| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 1,991,490 | +1,991,490 | 0.00 | 0.39 | +0.39 | buy |
| EcoR1 Capital, LLC | 0 | 1,958,847 | +1,958,847 | 0.00 | 1.53 | +1.53 | buy |
| FMR LLC | 9,573,348 | 11,183,478 | +1,610,130 | 0.01 | 0.02 | +0.01 | buy |
| Fairmount Funds Management LLC | 1,845,813 | 3,445,813 | +1,600,000 | 2.71 | 6.36 | +3.64 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,205,000 | +1,205,000 | 0.00 | 0.05 | +0.05 | buy |
| PERCEPTIVE ADVISORS LLC | 1,631,828 | 2,812,665 | +1,180,837 | 0.51 | 1.37 | +0.86 | buy |
| VANGUARD GROUP INC | 3,345,731 | 4,420,097 | +1,074,366 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,392,925 | 2,242,925 | +850,000 | 1.85 | 3.65 | +1.80 | buy |
| Kynam Capital Management, LP | 1,750,000 | 2,511,295 | +761,295 | 2.38 | 4.43 | +2.04 | buy |
| MORGAN STANLEY | 320,570 | 1,009,879 | +689,309 | 0.00 | 0.00 | +0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 633,090 | +633,090 | 0.00 | 2.00 | +2.00 | buy |
| Schonfeld Strategic Advisors LLC | 145,753 | 763,118 | +617,365 | 0.01 | 0.14 | +0.13 | buy |
| MARSHALL WACE, LLP | 72,974 | 684,799 | +611,825 | 0.00 | 0.02 | +0.02 | buy |
| Cutter Capital Management, LP | 0 | 518,677 | +518,677 | 0.00 | 3.48 | +3.48 | buy |
| Ikarian Capital, LLC | 0 | 499,977 | +499,977 | 0.00 | 3.53 | +3.53 | buy |
| MILLENNIUM MANAGEMENT LLC | 228,182 | 668,036 | +439,854 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 0 | 425,000 | +425,000 | 0.00 | 1.23 | +1.23 | buy |
| Woodline Partners LP | 400,915 | 818,995 | +418,080 | 0.05 | 0.16 | +0.11 | buy |
| LORD, ABBETT & CO. LLC | 0 | 391,958 | +391,958 | 0.00 | 0.03 | +0.03 | buy |
| Novo Holdings A/S | 2,000,000 | 2,385,000 | +385,000 | 1.40 | 2.69 | +1.29 | buy |
| Affinity Asset Advisors, LLC | 150,000 | 525,000 | +375,000 | 0.31 | 1.85 | +1.55 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 339,089 | +339,089 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 48,445 | 379,547 | +331,102 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 125,710 | 400,351 | +274,641 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 500,000 | 750,000 | +250,000 | 1.25 | 5.15 | +3.90 | buy |
| Integral Health Asset Management, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.67 | +0.67 | buy |
| Octagon Capital Advisors LP | 620,000 | 870,000 | +250,000 | 1.33 | 3.17 | +1.84 | buy |
| JANE STREET GROUP, LLC | 113,075 | 351,153 | +238,078 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 107,580 | 327,080 | +219,500 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,998,192 | 2,202,739 | +204,547 | 0.01 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 44,671 | 241,267 | +196,596 | 0.00 | 0.01 | +0.01 | buy |
| Exome Asset Management LLC | 0 | 174,400 | +174,400 | 0.00 | 2.68 | +2.68 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 168,433 | +168,433 | 0.00 | 0.02 | +0.02 | buy |
| Atika Capital Management LLC | 0 | 167,000 | +167,000 | 0.00 | 0.41 | +0.41 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 10,145 | 172,810 | +162,665 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 0 | 152,542 | +152,542 | 0.00 | 0.20 | +0.20 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 146,749 | +146,749 | 0.00 | 0.10 | +0.10 | buy |
| D. E. Shaw & Co., Inc. | 0 | 138,067 | +138,067 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 430,596 | 560,007 | +129,411 | 0.06 | 0.14 | +0.08 | buy |
| Eversept Partners, LP | 567,487 | 691,232 | +123,745 | 0.57 | 1.21 | +0.64 | buy |
| Jump Financial, LLC | 18,800 | 141,978 | +123,178 | 0.00 | 0.07 | +0.06 | buy |
| MACQUARIE GROUP LTD | 29,370 | 143,395 | +114,025 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 479,881 | 581,608 | +101,727 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 41,824 | 142,641 | +100,817 | 0.01 | 0.04 | +0.03 | buy |
| Fisher Asset Management, LLC | 395,497 | 494,924 | +99,427 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 349,631 | 442,334 | +92,703 | 0.01 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 86,094 | +86,094 | 0.00 | 0.32 | +0.32 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,411,360 | 1,493,311 | +81,951 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 58,847 | 125,397 | +66,550 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 419,820 | 482,136 | +62,316 | 0.01 | 0.02 | +0.01 | buy |
| ALGERT GLOBAL LLC | 55,493 | 114,913 | +59,420 | 0.02 | 0.07 | +0.05 | buy |
| Polar Asset Management Partners Inc. | 109,900 | 163,000 | +53,100 | 0.04 | 0.09 | +0.05 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 51,050 | +51,050 | 0.00 | 0.09 | +0.09 | buy |
| Cubist Systematic Strategies, LLC | 0 | 50,898 | +50,898 | 0.00 | 0.02 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 37,261 | +37,261 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 34,627 | +34,627 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 33,475 | +33,475 | 0.00 | 0.07 | +0.07 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 483,921 | 516,213 | +32,292 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 9,864 | 40,762 | +30,898 | 0.00 | 0.04 | +0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 29,002 | +29,002 | 0.00 | 0.04 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 28,050 | +28,050 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 26,860 | +26,860 | 0.00 | 0.12 | +0.12 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 49,211 | 75,909 | +26,698 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 2,528,032 | 2,550,124 | +22,092 | 2.25 | 3.63 | +1.38 | buy |
| AMERIPRISE FINANCIAL INC | 20,985 | 41,987 | +21,002 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 69,330 | 89,496 | +20,166 | 0.00 | 0.00 | +0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 19,997 | +19,997 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 27,203 | 46,217 | +19,014 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 18,566 | +18,566 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 178,855 | 197,401 | +18,546 | 0.12 | 0.21 | +0.09 | buy |
| Mesirow Financial Investment Management, Inc. | 0 | 16,350 | +16,350 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 92,600 | 108,100 | +15,500 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 13,987 | +13,987 | 0.00 | 0.01 | +0.01 | buy |
| ALTFEST L J & CO INC | 0 | 13,512 | +13,512 | 0.00 | 0.04 | +0.04 | buy |
| ProShare Advisors LLC | 0 | 11,823 | +11,823 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 37,458 | 49,004 | +11,546 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 9,130 | +9,130 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 41,533 | 49,069 | +7,536 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 6,543 | +6,543 | 0.00 | 0.03 | +0.03 | buy |
| ROYAL BANK OF CANADA | 0 | 6,421 | +6,421 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,324 | 13,987 | +3,663 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,022,104 | 1,025,337 | +3,233 | 0.02 | 0.03 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,490 | 34,410 | +2,920 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,961 | 13,997 | +2,036 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 8,000 | 9,206 | +1,206 | 0.02 | 0.04 | +0.01 | buy |
| SIGNATUREFD, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 911 | +911 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 13,178 | 13,888 | +710 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 44,419 | 45,012 | +593 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 20,571 | 20,749 | +178 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 11 | 187 | +176 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 6,884 | 7,011 | +127 | 0.04 | 0.07 | +0.03 | buy |
| StoneCrest Wealth Management, Inc. | 27,484 | 27,593 | +109 | 0.27 | 0.46 | +0.18 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 85 | +85 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 3,882,671 | 3,882,709 | +38 | 3.22 | 4.63 | +1.41 | buy |
| WOLFF WIESE MAGANA LLC | 0 | 38 | +38 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 38 | +38 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 40 | 70 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |