| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 12,222,986 | 12,238,803 | +15,817 | 0.01 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 5,708,110 | 5,521,035 | -187,075 | 0.00 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 5,380,449 | 5,380,449 | 0 | 2.35 | 2.42 | +0.07 | hold |
| Commodore Capital LP | 3,600,000 | 4,875,000 | +1,275,000 | 3.58 | 4.81 | +1.23 | buy |
| VANGUARD GROUP INC | 4,563,100 | 4,508,508 | -54,592 | 0.00 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 4,700,000 | 4,427,927 | -272,073 | 5.42 | 6.66 | +1.24 | sell |
| VR Adviser, LLC | 3,882,709 | 3,882,709 | 0 | 4.45 | 4.07 | -0.39 | hold |
| Fairmount Funds Management LLC | 3,445,813 | 3,459,913 | +14,100 | 7.21 | 6.27 | -0.94 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,688,129 | 2,895,265 | +1,207,136 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,792,925 | 2,842,925 | +50,000 | 2.08 | 2.01 | -0.07 | buy |
| Paradigm Biocapital Advisors LP | 2,095,079 | 2,741,576 | +646,497 | 1.30 | 1.64 | +0.34 | buy |
| STATE STREET CORP | 2,865,500 | 2,553,426 | -312,074 | 0.00 | 0.00 | -0.00 | sell |
| Novo Holdings A/S | 2,250,300 | 2,380,000 | +129,700 | 2.31 | 2.35 | +0.04 | buy |
| MAVERICK CAPITAL LTD | 2,061,274 | 2,257,010 | +195,736 | 0.50 | 0.48 | -0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,021,619 | 1,944,020 | -77,599 | 0.01 | 0.01 | -0.00 | sell |
| Eversept Partners, LP | 1,377,674 | 1,902,539 | +524,865 | 2.10 | 2.68 | +0.58 | buy |
| BAKER BROS. ADVISORS LP | 0 | 1,744,406 | +1,744,406 | 0.00 | 0.24 | +0.24 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,720,525 | 1,740,614 | +20,089 | 0.00 | 0.00 | -0.00 | buy |
| LOOMIS SAYLES & CO L P | 1,370,356 | 1,338,472 | -31,884 | 0.03 | 0.02 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 1,064,506 | 1,298,825 | +234,319 | 1.70 | 2.10 | +0.40 | buy |
| Pictet Asset Management Holding SA | 1,248,721 | 1,265,754 | +17,033 | 0.02 | 0.02 | -0.00 | buy |
| MARSHALL WACE, LLP | 1,084,040 | 1,207,871 | +123,831 | 0.02 | 0.02 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,114,586 | 1,108,586 | -6,000 | 0.03 | 0.03 | -0.00 | sell |
| Vivo Capital, LLC | 982,576 | 982,576 | 0 | 1.75 | 1.41 | -0.35 | hold |
| GOLDMAN SACHS GROUP INC | 1,231,092 | 899,825 | -331,267 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 880,430 | 862,273 | -18,157 | 0.07 | 0.07 | -0.00 | sell |
| Woodline Partners LP | 813,647 | 815,485 | +1,838 | 0.07 | 0.06 | -0.01 | buy |
| 5AM Venture Management, LLC | 736,595 | 736,595 | 0 | 3.76 | 3.96 | +0.20 | hold |
| Rosalind Advisors, Inc. | 595,000 | 700,000 | +105,000 | 3.91 | 4.74 | +0.83 | buy |
| CITADEL ADVISORS LLC | 88,547 | 649,543 | +560,996 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 702,517 | 596,883 | -105,634 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 565,963 | 574,021 | +8,058 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 552,850 | 564,790 | +11,940 | 0.01 | 0.01 | -0.00 | buy |
| UBS Group AG | 504,185 | 533,643 | +29,458 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 362,893 | 515,623 | +152,730 | 0.29 | 0.39 | +0.10 | buy |
| Fisher Asset Management, LLC | 537,024 | 509,959 | -27,065 | 0.00 | 0.00 | -0.00 | sell |
| Yiheng Capital Management, L.P. | 500,261 | 500,261 | 0 | 2.37 | 2.53 | +0.16 | hold |
| DIMENSIONAL FUND ADVISORS LP | 0 | 485,698 | +485,698 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 180,551 | 484,559 | +304,008 | 0.94 | 2.49 | +1.55 | buy |
| Ikarian Capital, LLC | 494,949 | 469,949 | -25,000 | 2.17 | 2.17 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 659,662 | 447,507 | -212,155 | 0.32 | 0.23 | -0.08 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 423,272 | 423,272 | 0 | 1.18 | 0.70 | -0.48 | hold |
| JPMORGAN CHASE & CO | 298,550 | 415,989 | +117,439 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 390,000 | 390,000 | 0 | 0.82 | 0.81 | -0.02 | hold |
| DEUTSCHE BANK AG\ | 396,808 | 386,938 | -9,870 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,270,481 | 376,846 | -893,635 | 0.17 | 0.04 | -0.12 | sell |
| PANAGORA ASSET MANAGEMENT INC | 354,739 | 351,852 | -2,887 | 0.02 | 0.02 | -0.00 | sell |
| ROYAL BANK OF CANADA | 0 | 345,898 | +345,898 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 318,240 | 332,089 | +13,849 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 249,170 | 270,543 | +21,373 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 124,063 | 231,104 | +107,041 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 180,123 | 230,844 | +50,721 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 248,628 | 223,235 | -25,393 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 208,836 | 203,836 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| Kopp Family Office, LLC | 205,407 | 203,230 | -2,177 | 1.91 | 1.84 | -0.08 | sell |
| MORGAN STANLEY | 341,795 | 200,367 | -141,428 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 198,177 | 192,524 | -5,653 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 138,864 | 190,229 | +51,365 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 130,570 | 190,104 | +59,534 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 145,318 | 182,452 | +37,134 | 0.07 | 0.08 | +0.01 | buy |
| J. Safra Sarasin Holding AG | 72,672 | 171,119 | +98,447 | 0.02 | 0.04 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 79,000 | 170,598 | +91,598 | 0.20 | 0.39 | +0.18 | buy |
| Hennion & Walsh Asset Management, Inc. | 199,193 | 168,324 | -30,869 | 0.12 | 0.10 | -0.02 | sell |
| MACQUARIE GROUP LTD | 160,948 | 157,167 | -3,781 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 81,509 | 138,751 | +57,242 | 0.01 | 0.01 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 107,088 | 131,294 | +24,206 | 0.03 | 0.05 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 109,984 | 126,023 | +16,039 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 162,063 | 122,061 | -40,002 | 1.75 | 1.06 | -0.68 | sell |
| Hudson Bay Capital Management LP | 0 | 119,562 | +119,562 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 177,166 | 111,545 | -65,621 | 0.04 | 0.04 | +0.00 | sell |
| Swiss National Bank | 107,500 | 108,900 | +1,400 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 104,559 | 107,385 | +2,826 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 122,892 | 104,567 | -18,325 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 204,702 | 104,043 | -100,659 | 0.01 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 118,594 | 100,777 | -17,817 | 0.06 | 0.04 | -0.01 | sell |
| Vestal Point Capital, LP | 0 | 100,000 | +100,000 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA ADVISERS, LP | 193,300 | 93,800 | -99,500 | 0.01 | 0.00 | -0.00 | sell |
| Merck & Co., Inc. | 93,414 | 93,414 | 0 | 0.77 | 0.61 | -0.16 | hold |
| Knott David M Jr | 30,000 | 91,483 | +61,483 | 0.19 | 0.58 | +0.39 | buy |
| TD ASSET MANAGEMENT INC | 32,600 | 89,600 | +57,000 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 57,841 | 89,164 | +31,323 | 0.16 | 0.24 | +0.08 | buy |
| Russell Investments Group, Ltd. | 198,258 | 87,885 | -110,373 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 0 | 86,500 | +86,500 | 0.00 | 1.21 | +1.21 | buy |
| WELLS FARGO & COMPANY/MN | 76,333 | 79,781 | +3,448 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 60,235 | 78,515 | +18,280 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 105,874 | 76,412 | -29,462 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 222,399 | 69,977 | -152,422 | 0.01 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 104,017 | 64,556 | -39,461 | 0.02 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 47,771 | 62,217 | +14,446 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 62,029 | 62,029 | 0 | 0.45 | 0.42 | -0.03 | hold |
| Legal & General Group Plc | 60,215 | 59,983 | -232 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 297,966 | 59,436 | -238,530 | 0.00 | 0.00 | -0.00 | sell |
| Knights of Columbus Asset Advisors LLC | 59,281 | 58,024 | -1,257 | 0.06 | 0.05 | -0.01 | sell |
| Graham Capital Management, L.P. | 18,183 | 55,196 | +37,013 | 0.01 | 0.02 | +0.02 | buy |
| Verition Fund Management LLC | 17,637 | 53,925 | +36,288 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 54,710 | 53,689 | -1,021 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 52,571 | +52,571 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 44,389 | 51,425 | +7,036 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 61,628 | 50,668 | -10,960 | 0.01 | 0.01 | -0.00 | sell |
| ALPS ADVISORS INC | 61,478 | 43,969 | -17,509 | 0.00 | 0.00 | -0.00 | sell |