| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 133,877 | 1,750,000 | +1,616,123 | 0.26 | 2.38 | +2.12 | buy |
| Novo Holdings A/S | 1,100,000 | 2,000,000 | +900,000 | 1.33 | 1.40 | +0.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 692,925 | 1,392,925 | +700,000 | 1.26 | 1.85 | +0.58 | buy |
| MAVERICK CAPITAL LTD | 2,692,414 | 3,307,945 | +615,531 | 0.91 | 0.82 | -0.10 | buy |
| Commodore Capital LP | 1,934,653 | 2,528,032 | +593,379 | 2.27 | 2.25 | -0.02 | buy |
| Candriam S.C.A. | 280,000 | 749,804 | +469,804 | 0.03 | 0.06 | +0.03 | buy |
| Deep Track Capital, LP | 3,456,053 | 3,923,849 | +467,796 | 1.74 | 1.52 | -0.21 | buy |
| Eversept Partners, LP | 142,075 | 567,487 | +425,412 | 0.17 | 0.51 | +0.34 | buy |
| Hennion & Walsh Asset Management, Inc. | 109,820 | 178,855 | +69,035 | 0.10 | 0.12 | +0.02 | buy |
| J. Goldman & Co LP | 44,264 | 74,985 | +30,721 | 0.02 | 0.03 | +0.00 | buy |
| Corton Capital Inc. | 19,070 | 31,732 | +12,662 | 0.12 | 0.22 | +0.09 | buy |
| Fisher Asset Management, LLC | 389,087 | 395,497 | +6,410 | 0.00 | 0.00 | -0.00 | buy |
| Cinctive Capital Management LP | 40,858 | 47,248 | +6,390 | 0.04 | 0.03 | -0.00 | buy |
| ALPS ADVISORS INC | 44,276 | 49,766 | +5,490 | 0.01 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 2,550 | 8,000 | +5,450 | 0.01 | 0.02 | +0.01 | buy |
| DCF Advisers, LLC | 14,500 | 17,750 | +3,250 | 0.15 | 0.12 | -0.03 | buy |
| VIRTUS ADVISERS, LLC | 4,479 | 6,884 | +2,405 | 0.04 | 0.04 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 78,822 | 79,974 | +1,152 | 0.10 | 0.07 | -0.03 | buy |
| Kopp Family Office, LLC | 205,640 | 205,737 | +97 | 2.06 | 1.66 | -0.40 | buy |
| StoneCrest Wealth Management, Inc. | 27,675 | 27,484 | -191 | 0.42 | 0.27 | -0.15 | sell |
| Polar Asset Management Partners Inc. | 111,400 | 109,900 | -1,500 | 0.03 | 0.03 | -0.00 | sell |
| Woodline Partners LP | 438,922 | 400,915 | -38,007 | 0.07 | 0.05 | -0.02 | sell |
| GREAT POINT PARTNERS LLC | 1,335,000 | 500,000 | -835,000 | 3.64 | 1.25 | -2.40 | sell |
| PERCEPTIVE ADVISORS LLC | 3,657,099 | 1,631,828 | -2,025,271 | 1.12 | 0.51 | -0.61 | sell |
| Paradigm Biocapital Advisors LP | 5,031,420 | 2,896,349 | -2,135,071 | 3.10 | 1.44 | -1.66 | sell |