| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 133,877 | 1,750,000 | +1,616,123 | 0.26 | 2.38 | +2.12 | buy |
| Novo Holdings A/S | 1,100,000 | 2,000,000 | +900,000 | 1.33 | 1.40 | +0.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 692,925 | 1,392,925 | +700,000 | 1.26 | 1.85 | +0.58 | buy |
| MAVERICK CAPITAL LTD | 2,692,414 | 3,307,945 | +615,531 | 0.91 | 0.82 | -0.10 | buy |
| Commodore Capital LP | 1,934,653 | 2,528,032 | +593,379 | 2.27 | 2.25 | -0.02 | buy |
| Candriam S.C.A. | 280,000 | 749,804 | +469,804 | 0.03 | 0.06 | +0.03 | buy |
| Deep Track Capital, LP | 3,456,053 | 3,923,849 | +467,796 | 1.74 | 1.52 | -0.21 | buy |
| GOLDMAN SACHS GROUP INC | 543,140 | 999,941 | +456,801 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 142,075 | 567,487 | +425,412 | 0.19 | 0.57 | +0.38 | buy |
| Walleye Capital LLC | 5,636 | 430,596 | +424,960 | 0.00 | 0.06 | +0.06 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,722,819 | 1,998,192 | +275,373 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,164,272 | 1,411,360 | +247,088 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 304,400 | 526,700 | +222,300 | 0.01 | 0.02 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 20,471 | 228,182 | +207,711 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 226,854 | 419,820 | +192,966 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 9,415,135 | 9,573,348 | +158,213 | 0.01 | 0.01 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.31 | +0.31 | buy |
| Squarepoint Ops LLC | 26,956 | 142,936 | +115,980 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 3,234,279 | 3,345,731 | +111,452 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 10,070 | 107,580 | +97,510 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 49,023 | 125,710 | +76,687 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 109,820 | 178,855 | +69,035 | 0.10 | 0.12 | +0.02 | buy |
| JANE STREET GROUP, LLC | 49,682 | 113,075 | +63,393 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 424,085 | 483,921 | +59,836 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 151,862 | 208,676 | +56,814 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 46,056 | +46,056 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 240,829 | 284,044 | +43,215 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 0 | 41,824 | +41,824 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 28,309 | 69,330 | +41,021 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 44,264 | 74,985 | +30,721 | 0.04 | 0.04 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 29,370 | +29,370 | 0.00 | 0.00 | +0.00 | buy |
| Belvedere Trading LLC | 0 | 28,720 | +28,720 | 0.00 | 0.02 | +0.02 | buy |
| Bayesian Capital Management, LP | 0 | 28,682 | +28,682 | 0.00 | 0.04 | +0.04 | buy |
| Russell Investments Group, Ltd. | 321,606 | 349,631 | +28,025 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 67,521 | 90,826 | +23,305 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 22,444 | +22,444 | 0.00 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 21,016 | +21,016 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 20,985 | +20,985 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 25,000 | 44,300 | +19,300 | 0.05 | 0.06 | +0.01 | buy |
| Nebula Research & Development LLC | 0 | 18,897 | +18,897 | 0.00 | 0.04 | +0.04 | buy |
| Jump Financial, LLC | 0 | 18,800 | +18,800 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 22,270 | 40,188 | +17,918 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 37,820 | 55,493 | +17,673 | 0.03 | 0.02 | -0.00 | buy |
| NORTHERN TRUST CORP | 462,680 | 479,881 | +17,201 | 0.00 | 0.00 | -0.00 | buy |
| Bridgefront Capital, LLC | 0 | 15,709 | +15,709 | 0.00 | 0.09 | +0.09 | buy |
| JANUS HENDERSON GROUP PLC | 13,421 | 27,472 | +14,051 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 13,794 | +13,794 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,369 | 44,419 | +13,050 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 19,070 | 31,732 | +12,662 | 0.12 | 0.22 | +0.09 | buy |
| MetLife Investment Management, LLC | 25,570 | 36,381 | +10,811 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 10,324 | +10,324 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 9,864 | +9,864 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 82,900 | 92,600 | +9,700 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,096 | 9,794 | +8,698 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,237 | 31,687 | +7,450 | 0.00 | 0.00 | -0.00 | buy |
| Fisher Asset Management, LLC | 389,087 | 395,497 | +6,410 | 0.00 | 0.00 | -0.00 | buy |
| Cinctive Capital Management LP | 40,858 | 47,248 | +6,390 | 0.04 | 0.03 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 14,985 | 20,950 | +5,965 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 5,569 | +5,569 | 0.00 | 0.03 | +0.03 | buy |
| ALPS ADVISORS INC | 44,276 | 49,766 | +5,490 | 0.01 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 2,550 | 8,000 | +5,450 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 32,128 | 37,458 | +5,330 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 1,364 | 6,056 | +4,692 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,596 | 47,225 | +4,629 | 0.00 | 0.00 | -0.00 | buy |
| DCF Advisers, LLC | 14,500 | 17,750 | +3,250 | 0.15 | 0.12 | -0.03 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 9,580 | 12,080 | +2,500 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 39,087 | 41,533 | +2,446 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,479 | 6,884 | +2,405 | 0.04 | 0.04 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,602 | 11,961 | +2,359 | 0.00 | 0.00 | -0.00 | buy |
| Catalyst Funds Management Pty Ltd | 2,700 | 5,000 | +2,300 | 0.01 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 18,730 | 20,571 | +1,841 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 17,946 | 19,719 | +1,773 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 11,490 | 13,178 | +1,688 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 46,773 | 48,445 | +1,672 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,961 | 6,130 | +1,169 | 0.00 | 0.00 | -0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 78,822 | 79,974 | +1,152 | 0.10 | 0.07 | -0.03 | buy |
| NISA INVESTMENT ADVISORS, LLC | 75 | 1,132 | +1,057 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 242 | 596 | +354 | 0.00 | 0.00 | -0.00 | buy |
| Clearstead Advisors, LLC | 0 | 126 | +126 | 0.00 | 0.00 | +0.00 | buy |
| Kopp Family Office, LLC | 205,640 | 205,737 | +97 | 2.06 | 1.66 | -0.40 | buy |
| CWM, LLC | 0 | 92 | +92 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 40 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 4 | 8 | +4 | 0.00 | 0.00 | 0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| HighVista Strategies LLC | 198,484 | 198,484 | 0 | 1.24 | 0.94 | -0.30 | hold |
| Yiheng Capital Management, L.P. | 948,130 | 948,130 | 0 | 2.38 | 1.74 | -0.64 | hold |
| Alyeska Investment Group, L.P. | 100,000 | 100,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| RTW INVESTMENTS, LP | 605,816 | 605,816 | 0 | 0.16 | 0.12 | -0.03 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 199,433 | 199,433 | 0 | 2.27 | 2.19 | -0.08 | hold |
| VR Adviser, LLC | 3,882,671 | 3,882,671 | 0 | 3.23 | 3.22 | -0.02 | hold |
| Rosalind Advisors, Inc. | 300,000 | 300,000 | 0 | 4.91 | 3.09 | -1.83 | hold |
| Vivo Capital, LLC | 1,678,207 | 1,678,207 | 0 | 2.31 | 2.02 | -0.29 | hold |
| 5AM Venture Management, LLC | 736,595 | 736,595 | 0 | 2.89 | 2.14 | -0.74 | hold |
| Fairmount Funds Management LLC | 1,845,813 | 1,845,813 | 0 | 3.52 | 2.71 | -0.81 | hold |
| Soleus Capital Management, L.P. | 340,000 | 340,000 | 0 | 0.52 | 0.39 | -0.13 | hold |
| Polar Capital Holdings Plc | 889,198 | 889,198 | 0 | 0.08 | 0.07 | -0.01 | hold |
| Octagon Capital Advisors LP | 620,000 | 620,000 | 0 | 1.32 | 1.33 | +0.01 | hold |
| Farther Finance Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOISARD ASSET MANAGEMENT GROUP, INC. | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BIT Capital GmbH | 145,556 | 145,556 | 0 | 0.23 | 0.17 | -0.05 | hold |