| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 4,265,428 | 5,158,231 | +892,803 | 0.69 | 1.02 | +0.33 | buy |
| EcoR1 Capital, LLC | 3,988,971 | 3,988,971 | 0 | 2.51 | 3.30 | +0.78 | hold |
| Vestal Point Capital, LP | 4,792,572 | 3,700,000 | -1,092,572 | 3.63 | 2.72 | -0.91 | sell |
| Avoro Capital Advisors LLC | 2,175,000 | 3,625,000 | +1,450,000 | 0.36 | 0.88 | +0.53 | buy |
| Aberdeen Group plc | 2,215,551 | 2,750,714 | +535,163 | 0.05 | 0.07 | +0.02 | buy |
| Jefferies Financial Group Inc. | 0 | 2,095,931 | +2,095,931 | 0.00 | 0.48 | +0.48 | buy |
| Nantahala Capital Management, LLC | 2,755,962 | 2,051,852 | -704,110 | 2.42 | 2.02 | -0.39 | sell |
| JPMORGAN CHASE & CO | 316,199 | 1,807,685 | +1,491,486 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,987,688 | 1,605,515 | -382,173 | 0.01 | 0.01 | -0.00 | sell |
| Sofinnova Investments, Inc. | 545,771 | 1,558,356 | +1,012,585 | 0.44 | 1.48 | +1.04 | buy |
| Integral Health Asset Management, LLC | 1,250,000 | 1,350,000 | +100,000 | 1.47 | 1.76 | +0.29 | buy |
| BlackRock, Inc. | 1,436,981 | 1,333,663 | -103,318 | 0.00 | 0.00 | +0.00 | sell |
| 683 Capital Management, LLC | 1,550,000 | 1,285,000 | -265,000 | 1.67 | 1.82 | +0.15 | sell |
| FMR LLC | 1,200,944 | 1,184,362 | -16,582 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 1,229,589 | 1,142,810 | -86,779 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 945,466 | 972,691 | +27,225 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 916,499 | 940,960 | +24,461 | 0.02 | 0.02 | +0.00 | buy |
| MORGAN STANLEY | 603,516 | 908,283 | +304,767 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 750,000 | 899,500 | +149,500 | 2.39 | 6.31 | +3.92 | buy |
| AMERIPRISE FINANCIAL INC | 549,730 | 761,948 | +212,218 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 706,166 | 706,166 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,190,121 | 693,283 | -496,838 | 0.01 | 0.01 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 668,494 | 659,700 | -8,794 | 0.02 | 0.02 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 610,971 | 603,210 | -7,761 | 0.00 | 0.00 | +0.00 | sell |
| STEMPOINT CAPITAL LP | 731,039 | 572,615 | -158,424 | 2.48 | 2.57 | +0.09 | sell |
| CITADEL ADVISORS LLC | 785,320 | 555,865 | -229,455 | 0.01 | 0.01 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 24,928 | 536,968 | +512,040 | 0.00 | 0.02 | +0.02 | buy |
| Pale Fire Capital SE | 462,359 | 529,798 | +67,439 | 0.59 | 0.77 | +0.18 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 481,450 | 503,672 | +22,222 | 0.00 | 0.01 | +0.00 | buy |
| Privium Fund Management B.V. | 579,139 | 447,486 | -131,653 | 1.60 | 1.35 | -0.25 | sell |
| Parkman Healthcare Partners LLC | 203,833 | 443,422 | +239,589 | 0.26 | 0.72 | +0.46 | buy |
| Catalio Capital Management, LP | 830,325 | 417,443 | -412,882 | 2.18 | 1.22 | -0.96 | sell |
| ROYAL BANK OF CANADA | 49,331 | 391,614 | +342,283 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 259,637 | 356,463 | +96,826 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 348,328 | +348,328 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 279,999 | 292,931 | +12,932 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 226,896 | 263,668 | +36,772 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 59,230 | 222,979 | +163,749 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 336,200 | 207,000 | -129,200 | 0.74 | 0.58 | -0.16 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 203,400 | 202,565 | -835 | 0.45 | 0.58 | +0.13 | sell |
| Caption Management, LLC | 20,359 | 176,911 | +156,552 | 0.01 | 0.23 | +0.22 | buy |
| Squarepoint Ops LLC | 178,332 | 176,002 | -2,330 | 0.00 | 0.01 | +0.00 | sell |
| Woodline Partners LP | 175,806 | 175,806 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 150,000 | 175,000 | +25,000 | 0.05 | 0.05 | -0.00 | buy |
| PFM Health Sciences, LP | 599,967 | 174,331 | -425,636 | 0.49 | 0.21 | -0.28 | sell |
| Invesco Ltd. | 485,305 | 166,799 | -318,506 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 151,700 | 148,182 | -3,518 | 0.01 | 0.01 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 380,852 | 141,810 | -239,042 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 0 | 140,060 | +140,060 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 400,000 | 135,000 | -265,000 | 0.66 | 0.28 | -0.39 | sell |
| Schonfeld Strategic Advisors LLC | 42,147 | 134,948 | +92,801 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 265,666 | 132,664 | -133,002 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 98,896 | 125,685 | +26,789 | 0.00 | 0.00 | +0.00 | buy |
| Voss Capital, LP | 0 | 125,000 | +125,000 | 0.00 | 0.12 | +0.12 | buy |
| Ikarian Capital, LLC | 0 | 119,986 | +119,986 | 0.00 | 0.55 | +0.55 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 110,576 | +110,576 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 303,632 | 106,490 | -197,142 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 130,075 | 105,939 | -24,136 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 81,849 | 99,383 | +17,534 | 0.25 | 0.32 | +0.06 | buy |
| Birchview Capital, LP | 88,697 | 98,697 | +10,000 | 0.82 | 1.37 | +0.55 | buy |
| SG Americas Securities, LLC | 0 | 94,759 | +94,759 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 96,534 | 92,591 | -3,943 | 0.01 | 0.01 | +0.00 | sell |
| BARCLAYS PLC | 67,744 | 89,014 | +21,270 | 0.00 | 0.00 | +0.00 | buy |
| DIAMOND HILL CAPITAL MANAGEMENT INC | 82,653 | 82,653 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Swiss National Bank | 0 | 77,500 | +77,500 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 77,495 | +77,495 | 0.00 | 0.05 | +0.05 | buy |
| Monaco Asset Management SAM | 75,000 | 70,000 | -5,000 | 0.40 | 0.37 | -0.03 | sell |
| Rafferty Asset Management, LLC | 82,589 | 68,807 | -13,782 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 49,055 | 67,260 | +18,205 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 55,768 | 66,981 | +11,213 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 47,524 | 64,259 | +16,735 | 0.02 | 0.02 | +0.01 | buy |
| GROUP ONE TRADING LLC | 3,545 | 63,681 | +60,136 | 0.00 | 0.03 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 114,889 | 63,475 | -51,414 | 0.03 | 0.02 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 62,538 | +62,538 | 0.00 | 0.02 | +0.02 | buy |
| Main Management ETF Advisors, LLC | 55,508 | 56,420 | +912 | 0.03 | 0.03 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 57,550 | 55,450 | -2,100 | 0.47 | 0.51 | +0.04 | sell |
| JANE STREET GROUP, LLC | 37,396 | 50,430 | +13,034 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 50,000 | +50,000 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,347 | 48,283 | +6,936 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 10,496 | 42,444 | +31,948 | 0.01 | 0.07 | +0.06 | buy |
| RAYMOND JAMES FINANCIAL INC | 42,186 | 40,289 | -1,897 | 0.00 | 0.00 | +0.00 | sell |
| Massar Capital Management, LP | 40,000 | 40,000 | 0 | 0.51 | 0.42 | -0.09 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 38,707 | +38,707 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 38,534 | 38,534 | 0 | 0.01 | 0.01 | +0.01 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,027 | 37,213 | -33,814 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 0 | 35,621 | +35,621 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 10,590 | 35,262 | +24,672 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 37,772 | 33,612 | -4,160 | 0.01 | 0.01 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 0 | 30,369 | +30,369 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 28,420 | +28,420 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 27,904 | +27,904 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 27,531 | +27,531 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 25,320 | 25,159 | -161 | 0.00 | 0.00 | +0.00 | sell |
| Militia Capital Partners, LP | 0 | 22,200 | +22,200 | 0.00 | 0.15 | +0.15 | buy |
| CITIGROUP INC | 94,197 | 20,482 | -73,715 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 19,850 | +19,850 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,456 | 19,804 | +17,348 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 22,500 | 19,610 | -2,890 | 0.01 | 0.01 | +0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 19,340 | +19,340 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 16,900 | +16,900 | 0.00 | 0.00 | +0.00 | buy |