| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| First Light Asset Management, LLC | 0 | 541,544 | +541,544 | 0.00 | 3.20 | +3.20 | buy |
| BVF INC/IL | 696,555 | 1,161,249 | +464,694 | 0.56 | 2.95 | +2.39 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 395,093 | +395,093 | 0.00 | 0.72 | +0.72 | buy |
| FEDERATED HERMES, INC. | 0 | 339,047 | +339,047 | 0.00 | 0.04 | +0.04 | buy |
| VANGUARD GROUP INC | 163,809 | 494,656 | +330,847 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 317,309 | +317,309 | 0.00 | 0.04 | +0.04 | buy |
| FRED ALGER MANAGEMENT, LLC | 13,542 | 186,751 | +173,209 | 0.00 | 0.05 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 166,535 | +166,535 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 85,329 | 236,630 | +151,301 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 102 | 110,446 | +110,344 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 714,463 | 822,400 | +107,937 | 0.61 | 1.56 | +0.96 | buy |
| JENNISON ASSOCIATES LLC | 0 | 106,910 | +106,910 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 67,423 | +67,423 | 0.00 | 0.69 | +0.69 | buy |
| Ikarian Capital, LLC | 0 | 64,746 | +64,746 | 0.00 | 0.82 | +0.82 | buy |
| STATE STREET CORP | 82,011 | 137,251 | +55,240 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 51,243 | +51,243 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 0 | 48,610 | +48,610 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 445,052 | 487,616 | +42,564 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 34,895 | +34,895 | 0.00 | 0.07 | +0.07 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 25,532 | +25,532 | 0.00 | 0.04 | +0.04 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 23,838 | +23,838 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 23,702 | +23,702 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 66,858 | 89,697 | +22,839 | 0.00 | 0.01 | +0.01 | buy |
| Mariner, LLC | 0 | 20,722 | +20,722 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 0 | 12,010 | +12,010 | 0.00 | 0.14 | +0.14 | buy |
| Eversept Partners, LP | 0 | 11,343 | +11,343 | 0.00 | 0.05 | +0.05 | buy |
| JANE STREET GROUP, LLC | 0 | 10,017 | +10,017 | 0.00 | 0.00 | +0.00 | buy |
| APIS CAPITAL ADVISORS, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.14 | +0.14 | buy |
| BROWN ADVISORY INC | 0 | 6,379 | +6,379 | 0.00 | 0.00 | +0.00 | buy |
| ASPIRIANT, LLC | 0 | 5,852 | +5,852 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 0 | 5,486 | +5,486 | 0.00 | 0.00 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 0 | 5,200 | +5,200 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 0 | 4,650 | +4,650 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 4,128 | +4,128 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 4,090 | +4,090 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 8,905 | 12,705 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 3,665 | 7,346 | +3,681 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 3,657 | +3,657 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 2,780 | +2,780 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 135,754 | 138,505 | +2,751 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 2,617 | +2,617 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 13,662 | 16,185 | +2,523 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 3,245 | 4,338 | +1,093 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 568 | +568 | 0.00 | 0.00 | +0.00 | buy |
| Archer Investment Corp | 0 | 449 | +449 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 1,639 | 1,974 | +335 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 316 | +316 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 192 | 449 | +257 | 0.00 | 0.00 | +0.00 | buy |
| Chung Wu Investment Group, LLC | 0 | 200 | +200 | 0.00 | 0.01 | +0.01 | buy |
| Clio Asset Management LLC | 91,508 | 91,641 | +133 | 1.62 | 4.26 | +2.65 | buy |
| Arax Advisory Partners | 0 | 91 | +91 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 57 | +57 | 0.00 | 0.00 | +0.00 | buy |
| PRIVATE TRUST CO NA | 0 | 51 | +51 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 27 | 47 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| FINANCIAL CONSULATE, INC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 428 | 429 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 700 | 700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DELTEC ASSET MANAGEMENT LLC | 12,500 | 12,500 | 0 | 0.05 | 0.13 | +0.08 | hold |
| Nantahala Capital Management, LLC | 250,062 | 250,062 | 0 | 0.40 | 0.97 | +0.57 | hold |
| MetLife Investment Management, LLC | 4,260 | 4,260 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AWM Investment Company, Inc. | 69,416 | 69,416 | 0 | 0.18 | 0.41 | +0.23 | hold |
| Allworth Financial LP | 5 | 5 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 14 | 14 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vermillion & White Wealth Management Group, LLC | 88 | 88 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Frazier Life Sciences Management, L.P. | 722,400 | 722,400 | 0 | 0.65 | 1.36 | +0.71 | hold |
| Legal & General Group Plc | 755 | 755 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,013 | 21,013 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 234 | 234 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 132 | 132 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 6,066 | 6,066 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 1 | 0 | -1 | 0.00 | 0.00 | 0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 12 | 0 | -12 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 9,956 | 9,871 | -85 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 54,503 | 54,003 | -500 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,750 | 3,174 | -576 | 0.00 | 0.00 | +0.00 | sell |
| Spire Wealth Management | 2,516 | 1,016 | -1,500 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,900 | 2,800 | -2,100 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 2,426 | 276 | -2,150 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 12,179 | 9,776 | -2,403 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 4,630 | 1,404 | -3,226 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 20,911 | 17,424 | -3,487 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 173,986 | 168,110 | -5,876 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17,384 | 8,008 | -9,376 | 0.00 | 0.00 | +0.00 | sell |
| TORONTO DOMINION BANK | 17,500 | 2,500 | -15,000 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 56,290 | 40,692 | -15,598 | 0.04 | 0.10 | +0.06 | sell |
| XTX Topco Ltd | 17,701 | 0 | -17,701 | 0.02 | 0.00 | -0.02 | sell |
| Strid Group, LLC | 18,166 | 0 | -18,166 | 0.06 | 0.00 | -0.06 | sell |
| UBS Group AG | 43,149 | 20,439 | -22,710 | 0.00 | 0.00 | +0.00 | sell |
| ROYCE & ASSOCIATES LP | 74,516 | 49,509 | -25,007 | 0.02 | 0.03 | +0.01 | sell |
| Blue Owl Capital Holdings LP | 125,259 | 95,259 | -30,000 | 0.91 | 1.85 | +0.94 | sell |
| DAFNA Capital Management LLC | 43,348 | 0 | -43,348 | 0.27 | 0.00 | -0.27 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 43,994 | 0 | -43,994 | 0.03 | 0.00 | -0.03 | sell |
| SECTORAL ASSET MANAGEMENT INC | 95,615 | 49,115 | -46,500 | 1.42 | 1.90 | +0.48 | sell |
| MARSHALL WACE, LLP | 49,077 | 0 | -49,077 | 0.00 | 0.00 | -0.00 | sell |