| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 822,400 | 892,400 | +70,000 | 1.56 | 2.33 | +0.77 | buy |
| BVF INC/IL | 1,161,249 | 879,009 | -282,240 | 2.95 | 3.10 | +0.15 | sell |
| Frazier Life Sciences Management, L.P. | 722,400 | 722,400 | 0 | 1.36 | 2.03 | +0.67 | hold |
| First Light Asset Management, LLC | 541,544 | 709,141 | +167,597 | 3.20 | 5.67 | +2.47 | buy |
| VANGUARD GROUP INC | 494,656 | 560,616 | +65,960 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 487,616 | 559,065 | +71,449 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 137,251 | 420,462 | +283,211 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 34,895 | 389,420 | +354,525 | 0.07 | 1.15 | +1.08 | buy |
| JENNISON ASSOCIATES LLC | 106,910 | 387,483 | +280,573 | 0.00 | 0.02 | +0.02 | buy |
| FEDERATED HERMES, INC. | 339,047 | 368,038 | +28,991 | 0.04 | 0.06 | +0.03 | buy |
| Woodline Partners LP | 345,749 | 300,536 | -45,213 | 0.10 | 0.12 | +0.02 | sell |
| ALLIANCEBERNSTEIN L.P. | 0 | 269,027 | +269,027 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 395,093 | 266,287 | -128,806 | 0.72 | 0.51 | -0.20 | sell |
| FMR LLC | 110,446 | 231,760 | +121,314 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 138,505 | 220,662 | +82,157 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 211,553 | +211,553 | 0.00 | 0.03 | +0.03 | buy |
| MPM BioImpact LLC | 67,423 | 205,745 | +138,322 | 0.69 | 2.46 | +1.77 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 168,110 | 178,992 | +10,882 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 186,751 | 150,026 | -36,725 | 0.05 | 0.06 | +0.02 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 166,535 | 108,880 | -57,655 | 0.02 | 0.02 | +0.00 | sell |
| Samsara BioCapital, LLC | 209,634 | 104,817 | -104,817 | 1.72 | 1.13 | -0.58 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 101,748 | +101,748 | 0.00 | 0.17 | +0.17 | buy |
| GOLDMAN SACHS GROUP INC | 236,630 | 98,935 | -137,695 | 0.00 | 0.00 | -0.00 | sell |
| Clio Asset Management LLC | 91,641 | 91,642 | +1 | 4.26 | 7.45 | +3.19 | buy |
| Point72 Asset Management, L.P. | 317,309 | 77,297 | -240,012 | 0.04 | 0.01 | -0.03 | sell |
| Siren, L.L.C. | 0 | 75,000 | +75,000 | 0.00 | 0.23 | +0.23 | buy |
| AWM Investment Company, Inc. | 69,416 | 69,416 | 0 | 0.41 | 0.70 | +0.29 | hold |
| Clearbridge Investments, LLC | 0 | 60,628 | +60,628 | 0.00 | 0.01 | +0.01 | buy |
| Artia Global Partners LP | 0 | 59,200 | +59,200 | 0.00 | 1.00 | +1.00 | buy |
| NORTHERN TRUST CORP | 54,003 | 54,490 | +487 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 48,610 | 54,273 | +5,663 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 47,681 | +47,681 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 44,901 | +44,901 | 0.00 | 0.00 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 0 | 41,470 | +41,470 | 0.00 | 1.03 | +1.03 | buy |
| Blue Owl Capital Holdings LP | 95,259 | 40,259 | -55,000 | 1.85 | 1.30 | -0.55 | sell |
| UBS Group AG | 20,439 | 36,505 | +16,066 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 30,272 | +30,272 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 49,509 | 30,010 | -19,499 | 0.03 | 0.03 | +0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 25,469 | +25,469 | 0.00 | 1.43 | +1.43 | buy |
| BARCLAYS PLC | 9,776 | 25,136 | +15,360 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 89,697 | 22,530 | -67,167 | 0.01 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 23,702 | 22,403 | -1,299 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 23,838 | 22,264 | -1,574 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,013 | 21,633 | +620 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 12,705 | 19,576 | +6,871 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 19,300 | +19,300 | 0.00 | 0.58 | +0.58 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,800 | 17,315 | +14,515 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 16,185 | 16,264 | +79 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 15,734 | +15,734 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 0 | 14,200 | +14,200 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 14,124 | +14,124 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 11,932 | +11,932 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 0 | 11,719 | +11,719 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 20,722 | 11,615 | -9,107 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 17,424 | 11,429 | -5,995 | 0.00 | 0.01 | +0.00 | sell |
| Legato Capital Management LLC | 0 | 11,385 | +11,385 | 0.00 | 0.10 | +0.10 | buy |
| WELLS FARGO & COMPANY/MN | 7,346 | 10,928 | +3,582 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 12,010 | 10,452 | -1,558 | 0.14 | 0.19 | +0.05 | sell |
| ALPS ADVISORS INC | 5,486 | 9,716 | +4,230 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 9,484 | +9,484 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 8,707 | +8,707 | 0.00 | 0.05 | +0.05 | buy |
| RHUMBLINE ADVISERS | 9,871 | 8,636 | -1,235 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 429 | 6,919 | +6,490 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 6,066 | 6,594 | +528 | 0.00 | 0.00 | +0.00 | buy |
| Sigma Planning Corp | 0 | 6,500 | +6,500 | 0.00 | 0.02 | +0.02 | buy |
| BROWN ADVISORY INC | 6,379 | 6,379 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ASPIRIANT, LLC | 5,852 | 5,852 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Legal & General Group Plc | 755 | 5,849 | +5,094 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 5,813 | +5,813 | 0.00 | 0.02 | +0.02 | buy |
| Brevan Howard Capital Management LP | 0 | 5,740 | +5,740 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 4,338 | 5,006 | +668 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 4,650 | 4,650 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 4,513 | +4,513 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,174 | 4,306 | +1,132 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 4,260 | 4,260 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XTX Topco Ltd | 0 | 4,103 | +4,103 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 4,090 | 4,090 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,657 | 4,090 | +433 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 3,600 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 5,200 | 3,500 | -1,700 | 0.01 | 0.01 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 26,874 | 3,480 | -23,394 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 4,128 | 3,469 | -659 | 0.00 | 0.00 | +0.00 | sell |
| LPL Financial LLC | 0 | 3,448 | +3,448 | 0.00 | 0.00 | +0.00 | buy |
| Baader Bank Aktiengesellschaft | 0 | 3,131 | +3,131 | 0.00 | 0.03 | +0.03 | buy |
| PEAPACK GLADSTONE FINANCIAL CORP | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| CERTUITY, LLC | 0 | 3,000 | +3,000 | 0.00 | 0.02 | +0.02 | buy |
| Creative Planning | 0 | 2,963 | +2,963 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 2,617 | 2,754 | +137 | 0.01 | 0.02 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 0 | 2,698 | +2,698 | 0.00 | 0.08 | +0.08 | buy |
| SG Americas Securities, LLC | 0 | 2,689 | +2,689 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 2,636 | +2,636 | 0.00 | 0.00 | +0.00 | buy |
| Chung Wu Investment Group, LLC | 200 | 2,600 | +2,400 | 0.01 | 0.22 | +0.21 | buy |
| DELTEC ASSET MANAGEMENT LLC | 12,500 | 2,400 | -10,100 | 0.13 | 0.04 | -0.09 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 2,300 | +2,300 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 2,780 | 2,297 | -483 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 2,270 | +2,270 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 276 | 2,004 | +1,728 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 1,974 | 1,974 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 0 | 1,600 | +1,600 | 0.00 | 0.01 | +0.01 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |