| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 3,326,262 | 4,700,000 | +1,373,738 | 4.21 | 5.42 | +1.22 | buy |
| Commodore Capital LP | 2,400,000 | 3,600,000 | +1,200,000 | 3.37 | 3.58 | +0.20 | buy |
| Deep Track Capital, LP | 4,522,741 | 5,380,449 | +857,708 | 3.25 | 2.35 | -0.90 | buy |
| Eversept Partners, LP | 779,998 | 1,377,674 | +597,676 | 1.33 | 1.89 | +0.56 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 53,375 | 362,893 | +309,518 | 0.06 | 0.29 | +0.23 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,492,925 | 2,792,925 | +300,000 | 3.16 | 2.08 | -1.08 | buy |
| Paradigm Biocapital Advisors LP | 1,820,079 | 2,095,079 | +275,000 | 1.21 | 1.30 | +0.09 | buy |
| Affinity Asset Advisors, LLC | 159,614 | 390,000 | +230,386 | 0.48 | 0.82 | +0.35 | buy |
| Candriam S.C.A. | 731,221 | 880,430 | +149,209 | 0.08 | 0.07 | -0.01 | buy |
| DIADEMA PARTNERS LP | 49,478 | 162,063 | +112,585 | 1.07 | 1.75 | +0.68 | buy |
| Artia Global Partners LP | 100,000 | 160,000 | +60,000 | 0.77 | 0.63 | -0.14 | buy |
| ADAR1 Capital Management, LLC | 26,000 | 79,000 | +53,000 | 0.10 | 0.20 | +0.10 | buy |
| J. Safra Sarasin Holding AG | 36,453 | 72,672 | +36,219 | 0.01 | 0.02 | +0.01 | buy |
| DCF Advisers, LLC | 29,750 | 62,029 | +32,279 | 0.29 | 0.45 | +0.16 | buy |
| HighVista Strategies LLC | 154,563 | 180,551 | +25,988 | 1.10 | 0.94 | -0.16 | buy |
| Ikarian Capital, LLC | 469,949 | 494,949 | +25,000 | 2.57 | 2.17 | -0.40 | buy |
| Fisher Asset Management, LLC | 518,027 | 537,024 | +18,997 | 0.00 | 0.00 | -0.00 | buy |
| Persistent Asset Partners Ltd | 25,237 | 37,211 | +11,974 | 0.42 | 0.44 | +0.02 | buy |
| MAVERICK CAPITAL LTD | 2,053,906 | 2,061,274 | +7,368 | 0.71 | 0.50 | -0.21 | buy |
| Knott David M Jr | 25,000 | 30,000 | +5,000 | 0.17 | 0.19 | +0.02 | buy |
| Knights of Columbus Asset Advisors LLC | 57,711 | 59,281 | +1,570 | 0.07 | 0.06 | -0.02 | buy |
| Novo Holdings A/S | 2,250,000 | 2,250,300 | +300 | 2.61 | 2.31 | -0.30 | buy |
| J.Safra Asset Management Corp | 21 | 180 | +159 | 0.00 | 0.00 | +0.00 | buy |
| StoneCrest Wealth Management, Inc. | 25,859 | 25,707 | -152 | 0.32 | 0.22 | -0.10 | sell |
| MOODY ALDRICH PARTNERS LLC | 58,688 | 57,841 | -847 | 0.21 | 0.16 | -0.05 | sell |
| ALPS ADVISORS INC | 64,057 | 61,478 | -2,579 | 0.01 | 0.00 | -0.00 | sell |
| Nebula Research & Development LLC | 17,132 | 12,531 | -4,601 | 0.04 | 0.02 | -0.02 | sell |
| PROFUND ADVISORS LLC | 33,390 | 22,343 | -11,047 | 0.02 | 0.01 | -0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 210,899 | 199,193 | -11,706 | 0.18 | 0.12 | -0.06 | sell |
| Parkman Healthcare Partners LLC | 1,087,634 | 1,064,506 | -23,128 | 2.78 | 1.70 | -1.07 | sell |
| LOOMIS SAYLES & CO L P | 1,400,381 | 1,370,356 | -30,025 | 0.03 | 0.03 | -0.01 | sell |
| J. Goldman & Co LP | 179,496 | 118,594 | -60,902 | 0.09 | 0.04 | -0.05 | sell |
| BIT Capital GmbH | 285,954 | 71,680 | -214,274 | 0.44 | 0.08 | -0.35 | sell |
| Yiheng Capital Management, L.P. | 750,261 | 500,261 | -250,000 | 0.55 | 0.63 | +0.07 | sell |
| Octagon Capital Advisors LP | 870,000 | 450,000 | -420,000 | 2.84 | 1.19 | -1.64 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,670,000 | 1,114,586 | -555,414 | 0.06 | 0.03 | -0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,875,876 | 1,270,481 | -605,395 | 0.30 | 0.17 | -0.13 | sell |
| PERCEPTIVE ADVISORS LLC | 1,486,508 | 659,662 | -826,846 | 0.79 | 0.31 | -0.47 | sell |