| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 0 | 3,400,000 | +3,400,000 | 0.00 | 2.40 | +2.40 | buy |
| Avoro Capital Advisors LLC | 0 | 2,175,000 | +2,175,000 | 0.00 | 0.54 | +0.54 | buy |
| RTW INVESTMENTS, LP | 10,000 | 903,625 | +893,625 | 0.00 | 0.24 | +0.24 | buy |
| Point72 Asset Management, L.P. | 976,893 | 1,771,352 | +794,459 | 0.02 | 0.09 | +0.07 | buy |
| Integral Health Asset Management, LLC | 400,000 | 1,100,000 | +700,000 | 0.23 | 1.72 | +1.49 | buy |
| FMR LLC | 350,572 | 966,650 | +616,078 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 536,422 | +536,422 | 0.00 | 0.06 | +0.06 | buy |
| Invesco Ltd. | 110,917 | 613,601 | +502,684 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,492,962 | 1,987,688 | +494,726 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 160,094 | 486,809 | +326,715 | 0.00 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 0 | 314,413 | +314,413 | 0.00 | 0.02 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 0 | 275,000 | +275,000 | 0.00 | 0.65 | +0.65 | buy |
| Pale Fire Capital SE | 336,468 | 580,708 | +244,240 | 0.26 | 2.40 | +2.14 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 177,179 | +177,179 | 0.00 | 0.01 | +0.01 | buy |
| PFM Health Sciences, LP | 121,628 | 283,158 | +161,530 | 0.03 | 0.38 | +0.35 | buy |
| UBS Group AG | 0 | 143,826 | +143,826 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 143,080 | +143,080 | 0.00 | 0.03 | +0.03 | buy |
| Woodline Partners LP | 0 | 140,631 | +140,631 | 0.00 | 0.02 | +0.02 | buy |
| Jump Financial, LLC | 72,152 | 211,776 | +139,624 | 0.01 | 0.08 | +0.07 | buy |
| Monaco Asset Management SAM | 0 | 136,708 | +136,708 | 0.00 | 1.07 | +1.07 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 233,491 | 359,173 | +125,682 | 0.00 | 0.01 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 123,210 | +123,210 | 0.00 | 0.17 | +0.17 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.39 | +0.39 | buy |
| STEMPOINT CAPITAL LP | 0 | 90,000 | +90,000 | 0.00 | 0.40 | +0.40 | buy |
| TWO SIGMA INVESTMENTS, LP | 804,896 | 878,884 | +73,988 | 0.01 | 0.04 | +0.03 | buy |
| JPMORGAN CHASE & CO | 395,538 | 453,784 | +58,246 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 100,000 | 150,000 | +50,000 | 0.01 | 0.05 | +0.04 | buy |
| Quinn Opportunity Partners LLC | 24,000 | 69,000 | +45,000 | 0.01 | 0.09 | +0.08 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 427,191 | 468,357 | +41,166 | 0.00 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 90,142 | 130,423 | +40,281 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 38,534 | +38,534 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 40,992 | 77,639 | +36,647 | 0.01 | 0.04 | +0.03 | buy |
| SANDERS MORRIS HARRIS LLC | 68,070 | 102,104 | +34,034 | 0.06 | 0.27 | +0.21 | buy |
| ALLIANCEBERNSTEIN L.P. | 178,600 | 203,919 | +25,319 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 24,749 | +24,749 | 0.00 | 0.16 | +0.16 | buy |
| Lighthouse Investment Partners, LLC | 0 | 22,500 | +22,500 | 0.00 | 0.02 | +0.02 | buy |
| Bellevue Group AG | 0 | 22,500 | +22,500 | 0.00 | 0.01 | +0.01 | buy |
| WOLVERINE TRADING, LLC | 10,341 | 30,724 | +20,383 | 0.00 | 0.01 | +0.01 | buy |
| Headlands Technologies LLC | 0 | 18,450 | +18,450 | 0.00 | 0.03 | +0.03 | buy |
| OPPENHEIMER & CO INC | 0 | 18,100 | +18,100 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 174,902 | 192,533 | +17,631 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 16,279 | +16,279 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 508,602 | 520,553 | +11,951 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 746,500 | 756,900 | +10,400 | 0.01 | 0.03 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.04 | +0.04 | buy |
| FNY Investment Advisers, LLC | 0 | 5,004 | +5,004 | 0.00 | 0.05 | +0.05 | buy |
| BARCLAYS PLC | 2,669 | 7,243 | +4,574 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,295 | 8,722 | +4,427 | 0.00 | 0.00 | +0.00 | buy |
| Twin Tree Management, LP | 0 | 4,387 | +4,387 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 66,982 | 70,978 | +3,996 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 93,668 | 95,591 | +1,923 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,791 | 12,294 | +1,503 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 23,413 | 24,784 | +1,371 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,093 | 11,062 | +969 | 0.01 | 0.02 | +0.01 | buy |
| Vanguard Personalized Indexing Management, LLC | 13,136 | 13,952 | +816 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 425 | 676 | +251 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 234 | +234 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 1,205 | 1,438 | +233 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 199 | +199 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 187 | +187 | 0.00 | 0.00 | +0.00 | buy |
| Accent Capital Management, LLC | 0 | 160 | +160 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 298 | 328 | +30 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 706,166 | 706,166 | 0 | 0.00 | 0.02 | +0.01 | hold |
| Daiwa Securities Group Inc. | 158 | 158 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 164 | 164 | 0 | 0.00 | 0.00 | +0.00 | hold |
| First Horizon Advisors, Inc. | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Birchview Capital, LP | 20,000 | 20,000 | 0 | 0.09 | 0.29 | +0.20 | hold |
| EverSource Wealth Advisors, LLC | 109 | 109 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Future Financial Wealth Managment LLC | 4,000 | 4,000 | 0 | 0.01 | 0.05 | +0.04 | hold |
| Coppell Advisory Solutions LLC | 4,000 | 4,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Activest Wealth Management | 5,000 | 5,000 | 0 | 0.01 | 0.02 | +0.02 | hold |
| Corient Private Wealth LLC | 10,630 | 10,630 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Marex Group plc | 80,000 | 80,000 | 0 | 0.01 | 0.02 | +0.02 | hold |
| GAMMA Investing LLC | 60 | 60 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pineridge Advisors LLC | 38 | 38 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUNTINGTON NATIONAL BANK | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TOTH FINANCIAL ADVISORY CORP | 165 | 165 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SALEM INVESTMENT COUNSELORS INC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Wilmington Savings Fund Society, FSB | 352 | 352 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 (DIFC) Ltd | 53 | 52 | -1 | 0.00 | 0.00 | +0.00 | sell |
| SIGNATUREFD, LLC | 208 | 152 | -56 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 1,761 | 1,624 | -137 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,376 | 2,096 | -280 | 0.00 | 0.00 | +0.00 | sell |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 373 | 0 | -373 | 0.00 | 0.00 | -0.00 | sell |
| Global Retirement Partners, LLC | 632 | 0 | -632 | 0.00 | 0.00 | -0.00 | sell |
| Riggs Asset Managment Co. Inc. | 750 | 0 | -750 | 0.00 | 0.00 | -0.00 | sell |
| Total Clarity Wealth Management, Inc. | 16,450 | 15,350 | -1,100 | 0.03 | 0.09 | +0.06 | sell |
| nVerses Capital, LLC | 1,100 | 0 | -1,100 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,069 | 849 | -1,220 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 83,579 | 82,267 | -1,312 | 0.00 | 0.00 | +0.00 | sell |
| Sigma Planning Corp | 48,245 | 46,745 | -1,500 | 0.01 | 0.03 | +0.02 | sell |
| EARNED WEALTH ADVISORS, LLC | 2,180 | 0 | -2,180 | 0.00 | 0.00 | -0.00 | sell |
| Clear Harbor Asset Management, LLC | 19,500 | 17,000 | -2,500 | 0.01 | 0.02 | +0.02 | sell |
| Privium Fund Management B.V. | 744,916 | 742,162 | -2,754 | 0.91 | 2.97 | +2.05 | sell |
| Covestor Ltd | 2,864 | 0 | -2,864 | 0.01 | 0.00 | -0.01 | sell |
| MORGAN STANLEY | 700,704 | 697,324 | -3,380 | 0.00 | 0.00 | +0.00 | sell |
| Caption Management, LLC | 4,424 | 0 | -4,424 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 60,996 | 56,168 | -4,828 | 0.00 | 0.00 | +0.00 | sell |