| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 2,341,652 | 6,453,877 | +4,112,225 | 2.91 | 6.55 | +3.65 | buy |
| Paradigm Biocapital Advisors LP | 3,148,893 | 6,723,788 | +3,574,895 | 1.26 | 2.31 | +1.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,206,035 | 5,748,410 | +2,542,375 | 0.01 | 0.01 | +0.00 | buy |
| Deep Track Capital, LP | 1,393,944 | 3,592,740 | +2,198,796 | 0.56 | 0.97 | +0.41 | buy |
| Caligan Partners LP | 0 | 2,193,981 | +2,193,981 | 0.00 | 1.94 | +1.94 | buy |
| Point72 Asset Management, L.P. | 322,836 | 2,343,208 | +2,020,372 | 0.01 | 0.07 | +0.05 | buy |
| STATE STREET CORP | 4,672,885 | 6,124,976 | +1,452,091 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 15,379,377 | 16,604,740 | +1,225,363 | 0.02 | 0.01 | -0.00 | buy |
| Fairmount Funds Management LLC | 3,914,458 | 5,090,928 | +1,176,470 | 5.53 | 6.18 | +0.65 | buy |
| UBS Group AG | 307,134 | 1,428,843 | +1,121,709 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 23,279 | 1,112,413 | +1,089,134 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 529,763 | 1,611,521 | +1,081,758 | 0.00 | 0.01 | +0.00 | buy |
| Avoro Capital Advisors LLC | 1,500,000 | 2,500,000 | +1,000,000 | 0.29 | 0.41 | +0.12 | buy |
| Candriam S.C.A. | 711,739 | 1,707,698 | +995,959 | 0.07 | 0.14 | +0.07 | buy |
| Parkman Healthcare Partners LLC | 557,936 | 1,377,576 | +819,640 | 1.13 | 2.60 | +1.47 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 815,027 | +815,027 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 793,508 | +793,508 | 0.00 | 0.08 | +0.08 | buy |
| First Turn Management, LLC | 911,337 | 1,670,000 | +758,663 | 1.99 | 3.28 | +1.29 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 266,399 | 1,012,138 | +745,739 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 7,831,475 | 8,551,488 | +720,013 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 203,100 | 768,600 | +565,500 | 0.01 | 0.02 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 541,058 | +541,058 | 0.00 | 0.19 | +0.19 | buy |
| EMERALD ADVISERS, LLC | 0 | 537,328 | +537,328 | 0.00 | 0.23 | +0.23 | buy |
| Ikarian Capital, LLC | 0 | 425,000 | +425,000 | 0.00 | 1.28 | +1.28 | buy |
| BAKER BROS. ADVISORS LP | 1,971,678 | 2,383,025 | +411,347 | 0.22 | 0.22 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 395,546 | +395,546 | 0.00 | 0.26 | +0.26 | buy |
| Jump Financial, LLC | 64,111 | 398,251 | +334,140 | 0.02 | 0.07 | +0.05 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 898,611 | 1,175,906 | +277,295 | 0.98 | 1.05 | +0.07 | buy |
| Blue Owl Capital Holdings LP | 0 | 260,000 | +260,000 | 0.00 | 0.73 | +0.73 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 197,848 | +197,848 | 0.00 | 0.03 | +0.03 | buy |
| Yiheng Capital Management, L.P. | 208,735 | 400,464 | +191,729 | 1.77 | 3.14 | +1.37 | buy |
| TD ASSET MANAGEMENT INC | 55,386 | 235,606 | +180,220 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,333,213 | 2,501,869 | +168,656 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 696,999 | 863,491 | +166,492 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 2,000,000 | 2,135,000 | +135,000 | 3.17 | 2.28 | -0.89 | buy |
| F/m Investments LLC | 0 | 134,761 | +134,761 | 0.00 | 0.13 | +0.13 | buy |
| Squarepoint Ops LLC | 43,909 | 176,955 | +133,046 | 0.00 | 0.01 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 120,000 | +120,000 | 0.00 | 0.07 | +0.07 | buy |
| Eversept Partners, LP | 713,269 | 831,142 | +117,873 | 0.92 | 0.83 | -0.09 | buy |
| CITIGROUP INC | 23,458 | 140,415 | +116,957 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 888,298 | 999,915 | +111,617 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 0 | 111,572 | +111,572 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 20,208 | 127,301 | +107,093 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 101,414 | +101,414 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 100,000 | +100,000 | 0.00 | 0.65 | +0.65 | buy |
| GOLDMAN SACHS GROUP INC | 1,591,945 | 1,691,304 | +99,359 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 81,425 | 180,348 | +98,923 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 96,756 | +96,756 | 0.00 | 0.04 | +0.04 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 727,937 | 815,027 | +87,090 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,277 | 130,284 | +76,007 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 62,184 | +62,184 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 473 | 60,846 | +60,373 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 216,525 | 268,060 | +51,535 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,078,554 | 3,128,362 | +49,808 | 0.01 | 0.01 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 49,177 | +49,177 | 0.00 | 0.06 | +0.06 | buy |
| SG Americas Securities, LLC | 60,044 | 109,073 | +49,029 | 0.00 | 0.00 | -0.00 | buy |
| Advisory Services Network, LLC | 100 | 47,860 | +47,760 | 0.00 | 0.01 | +0.01 | buy |
| Handelsbanken Fonder AB | 0 | 45,400 | +45,400 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 45,078 | +45,078 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 45,127 | 86,040 | +40,913 | 0.04 | 0.06 | +0.01 | buy |
| J. Safra Sarasin Holding AG | 73,058 | 107,839 | +34,781 | 0.02 | 0.03 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 174,894 | 209,092 | +34,198 | 0.12 | 0.11 | -0.01 | buy |
| DOLIVER ADVISORS, LP | 0 | 30,000 | +30,000 | 0.00 | 0.12 | +0.12 | buy |
| Swiss National Bank | 128,600 | 155,100 | +26,500 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 134,229 | 159,885 | +25,656 | 0.72 | 0.67 | -0.06 | buy |
| Persistent Asset Partners Ltd | 0 | 25,490 | +25,490 | 0.00 | 0.15 | +0.15 | buy |
| WELLS FARGO & COMPANY/MN | 93,204 | 115,563 | +22,359 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 21,949 | +21,949 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 253,972 | 275,165 | +21,193 | 0.09 | 0.07 | -0.02 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 21,070 | +21,070 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 15,984 | 35,775 | +19,791 | 0.00 | 0.00 | +0.00 | buy |
| Bayforest Capital Ltd | 0 | 19,775 | +19,775 | 0.00 | 0.34 | +0.34 | buy |
| RHUMBLINE ADVISERS | 100,033 | 117,747 | +17,714 | 0.00 | 0.00 | -0.00 | buy |
| ALLSTATE CORP | 0 | 14,955 | +14,955 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 33,223 | 46,544 | +13,321 | 0.07 | 0.09 | +0.02 | buy |
| Knights of Columbus Asset Advisors LLC | 57,789 | 70,553 | +12,764 | 0.06 | 0.06 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 8,439 | 20,012 | +11,573 | 0.05 | 0.09 | +0.04 | buy |
| Aquatic Capital Management LLC | 68,461 | 79,845 | +11,384 | 0.04 | 0.05 | +0.01 | buy |
| NATIONS FINANCIAL GROUP INC, /IA/ /ADV | 0 | 11,272 | +11,272 | 0.00 | 0.01 | +0.01 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 11,100 | +11,100 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 313,700 | 324,658 | +10,958 | 0.02 | 0.02 | -0.00 | buy |
| Man Group plc | 0 | 10,740 | +10,740 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 81,021 | 91,402 | +10,381 | 0.00 | 0.00 | -0.00 | buy |
| LMR Partners LLP | 1,159 | 10,000 | +8,841 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 37,462 | 45,760 | +8,298 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 7,000 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 922 | 7,782 | +6,860 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 6,851 | +6,851 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 22,781 | 29,283 | +6,502 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 48,195 | 54,051 | +5,856 | 0.00 | 0.00 | -0.00 | buy |
| DCF Advisers, LLC | 32,150 | 38,000 | +5,850 | 0.24 | 0.18 | -0.05 | buy |
| Bellevue Group AG | 6,726,144 | 6,731,909 | +5,765 | 3.13 | 2.60 | -0.53 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 5,386 | +5,386 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 59,625 | 64,788 | +5,163 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 21,485 | 26,641 | +5,156 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 13,101 | 18,108 | +5,007 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 15,515 | 19,501 | +3,986 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 6,450 | 10,100 | +3,650 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 13,900 | 17,500 | +3,600 | 0.00 | 0.00 | -0.00 | buy |