| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 1,730,212 | 3,657,099 | +1,926,887 | 0.84 | 1.12 | +0.28 | buy |
| MPM BioImpact LLC | 100,000 | 614,010 | +514,010 | 0.51 | 1.73 | +1.22 | buy |
| Fairmount Funds Management LLC | 1,369,623 | 1,845,813 | +476,190 | 3.15 | 3.52 | +0.37 | buy |
| MAVERICK CAPITAL LTD | 2,325,841 | 2,692,414 | +366,573 | 1.04 | 0.91 | -0.13 | buy |
| Paradigm Biocapital Advisors LP | 4,794,488 | 5,031,420 | +236,932 | 4.89 | 3.10 | -1.79 | buy |
| Soleus Capital Management, L.P. | 138,000 | 340,000 | +202,000 | 0.33 | 0.52 | +0.19 | buy |
| 5AM Venture Management, LLC | 586,595 | 736,595 | +150,000 | 3.39 | 2.89 | -0.50 | buy |
| BIT Capital GmbH | 6,593 | 145,556 | +138,963 | 0.01 | 0.19 | +0.17 | buy |
| Logos Global Management LP | 600,000 | 700,000 | +100,000 | 1.45 | 1.29 | -0.16 | buy |
| Hennion & Walsh Asset Management, Inc. | 75,780 | 109,820 | +34,040 | 0.09 | 0.10 | +0.01 | buy |
| Commodore Capital LP | 1,924,074 | 1,934,653 | +10,579 | 3.66 | 2.27 | -1.40 | buy |
| ALPS ADVISORS INC | 34,854 | 44,276 | +9,422 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 10,875 | 19,323 | +8,448 | 0.02 | 0.02 | +0.01 | buy |
| DCF Advisers, LLC | 9,500 | 14,500 | +5,000 | 0.14 | 0.15 | +0.01 | buy |
| Eversept Partners, LP | 137,343 | 142,075 | +4,732 | 0.26 | 0.17 | -0.10 | buy |
| Corton Capital Inc. | 18,509 | 19,070 | +561 | 0.13 | 0.12 | -0.01 | buy |
| VR Adviser, LLC | 3,882,623 | 3,882,671 | +48 | 5.80 | 3.23 | -2.57 | buy |
| Kopp Family Office, LLC | 205,600 | 205,640 | +40 | 2.60 | 2.06 | -0.54 | buy |
| StoneCrest Wealth Management, Inc. | 27,791 | 27,675 | -116 | 0.58 | 0.42 | -0.16 | sell |
| VIRTUS ADVISERS, LLC | 4,787 | 4,479 | -308 | 0.07 | 0.04 | -0.02 | sell |
| Cinctive Capital Management LP | 41,168 | 40,858 | -310 | 0.06 | 0.04 | -0.03 | sell |
| Bellevue Group AG | 30,000 | 19,100 | -10,900 | 0.01 | 0.01 | -0.00 | sell |
| Cutter Capital Management, LP | 307,721 | 278,638 | -29,083 | 3.20 | 1.88 | -1.32 | sell |
| Rosalind Advisors, Inc. | 360,332 | 300,000 | -60,332 | 6.46 | 4.91 | -1.56 | sell |
| Knights of Columbus Asset Advisors LLC | 153,949 | 78,822 | -75,127 | 0.22 | 0.10 | -0.12 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 281,500 | 199,433 | -82,067 | 3.45 | 2.27 | -1.18 | sell |
| Polar Capital Holdings Plc | 979,917 | 889,198 | -90,719 | 0.13 | 0.08 | -0.05 | sell |
| Deep Track Capital, LP | 3,631,728 | 3,456,053 | -175,675 | 2.77 | 1.74 | -1.03 | sell |
| Yiheng Capital Management, L.P. | 1,228,534 | 948,130 | -280,404 | 1.54 | 0.92 | -0.62 | sell |
| Kynam Capital Management, LP | 607,915 | 133,877 | -474,038 | 1.50 | 0.26 | -1.24 | sell |