| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 6,150,000 | 5,959,595 | -190,405 | 1.45 | 0.96 | -0.49 | sell |
| Aberdeen Group plc | 3,678,640 | 5,306,386 | +1,627,746 | 0.14 | 0.14 | +0.00 | buy |
| JPMORGAN CHASE & CO | 2,934,626 | 2,837,466 | -97,160 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,451,284 | 2,675,871 | +1,224,587 | 0.05 | 0.04 | -0.02 | buy |
| RTW INVESTMENTS, LP | 3,711,462 | 2,586,356 | -1,125,106 | 0.89 | 0.42 | -0.47 | sell |
| STATE STREET CORP | 3,231,043 | 2,260,512 | -970,531 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 737,400 | 2,136,149 | +1,398,749 | 0.36 | 0.76 | +0.40 | buy |
| FMR LLC | 6,240,936 | 1,743,808 | -4,497,128 | 0.01 | 0.00 | -0.01 | sell |
| BlackRock, Inc. | 1,974,988 | 1,733,458 | -241,530 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 1,381,628 | 1,369,231 | -12,397 | 3.78 | 1.73 | -2.05 | sell |
| Two Seas Capital LP | 0 | 1,300,000 | +1,300,000 | 0.00 | 0.98 | +0.98 | buy |
| GOLDMAN SACHS GROUP INC | 1,167,608 | 1,263,236 | +95,628 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,371,190 | 1,233,789 | -137,401 | 0.02 | 0.01 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,218,350 | 1,002,800 | -215,550 | 0.04 | 0.02 | -0.02 | sell |
| Siren, L.L.C. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.45 | +0.45 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 135,644 | 964,290 | +828,646 | 0.01 | 0.03 | +0.02 | buy |
| Integral Health Asset Management, LLC | 900,000 | 900,000 | 0 | 1.09 | 0.78 | -0.31 | hold |
| Fiera Capital Corp | 768,510 | 816,893 | +48,383 | 0.06 | 0.05 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 776,071 | 804,610 | +28,539 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 803,605 | 792,756 | -10,849 | 0.01 | 0.01 | -0.00 | sell |
| SG Americas Securities, LLC | 64,326 | 776,604 | +712,278 | 0.00 | 0.01 | +0.01 | buy |
| MAVERICK CAPITAL LTD | 661,820 | 697,640 | +35,820 | 0.17 | 0.13 | -0.04 | buy |
| Boxer Capital Management, LLC | 290,000 | 662,000 | +372,000 | 1.52 | 1.42 | -0.10 | buy |
| Whitefort Capital Management, LP | 459,000 | 657,611 | +198,611 | 3.32 | 3.27 | -0.05 | buy |
| JANE STREET GROUP, LLC | 0 | 635,995 | +635,995 | 0.00 | 0.01 | +0.01 | buy |
| First Turn Management, LLC | 321,655 | 615,489 | +293,834 | 0.88 | 1.12 | +0.24 | buy |
| Voss Capital, LP | 210,000 | 605,000 | +395,000 | 0.27 | 0.57 | +0.30 | buy |
| CITIGROUP INC | 184,765 | 531,885 | +347,120 | 0.00 | 0.01 | +0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 521,677 | 521,677 | 0 | 1.11 | 0.72 | -0.38 | hold |
| READYSTATE ASSET MANAGEMENT LP | 361,560 | 504,702 | +143,142 | 0.38 | 0.48 | +0.10 | buy |
| 683 Capital Management, LLC | 384,950 | 500,000 | +115,050 | 0.77 | 0.76 | -0.01 | buy |
| Catalio Capital Management, LP | 288,345 | 491,116 | +202,771 | 1.22 | 1.68 | +0.46 | buy |
| UBS Group AG | 491,454 | 487,838 | -3,616 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management B.V. | 416,270 | 486,520 | +70,250 | 1.83 | 1.66 | -0.18 | buy |
| FRANKLIN RESOURCES INC | 746,602 | 480,866 | -265,736 | 0.00 | 0.00 | -0.00 | sell |
| MAK CAPITAL ONE LLC | 0 | 441,205 | +441,205 | 0.00 | 1.19 | +1.19 | buy |
| ExodusPoint Capital Management, LP | 73,775 | 436,467 | +362,692 | 0.02 | 0.07 | +0.05 | buy |
| Massar Capital Management, LP | 40,529 | 426,029 | +385,500 | 0.19 | 1.39 | +1.20 | buy |
| CITADEL ADVISORS LLC | 469,300 | 404,565 | -64,735 | 0.01 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 362,878 | 375,852 | +12,974 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 716,927 | 366,117 | -350,810 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 0 | 358,996 | +358,996 | 0.00 | 0.16 | +0.16 | buy |
| Squarepoint Ops LLC | 176,000 | 345,983 | +169,983 | 0.01 | 0.01 | +0.00 | buy |
| Caption Management, LLC | 177,277 | 303,231 | +125,954 | 0.19 | 0.24 | +0.05 | buy |
| Engineers Gate Manager LP | 43,356 | 299,757 | +256,401 | 0.01 | 0.06 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 329,525 | 246,851 | -82,674 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 699,298 | 237,078 | -462,220 | 1.00 | 0.24 | -0.76 | sell |
| SIMPLEX TRADING, LLC | 110,675 | 231,769 | +121,094 | 0.07 | 0.12 | +0.04 | buy |
| Parkman Healthcare Partners LLC | 257,382 | 206,842 | -50,540 | 0.59 | 0.35 | -0.24 | sell |
| GROUP ONE TRADING LLC | 0 | 179,000 | +179,000 | 0.00 | 0.10 | +0.10 | buy |
| NORTHERN TRUST CORP | 168,820 | 169,959 | +1,139 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 209,790 | 167,732 | -42,058 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 131,956 | 160,714 | +28,758 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 125,500 | 158,500 | +33,000 | 0.02 | 0.02 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 147,549 | 147,549 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Assenagon Asset Management S.A. | 606,923 | 146,749 | -460,174 | 0.02 | 0.00 | -0.02 | sell |
| Susquehanna Portfolio Strategies, LLC | 28,708 | 138,969 | +110,261 | 0.01 | 0.03 | +0.02 | buy |
| MARSHALL WACE, LLP | 21,159 | 122,736 | +101,577 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 75,000 | 122,222 | +47,222 | 0.04 | 0.07 | +0.04 | buy |
| Tejara Capital Ltd | 42,000 | 122,092 | +80,092 | 0.42 | 0.66 | +0.24 | buy |
| K2 PRINCIPAL FUND, L.P. | 0 | 118,600 | +118,600 | 0.00 | 0.20 | +0.20 | buy |
| NAN FUNG TRINITY (HK) Ltd | 115,494 | 115,494 | 0 | 0.22 | 0.21 | -0.01 | hold |
| Y-Intercept (Hong Kong) Ltd | 45,778 | 113,952 | +68,174 | 0.02 | 0.04 | +0.01 | buy |
| Pekin Hardy Strauss, Inc. | 29,300 | 112,575 | +83,275 | 0.06 | 0.19 | +0.13 | buy |
| Brevan Howard Capital Management LP | 0 | 108,632 | +108,632 | 0.00 | 0.02 | +0.02 | buy |
| ROYAL BANK OF CANADA | 85,640 | 107,888 | +22,248 | 0.00 | 0.00 | -0.00 | buy |
| Propel Bio Management, LLC | 0 | 104,772 | +104,772 | 0.00 | 1.08 | +1.08 | buy |
| WELLS FARGO & COMPANY/MN | 70,236 | 103,446 | +33,210 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 30,789 | 100,697 | +69,908 | 0.43 | 0.94 | +0.51 | buy |
| Irenic Capital Management LP | 0 | 100,000 | +100,000 | 0.00 | 0.15 | +0.15 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 99,593 | 96,559 | -3,034 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 30,448 | 91,615 | +61,167 | 0.02 | 0.03 | +0.02 | buy |
| Ikarian Capital, LLC | 91,060 | 91,060 | 0 | 0.28 | 0.21 | -0.07 | hold |
| Rafferty Asset Management, LLC | 164,937 | 90,277 | -74,660 | 0.01 | 0.01 | -0.01 | sell |
| Walleye Capital LLC | 78,996 | 88,479 | +9,483 | 0.01 | 0.01 | -0.00 | buy |
| Newtyn Management, LLC | 0 | 87,684 | +87,684 | 0.00 | 0.15 | +0.15 | buy |
| Clearline Capital LP | 83,681 | 83,681 | 0 | 0.15 | 0.11 | -0.04 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 80,249 | 82,633 | +2,384 | 0.00 | 0.00 | -0.00 | buy |
| Marex Group plc | 85,993 | 80,013 | -5,980 | 0.02 | 0.01 | -0.01 | sell |
| Swiss National Bank | 79,000 | 79,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STEMPOINT CAPITAL LP | 43,485 | 78,066 | +34,581 | 0.18 | 0.25 | +0.07 | buy |
| Cinctive Capital Management LP | 0 | 77,345 | +77,345 | 0.00 | 0.08 | +0.08 | buy |
| ADAR1 Capital Management, LLC | 235,155 | 76,206 | -158,949 | 0.42 | 0.07 | -0.35 | sell |
| Senvest Management, LLC | 50,000 | 72,300 | +22,300 | 0.04 | 0.04 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 67,739 | 68,547 | +808 | 0.06 | 0.04 | -0.02 | buy |
| Shay Capital LLC | 41,073 | 67,527 | +26,454 | 0.16 | 0.16 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 70,796 | 57,133 | -13,663 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 55,015 | 55,015 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DCF Advisers, LLC | 0 | 49,000 | +49,000 | 0.00 | 0.30 | +0.30 | buy |
| Schonfeld Strategic Advisors LLC | 122,529 | 48,824 | -73,705 | 0.01 | 0.01 | -0.01 | sell |
| STIFEL FINANCIAL CORP | 45,987 | 47,084 | +1,097 | 0.00 | 0.00 | -0.00 | buy |
| IMC-Chicago, LLC | 0 | 45,080 | +45,080 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 43,309 | 42,914 | -395 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44,250 | 42,836 | -1,414 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 39,499 | 42,635 | +3,136 | 0.10 | 0.07 | -0.02 | buy |
| PROFUND ADVISORS LLC | 59,463 | 39,350 | -20,113 | 0.04 | 0.02 | -0.02 | sell |
| RAYMOND JAMES FINANCIAL INC | 0 | 36,756 | +36,756 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,947 | 35,947 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MONIMUS CAPITAL MANAGEMENT, LP | 25,878 | 34,427 | +8,549 | 0.41 | 0.16 | -0.25 | buy |
| DIAMOND HILL CAPITAL MANAGEMENT INC | 33,333 | 33,333 | 0 | 0.00 | 0.00 | -0.00 | hold |