| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 2,175,000 | 3,625,000 | +1,450,000 | 0.36 | 0.88 | +0.53 | buy |
| Sofinnova Investments, Inc. | 545,771 | 1,558,356 | +1,012,585 | 0.38 | 1.33 | +0.95 | buy |
| RTW INVESTMENTS, LP | 4,265,428 | 5,158,231 | +892,803 | 0.69 | 1.02 | +0.33 | buy |
| Aberdeen Group plc | 2,215,551 | 2,750,714 | +535,163 | 0.05 | 0.07 | +0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,190,121 | 693,283 | +496,838 | 0.01 | 0.01 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 203,833 | 443,422 | +239,589 | 0.26 | 0.72 | +0.46 | buy |
| Boxer Capital Management, LLC | 750,000 | 899,500 | +149,500 | 2.39 | 6.31 | +3.92 | buy |
| Integral Health Asset Management, LLC | 1,250,000 | 1,350,000 | +100,000 | 1.47 | 1.76 | +0.29 | buy |
| Pale Fire Capital SE | 462,359 | 529,798 | +67,439 | 0.59 | 0.77 | +0.18 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 114,889 | 63,475 | +51,414 | 0.10 | 0.05 | 0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 150,000 | 175,000 | +25,000 | 0.03 | 0.03 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 916,499 | 940,960 | +24,461 | 0.02 | 0.03 | 0.00 | buy |
| Shay Capital LLC | 81,849 | 99,383 | +17,534 | 0.25 | 0.32 | +0.06 | buy |
| Birchview Capital, LP | 88,697 | 98,697 | +10,000 | 0.82 | 1.37 | +0.55 | buy |
| Main Management ETF Advisors, LLC | 55,508 | 56,420 | +912 | 0.03 | 0.03 | +0.00 | buy |
| DnB Asset Management AS | 25,320 | 25,159 | -161 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,574 | 10,996 | -578 | 0.01 | 0.01 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 203,400 | 202,565 | -835 | 0.45 | 0.58 | +0.13 | sell |
| Clear Harbor Asset Management, LLC | 13,500 | 12,250 | -1,250 | 0.01 | 0.01 | +0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 57,550 | 55,450 | -2,100 | 0.47 | 0.51 | +0.04 | sell |
| PROFUND ADVISORS LLC | 16,348 | 13,716 | -2,632 | 0.01 | 0.01 | -0.00 | sell |
| Bellevue Group AG | 22,500 | 19,610 | -2,890 | 0.01 | 0.01 | +0.00 | sell |
| Total Clarity Wealth Management, Inc. | 15,350 | 12,450 | -2,900 | 0.09 | 0.05 | -0.04 | sell |
| Monaco Asset Management SAM | 75,000 | 70,000 | -5,000 | 0.40 | 0.37 | -0.03 | sell |
| Virtus Investment Advisers, LLC | 10,906 | 5,881 | -5,025 | 0.03 | 0.03 | -0.00 | sell |
| Rafferty Asset Management, LLC | 82,589 | 68,807 | -13,782 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 336,200 | 207,000 | -129,200 | 0.74 | 0.58 | -0.16 | sell |
| Privium Fund Management B.V. | 579,139 | 447,486 | -131,653 | 1.60 | 1.35 | -0.25 | sell |
| STEMPOINT CAPITAL LP | 731,039 | 572,615 | -158,424 | 2.48 | 2.57 | +0.09 | sell |
| Affinity Asset Advisors, LLC | 400,000 | 135,000 | -265,000 | 0.66 | 0.28 | -0.39 | sell |
| 683 Capital Management, LLC | 1,550,000 | 1,285,000 | -265,000 | 1.13 | 1.18 | +0.04 | sell |
| Catalio Capital Management, LP | 830,325 | 417,443 | -412,882 | 2.18 | 1.22 | -0.96 | sell |
| PFM Health Sciences, LP | 599,967 | 174,331 | -425,636 | 0.46 | 0.21 | -0.25 | sell |
| Nantahala Capital Management, LLC | 2,755,962 | 2,051,852 | -704,110 | 1.16 | 1.12 | -0.04 | sell |
| Vestal Point Capital, LP | 4,792,572 | 3,700,000 | -1,092,572 | 3.63 | 2.72 | -0.91 | sell |