| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 5,959,595 | 6,727,777 | +768,182 | 0.96 | 2.78 | +1.82 | buy |
| JPMORGAN CHASE & CO | 2,837,466 | 4,867,755 | +2,030,289 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 2,586,356 | 3,941,572 | +1,355,216 | 0.42 | 1.55 | +1.13 | buy |
| STATE STREET CORP | 2,260,512 | 2,903,825 | +643,313 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 5,306,386 | 2,848,117 | -2,458,269 | 0.14 | 0.18 | +0.04 | sell |
| BlackRock, Inc. | 1,733,458 | 1,877,453 | +143,995 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,136,149 | 1,807,486 | -328,663 | 0.76 | 1.58 | +0.82 | sell |
| JANE STREET GROUP, LLC | 635,995 | 1,610,483 | +974,488 | 0.01 | 0.05 | +0.04 | buy |
| JENNISON ASSOCIATES LLC | 1,233,789 | 1,561,412 | +327,623 | 0.01 | 0.04 | +0.03 | buy |
| Boxer Capital Management, LLC | 662,000 | 1,503,300 | +841,300 | 1.42 | 5.21 | +3.79 | buy |
| GOLDMAN SACHS GROUP INC | 1,263,236 | 1,475,956 | +212,720 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,675,871 | 1,462,024 | -1,213,847 | 0.04 | 0.05 | +0.01 | sell |
| Two Seas Capital LP | 1,300,000 | 1,441,410 | +141,410 | 0.98 | 2.53 | +1.55 | buy |
| FMR LLC | 1,743,808 | 1,270,068 | -473,740 | 0.00 | 0.00 | +0.00 | sell |
| MAK CAPITAL ONE LLC | 441,205 | 1,232,051 | +790,846 | 1.19 | 7.95 | +6.76 | buy |
| MPM BioImpact LLC | 1,369,231 | 1,225,855 | -143,376 | 1.73 | 3.44 | +1.71 | sell |
| MORGAN STANLEY | 366,117 | 1,066,639 | +700,522 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 358,996 | 935,000 | +576,004 | 0.16 | 1.01 | +0.84 | buy |
| MAVERICK CAPITAL LTD | 697,640 | 925,383 | +227,743 | 0.13 | 0.38 | +0.25 | buy |
| CITADEL ADVISORS LLC | 404,565 | 910,338 | +505,773 | 0.00 | 0.02 | +0.02 | buy |
| Fiera Capital Corp | 816,893 | 909,141 | +92,248 | 0.05 | 0.15 | +0.11 | buy |
| Integral Health Asset Management, LLC | 900,000 | 900,000 | 0 | 0.78 | 1.70 | +0.92 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 804,610 | 860,631 | +56,021 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 804,594 | +804,594 | 0.00 | 1.07 | +1.07 | buy |
| Invesco Ltd. | 0 | 627,823 | +627,823 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 615,489 | 608,925 | -6,564 | 1.12 | 3.00 | +1.88 | sell |
| Point72 Asset Management, L.P. | 0 | 606,212 | +606,212 | 0.00 | 0.04 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 964,290 | 586,582 | -377,708 | 0.03 | 0.05 | +0.02 | sell |
| Kinetic Partners Management, LP | 0 | 581,000 | +581,000 | 0.00 | 0.64 | +0.64 | buy |
| BANK OF AMERICA CORP /DE/ | 246,851 | 578,786 | +331,935 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 500,000 | 575,000 | +75,000 | 0.76 | 2.44 | +1.68 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 530,979 | +530,979 | 0.00 | 0.25 | +0.25 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 521,677 | 521,677 | 0 | 0.72 | 1.32 | +0.59 | hold |
| Assenagon Asset Management S.A. | 146,749 | 513,530 | +366,781 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,002,800 | 496,897 | -505,903 | 0.02 | 0.02 | -0.00 | sell |
| UBS Group AG | 487,838 | 467,571 | -20,267 | 0.00 | 0.00 | +0.00 | sell |
| Nantahala Capital Management, LLC | 237,078 | 455,660 | +218,582 | 0.24 | 1.27 | +1.03 | buy |
| Voss Capital, LP | 605,000 | 450,361 | -154,639 | 0.57 | 1.04 | +0.47 | sell |
| Rubric Capital Management LP | 0 | 408,581 | +408,581 | 0.00 | 0.17 | +0.17 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 403,338 | +403,338 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 375,852 | 403,338 | +27,486 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 504,702 | 400,989 | -103,713 | 0.48 | 0.75 | +0.27 | sell |
| MILLENNIUM MANAGEMENT LLC | 792,756 | 343,126 | -449,630 | 0.01 | 0.01 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 328,889 | +328,889 | 0.00 | 0.06 | +0.06 | buy |
| Privium Fund Management B.V. | 486,520 | 328,322 | -158,198 | 1.66 | 2.78 | +1.12 | sell |
| ADAR1 Capital Management, LLC | 76,206 | 324,672 | +248,466 | 0.07 | 0.70 | +0.63 | buy |
| MARSHALL WACE, LLP | 122,736 | 304,702 | +181,966 | 0.00 | 0.01 | +0.01 | buy |
| BRAIDWELL LP | 0 | 301,652 | +301,652 | 0.00 | 0.51 | +0.51 | buy |
| Squarepoint Ops LLC | 345,983 | 280,300 | -65,683 | 0.01 | 0.03 | +0.01 | sell |
| FRANKLIN RESOURCES INC | 480,866 | 245,272 | -235,594 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 147,549 | 244,238 | +96,689 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 169,959 | 212,935 | +42,976 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 206,842 | 208,170 | +1,328 | 0.35 | 0.98 | +0.63 | buy |
| D. E. Shaw & Co., Inc. | 160,714 | 207,629 | +46,915 | 0.00 | 0.01 | +0.00 | buy |
| Diametric Capital, LP | 18,395 | 197,242 | +178,847 | 0.08 | 0.97 | +0.89 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 181,215 | +181,215 | 0.00 | 0.08 | +0.08 | buy |
| Affinity Asset Advisors, LLC | 0 | 175,000 | +175,000 | 0.00 | 0.39 | +0.39 | buy |
| Trexquant Investment LP | 0 | 171,149 | +171,149 | 0.00 | 0.05 | +0.05 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 168,000 | +168,000 | 0.00 | 0.12 | +0.12 | buy |
| Freshford Capital Management, LLC | 0 | 161,855 | +161,855 | 0.00 | 2.55 | +2.55 | buy |
| AMERIPRISE FINANCIAL INC | 57,133 | 152,343 | +95,210 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.35 | +0.35 | buy |
| WELLS FARGO & COMPANY/MN | 103,446 | 149,971 | +46,525 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 68,547 | 142,113 | +73,566 | 0.04 | 0.19 | +0.15 | buy |
| HRT FINANCIAL LP | 0 | 135,641 | +135,641 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 531,885 | 127,944 | -403,941 | 0.01 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 96,559 | 126,576 | +30,017 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 107,888 | 124,293 | +16,405 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 138,969 | 121,869 | -17,100 | 0.03 | 0.09 | +0.06 | sell |
| Hudson Bay Capital Management LP | 158,500 | 120,000 | -38,500 | 0.02 | 0.03 | +0.01 | sell |
| NAN FUNG TRINITY (HK) Ltd | 115,494 | 115,494 | 0 | 0.21 | 0.53 | +0.32 | hold |
| SIMPLEX TRADING, LLC | 231,769 | 110,219 | -121,550 | 0.12 | 0.13 | +0.02 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 105,000 | +105,000 | 0.00 | 0.54 | +0.54 | buy |
| Ghisallo Capital Management LLC | 0 | 100,000 | +100,000 | 0.00 | 0.09 | +0.09 | buy |
| LORD, ABBETT & CO. LLC | 0 | 95,322 | +95,322 | 0.00 | 0.01 | +0.01 | buy |
| Pekin Hardy Strauss, Inc. | 112,575 | 94,250 | -18,325 | 0.19 | 0.38 | +0.19 | sell |
| Swiss National Bank | 79,000 | 94,100 | +15,100 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 78,066 | 88,115 | +10,049 | 0.25 | 0.70 | +0.46 | buy |
| FourWorld Capital Management LLC | 0 | 87,000 | +87,000 | 0.00 | 4.63 | +4.63 | buy |
| Marex Group plc | 80,013 | 81,500 | +1,487 | 0.01 | 0.03 | +0.01 | buy |
| Exome Asset Management LLC | 0 | 81,056 | +81,056 | 0.00 | 2.30 | +2.30 | buy |
| K2 PRINCIPAL FUND, L.P. | 118,600 | 78,601 | -39,999 | 0.20 | 0.33 | +0.13 | sell |
| Alyeska Investment Group, L.P. | 0 | 75,000 | +75,000 | 0.00 | 0.01 | +0.01 | buy |
| Burkehill Global Management, LP | 0 | 75,000 | +75,000 | 0.00 | 0.12 | +0.12 | buy |
| FRED ALGER MANAGEMENT, LLC | 21,655 | 69,561 | +47,906 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,836 | 67,428 | +24,592 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 66,665 | +66,665 | 0.00 | 0.04 | +0.04 | buy |
| Rafferty Asset Management, LLC | 90,277 | 66,438 | -23,839 | 0.01 | 0.01 | +0.00 | sell |
| Russell Investments Group, Ltd. | 10,656 | 62,276 | +51,620 | 0.00 | 0.00 | +0.00 | buy |
| Massar Capital Management, LP | 426,029 | 61,314 | -364,715 | 1.39 | 0.97 | -0.42 | sell |
| Holocene Advisors, LP | 0 | 59,856 | +59,856 | 0.00 | 0.01 | +0.01 | buy |
| Clearline Capital LP | 83,681 | 58,055 | -25,626 | 0.11 | 0.17 | +0.07 | sell |
| Engineers Gate Manager LP | 299,757 | 56,064 | -243,693 | 0.06 | 0.03 | -0.03 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,947 | 52,611 | +16,664 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 88,479 | 51,225 | -37,254 | 0.01 | 0.01 | +0.00 | sell |
| MONIMUS CAPITAL MANAGEMENT, LP | 34,427 | 51,066 | +16,639 | 0.16 | 0.60 | +0.44 | buy |
| Birchview Capital, LP | 100,697 | 50,697 | -50,000 | 0.94 | 1.09 | +0.15 | sell |
| Monashee Investment Management LLC | 0 | 45,000 | +45,000 | 0.00 | 3.48 | +3.48 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 42,716 | +42,716 | 0.00 | 0.00 | +0.00 | buy |
| Senvest Management, LLC | 72,300 | 42,300 | -30,000 | 0.04 | 0.06 | +0.02 | sell |