| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 903,625 | 4,265,428 | +3,361,803 | 0.24 | 0.69 | +0.45 | buy |
| Vestal Point Capital, LP | 3,025,000 | 4,792,572 | +1,767,572 | 3.17 | 3.63 | +0.46 | buy |
| Aberdeen Group plc | 1,509,335 | 2,215,551 | +706,216 | 0.05 | 0.05 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 90,000 | 731,039 | +641,039 | 0.40 | 2.48 | +2.08 | buy |
| EcoR1 Capital, LLC | 3,400,000 | 3,988,971 | +588,971 | 2.27 | 2.51 | +0.24 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 834,075 | 1,190,121 | +356,046 | 0.01 | 0.01 | +0.00 | buy |
| PFM Health Sciences, LP | 283,158 | 599,967 | +316,809 | 0.31 | 0.46 | +0.15 | buy |
| Nantahala Capital Management, LLC | 2,453,364 | 2,755,962 | +302,598 | 1.86 | 1.16 | -0.70 | buy |
| Integral Health Asset Management, LLC | 1,100,000 | 1,250,000 | +150,000 | 1.66 | 1.41 | -0.25 | buy |
| Avidity Partners Management LP | 222,000 | 336,200 | +114,200 | 0.39 | 0.68 | +0.29 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 100,000 | 203,400 | +103,400 | 0.39 | 0.45 | +0.06 | buy |
| LORD, ABBETT & CO. LLC | 314,413 | 400,785 | +86,372 | 0.02 | 0.02 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 192,223 | 114,889 | +77,334 | 0.27 | 0.10 | 0.00 | sell |
| J. Goldman & Co LP | 51,110 | 128,026 | +76,916 | 0.02 | 0.03 | +0.01 | buy |
| Birchview Capital, LP | 20,000 | 88,697 | +68,697 | 0.29 | 0.82 | +0.53 | buy |
| TWO SIGMA INVESTMENTS, LP | 878,884 | 916,499 | +37,615 | 0.04 | 0.02 | 0.00 | buy |
| Woodline Partners LP | 140,631 | 175,806 | +35,175 | 0.02 | 0.01 | -0.00 | buy |
| Shay Capital LLC | 56,824 | 81,849 | +25,025 | 0.15 | 0.13 | -0.03 | buy |
| 683 Capital Management, LLC | 1,525,000 | 1,550,000 | +25,000 | 1.67 | 1.13 | -0.54 | buy |
| DIAMOND HILL CAPITAL MANAGEMENT INC | 67,320 | 82,653 | +15,333 | 0.01 | 0.00 | -0.00 | buy |
| SANDERS MORRIS HARRIS LLC | 102,104 | 114,887 | +12,783 | 0.27 | 0.18 | -0.09 | buy |
| DnB Asset Management AS | 22,028 | 25,320 | +3,292 | 0.00 | 0.00 | -0.00 | buy |
| Palumbo Wealth Management LLC | 24,749 | 25,400 | +651 | 0.16 | 0.09 | -0.07 | buy |
| China Universal Asset Management Co., Ltd. | 11,062 | 11,574 | +512 | 0.02 | 0.01 | -0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,023 | 1,248 | +225 | 0.00 | 0.00 | -0.00 | buy |
| PDT Partners, LLC | 31,098 | 31,047 | -51 | 0.05 | 0.02 | -0.03 | sell |
| Clear Harbor Asset Management, LLC | 17,000 | 13,500 | -3,500 | 0.02 | 0.01 | -0.01 | sell |
| Quinn Opportunity Partners LLC | 69,000 | 64,000 | -5,000 | 0.08 | 0.05 | -0.04 | sell |
| SECTORAL ASSET MANAGEMENT INC | 71,500 | 57,550 | -13,950 | 0.84 | 0.47 | -0.37 | sell |
| Monaco Asset Management SAM | 136,708 | 75,000 | -61,708 | 1.07 | 0.40 | -0.67 | sell |
| Parkman Healthcare Partners LLC | 275,000 | 203,833 | -71,167 | 0.65 | 0.26 | -0.39 | sell |
| Catalio Capital Management, LP | 901,973 | 830,325 | -71,648 | 3.48 | 2.18 | -1.30 | sell |
| Pale Fire Capital SE | 580,708 | 462,359 | -118,349 | 2.40 | 0.59 | -1.81 | sell |
| Privium Fund Management B.V. | 742,162 | 579,139 | -163,023 | 2.97 | 1.60 | -1.37 | sell |