| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 2,586,356 | 3,941,572 | +1,355,216 | 0.42 | 1.55 | +1.13 | buy |
| MAK CAPITAL ONE LLC | 441,205 | 1,232,051 | +790,846 | 1.19 | 7.95 | +6.76 | buy |
| CITADEL ADVISORS LLC | 404,565 | 910,338 | +505,773 | 0.00 | 0.02 | +0.02 | buy |
| Assenagon Asset Management S.A. | 146,749 | 513,530 | +366,781 | 0.00 | 0.03 | +0.03 | buy |
| Nantahala Capital Management, LLC | 237,078 | 455,660 | +218,582 | 0.24 | 1.27 | +1.03 | buy |
| MARSHALL WACE, LLP | 122,736 | 304,702 | +181,966 | 0.00 | 0.01 | +0.01 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 181,215 | +181,215 | 0.00 | 0.08 | +0.08 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 168,000 | +168,000 | 0.00 | 0.12 | +0.12 | buy |
| Freshford Capital Management, LLC | 0 | 161,855 | +161,855 | 0.00 | 2.55 | +2.55 | buy |
| Casdin Capital, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.35 | +0.35 | buy |
| HRT FINANCIAL LP | 0 | 135,641 | +135,641 | 0.00 | 0.01 | +0.01 | buy |
| Fiera Capital Corp | 816,893 | 909,141 | +92,248 | 0.05 | 0.15 | +0.11 | buy |
| 683 Capital Management, LLC | 500,000 | 575,000 | +75,000 | 0.76 | 2.44 | +1.68 | buy |
| Alyeska Investment Group, L.P. | 0 | 75,000 | +75,000 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 804,610 | 860,631 | +56,021 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 160,714 | 207,629 | +46,915 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 42,716 | +42,716 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 32,229 | +32,229 | 0.00 | 0.11 | +0.11 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 96,559 | 126,576 | +30,017 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 25,420 | +25,420 | 0.00 | 0.00 | +0.00 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 25,000 | +25,000 | 0.00 | 0.27 | +0.27 | buy |
| ALGERT GLOBAL LLC | 0 | 22,980 | +22,980 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,947 | 52,611 | +16,664 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 107,888 | 124,293 | +16,405 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 16,296 | +16,296 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 79,000 | 94,100 | +15,100 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 15,042 | +15,042 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 14,489 | +14,489 | 0.00 | 0.02 | +0.02 | buy |
| NATIXIS ADVISORS, LLC | 0 | 12,899 | +12,899 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 15,909 | 27,935 | +12,026 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 10,468 | +10,468 | 0.00 | 0.03 | +0.03 | buy |
| Orion Porfolio Solutions, LLC | 13,494 | 23,736 | +10,242 | 0.00 | 0.01 | +0.01 | buy |
| Atria Investments, Inc | 0 | 9,822 | +9,822 | 0.00 | 0.00 | +0.00 | buy |
| Financial Engines Advisors L.L.C. | 0 | 8,863 | +8,863 | 0.00 | 0.00 | +0.00 | buy |
| Mraz, Amerine & Associates, Inc. | 0 | 8,465 | +8,465 | 0.00 | 0.06 | +0.06 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 0 | 7,736 | +7,736 | 0.00 | 0.00 | +0.00 | buy |
| SCS Capital Management LLC | 0 | 6,164 | +6,164 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 6,000 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| Ballentine Partners, LLC | 0 | 5,462 | +5,462 | 0.00 | 0.00 | +0.00 | buy |
| PEAK6 LLC | 3,039 | 6,047 | +3,008 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Trading LLC | 14,435 | 16,952 | +2,517 | 0.00 | 0.01 | +0.01 | buy |
| Arizona State Retirement System | 10,998 | 12,940 | +1,942 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 1,623 | +1,623 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 11,933 | 13,502 | +1,569 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 13,685 | 15,164 | +1,479 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 7,903 | 9,070 | +1,167 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 30 | 487 | +457 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,564 | 18,978 | +414 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 91 | 278 | +187 | 0.00 | 0.00 | +0.00 | buy |
| Transamerica Financial Advisors, LLC | 109 | 202 | +93 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 15,520 | 15,520 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AdvisorNet Financial, Inc | 214 | 214 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 206 | 206 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MAI Capital Management | 32 | 0 | -32 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 53 | 0 | -53 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 393 | 0 | -393 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 3,249 | 2,821 | -428 | 0.00 | 0.00 | +0.00 | sell |
| Sigma Planning Corp | 16,900 | 16,400 | -500 | 0.01 | 0.02 | +0.01 | sell |
| Ensign Peak Advisors, Inc | 3,650 | 2,700 | -950 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 8,734 | 6,244 | -2,490 | 0.00 | 0.00 | +0.00 | sell |
| Rangeley Capital, LLC | 13,000 | 10,000 | -3,000 | 0.23 | 0.43 | +0.20 | sell |
| Clear Harbor Asset Management, LLC | 9,400 | 4,300 | -5,100 | 0.01 | 0.01 | +0.00 | sell |
| PROFUND ADVISORS LLC | 39,350 | 32,331 | -7,019 | 0.02 | 0.04 | +0.02 | sell |
| Tower Research Capital LLC (TRC) | 7,778 | 461 | -7,317 | 0.00 | 0.00 | -0.00 | sell |
| Handelsbanken Fonder AB | 14,900 | 0 | -14,900 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 14,900 | 0 | -14,900 | 0.00 | 0.00 | -0.00 | sell |
| DIAMOND HILL CAPITAL MANAGEMENT INC | 33,333 | 17,463 | -15,870 | 0.00 | 0.01 | +0.00 | sell |
| Graham Capital Management, L.P. | 15,871 | 0 | -15,871 | 0.01 | 0.00 | -0.01 | sell |
| PFM Health Sciences, LP | 42,635 | 26,396 | -16,239 | 0.07 | 0.11 | +0.03 | sell |
| Pekin Hardy Strauss, Inc. | 112,575 | 94,250 | -18,325 | 0.19 | 0.38 | +0.19 | sell |
| SANDERS MORRIS HARRIS LLC | 19,356 | 0 | -19,356 | 0.05 | 0.00 | -0.05 | sell |
| NOMURA HOLDINGS INC | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 21,120 | 0 | -21,120 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 90,277 | 66,438 | -23,839 | 0.01 | 0.01 | +0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 25,055 | 0 | -25,055 | 0.06 | 0.00 | -0.06 | sell |
| Bank of New York Mellon Corp | 42,914 | 16,598 | -26,316 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 29,245 | 0 | -29,245 | 0.41 | 0.00 | -0.41 | sell |
| Senvest Management, LLC | 72,300 | 42,300 | -30,000 | 0.04 | 0.06 | +0.02 | sell |
| GSA CAPITAL PARTNERS LLP | 32,607 | 0 | -32,607 | 0.03 | 0.00 | -0.03 | sell |
| Hudson Bay Capital Management LP | 158,500 | 120,000 | -38,500 | 0.02 | 0.03 | +0.01 | sell |
| K2 PRINCIPAL FUND, L.P. | 118,600 | 78,601 | -39,999 | 0.20 | 0.33 | +0.13 | sell |
| IMC-Chicago, LLC | 45,080 | 0 | -45,080 | 0.01 | 0.00 | -0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 55,015 | 0 | -55,015 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 91,615 | 28,551 | -63,064 | 0.03 | 0.02 | -0.01 | sell |
| Newtyn Management, LLC | 87,684 | 0 | -87,684 | 0.15 | 0.00 | -0.15 | sell |
| Brevan Howard Capital Management LP | 108,632 | 0 | -108,632 | 0.02 | 0.00 | -0.02 | sell |
| SIMPLEX TRADING, LLC | 231,769 | 110,219 | -121,550 | 0.12 | 0.13 | +0.02 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 122,222 | 0 | -122,222 | 0.07 | 0.00 | -0.07 | sell |
| ORBIMED ADVISORS LLC | 2,136,149 | 1,807,486 | -328,663 | 0.76 | 1.58 | +0.82 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 964,290 | 586,582 | -377,708 | 0.03 | 0.05 | +0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 792,756 | 343,126 | -449,630 | 0.01 | 0.01 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,002,800 | 496,897 | -505,903 | 0.02 | 0.02 | -0.00 | sell |
| SG Americas Securities, LLC | 776,604 | 41,146 | -735,458 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 2,675,871 | 1,462,024 | -1,213,847 | 0.04 | 0.05 | +0.01 | sell |