| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 1,500,000 | 2,500,000 | +1,000,000 | 0.29 | 0.41 | +0.12 | buy |
| Candriam S.C.A. | 711,739 | 1,707,698 | +995,959 | 0.07 | 0.14 | +0.07 | buy |
| BAKER BROS. ADVISORS LP | 1,971,678 | 2,383,025 | +411,347 | 0.22 | 0.22 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 898,611 | 1,175,906 | +277,295 | 0.98 | 1.05 | +0.07 | buy |
| Yiheng Capital Management, L.P. | 208,735 | 400,464 | +191,729 | 1.77 | 2.53 | +0.76 | buy |
| Novo Holdings A/S | 2,000,000 | 2,135,000 | +135,000 | 3.17 | 2.28 | -0.89 | buy |
| Eversept Partners, LP | 713,269 | 831,142 | +117,873 | 0.74 | 0.79 | +0.06 | buy |
| J. Safra Sarasin Holding AG | 73,058 | 107,839 | +34,781 | 0.02 | 0.03 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 174,894 | 209,092 | +34,198 | 0.12 | 0.11 | -0.01 | buy |
| HighVista Strategies LLC | 134,229 | 159,885 | +25,656 | 0.72 | 0.67 | -0.06 | buy |
| Headlands Technologies LLC | 33,223 | 46,544 | +13,321 | 0.07 | 0.09 | +0.02 | buy |
| Knights of Columbus Asset Advisors LLC | 57,789 | 70,553 | +12,764 | 0.06 | 0.06 | +0.00 | buy |
| Bellevue Group AG | 6,726,144 | 6,731,909 | +5,765 | 3.13 | 2.60 | -0.53 | buy |
| J.Safra Asset Management Corp | 816 | 952 | +136 | 0.00 | 0.00 | -0.00 | buy |
| Voleon Capital Management LP | 269,742 | 97,598 | -172,144 | 0.11 | 0.03 | -0.08 | sell |
| PERCEPTIVE ADVISORS LLC | 1,170,829 | 581,980 | -588,849 | 0.45 | 0.16 | -0.29 | sell |
| VR Adviser, LLC | 3,882,709 | 3,257,917 | -624,792 | 2.83 | 1.81 | -1.02 | sell |