| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 1,184,362 | 6,059,574 | +4,875,212 | 0.00 | 0.02 | +0.02 | buy |
| Avoro Capital Advisors LLC | 3,625,000 | 4,444,444 | +819,444 | 0.88 | 3.36 | +2.47 | buy |
| RTW INVESTMENTS, LP | 5,158,231 | 4,424,968 | -733,263 | 1.02 | 3.18 | +2.16 | sell |
| EcoR1 Capital, LLC | 3,988,971 | 3,988,971 | 0 | 3.30 | 11.17 | +7.88 | hold |
| Aberdeen Group plc | 2,750,714 | 2,939,743 | +189,029 | 0.07 | 0.27 | +0.21 | buy |
| FRANKLIN RESOURCES INC | 1,605,515 | 1,988,581 | +383,066 | 0.01 | 0.03 | +0.02 | buy |
| BlackRock, Inc. | 1,333,663 | 1,446,099 | +112,436 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,142,810 | 1,444,010 | +301,200 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 1,290,391 | +1,290,391 | 0.00 | 0.29 | +0.29 | buy |
| JPMORGAN CHASE & CO | 1,807,685 | 1,149,351 | -658,334 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 972,691 | 1,125,108 | +152,417 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 1,285,000 | 1,070,000 | -215,000 | 1.82 | 5.67 | +3.86 | sell |
| Nantahala Capital Management, LLC | 2,051,852 | 1,007,492 | -1,044,360 | 2.02 | 3.63 | +1.61 | sell |
| JENNISON ASSOCIATES LLC | 140,060 | 999,484 | +859,424 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 913,180 | +913,180 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 940,960 | 897,538 | -43,422 | 0.02 | 0.08 | +0.06 | sell |
| Eversept Partners, LP | 0 | 877,373 | +877,373 | 0.00 | 3.92 | +3.92 | buy |
| Boxer Capital Management, LLC | 899,500 | 800,000 | -99,500 | 6.31 | 14.88 | +8.57 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 603,210 | 721,652 | +118,442 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 356,463 | 662,208 | +305,745 | 0.00 | 0.01 | +0.00 | buy |
| Artia Global Partners LP | 0 | 658,839 | +658,839 | 0.00 | 6.77 | +6.77 | buy |
| Integral Health Asset Management, LLC | 1,350,000 | 600,000 | -750,000 | 1.76 | 2.55 | +0.79 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 14,000 | 565,000 | +551,000 | 0.00 | 0.19 | +0.19 | buy |
| STEMPOINT CAPITAL LP | 572,615 | 522,155 | -50,460 | 2.57 | 6.15 | +3.58 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 521,677 | +521,677 | 0.00 | 2.35 | +2.35 | buy |
| Deep Track Capital, LP | 0 | 483,092 | +483,092 | 0.00 | 0.79 | +0.79 | buy |
| ORBIMED ADVISORS LLC | 0 | 458,500 | +458,500 | 0.00 | 0.64 | +0.64 | buy |
| Caption Management, LLC | 176,911 | 458,300 | +281,389 | 0.23 | 1.56 | +1.33 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 202,565 | 455,000 | +252,435 | 0.58 | 3.84 | +3.27 | buy |
| CITADEL ADVISORS LLC | 555,865 | 429,710 | -126,155 | 0.01 | 0.02 | +0.01 | sell |
| TWO SIGMA ADVISERS, LP | 659,700 | 409,500 | -250,200 | 0.02 | 0.05 | +0.03 | sell |
| Darwin Global Management, Ltd. | 0 | 400,000 | +400,000 | 0.00 | 0.66 | +0.66 | buy |
| Privium Fund Management B.V. | 447,486 | 386,000 | -61,486 | 1.35 | 4.05 | +2.70 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 503,672 | 385,609 | -118,063 | 0.01 | 0.02 | +0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 292,931 | 357,685 | +64,754 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 443,422 | 345,356 | -98,066 | 0.72 | 2.21 | +1.50 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 536,968 | 333,235 | -203,733 | 0.02 | 0.04 | +0.02 | sell |
| MORGAN STANLEY | 908,283 | 321,501 | -586,782 | 0.00 | 0.00 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 135,000 | 300,000 | +165,000 | 0.28 | 1.63 | +1.35 | buy |
| Logos Global Management LP | 0 | 300,000 | +300,000 | 0.00 | 1.73 | +1.73 | buy |
| BANK OF AMERICA CORP /DE/ | 141,810 | 295,131 | +153,321 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 417,443 | 282,940 | -134,503 | 1.22 | 3.05 | +1.83 | sell |
| Siren, L.L.C. | 0 | 275,200 | +275,200 | 0.00 | 0.63 | +0.63 | buy |
| MACQUARIE GROUP LTD | 706,166 | 258,211 | -447,955 | 0.01 | 0.02 | +0.01 | sell |
| Point72 Asset Management, L.P. | 105,939 | 254,082 | +148,143 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 48,283 | 225,540 | +177,257 | 0.00 | 0.02 | +0.02 | buy |
| Vestal Point Capital, LP | 3,700,000 | 225,000 | -3,475,000 | 2.72 | 0.60 | -2.12 | sell |
| ROYAL BANK OF CANADA | 391,614 | 211,413 | -180,201 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 263,668 | 204,989 | -58,679 | 0.00 | 0.00 | +0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 200,000 | +200,000 | 0.00 | 0.14 | +0.14 | buy |
| Soleus Capital Management, L.P. | 0 | 200,000 | +200,000 | 0.00 | 0.62 | +0.62 | buy |
| MILLENNIUM MANAGEMENT LLC | 132,664 | 191,600 | +58,936 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 134,948 | 188,197 | +53,249 | 0.01 | 0.08 | +0.06 | buy |
| Squarepoint Ops LLC | 176,002 | 181,902 | +5,900 | 0.01 | 0.02 | +0.02 | buy |
| LORD, ABBETT & CO. LLC | 0 | 176,025 | +176,025 | 0.00 | 0.03 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 761,948 | 158,943 | -603,005 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 125,685 | 152,437 | +26,752 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 106,490 | 149,851 | +43,361 | 0.00 | 0.01 | +0.01 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 147,317 | +147,317 | 0.00 | 2.82 | +2.82 | buy |
| GROUP ONE TRADING LLC | 63,681 | 140,227 | +76,546 | 0.03 | 0.24 | +0.22 | buy |
| Sofinnova Investments, Inc. | 1,558,356 | 136,862 | -1,421,494 | 1.48 | 0.49 | -0.99 | sell |
| ADAR1 Capital Management, LLC | 0 | 133,316 | +133,316 | 0.00 | 0.77 | +0.77 | buy |
| Woodline Partners LP | 175,806 | 130,615 | -45,191 | 0.01 | 0.04 | +0.02 | sell |
| Rosalind Advisors, Inc. | 0 | 125,000 | +125,000 | 0.00 | 2.58 | +2.58 | buy |
| Voss Capital, LP | 125,000 | 125,000 | 0 | 0.12 | 0.42 | +0.30 | hold |
| BARCLAYS PLC | 89,014 | 115,562 | +26,548 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 222,979 | 108,210 | -114,769 | 0.00 | 0.01 | +0.00 | sell |
| Quinn Opportunity Partners LLC | 0 | 107,600 | +107,600 | 0.00 | 0.46 | +0.46 | buy |
| Walleye Capital LLC | 0 | 102,909 | +102,909 | 0.00 | 0.05 | +0.05 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 67,260 | 102,124 | +34,864 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 0 | 95,144 | +95,144 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 2,095,931 | 90,542 | -2,005,389 | 0.48 | 0.05 | -0.43 | sell |
| Atika Capital Management LLC | 0 | 90,000 | +90,000 | 0.00 | 0.45 | +0.45 | buy |
| SANDERS MORRIS HARRIS LLC | 0 | 87,054 | +87,054 | 0.00 | 0.67 | +0.67 | buy |
| Marex Group plc | 0 | 86,859 | +86,859 | 0.00 | 0.06 | +0.06 | buy |
| Rafferty Asset Management, LLC | 68,807 | 82,856 | +14,049 | 0.00 | 0.02 | +0.01 | buy |
| Birchview Capital, LP | 98,697 | 78,728 | -19,969 | 1.37 | 3.47 | +2.10 | sell |
| Swiss National Bank | 77,500 | 76,300 | -1,200 | 0.00 | 0.00 | +0.00 | sell |
| Patient Square Capital LP | 0 | 75,000 | +75,000 | 0.00 | 1.17 | +1.17 | buy |
| SIMPLEX TRADING, LLC | 64,259 | 67,995 | +3,736 | 0.02 | 0.09 | +0.06 | buy |
| SEI INVESTMENTS CO | 0 | 67,273 | +67,273 | 0.00 | 0.00 | +0.00 | buy |
| APIS CAPITAL ADVISORS, LLC | 0 | 63,800 | +63,800 | 0.00 | 0.82 | +0.82 | buy |
| Cubist Systematic Strategies, LLC | 0 | 62,365 | +62,365 | 0.00 | 0.05 | +0.05 | buy |
| Ikarian Capital, LLC | 119,986 | 58,610 | -61,376 | 0.55 | 0.69 | +0.14 | sell |
| STIFEL FINANCIAL CORP | 66,981 | 58,276 | -8,705 | 0.00 | 0.00 | +0.00 | sell |
| Verition Fund Management LLC | 92,591 | 57,968 | -34,623 | 0.01 | 0.02 | +0.01 | sell |
| Headlands Technologies LLC | 42,444 | 57,408 | +14,964 | 0.07 | 0.27 | +0.20 | buy |
| Longaeva Partners L.P. | 0 | 55,000 | +55,000 | 0.00 | 0.68 | +0.68 | buy |
| Hennion & Walsh Asset Management, Inc. | 30,369 | 51,613 | +21,244 | 0.02 | 0.11 | +0.09 | buy |
| Owl Creek Asset Management, L.P. | 0 | 49,389 | +49,389 | 0.00 | 0.33 | +0.33 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 48,762 | +48,762 | 0.00 | 0.00 | +0.00 | buy |
| CI INVESTMENTS INC. | 0 | 47,436 | +47,436 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Trading LLC | 0 | 47,321 | +47,321 | 0.00 | 0.04 | +0.04 | buy |
| Atom Investors LP | 0 | 47,291 | +47,291 | 0.00 | 0.21 | +0.21 | buy |
| PFM Health Sciences, LP | 174,331 | 46,353 | -127,978 | 0.21 | 0.23 | +0.02 | sell |
| LPL Financial LLC | 0 | 46,114 | +46,114 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 40,976 | +40,976 | 0.00 | 0.09 | +0.09 | buy |
| Alyeska Investment Group, L.P. | 0 | 40,000 | +40,000 | 0.00 | 0.01 | +0.01 | buy |
| Monashee Investment Management LLC | 0 | 40,000 | +40,000 | 0.00 | 1.16 | +1.16 | buy |
| Monaco Asset Management SAM | 70,000 | 39,913 | -30,087 | 0.37 | 0.87 | +0.50 | sell |