| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 903,625 | 4,265,428 | +3,361,803 | 0.24 | 0.69 | +0.45 | buy |
| Vestal Point Capital, LP | 3,025,000 | 4,792,572 | +1,767,572 | 3.17 | 3.63 | +0.46 | buy |
| STATE STREET CORP | 192,533 | 1,229,589 | +1,037,056 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 12,006 | 785,320 | +773,314 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 1,509,335 | 2,215,551 | +706,216 | 0.05 | 0.05 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 90,000 | 731,039 | +641,039 | 0.40 | 2.48 | +2.08 | buy |
| EcoR1 Capital, LLC | 3,400,000 | 3,988,971 | +588,971 | 2.40 | 2.51 | +0.11 | buy |
| Sofinnova Investments, Inc. | 0 | 545,771 | +545,771 | 0.00 | 0.44 | +0.44 | buy |
| Affinity Asset Advisors, LLC | 0 | 400,000 | +400,000 | 0.00 | 0.66 | +0.66 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 834,075 | 1,190,121 | +356,046 | 0.01 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 177,179 | 500,977 | +323,798 | 0.01 | 0.02 | +0.01 | buy |
| PFM Health Sciences, LP | 283,158 | 599,967 | +316,809 | 0.38 | 0.49 | +0.11 | buy |
| BANK OF AMERICA CORP /DE/ | 69,064 | 380,852 | +311,788 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 303,632 | +303,632 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 2,453,364 | 2,755,962 | +302,598 | 3.03 | 2.42 | -0.61 | buy |
| Assenagon Asset Management S.A. | 73,571 | 334,894 | +261,323 | 0.00 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 241,684 | +241,684 | 0.00 | 0.03 | +0.03 | buy |
| FMR LLC | 966,650 | 1,200,944 | +234,294 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 79,324 | 259,637 | +180,313 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 167,659 | +167,659 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 14,587 | 178,332 | +163,745 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 1,100,000 | 1,250,000 | +150,000 | 1.72 | 1.47 | -0.25 | buy |
| Walleye Capital LLC | 130,423 | 266,726 | +136,303 | 0.02 | 0.03 | +0.01 | buy |
| Avidity Partners Management LP | 222,000 | 336,200 | +114,200 | 0.39 | 0.74 | +0.34 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 100,000 | 203,400 | +103,400 | 0.39 | 0.45 | +0.06 | buy |
| Verition Fund Management LLC | 0 | 96,534 | +96,534 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 520,553 | 610,971 | +90,418 | 0.00 | 0.00 | -0.00 | buy |
| LORD, ABBETT & CO. LLC | 314,413 | 400,785 | +86,372 | 0.02 | 0.02 | -0.00 | buy |
| CITIGROUP INC | 8,722 | 94,197 | +85,475 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 143,826 | 226,896 | +83,070 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 82,589 | +82,589 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 51,110 | 128,026 | +76,916 | 0.03 | 0.05 | +0.02 | buy |
| Birchview Capital, LP | 20,000 | 88,697 | +68,697 | 0.29 | 0.82 | +0.53 | buy |
| BARCLAYS PLC | 7,243 | 67,744 | +60,501 | 0.00 | 0.00 | +0.00 | buy |
| Main Management ETF Advisors, LLC | 0 | 55,508 | +55,508 | 0.00 | 0.03 | +0.03 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 40,300 | +40,300 | 0.00 | 0.02 | +0.02 | buy |
| Massar Capital Management, LP | 0 | 40,000 | +40,000 | 0.00 | 0.51 | +0.51 | buy |
| TWO SIGMA INVESTMENTS, LP | 878,884 | 916,499 | +37,615 | 0.04 | 0.02 | -0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 36,500 | +36,500 | 0.00 | 0.31 | +0.31 | buy |
| Woodline Partners LP | 140,631 | 175,806 | +35,175 | 0.02 | 0.01 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 28,643 | +28,643 | 0.00 | 0.03 | +0.03 | buy |
| Shay Capital LLC | 56,824 | 81,849 | +25,025 | 0.25 | 0.25 | +0.01 | buy |
| 683 Capital Management, LLC | 1,525,000 | 1,550,000 | +25,000 | 2.65 | 1.67 | -0.98 | buy |
| NOMURA HOLDINGS INC | 0 | 23,081 | +23,081 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,415,558 | 1,436,981 | +21,423 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 16,279 | 36,999 | +20,720 | 0.02 | 0.02 | -0.00 | buy |
| Caption Management, LLC | 0 | 20,359 | +20,359 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 531,830 | 549,730 | +17,900 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 16,348 | +16,348 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 21,669 | 37,396 | +15,727 | 0.00 | 0.00 | +0.00 | buy |
| DIAMOND HILL CAPITAL MANAGEMENT INC | 67,320 | 82,653 | +15,333 | 0.01 | 0.00 | -0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 14,300 | +14,300 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 23,659 | 37,772 | +14,113 | 0.01 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 14,000 | +14,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 468,357 | 481,450 | +13,093 | 0.01 | 0.00 | -0.00 | buy |
| SANDERS MORRIS HARRIS LLC | 102,104 | 114,887 | +12,783 | 0.27 | 0.18 | -0.09 | buy |
| Virtus Investment Advisers, LLC | 0 | 10,906 | +10,906 | 0.00 | 0.03 | +0.03 | buy |
| Aquatic Capital Management LLC | 0 | 10,590 | +10,590 | 0.00 | 0.00 | +0.00 | buy |
| Mraz, Amerine & Associates, Inc. | 0 | 10,019 | +10,019 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 269,980 | 279,999 | +10,019 | 0.00 | 0.00 | -0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 8,386 | +8,386 | 0.00 | 0.08 | +0.08 | buy |
| PEAK6 LLC | 18,187 | 22,057 | +3,870 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 95,591 | 98,896 | +3,305 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 22,028 | 25,320 | +3,292 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 849 | 1,547 | +698 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 24,749 | 25,400 | +651 | 0.16 | 0.09 | -0.07 | buy |
| China Universal Asset Management Co., Ltd. | 11,062 | 11,574 | +512 | 0.02 | 0.01 | -0.01 | buy |
| SIGNATUREFD, LLC | 152 | 524 | +372 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,096 | 2,456 | +360 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,023 | 1,248 | +225 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,624 | 1,809 | +185 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 63 | +63 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 70,978 | 71,027 | +49 | 0.00 | 0.00 | -0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 47 | +47 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 12,294 | 12,330 | +36 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 49,055 | 49,055 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 706,166 | 706,166 | 0 | 0.02 | 0.01 | -0.01 | hold |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 38,534 | 38,534 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 150,000 | 150,000 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Daiwa Securities Group Inc. | 158 | 158 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 234 | 234 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 164 | 164 | 0 | 0.00 | 0.00 | -0.00 | hold |
| First Horizon Advisors, Inc. | 11 | 11 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avoro Capital Advisors LLC | 2,175,000 | 2,175,000 | 0 | 0.54 | 0.36 | -0.18 | hold |
| QUADRANT CAPITAL GROUP LLC | 187 | 187 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bellevue Group AG | 22,500 | 22,500 | 0 | 0.01 | 0.01 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 109 | 109 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Versant Capital Management, Inc | 328 | 328 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Future Financial Wealth Managment LLC | 4,000 | 4,000 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Total Clarity Wealth Management, Inc. | 15,350 | 15,350 | 0 | 0.09 | 0.09 | +0.00 | hold |
| SBI Securities Co., Ltd. | 727 | 727 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Activest Wealth Management | 5,000 | 5,000 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Corient Private Wealth LLC | 10,630 | 10,630 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Marex Group plc | 80,000 | 80,000 | 0 | 0.02 | 0.02 | -0.01 | hold |
| Boxer Capital Management, LLC | 750,000 | 750,000 | 0 | 1.13 | 2.39 | +1.26 | hold |
| US BANCORP \DE\ | 676 | 676 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 1,987,688 | 1,987,688 | 0 | 0.01 | 0.01 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TOTH FINANCIAL ADVISORY CORP | 165 | 165 | 0 | 0.00 | 0.00 | -0.00 | hold |