| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 4,444,444 | 6,150,000 | +1,705,556 | 3.35 | 1.45 | -1.91 | buy |
| Aberdeen Group plc | 2,939,743 | 3,678,640 | +738,897 | 0.27 | 0.14 | -0.14 | buy |
| Logos Global Management LP | 300,000 | 675,000 | +375,000 | 1.73 | 1.08 | -0.65 | buy |
| JENNISON ASSOCIATES LLC | 999,484 | 1,371,190 | +371,706 | 0.03 | 0.02 | -0.01 | buy |
| Artia Global Partners LP | 658,839 | 1,023,539 | +364,700 | 6.77 | 3.94 | -2.83 | buy |
| Integral Health Asset Management, LLC | 600,000 | 900,000 | +300,000 | 2.55 | 1.09 | -1.46 | buy |
| ORBIMED ADVISORS LLC | 458,500 | 737,400 | +278,900 | 0.64 | 0.36 | -0.28 | buy |
| Alyeska Investment Group, L.P. | 40,000 | 151,058 | +111,058 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 133,316 | 235,155 | +101,839 | 0.77 | 0.42 | -0.35 | buy |
| Voss Capital, LP | 125,000 | 210,000 | +85,000 | 0.42 | 0.27 | -0.15 | buy |
| Rafferty Asset Management, LLC | 82,856 | 164,937 | +82,081 | 0.02 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 17,084 | 59,463 | +42,379 | 0.03 | 0.04 | 0.00 | buy |
| Sofinnova Investments, Inc. | 136,862 | 176,513 | +39,651 | 0.44 | 0.18 | -0.25 | buy |
| Ikarian Capital, LLC | 58,610 | 91,060 | +32,450 | 0.69 | 0.28 | -0.41 | buy |
| Atom Investors LP | 47,291 | 78,209 | +30,918 | 0.21 | 0.15 | -0.06 | buy |
| Privium Fund Management B.V. | 386,000 | 416,270 | +30,270 | 4.05 | 1.83 | -2.22 | buy |
| Y-Intercept (Hong Kong) Ltd | 22,704 | 45,778 | +23,074 | 0.03 | 0.03 | 0.00 | buy |
| SummitTX Capital, L.P. | 5,698 | 27,708 | +22,010 | 0.01 | 0.02 | +0.01 | buy |
| Massar Capital Management, LP | 20,000 | 40,529 | +20,529 | 0.42 | 0.19 | -0.23 | buy |
| Hennion & Walsh Asset Management, Inc. | 51,613 | 67,739 | +16,126 | 0.11 | 0.06 | -0.05 | buy |
| DnB Asset Management AS | 11,802 | 27,342 | +15,540 | 0.00 | 0.00 | -0.00 | buy |
| Clear Harbor Asset Management, LLC | 7,000 | 16,900 | +9,900 | 0.03 | 0.03 | -0.00 | buy |
| WINTON GROUP Ltd | 40,976 | 48,185 | +7,209 | 0.09 | 0.04 | -0.05 | buy |
| Virtus Investment Advisers, LLC | 7,116 | 13,636 | +6,520 | 0.12 | 0.09 | -0.03 | buy |
| Diametric Capital, LP | 5,383 | 11,822 | +6,439 | 0.12 | 0.08 | -0.04 | buy |
| Shay Capital LLC | 34,997 | 41,073 | +6,076 | 0.37 | 0.16 | -0.21 | buy |
| Catalio Capital Management, LP | 282,940 | 288,345 | +5,405 | 3.05 | 1.22 | -1.83 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12,160 | 15,739 | +3,579 | 0.06 | 0.03 | -0.03 | buy |
| Knott David M Jr | 2,000 | 4,000 | +2,000 | 0.05 | 0.04 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,617 | 10,150 | +533 | 0.05 | 0.02 | -0.03 | buy |
| FNY Investment Advisers, LLC | 1,654 | 2,080 | +426 | 0.03 | 0.01 | -0.02 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,180 | 1,223 | +43 | 0.00 | 0.00 | -0.00 | buy |
| TOTH FINANCIAL ADVISORY CORP | 165 | 100 | -65 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 30,740 | 30,585 | -155 | 1.11 | 0.59 | -0.52 | sell |
| Mraz, Amerine & Associates, Inc. | 9,319 | 8,495 | -824 | 0.08 | 0.03 | -0.05 | sell |
| Susquehanna Portfolio Strategies, LLC | 29,548 | 28,708 | -840 | 0.03 | 0.01 | -0.02 | sell |
| Marex Group plc | 86,859 | 85,993 | -866 | 0.06 | 0.02 | -0.04 | sell |
| Sassicaia Capital Advisers LLC | 16,000 | 10,400 | -5,600 | 0.42 | 0.55 | +0.13 | sell |
| PFM Health Sciences, LP | 46,353 | 39,499 | -6,854 | 0.21 | 0.09 | -0.11 | sell |
| CI INVESTMENTS INC. | 47,436 | 37,841 | -9,595 | 0.01 | 0.00 | -0.01 | sell |
| Monaco Asset Management SAM | 39,913 | 25,000 | -14,913 | 0.87 | 0.18 | -0.69 | sell |
| Headlands Technologies LLC | 57,408 | 39,616 | -17,792 | 0.27 | 0.08 | -0.19 | sell |
| Scientech Research LLC | 29,295 | 10,203 | -19,092 | 0.60 | 0.15 | -0.44 | sell |
| Militia Capital Partners, LP | 35,000 | 8,500 | -26,500 | 0.96 | 0.08 | -0.88 | sell |
| Birchview Capital, LP | 78,728 | 30,789 | -47,939 | 3.47 | 0.43 | -3.04 | sell |
| Parkman Healthcare Partners LLC | 345,356 | 257,382 | -87,974 | 2.21 | 0.59 | -1.63 | sell |
| Quinn Opportunity Partners LLC | 107,600 | 10,000 | -97,600 | 0.45 | 0.01 | -0.43 | sell |
| Affinity Asset Advisors, LLC | 300,000 | 50,000 | -250,000 | 1.63 | 0.09 | -1.54 | sell |
| Nantahala Capital Management, LLC | 1,007,492 | 699,298 | -308,194 | 2.04 | 0.55 | -1.49 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 455,000 | 126,047 | -328,953 | 3.84 | 0.44 | -3.41 | sell |
| STEMPOINT CAPITAL LP | 522,155 | 43,485 | -478,670 | 6.15 | 0.18 | -5.97 | sell |
| Boxer Capital Management, LLC | 800,000 | 290,000 | -510,000 | 14.88 | 1.52 | -13.37 | sell |
| 683 Capital Management, LLC | 1,070,000 | 384,950 | -685,050 | 3.26 | 0.40 | -2.86 | sell |
| RTW INVESTMENTS, LP | 4,424,968 | 3,711,462 | -713,506 | 3.18 | 0.89 | -2.29 | sell |
| Eversept Partners, LP | 877,373 | 62,820 | -814,553 | 3.53 | 0.08 | -3.45 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,290,391 | 344,878 | -945,513 | 0.29 | 0.03 | -0.26 | sell |