| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 3,600,000 | 4,875,000 | +1,275,000 | 3.58 | 4.81 | +1.23 | buy |
| Paradigm Biocapital Advisors LP | 2,095,079 | 2,741,576 | +646,497 | 1.30 | 1.64 | +0.34 | buy |
| Eversept Partners, LP | 1,377,674 | 1,902,539 | +524,865 | 1.89 | 2.45 | +0.56 | buy |
| HighVista Strategies LLC | 180,551 | 484,559 | +304,008 | 0.94 | 2.49 | +1.55 | buy |
| Parkman Healthcare Partners LLC | 1,064,506 | 1,298,825 | +234,319 | 1.70 | 2.09 | +0.38 | buy |
| MAVERICK CAPITAL LTD | 2,061,274 | 2,257,010 | +195,736 | 0.50 | 0.48 | -0.02 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 362,893 | 515,623 | +152,730 | 0.29 | 0.39 | +0.10 | buy |
| Novo Holdings A/S | 2,250,300 | 2,380,000 | +129,700 | 2.31 | 2.35 | +0.04 | buy |
| Rosalind Advisors, Inc. | 595,000 | 700,000 | +105,000 | 3.90 | 4.64 | +0.74 | buy |
| J. Safra Sarasin Holding AG | 72,672 | 171,119 | +98,447 | 0.02 | 0.04 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 79,000 | 170,598 | +91,598 | 0.20 | 0.39 | +0.18 | buy |
| Knott David M Jr | 30,000 | 91,483 | +61,483 | 0.19 | 0.58 | +0.39 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,792,925 | 2,842,925 | +50,000 | 2.08 | 2.01 | -0.07 | buy |
| MOODY ALDRICH PARTNERS LLC | 57,841 | 89,164 | +31,323 | 0.16 | 0.24 | +0.08 | buy |
| Fairmount Funds Management LLC | 3,445,813 | 3,459,913 | +14,100 | 7.21 | 6.27 | -0.94 | buy |
| Woodline Partners LP | 813,647 | 815,485 | +1,838 | 0.07 | 0.06 | -0.01 | buy |
| EntryPoint Capital, LLC | 13,742 | 13,232 | -510 | 0.08 | 0.09 | +0.01 | sell |
| StoneCrest Wealth Management, Inc. | 25,707 | 25,070 | -637 | 0.22 | 0.17 | -0.05 | sell |
| Knights of Columbus Asset Advisors LLC | 59,281 | 58,024 | -1,257 | 0.06 | 0.05 | -0.01 | sell |
| Kopp Family Office, LLC | 205,407 | 203,230 | -2,177 | 1.91 | 1.84 | -0.08 | sell |
| Virtus Investment Advisers, LLC | 9,129 | 6,001 | -3,128 | 0.03 | 0.03 | -0.01 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 18,200 | 12,900 | -5,300 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 22,343 | 16,465 | -5,878 | 0.01 | 0.01 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,114,586 | 1,108,586 | -6,000 | 0.03 | 0.03 | -0.00 | sell |
| Persistent Asset Partners Ltd | 37,211 | 28,032 | -9,179 | 0.44 | 0.34 | -0.10 | sell |
| J. Goldman & Co LP | 118,594 | 100,777 | -17,817 | 0.04 | 0.03 | -0.01 | sell |
| Candriam S.C.A. | 880,430 | 862,273 | -18,157 | 0.07 | 0.07 | -0.00 | sell |
| Ikarian Capital, LLC | 494,949 | 469,949 | -25,000 | 0.82 | 1.26 | +0.44 | sell |
| Fisher Asset Management, LLC | 537,024 | 509,959 | -27,065 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 199,193 | 168,324 | -30,869 | 0.12 | 0.10 | -0.02 | sell |
| LOOMIS SAYLES & CO L P | 1,370,356 | 1,338,472 | -31,884 | 0.03 | 0.02 | -0.00 | sell |
| DIADEMA PARTNERS LP | 162,063 | 122,061 | -40,002 | 1.75 | 1.06 | -0.68 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 67,669 | 17,401 | -50,268 | 0.07 | 0.02 | -0.05 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 177,166 | 111,545 | -65,621 | 0.03 | 0.04 | +0.01 | sell |
| BIT Capital GmbH | 71,680 | 3,533 | -68,147 | 0.08 | 0.00 | -0.08 | sell |
| PERCEPTIVE ADVISORS LLC | 659,662 | 447,507 | -212,155 | 0.31 | 0.23 | -0.08 | sell |
| Kynam Capital Management, LP | 4,700,000 | 4,427,927 | -272,073 | 5.42 | 6.66 | +1.24 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,270,481 | 376,846 | -893,635 | 0.17 | 0.04 | -0.12 | sell |