| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 3,326,262 | 4,700,000 | +1,373,738 | 4.21 | 5.42 | +1.22 | buy |
| Commodore Capital LP | 2,400,000 | 3,600,000 | +1,200,000 | 3.37 | 3.58 | +0.20 | buy |
| MARSHALL WACE, LLP | 0 | 1,084,040 | +1,084,040 | 0.00 | 0.02 | +0.02 | buy |
| Deep Track Capital, LP | 4,522,741 | 5,380,449 | +857,708 | 3.25 | 2.35 | -0.90 | buy |
| Eversept Partners, LP | 779,998 | 1,377,674 | +597,676 | 1.54 | 2.10 | +0.56 | buy |
| Rosalind Advisors, Inc. | 0 | 595,000 | +595,000 | 0.00 | 3.91 | +3.91 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,326,811 | 1,688,129 | +361,318 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 11,881,912 | 12,222,986 | +341,074 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 920,094 | 1,231,092 | +310,998 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 53,375 | 362,893 | +309,518 | 0.06 | 0.29 | +0.23 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,492,925 | 2,792,925 | +300,000 | 3.16 | 2.08 | -1.08 | buy |
| Paradigm Biocapital Advisors LP | 1,820,079 | 2,095,079 | +275,000 | 1.21 | 1.30 | +0.09 | buy |
| Affinity Asset Advisors, LLC | 159,614 | 390,000 | +230,386 | 0.48 | 0.82 | +0.35 | buy |
| Exome Asset Management LLC | 0 | 217,294 | +217,294 | 0.00 | 2.62 | +2.62 | buy |
| Point72 Asset Management, L.P. | 0 | 204,702 | +204,702 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 177,166 | +177,166 | 0.00 | 0.04 | +0.04 | buy |
| Candriam S.C.A. | 731,221 | 880,430 | +149,209 | 0.08 | 0.07 | -0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 410,440 | 552,850 | +142,410 | 0.01 | 0.01 | -0.00 | buy |
| DIADEMA PARTNERS LP | 49,478 | 162,063 | +112,585 | 1.07 | 1.75 | +0.68 | buy |
| PANAGORA ASSET MANAGEMENT INC | 253,022 | 354,739 | +101,717 | 0.02 | 0.02 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 13,285 | 113,646 | +100,361 | 0.04 | 0.07 | +0.03 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 67,669 | +67,669 | 0.00 | 0.09 | +0.09 | buy |
| Squarepoint Ops LLC | 33,251 | 99,372 | +66,121 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 44,600 | 107,088 | +62,488 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,658,980 | 1,720,525 | +61,545 | 0.00 | 0.00 | -0.00 | buy |
| Artia Global Partners LP | 100,000 | 160,000 | +60,000 | 0.77 | 0.63 | -0.14 | buy |
| ADAR1 Capital Management, LLC | 26,000 | 79,000 | +53,000 | 0.10 | 0.20 | +0.10 | buy |
| HSBC HOLDINGS PLC | 0 | 39,452 | +39,452 | 0.00 | 0.00 | +0.00 | buy |
| J. Safra Sarasin Holding AG | 36,453 | 72,672 | +36,219 | 0.01 | 0.02 | +0.01 | buy |
| DCF Advisers, LLC | 29,750 | 62,029 | +32,279 | 0.29 | 0.45 | +0.16 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 178,444 | 208,836 | +30,392 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 48,022 | 75,186 | +27,164 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 154,563 | 180,551 | +25,988 | 1.10 | 0.94 | -0.16 | buy |
| Ikarian Capital, LLC | 469,949 | 494,949 | +25,000 | 2.57 | 2.17 | -0.40 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 224,484 | 249,170 | +24,686 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 39,575 | 61,628 | +22,053 | 0.01 | 0.01 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 19,631 | +19,631 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 518,027 | 537,024 | +18,997 | 0.00 | 0.00 | -0.00 | buy |
| MACQUARIE GROUP LTD | 142,393 | 160,948 | +18,555 | 0.00 | 0.00 | -0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 18,200 | +18,200 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 17,637 | +17,637 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 16,557 | +16,557 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 115,782 | 130,570 | +14,788 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 33,099 | 47,771 | +14,672 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 95,865 | 109,984 | +14,119 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 13,742 | +13,742 | 0.00 | 0.08 | +0.08 | buy |
| Quantbot Technologies LP | 8,575 | 21,131 | +12,556 | 0.01 | 0.01 | +0.00 | buy |
| Persistent Asset Partners Ltd | 25,237 | 37,211 | +11,974 | 0.42 | 0.44 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 64,447 | 76,333 | +11,886 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 49,720 | 60,235 | +10,515 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 34,419 | 44,389 | +9,970 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 48,793 | 58,271 | +9,478 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 113,562 | 122,892 | +9,330 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 9,129 | +9,129 | 0.00 | 0.03 | +0.03 | buy |
| SIMPLEX TRADING, LLC | 0 | 8,412 | +8,412 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 694,142 | 702,517 | +8,375 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 137,918 | 145,318 | +7,400 | 0.08 | 0.07 | -0.01 | buy |
| MAVERICK CAPITAL LTD | 2,053,906 | 2,061,274 | +7,368 | 0.71 | 0.50 | -0.21 | buy |
| Graham Capital Management, L.P. | 12,900 | 18,183 | +5,283 | 0.01 | 0.01 | +0.00 | buy |
| Knott David M Jr | 25,000 | 30,000 | +5,000 | 0.17 | 0.19 | +0.02 | buy |
| Point72 (DIFC) Ltd | 0 | 4,773 | +4,773 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 99,938 | 104,559 | +4,621 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 313,787 | 318,240 | +4,453 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 196,522 | 198,177 | +1,655 | 0.00 | 0.00 | -0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 57,711 | 59,281 | +1,570 | 0.07 | 0.06 | -0.02 | buy |
| Brooklyn Investment Group | 0 | 1,413 | +1,413 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 31,085 | 31,972 | +887 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 48,400 | 49,276 | +876 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 1,691 | 2,531 | +840 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 898 | 1,490 | +592 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 211 | 625 | +414 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 2,250,000 | 2,250,300 | +300 | 2.61 | 2.31 | -0.30 | buy |
| Versant Capital Management, Inc | 82 | 313 | +231 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 36,336 | 36,556 | +220 | 0.00 | 0.00 | -0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 174 | +174 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 21 | 180 | +159 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 134 | +134 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 128 | 234 | +106 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,241 | 1,327 | +86 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 75 | 115 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 369 | 393 | +24 | 0.00 | 0.00 | -0.00 | buy |
| TD PRIVATE CLIENT WEALTH LLC | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 6 | 20 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 60,202 | 60,215 | +13 | 0.00 | 0.00 | -0.00 | buy |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 78 | 83 | +5 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 7,646 | 7,646 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 54,710 | 54,710 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 9 | 9 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 27,472 | 27,472 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GREAT POINT PARTNERS LLC | 750,000 | 750,000 | 0 | 6.78 | 5.50 | -1.28 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,664 | 18,664 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mesirow Financial Investment Management, Inc. | 16,534 | 16,534 | 0 | 0.01 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 3,882,709 | 3,882,709 | 0 | 5.11 | 4.45 | -0.65 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |