTHERN TRUST CORP | 64,371 | 97,193 | +32,822 | 0.00 | 0.00 | +0.00 | buy |
| Clio Asset Management LLC | 90,757 | 86,343 | -4,414 | 9.48 | 10.49 | +1.01 | sell |
| Neuberger Berman Group LLC | 49,103 | 83,107 | +34,004 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 104,537 | 72,526 | -32,011 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 70,000 | 70,000 | 0 | 1.77 | 1.71 | -0.05 | hold |
| AWM Investment Company, Inc. | 69,416 | 69,416 | 0 | 0.96 | 0.92 | -0.04 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 69,901 | 67,469 | -2,432 | 0.00 | 0.00 | +0.00 | sell |
| SEVEN GRAND MANAGERS, LLC | 60,000 | 60,000 | 0 | 0.50 | 0.37 | -0.13 | hold |
| Clearbridge Investments, LLC | 59,410 | 59,341 | -69 | 0.01 | 0.01 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 37,972 | 54,554 | +16,582 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 17,970 | 53,270 | +35,300 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 93,646 | 52,212 | -41,434 | 0.01 | 0.01 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 39,223 | 51,660 | +12,437 | 0.01 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 50,001 | +50,001 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 27,603 | 49,718 | +22,115 | 0.25 | 0.43 | +0.18 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 96,726 | 44,536 | -52,190 | 0.02 | 0.01 | -0.01 | sell |
| Lisanti Capital Growth, LLC | 41,445 | 42,975 | +1,530 | 1.30 | 1.44 | +0.14 | buy |
| ROYCE & ASSOCIATES LP | 31,507 | 40,509 | +9,002 | 0.04 | 0.05 | +0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 39,964 | 40,140 | +176 | 0.01 | 0.01 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 39,865 | +39,865 | 0.00 | 0.04 | +0.04 | buy |
| Jump Financial, LLC | 6,743 | 39,413 | +32,670 | 0.01 | 0.05 | +0.04 | buy |
| APIS CAPITAL ADVISORS, LLC | 89,000 | 39,000 | -50,000 | 1.71 | 0.58 | -1.13 | sell |
| Blue Owl Capital Holdings LP | 31,259 | 36,259 | +5,000 | 1.05 | 0.84 | -0.20 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 34,040 | 35,594 | +1,554 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 19,947 | 35,585 | +15,638 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 48,527 | 33,652 | -14,875 | 0.00 | 0.00 | -0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 32,583 | +32,583 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,970 | 32,583 | +9,613 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 21,236 | 31,424 | +10,188 | 0.01 | 0.02 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 31,318 | +31,318 | 0.00 | 0.05 | +0.05 | buy |
| Bank of New York Mellon Corp | 18,041 | 30,587 | +12,546 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 20,834 | 25,231 | +4,397 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 25,000 | 25,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| NOMURA HOLDINGS INC | 24,008 | 23,963 | -45 | 0.02 | 0.02 | -0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 25,446 | 23,663 | -1,783 | 0.00 | 0.00 | +0.00 | sell |
| Legato Capital Management LLC | 16,023 | 23,490 | +7,467 | 0.18 | 0.30 | +0.12 | buy |
| TD ASSET MANAGEMENT INC | 22,746 | 22,746 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 13,527 | 21,687 | +8,160 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 19,400 | 19,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Informed Momentum Co LLC | 29,328 | 18,849 | -10,479 | 0.42 | 0.26 | -0.17 | sell |
| F/m Investments LLC | 13,839 | 17,446 | +3,607 | 0.11 | 0.14 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,808 | 17,397 | -1,411 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,907 | 15,545 | -2,362 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 2,504 | 15,493 | +12,989 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 11,132 | 14,356 | +3,224 | 0.01 | 0.01 | +0.00 | buy |
| Capricorn Fund Managers Ltd | 0 | 14,088 | +14,088 | 0.00 | 0.17 | +0.17 | buy |
| RHUMBLINE ADVISERS | 9,129 | 13,528 | +4,399 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 36,639 | 13,495 | -23,144 | 0.03 | 0.01 | -0.02 | sell |
| WELLS FARGO & COMPANY/MN | 5,824 | 13,008 | +7,184 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 16,663 | 12,807 | -3,856 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 4,890 | 12,294 | +7,404 | 0.00 | 0.00 | +0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 0 | 12,038 | +12,038 | 0.00 | 0.10 | +0.10 | buy |
| DEUTSCHE BANK AG\ | 7,784 | 11,838 | +4,054 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 11,860 | 11,629 | -231 | 0.01 | 0.01 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 11,403 | 11,531 | +128 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 14,590 | 11,361 | -3,229 | 0.01 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,895 | 11,162 | +4,267 | 0.00 | 0.00 | +0.00 | buy |
| Calamos Advisors LLC | 9,804 | 10,479 | +675 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,142 | 10,430 | -10,712 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 4,420 | 10,361 | +5,941 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 7,758 | 10,031 | +2,273 | 0.05 | 0.08 | +0.02 | buy |
| XTX Topco Ltd | 5,828 | 8,861 | +3,033 | 0.01 | 0.02 | +0.00 | buy |
| JPMORGAN CHASE & CO | 5,519 | 8,420 | +2,901 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 8,406 | +8,406 | 0.00 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 7,446 | 7,994 | +548 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 7,906 | +7,906 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 4,260 | 6,405 | +2,145 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 5,929 | 6,392 | +463 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,688 | 6,372 | +1,684 | 0.00 | 0.00 | +0.00 | buy |
| PEAPACK GLADSTONE FINANCIAL CORP | 4,600 | 5,875 | +1,275 | 0.01 | 0.01 | +0.00 | buy |
| ASPIRIANT, LLC | 5,852 | 5,852 | 0 | 0.02 | 0.02 | +0.00 | hold |
| PROFUND ADVISORS LLC | 6,498 | 5,753 | -745 | 0.03 | 0.02 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 5,152 | 5,716 | +564 | 0.00 | 0.00 | +0.00 | buy |
| Penn Capital Management Company, LLC | 0 | 5,506 | +5,506 | 0.00 | 0.05 | +0.05 | buy |