| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,625,542 | 9,415,135 | +1,789,593 | 0.01 | 0.01 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 4,794,488 | 5,031,420 | +236,932 | 4.89 | 3.10 | -1.79 | buy |
| STATE STREET CORP | 2,708,383 | 4,488,615 | +1,780,232 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 3,882,623 | 3,882,671 | +48 | 5.80 | 3.23 | -2.57 | buy |
| PERCEPTIVE ADVISORS LLC | 1,730,212 | 3,657,099 | +1,926,887 | 0.84 | 1.13 | +0.29 | buy |
| Deep Track Capital, LP | 3,631,728 | 3,456,053 | -175,675 | 2.77 | 1.74 | -1.03 | sell |
| VANGUARD GROUP INC | 3,000,948 | 3,234,279 | +233,331 | 0.00 | 0.00 | -0.00 | buy |
| MAVERICK CAPITAL LTD | 2,325,841 | 2,692,414 | +366,573 | 1.04 | 0.91 | -0.13 | buy |
| Commodore Capital LP | 1,924,074 | 1,934,653 | +10,579 | 3.66 | 2.27 | -1.40 | buy |
| Fairmount Funds Management LLC | 1,369,623 | 1,845,813 | +476,190 | 3.15 | 3.52 | +0.37 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,059,464 | 1,722,819 | -336,645 | 0.02 | 0.01 | -0.01 | sell |
| Vivo Capital, LLC | 1,678,207 | 1,678,207 | 0 | 2.99 | 2.31 | -0.68 | hold |
| GREAT POINT PARTNERS LLC | 0 | 1,335,000 | +1,335,000 | 0.00 | 3.64 | +3.64 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 994,468 | 1,164,272 | +169,804 | 0.00 | 0.00 | -0.00 | buy |
| Novo Holdings A/S | 0 | 1,100,000 | +1,100,000 | 0.00 | 1.33 | +1.33 | buy |
| Pictet Asset Management Holding SA | 1,050,876 | 1,095,441 | +44,565 | 0.03 | 0.02 | -0.00 | buy |
| Yiheng Capital Management, L.P. | 1,228,534 | 948,130 | -280,404 | 3.31 | 2.38 | -0.93 | sell |
| Polar Capital Holdings Plc | 979,917 | 889,198 | -90,719 | 0.13 | 0.08 | -0.05 | sell |
| CITADEL ADVISORS LLC | 886,641 | 762,411 | -124,230 | 0.02 | 0.01 | -0.01 | sell |
| 5AM Venture Management, LLC | 586,595 | 736,595 | +150,000 | 3.39 | 2.89 | -0.50 | buy |
| Logos Global Management LP | 600,000 | 700,000 | +100,000 | 1.45 | 1.29 | -0.16 | buy |
| TANG CAPITAL MANAGEMENT LLC | 692,925 | 692,925 | 0 | 1.39 | 1.26 | -0.13 | hold |
| Octagon Capital Advisors LP | 620,000 | 620,000 | 0 | 2.16 | 1.32 | -0.84 | hold |
| MPM BioImpact LLC | 100,000 | 614,010 | +514,010 | 0.51 | 1.73 | +1.22 | buy |
| RTW INVESTMENTS, LP | 605,816 | 605,816 | 0 | 0.21 | 0.16 | -0.05 | hold |
| MORGAN STANLEY | 524,901 | 562,541 | +37,640 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 381,737 | 543,140 | +161,403 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 286,448 | 475,733 | +189,285 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 413,641 | 462,680 | +49,039 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 0 | 438,922 | +438,922 | 0.00 | 0.07 | +0.07 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 371,311 | 424,085 | +52,774 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 202,491 | 408,887 | +206,396 | 0.02 | 0.03 | +0.01 | buy |
| Fisher Asset Management, LLC | 0 | 389,087 | +389,087 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 143,386 | 379,584 | +236,198 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 84,287 | 347,913 | +263,626 | 0.00 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 138,000 | 340,000 | +202,000 | 0.33 | 0.52 | +0.19 | buy |
| Russell Investments Group, Ltd. | 329,484 | 321,606 | -7,878 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 100,300 | 304,400 | +204,100 | 0.01 | 0.01 | +0.01 | buy |
| Rosalind Advisors, Inc. | 360,332 | 300,000 | -60,332 | 6.57 | 4.91 | -1.65 | sell |
| Candriam S.C.A. | 0 | 280,000 | +280,000 | 0.00 | 0.03 | +0.03 | buy |
| Cutter Capital Management, LP | 307,721 | 278,638 | -29,083 | 3.20 | 1.88 | -1.32 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 13,400 | 261,700 | +248,300 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 192,097 | 240,829 | +48,732 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 226,854 | +226,854 | 0.00 | 0.01 | +0.01 | buy |
| Kopp Family Office, LLC | 205,600 | 205,640 | +40 | 2.62 | 2.06 | -0.56 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 281,500 | 199,433 | -82,067 | 3.45 | 2.27 | -1.18 | sell |
| HighVista Strategies LLC | 198,484 | 198,484 | 0 | 1.57 | 1.24 | -0.33 | hold |
| Schonfeld Strategic Advisors LLC | 178,919 | 164,013 | -14,906 | 0.03 | 0.02 | -0.01 | sell |
| Bank of New York Mellon Corp | 149,811 | 151,862 | +2,051 | 0.00 | 0.00 | -0.00 | buy |
| BIT Capital GmbH | 6,593 | 145,556 | +138,963 | 0.02 | 0.23 | +0.21 | buy |
| Eversept Partners, LP | 137,343 | 142,075 | +4,732 | 0.29 | 0.19 | -0.11 | buy |
| Kynam Capital Management, LP | 607,915 | 133,877 | -474,038 | 1.50 | 0.26 | -1.24 | sell |
| BARCLAYS PLC | 219,593 | 124,148 | -95,445 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 159,700 | 111,400 | -48,300 | 0.09 | 0.05 | -0.04 | sell |
| Hennion & Walsh Asset Management, Inc. | 75,780 | 109,820 | +34,040 | 0.09 | 0.10 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 67,200 | 82,900 | +15,700 | 0.00 | 0.00 | -0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 153,949 | 78,822 | -75,127 | 0.22 | 0.10 | -0.12 | sell |
| MARSHALL WACE, LLP | 301,289 | 78,701 | -222,588 | 0.01 | 0.00 | -0.01 | sell |
| Cubist Systematic Strategies, LLC | 0 | 69,430 | +69,430 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 60,434 | 67,521 | +7,087 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 32,991 | 63,011 | +30,020 | 0.03 | 0.04 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,318 | 54,440 | +29,122 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 67,968 | 49,682 | -18,286 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 56,938 | 49,023 | -7,915 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 42,791 | 46,773 | +3,982 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 34,854 | 44,276 | +9,422 | 0.01 | 0.01 | -0.00 | buy |
| J. Goldman & Co LP | 0 | 44,264 | +44,264 | 0.00 | 0.04 | +0.04 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,394 | 42,596 | +5,202 | 0.00 | 0.00 | -0.00 | buy |
| Cinctive Capital Management LP | 41,168 | 40,858 | -310 | 0.06 | 0.04 | -0.03 | sell |
| Legal & General Group Plc | 34,566 | 39,087 | +4,521 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 37,820 | +37,820 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 25,893 | 32,128 | +6,235 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,940 | 31,369 | +5,429 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 27,687 | 28,822 | +1,135 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 28,406 | +28,406 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15,161 | 28,309 | +13,148 | 0.00 | 0.00 | +0.00 | buy |
| StoneCrest Wealth Management, Inc. | 27,791 | 27,675 | -116 | 0.58 | 0.42 | -0.16 | sell |
| Squarepoint Ops LLC | 0 | 26,956 | +26,956 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 22,271 | 25,570 | +3,299 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.05 | +0.05 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 21,249 | 24,515 | +3,266 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,055 | 24,237 | +8,182 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 58,325 | 22,270 | -36,055 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 224,789 | 20,471 | -204,318 | 0.00 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 10,875 | 19,323 | +8,448 | 0.02 | 0.02 | +0.01 | buy |
| Bellevue Group AG | 30,000 | 19,100 | -10,900 | 0.01 | 0.01 | -0.00 | sell |
| Corton Capital Inc. | 18,509 | 19,070 | +561 | 0.13 | 0.12 | -0.01 | buy |
| Invesco Ltd. | 144,765 | 18,730 | -126,035 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 17,495 | 17,946 | +451 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 30,000 | 16,457 | -13,543 | 0.02 | 0.01 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 16,682 | 14,985 | -1,697 | 0.00 | 0.00 | -0.00 | sell |
| DCF Advisers, LLC | 9,500 | 14,500 | +5,000 | 0.14 | 0.15 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 13,364 | 13,421 | +57 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 10,857 | 11,915 | +1,058 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 9,533 | 11,490 | +1,957 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 10,070 | 10,070 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,369 | 9,602 | +1,233 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,080 | 9,580 | -2,500 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 241,411 | 5,636 | -235,775 | 0.07 | 0.00 | -0.07 | sell |