| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 1,279,502 | 2,963,267 | +1,683,765 | 1.42 | 1.76 | +0.34 | buy |
| Paradigm Biocapital Advisors LP | 2,415,256 | 3,681,747 | +1,266,491 | 4.65 | 3.85 | -0.80 | buy |
| BRAIDWELL LP | 1,206,300 | 1,735,182 | +528,882 | 0.94 | 0.84 | -0.10 | buy |
| Octagon Capital Advisors LP | 923,000 | 1,067,143 | +144,143 | 3.06 | 2.88 | -0.18 | buy |
| 5AM Venture Management, LLC | 280,000 | 410,000 | +130,000 | 1.66 | 1.81 | +0.15 | buy |
| PFM Health Sciences, LP | 293,140 | 360,830 | +67,690 | 0.28 | 0.26 | -0.02 | buy |
| Bellevue Group AG | 44,400 | 63,770 | +19,370 | 0.02 | 0.02 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 14,305 | 27,112 | +12,807 | 0.02 | 0.03 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 45,000 | 47,438 | +2,438 | 0.36 | 0.27 | -0.09 | buy |
| Knights of Columbus Asset Advisors LLC | 28,730 | 29,553 | +823 | 0.06 | 0.04 | -0.02 | buy |
| ALPS ADVISORS INC | 31,707 | 32,262 | +555 | 0.01 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 13,122 | 13,437 | +315 | 0.02 | 0.02 | -0.01 | buy |
| PROFUND ADVISORS LLC | 44,170 | 43,959 | -211 | 0.06 | 0.04 | -0.02 | sell |
| VIRTUS ADVISERS, LLC | 3,930 | 3,572 | -358 | 0.06 | 0.03 | -0.02 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 224,707 | 224,339 | -368 | 3.62 | 2.50 | -1.12 | sell |
| HighVista Strategies LLC | 108,765 | 104,756 | -4,009 | 1.18 | 0.74 | -0.44 | sell |
| DCF Advisers, LLC | 19,000 | 13,500 | -5,500 | 0.31 | 0.14 | -0.17 | sell |
| Kynam Capital Management, LP | 709,498 | 699,681 | -9,817 | 2.59 | 1.78 | -0.80 | sell |
| TANG CAPITAL MANAGEMENT LLC | 692,925 | 669,125 | -23,800 | 2.43 | 1.45 | -0.98 | sell |
| Logos Global Management LP | 1,125,000 | 1,050,000 | -75,000 | 3.70 | 2.30 | -1.40 | sell |
| PERCEPTIVE ADVISORS LLC | 1,776,386 | 1,011,205 | -765,181 | 1.23 | 0.52 | -0.71 | sell |