| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 14,384,456 | 15,379,377 | +994,921 | 0.02 | 0.02 | -0.01 | buy |
| BlackRock, Inc. | 6,431,923 | 7,831,475 | +1,399,552 | 0.00 | 0.00 | -0.00 | buy |
| Bellevue Group AG | 4,358,527 | 6,726,144 | +2,367,617 | 2.57 | 3.13 | +0.56 | buy |
| STATE STREET CORP | 3,466,560 | 4,672,885 | +1,206,325 | 0.00 | 0.00 | -0.00 | buy |
| Fairmount Funds Management LLC | 3,914,458 | 3,914,458 | 0 | 9.27 | 5.53 | -3.74 | hold |
| VR Adviser, LLC | 3,882,709 | 3,882,709 | 0 | 5.97 | 2.83 | -3.13 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,439,414 | 3,206,035 | -233,379 | 0.01 | 0.01 | -0.00 | sell |
| Paradigm Biocapital Advisors LP | 1,443,102 | 3,148,893 | +1,705,791 | 1.20 | 1.26 | +0.06 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,971,411 | 3,078,554 | +1,107,143 | 0.01 | 0.01 | +0.00 | buy |
| Kynam Capital Management, LP | 1,470,541 | 2,341,652 | +871,111 | 2.98 | 2.91 | -0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,992,174 | 2,333,213 | +341,039 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 679,694 | 2,318,234 | +1,638,540 | 0.01 | 0.03 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 503,868 | 2,315,957 | +1,812,089 | 0.03 | 0.09 | +0.06 | buy |
| Novo Holdings A/S | 2,380,000 | 2,000,000 | -380,000 | 5.75 | 3.17 | -2.58 | sell |
| BAKER BROS. ADVISORS LP | 1,971,678 | 1,971,678 | 0 | 0.36 | 0.22 | -0.14 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,792,626 | 1,792,626 | 0 | 2.76 | 1.78 | -0.97 | hold |
| Fisher Asset Management, LLC | 1,780,284 | 1,768,295 | -11,989 | 0.02 | 0.01 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 1,264,047 | 1,591,945 | +327,898 | 0.01 | 0.00 | -0.00 | buy |
| Avoro Capital Advisors LLC | 1,500,000 | 1,500,000 | 0 | 0.46 | 0.29 | -0.17 | hold |
| Deep Track Capital, LP | 2,524,833 | 1,393,944 | -1,130,889 | 1.79 | 0.56 | -1.23 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,414,181 | 1,392,072 | -22,109 | 0.01 | 0.01 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 1,000,717 | 1,262,540 | +261,823 | 0.02 | 0.02 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 3,042,703 | 1,170,829 | -1,871,874 | 1.73 | 0.45 | -1.28 | sell |
| BANK OF AMERICA CORP /DE/ | 990,117 | 1,163,615 | +173,498 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 1,010,260 | 1,059,864 | +49,604 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 479,758 | 1,032,316 | +552,558 | 0.00 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 790,018 | 970,018 | +180,000 | 0.04 | 0.03 | -0.01 | buy |
| LOOMIS SAYLES & CO L P | 1,481,135 | 927,717 | -553,418 | 0.06 | 0.02 | -0.03 | sell |
| First Turn Management, LLC | 690,528 | 911,337 | +220,809 | 2.46 | 1.99 | -0.46 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 884,532 | 898,611 | +14,079 | 1.52 | 0.98 | -0.54 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 139,360 | 888,298 | +748,938 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,738,225 | 870,162 | -868,063 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 748,961 | 727,937 | -21,024 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 1,782,235 | 713,269 | -1,068,966 | 3.11 | 0.92 | -2.19 | sell |
| Candriam S.C.A. | 785,098 | 711,739 | -73,359 | 0.12 | 0.07 | -0.05 | sell |
| MetLife Investment Management, LLC | 43,985 | 708,527 | +664,542 | 0.01 | 0.07 | +0.06 | buy |
| Woodline Partners LP | 1,115,929 | 700,929 | -415,000 | 0.13 | 0.05 | -0.08 | sell |
| NORTHERN TRUST CORP | 668,417 | 696,999 | +28,582 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 416,358 | 668,968 | +252,610 | 0.02 | 0.02 | -0.00 | buy |
| MPM BioImpact LLC | 0 | 649,873 | +649,873 | 0.00 | 0.98 | +0.98 | buy |
| Nuveen, LLC | 742,337 | 604,914 | -137,423 | 0.01 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 425,039 | 563,999 | +138,960 | 0.21 | 0.17 | -0.04 | buy |
| Parkman Healthcare Partners LLC | 788,076 | 557,936 | -230,140 | 2.33 | 1.13 | -1.20 | sell |
| DIMENSIONAL FUND ADVISORS LP | 555,594 | 529,763 | -25,831 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 92,697 | 330,390 | +237,693 | 0.03 | 0.06 | +0.03 | buy |
| Point72 Asset Management, L.P. | 254,285 | 322,836 | +68,551 | 0.01 | 0.01 | -0.00 | buy |
| Pictet Asset Management Holding SA | 922,767 | 314,031 | -608,736 | 0.03 | 0.01 | -0.02 | sell |
| PANAGORA ASSET MANAGEMENT INC | 324,746 | 313,700 | -11,046 | 0.04 | 0.02 | -0.01 | sell |
| UBS Group AG | 164,820 | 307,134 | +142,314 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 77,198 | 304,422 | +227,224 | 0.18 | 0.36 | +0.18 | buy |
| FIRST TRUST ADVISORS LP | 119,892 | 301,529 | +181,637 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 303,774 | 293,308 | -10,466 | 0.00 | 0.00 | -0.00 | sell |
| Voleon Capital Management LP | 345,713 | 269,742 | -75,971 | 0.23 | 0.11 | -0.12 | sell |
| MARSHALL WACE, LLP | 1,375,739 | 269,587 | -1,106,152 | 0.04 | 0.01 | -0.04 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 517,398 | 266,399 | -250,999 | 0.01 | 0.00 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 13,761 | 262,017 | +248,256 | 0.00 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 47,033 | 253,972 | +206,939 | 0.04 | 0.09 | +0.05 | buy |
| Rosalind Advisors, Inc. | 450,000 | 250,401 | -199,599 | 5.10 | 2.01 | -3.10 | sell |
| Affinity Asset Advisors, LLC | 250,000 | 250,000 | 0 | 0.56 | 0.29 | -0.27 | hold |
| Russell Investments Group, Ltd. | 193,479 | 234,551 | +41,072 | 0.01 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 129,532 | 231,270 | +101,738 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 215,866 | 216,525 | +659 | 0.00 | 0.00 | -0.00 | buy |
| Propel Bio Management, LLC | 282,531 | 210,163 | -72,368 | 7.51 | 2.58 | -4.93 | sell |
| Yiheng Capital Management, L.P. | 208,735 | 208,735 | 0 | 2.83 | 1.77 | -1.06 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 203,100 | +203,100 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 226,817 | 188,177 | -38,640 | 0.00 | 0.00 | -0.00 | sell |
| Knott David M Jr | 145,000 | 181,000 | +36,000 | 2.09 | 2.11 | +0.02 | buy |
| Hennion & Walsh Asset Management, Inc. | 169,167 | 174,894 | +5,727 | 0.18 | 0.12 | -0.07 | buy |
| Privium Fund Management B.V. | 173,516 | 173,516 | 0 | 0.99 | 0.71 | -0.29 | hold |
| Vivo Capital, LLC | 982,576 | 166,288 | -816,288 | 1.98 | 0.27 | -1.71 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 158,371 | +158,371 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 183,468 | 152,596 | -30,872 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 99,750 | 141,977 | +42,227 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 460,125 | 140,595 | -319,530 | 0.01 | 0.00 | -0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 896 | 140,260 | +139,364 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 372,472 | 134,229 | -238,243 | 2.99 | 0.72 | -2.26 | sell |
| Swiss National Bank | 128,600 | 128,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nicholas Investment Partners, LP | 67,082 | 124,257 | +57,175 | 0.15 | 0.18 | +0.02 | buy |
| BARCLAYS PLC | 244,273 | 100,598 | -143,675 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 97,451 | 100,033 | +2,582 | 0.00 | 0.00 | -0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 96,187 | 95,235 | -952 | 0.56 | 0.34 | -0.22 | sell |
| Merck & Co., Inc. | 93,414 | 93,414 | 0 | 1.05 | 0.52 | -0.53 | hold |
| WELLS FARGO & COMPANY/MN | 147,316 | 93,204 | -54,112 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 86,500 | 91,123 | +4,623 | 1.57 | 1.12 | -0.45 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 112,682 | 81,425 | -31,257 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 63,297 | 81,021 | +17,724 | 0.00 | 0.00 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 47,681 | 76,884 | +29,203 | 0.11 | 0.16 | +0.05 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 175,930 | 75,200 | -100,730 | 0.00 | 0.00 | -0.00 | sell |
| J. Safra Sarasin Holding AG | 88,271 | 73,058 | -15,213 | 0.04 | 0.02 | -0.02 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 67,794 | 70,244 | +2,450 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 24,464 | 68,461 | +43,997 | 0.02 | 0.04 | +0.02 | buy |
| SEI INVESTMENTS CO | 30,318 | 65,777 | +35,459 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 65,080 | +65,080 | 0.00 | 1.06 | +1.06 | buy |
| Burkehill Global Management, LP | 65,000 | 65,000 | 0 | 0.13 | 0.06 | -0.07 | hold |
| Caitong International Asset Management Co., Ltd | 4 | 64,980 | +64,976 | 0.00 | 0.23 | +0.23 | buy |
| Jump Financial, LLC | 0 | 64,111 | +64,111 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 37,514 | 63,341 | +25,827 | 0.04 | 0.05 | +0.01 | buy |
| JANE STREET GROUP, LLC | 279,607 | 60,815 | -218,792 | 0.01 | 0.00 | -0.01 | sell |
| SG Americas Securities, LLC | 33,088 | 60,044 | +26,956 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 67,058 | 59,625 | -7,433 | 0.00 | 0.00 | -0.00 | sell |