| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 6,059,574 | 6,240,936 | +181,362 | 0.02 | 0.01 | -0.01 | buy |
| Avoro Capital Advisors LLC | 4,444,444 | 6,150,000 | +1,705,556 | 3.36 | 1.45 | -1.91 | buy |
| RTW INVESTMENTS, LP | 4,424,968 | 3,711,462 | -713,506 | 3.18 | 0.89 | -2.29 | sell |
| Aberdeen Group plc | 2,939,743 | 3,678,640 | +738,897 | 0.27 | 0.14 | -0.14 | buy |
| STATE STREET CORP | 1,444,010 | 3,231,043 | +1,787,033 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 1,149,351 | 2,934,626 | +1,785,275 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,446,099 | 1,974,988 | +528,889 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 897,538 | 1,451,284 | +553,746 | 0.08 | 0.05 | -0.03 | buy |
| MPM BioImpact LLC | 0 | 1,381,628 | +1,381,628 | 0.00 | 3.78 | +3.78 | buy |
| JENNISON ASSOCIATES LLC | 999,484 | 1,371,190 | +371,706 | 0.03 | 0.02 | -0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 225,540 | 1,218,350 | +992,810 | 0.02 | 0.04 | +0.02 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 1,216,734 | +1,216,734 | 0.00 | 0.73 | +0.73 | buy |
| GOLDMAN SACHS GROUP INC | 662,208 | 1,167,608 | +505,400 | 0.01 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 409,500 | 1,110,400 | +700,900 | 0.05 | 0.05 | +0.00 | buy |
| VANGUARD GROUP INC | 1,125,108 | 1,051,379 | -73,729 | 0.00 | 0.00 | -0.00 | sell |
| Artia Global Partners LP | 658,839 | 1,023,539 | +364,700 | 6.77 | 3.94 | -2.83 | buy |
| Integral Health Asset Management, LLC | 600,000 | 900,000 | +300,000 | 2.55 | 1.09 | -1.46 | buy |
| MILLENNIUM MANAGEMENT LLC | 191,600 | 803,605 | +612,005 | 0.01 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 721,652 | 776,071 | +54,419 | 0.00 | 0.00 | -0.00 | buy |
| Fiera Capital Corp | 0 | 768,510 | +768,510 | 0.00 | 0.06 | +0.06 | buy |
| FRANKLIN RESOURCES INC | 1,988,581 | 746,602 | -1,241,979 | 0.03 | 0.00 | -0.02 | sell |
| ORBIMED ADVISORS LLC | 458,500 | 737,400 | +278,900 | 0.64 | 0.36 | -0.28 | buy |
| MORGAN STANLEY | 321,501 | 716,927 | +395,426 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 1,007,492 | 699,298 | -308,194 | 3.63 | 1.00 | -2.63 | sell |
| Logos Global Management LP | 300,000 | 675,000 | +375,000 | 1.73 | 1.08 | -0.65 | buy |
| Tyro Capital Management LLC | 0 | 663,929 | +663,929 | 0.00 | 4.94 | +4.94 | buy |
| MAVERICK CAPITAL LTD | 0 | 661,820 | +661,820 | 0.00 | 0.17 | +0.17 | buy |
| Assenagon Asset Management S.A. | 0 | 606,923 | +606,923 | 0.00 | 0.02 | +0.02 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 521,677 | 521,677 | 0 | 2.35 | 1.11 | -1.24 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 498,212 | +498,212 | 0.00 | 0.19 | +0.19 | buy |
| UBS Group AG | 204,989 | 491,454 | +286,465 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 429,710 | 469,300 | +39,590 | 0.02 | 0.01 | -0.01 | buy |
| Whitefort Capital Management, LP | 0 | 459,000 | +459,000 | 0.00 | 3.32 | +3.32 | buy |
| Privium Fund Management B.V. | 386,000 | 416,270 | +30,270 | 4.05 | 1.83 | -2.22 | buy |
| 683 Capital Management, LLC | 1,070,000 | 384,950 | -685,050 | 5.67 | 0.77 | -4.91 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 357,685 | 362,878 | +5,193 | 0.00 | 0.00 | -0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 361,560 | +361,560 | 0.00 | 0.38 | +0.38 | buy |
| FRED ALGER MANAGEMENT, LLC | 1,290,391 | 344,878 | -945,513 | 0.29 | 0.03 | -0.26 | sell |
| BANK OF AMERICA CORP /DE/ | 295,131 | 329,525 | +34,394 | 0.00 | 0.00 | -0.00 | buy |
| First Turn Management, LLC | 0 | 321,655 | +321,655 | 0.00 | 0.88 | +0.88 | buy |
| HRT FINANCIAL LP | 0 | 310,050 | +310,050 | 0.00 | 0.02 | +0.02 | buy |
| Jump Financial, LLC | 3,826 | 306,131 | +302,305 | 0.00 | 0.09 | +0.09 | buy |
| Boxer Capital Management, LLC | 800,000 | 290,000 | -510,000 | 14.88 | 1.52 | -13.37 | sell |
| Catalio Capital Management, LP | 282,940 | 288,345 | +5,405 | 3.05 | 1.22 | -1.83 | buy |
| Parkman Healthcare Partners LLC | 345,356 | 257,382 | -87,974 | 2.21 | 0.59 | -1.63 | sell |
| ADAR1 Capital Management, LLC | 133,316 | 235,155 | +101,839 | 0.77 | 0.42 | -0.35 | buy |
| Freshford Capital Management, LLC | 0 | 229,613 | +229,613 | 0.00 | 2.20 | +2.20 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 385,609 | 221,343 | -164,266 | 0.02 | 0.00 | -0.01 | sell |
| Voss Capital, LP | 125,000 | 210,000 | +85,000 | 0.42 | 0.27 | -0.15 | buy |
| BARCLAYS PLC | 115,562 | 209,790 | +94,228 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 913,180 | 208,646 | -704,534 | 0.01 | 0.00 | -0.01 | sell |
| Eagle Health Investments LP | 0 | 205,247 | +205,247 | 0.00 | 1.08 | +1.08 | buy |
| CITIGROUP INC | 11,575 | 184,765 | +173,190 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 458,300 | 177,277 | -281,023 | 1.56 | 0.19 | -1.37 | sell |
| Sofinnova Investments, Inc. | 136,862 | 176,513 | +39,651 | 0.49 | 0.18 | -0.31 | buy |
| Squarepoint Ops LLC | 181,902 | 176,000 | -5,902 | 0.02 | 0.01 | -0.01 | sell |
| NORTHERN TRUST CORP | 152,437 | 168,820 | +16,383 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 82,856 | 164,937 | +82,081 | 0.02 | 0.01 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 156,000 | +156,000 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 40,000 | 151,058 | +111,058 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 147,549 | +147,549 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 333,235 | 135,644 | -197,591 | 0.04 | 0.01 | -0.03 | sell |
| D. E. Shaw & Co., Inc. | 32,537 | 131,956 | +99,419 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 455,000 | 126,047 | -328,953 | 3.84 | 0.44 | -3.41 | sell |
| Hudson Bay Capital Management LP | 4,318 | 125,500 | +121,182 | 0.00 | 0.02 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 188,197 | 122,529 | -65,668 | 0.08 | 0.01 | -0.06 | sell |
| NAN FUNG TRINITY (HK) Ltd | 0 | 115,494 | +115,494 | 0.00 | 0.22 | +0.22 | buy |
| SIMPLEX TRADING, LLC | 67,995 | 110,675 | +42,680 | 0.09 | 0.07 | -0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 11,549 | 99,593 | +88,044 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 58,610 | 91,060 | +32,450 | 0.69 | 0.28 | -0.41 | buy |
| Jefferies Financial Group Inc. | 90,542 | 90,542 | 0 | 0.05 | 0.02 | -0.03 | hold |
| Marex Group plc | 86,859 | 85,993 | -866 | 0.06 | 0.02 | -0.04 | sell |
| ROYAL BANK OF CANADA | 211,413 | 85,640 | -125,773 | 0.00 | 0.00 | -0.00 | sell |
| Clearline Capital LP | 0 | 83,681 | +83,681 | 0.00 | 0.15 | +0.15 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 82,978 | +82,978 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 80,249 | +80,249 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 79,375 | +79,375 | 0.00 | 0.18 | +0.18 | buy |
| Swiss National Bank | 76,300 | 79,000 | +2,700 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 102,909 | 78,996 | -23,913 | 0.05 | 0.01 | -0.04 | sell |
| Atom Investors LP | 47,291 | 78,209 | +30,918 | 0.21 | 0.15 | -0.06 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 75,000 | +75,000 | 0.00 | 0.04 | +0.04 | buy |
| TUDOR INVESTMENT CORP ET AL | 28,717 | 74,036 | +45,319 | 0.01 | 0.01 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 73,775 | +73,775 | 0.00 | 0.02 | +0.02 | buy |
| ALGERT GLOBAL LLC | 22,810 | 72,150 | +49,340 | 0.02 | 0.03 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 158,943 | 70,796 | -88,147 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 10,843 | 70,236 | +59,393 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 51,613 | 67,739 | +16,126 | 0.11 | 0.06 | -0.05 | buy |
| SG Americas Securities, LLC | 10,579 | 64,326 | +53,747 | 0.00 | 0.00 | -0.00 | buy |
| Eversept Partners, LP | 877,373 | 62,820 | -814,553 | 3.92 | 0.08 | -3.84 | sell |
| PROFUND ADVISORS LLC | 17,084 | 59,463 | +42,379 | 0.03 | 0.04 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 55,015 | +55,015 | 0.00 | 0.00 | +0.00 | buy |
| Senvest Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| Affinity Asset Advisors, LLC | 300,000 | 50,000 | -250,000 | 1.63 | 0.09 | -1.54 | sell |
| WINTON GROUP Ltd | 40,976 | 48,185 | +7,209 | 0.09 | 0.04 | -0.05 | buy |
| STIFEL FINANCIAL CORP | 58,276 | 45,987 | -12,289 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 22,704 | 45,778 | +23,074 | 0.03 | 0.02 | -0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 45,000 | +45,000 | 0.00 | 0.64 | +0.64 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,289 | 44,250 | +6,961 | 0.00 | 0.00 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 522,155 | 43,485 | -478,670 | 6.15 | 0.18 | -5.97 | sell |
| Engineers Gate Manager LP | 0 | 43,356 | +43,356 | 0.00 | 0.01 | +0.01 | buy |