| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 15,379,377 | 16,604,740 | +1,225,363 | 0.02 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 7,831,475 | 8,551,488 | +720,013 | 0.00 | 0.00 | -0.00 | buy |
| Bellevue Group AG | 6,726,144 | 6,731,909 | +5,765 | 3.13 | 2.60 | -0.53 | buy |
| Paradigm Biocapital Advisors LP | 3,148,893 | 6,723,788 | +3,574,895 | 1.26 | 2.31 | +1.05 | buy |
| Kynam Capital Management, LP | 2,341,652 | 6,453,877 | +4,112,225 | 2.91 | 6.55 | +3.65 | buy |
| STATE STREET CORP | 4,672,885 | 6,124,976 | +1,452,091 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,206,035 | 5,748,410 | +2,542,375 | 0.01 | 0.01 | +0.00 | buy |
| Fairmount Funds Management LLC | 3,914,458 | 5,090,928 | +1,176,470 | 5.53 | 6.18 | +0.65 | buy |
| Deep Track Capital, LP | 1,393,944 | 3,592,740 | +2,198,796 | 0.56 | 0.97 | +0.41 | buy |
| VR Adviser, LLC | 3,882,709 | 3,257,917 | -624,792 | 2.83 | 1.81 | -1.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,078,554 | 3,128,362 | +49,808 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,333,213 | 2,501,869 | +168,656 | 0.00 | 0.00 | -0.00 | buy |
| Avoro Capital Advisors LLC | 1,500,000 | 2,500,000 | +1,000,000 | 0.29 | 0.41 | +0.12 | buy |
| BAKER BROS. ADVISORS LP | 1,971,678 | 2,383,025 | +411,347 | 0.22 | 0.22 | -0.00 | buy |
| Point72 Asset Management, L.P. | 322,836 | 2,343,208 | +2,020,372 | 0.01 | 0.07 | +0.05 | buy |
| Caligan Partners LP | 0 | 2,193,981 | +2,193,981 | 0.00 | 1.94 | +1.94 | buy |
| Novo Holdings A/S | 2,000,000 | 2,135,000 | +135,000 | 3.17 | 2.28 | -0.89 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,792,626 | 1,792,626 | 0 | 1.78 | 1.50 | -0.29 | hold |
| Fisher Asset Management, LLC | 1,768,295 | 1,750,850 | -17,445 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 711,739 | 1,707,698 | +995,959 | 0.07 | 0.14 | +0.07 | buy |
| GOLDMAN SACHS GROUP INC | 1,591,945 | 1,691,304 | +99,359 | 0.00 | 0.00 | -0.00 | buy |
| First Turn Management, LLC | 911,337 | 1,670,000 | +758,663 | 1.99 | 3.28 | +1.29 | buy |
| DIMENSIONAL FUND ADVISORS LP | 529,763 | 1,611,521 | +1,081,758 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 307,134 | 1,428,843 | +1,121,709 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,392,072 | 1,391,639 | -433 | 0.01 | 0.01 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 557,936 | 1,377,576 | +819,640 | 1.13 | 2.60 | +1.47 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,315,957 | 1,279,859 | -1,036,098 | 0.09 | 0.04 | -0.05 | sell |
| D. E. Shaw & Co., Inc. | 1,262,540 | 1,182,222 | -80,318 | 0.02 | 0.01 | -0.01 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 898,611 | 1,175,906 | +277,295 | 0.98 | 1.05 | +0.07 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 23,279 | 1,112,413 | +1,089,134 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 266,399 | 1,012,138 | +745,739 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 888,298 | 999,915 | +111,617 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,163,615 | 944,345 | -219,270 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 696,999 | 863,491 | +166,492 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 713,269 | 831,142 | +117,873 | 0.92 | 0.83 | -0.09 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 815,027 | +815,027 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 727,937 | 815,027 | +87,090 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 793,508 | +793,508 | 0.00 | 0.08 | +0.08 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 203,100 | 768,600 | +565,500 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 870,162 | 728,817 | -141,345 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 700,929 | 700,929 | 0 | 0.05 | 0.04 | -0.01 | hold |
| JPMORGAN CHASE & CO | 1,059,864 | 639,929 | -419,935 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 1,170,829 | 581,980 | -588,849 | 0.45 | 0.17 | -0.29 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 541,058 | +541,058 | 0.00 | 0.19 | +0.19 | buy |
| EMERALD ADVISERS, LLC | 0 | 537,328 | +537,328 | 0.00 | 0.23 | +0.23 | buy |
| DEUTSCHE BANK AG\ | 1,032,316 | 482,875 | -549,441 | 0.01 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 563,999 | 482,237 | -81,762 | 0.17 | 0.11 | -0.06 | sell |
| Ikarian Capital, LLC | 0 | 425,000 | +425,000 | 0.00 | 1.28 | +1.28 | buy |
| Yiheng Capital Management, L.P. | 208,735 | 400,464 | +191,729 | 1.77 | 3.14 | +1.37 | buy |
| Jump Financial, LLC | 64,111 | 398,251 | +334,140 | 0.02 | 0.07 | +0.05 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 395,546 | +395,546 | 0.00 | 0.26 | +0.26 | buy |
| PANAGORA ASSET MANAGEMENT INC | 313,700 | 324,658 | +10,958 | 0.02 | 0.02 | -0.00 | buy |
| XTX Topco Ltd | 253,972 | 275,165 | +21,193 | 0.09 | 0.07 | -0.02 | buy |
| Bank of New York Mellon Corp | 216,525 | 268,060 | +51,535 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 260,000 | +260,000 | 0.00 | 0.73 | +0.73 | buy |
| Affinity Asset Advisors, LLC | 250,000 | 250,000 | 0 | 0.29 | 0.22 | -0.06 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 262,017 | 249,763 | -12,254 | 0.01 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 55,386 | 235,606 | +180,220 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 174,894 | 209,092 | +34,198 | 0.12 | 0.11 | -0.01 | buy |
| Nuveen, LLC | 604,914 | 199,230 | -405,684 | 0.00 | 0.00 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 197,848 | +197,848 | 0.00 | 0.03 | +0.03 | buy |
| FIRST TRUST ADVISORS LP | 301,529 | 181,234 | -120,295 | 0.00 | 0.00 | -0.00 | sell |
| Knott David M Jr | 181,000 | 181,000 | 0 | 2.11 | 1.76 | -0.35 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 81,425 | 180,348 | +98,923 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 43,909 | 176,955 | +133,046 | 0.00 | 0.01 | +0.00 | buy |
| Privium Fund Management B.V. | 173,516 | 173,516 | 0 | 0.71 | 0.59 | -0.12 | hold |
| HighVista Strategies LLC | 134,229 | 159,885 | +25,656 | 0.72 | 0.67 | -0.06 | buy |
| Swiss National Bank | 128,600 | 155,100 | +26,500 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 23,458 | 140,415 | +116,957 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 0 | 134,761 | +134,761 | 0.00 | 0.13 | +0.13 | buy |
| BNP Paribas Asset Management Holding S.A. | 140,260 | 134,455 | -5,805 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,277 | 130,284 | +76,007 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 20,208 | 127,301 | +107,093 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 120,000 | +120,000 | 0.00 | 0.07 | +0.07 | buy |
| RHUMBLINE ADVISERS | 100,033 | 117,747 | +17,714 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 93,204 | 115,563 | +22,359 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 234,551 | 114,359 | -120,192 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 0 | 111,572 | +111,572 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 60,044 | 109,073 | +49,029 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 141,977 | 108,749 | -33,228 | 0.01 | 0.00 | -0.01 | sell |
| J. Safra Sarasin Holding AG | 73,058 | 107,839 | +34,781 | 0.02 | 0.03 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 101,414 | +101,414 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 152,596 | 100,895 | -51,701 | 0.00 | 0.00 | -0.00 | sell |
| DIADEMA PARTNERS LP | 0 | 100,000 | +100,000 | 0.00 | 0.65 | +0.65 | buy |
| Voleon Capital Management LP | 269,742 | 97,598 | -172,144 | 0.11 | 0.03 | -0.08 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 96,756 | +96,756 | 0.00 | 0.04 | +0.04 | buy |
| Merck & Co., Inc. | 93,414 | 93,414 | 0 | 0.52 | 0.33 | -0.20 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 81,021 | 91,402 | +10,381 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 45,127 | 86,040 | +40,913 | 0.04 | 0.06 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 188,177 | 81,629 | -106,548 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 100,598 | 81,429 | -19,169 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 68,461 | 79,845 | +11,384 | 0.04 | 0.05 | +0.01 | buy |
| Knights of Columbus Asset Advisors LLC | 57,789 | 70,553 | +12,764 | 0.06 | 0.06 | +0.00 | buy |
| Burkehill Global Management, LP | 65,000 | 65,000 | 0 | 0.06 | 0.04 | -0.02 | hold |
| Legal & General Group Plc | 59,625 | 64,788 | +5,163 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 62,184 | +62,184 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 473 | 60,846 | +60,373 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 63,341 | 54,773 | -8,568 | 0.05 | 0.03 | -0.02 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 48,195 | 54,051 | +5,856 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 708,527 | 52,709 | -655,818 | 0.07 | 0.00 | -0.07 | sell |