| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Fairmount Funds Management LLC | 1,845,813 | 3,445,813 | +1,600,000 | 2.71 | 6.36 | +3.64 | buy |
| PERCEPTIVE ADVISORS LLC | 1,631,828 | 2,812,665 | +1,180,837 | 0.51 | 1.35 | +0.84 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,392,925 | 2,242,925 | +850,000 | 1.85 | 3.65 | +1.80 | buy |
| Kynam Capital Management, LP | 1,750,000 | 2,511,295 | +761,295 | 2.38 | 4.43 | +2.04 | buy |
| Woodline Partners LP | 400,915 | 818,995 | +418,080 | 0.05 | 0.16 | +0.11 | buy |
| Novo Holdings A/S | 2,000,000 | 2,385,000 | +385,000 | 1.40 | 2.69 | +1.29 | buy |
| Affinity Asset Advisors, LLC | 150,000 | 525,000 | +375,000 | 0.22 | 1.63 | +1.41 | buy |
| Octagon Capital Advisors LP | 620,000 | 870,000 | +250,000 | 1.33 | 3.17 | +1.84 | buy |
| GREAT POINT PARTNERS LLC | 500,000 | 750,000 | +250,000 | 1.25 | 5.02 | +3.78 | buy |
| Eversept Partners, LP | 567,487 | 691,232 | +123,745 | 0.51 | 1.08 | +0.57 | buy |
| Fisher Asset Management, LLC | 395,497 | 494,924 | +99,427 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 109,900 | 163,000 | +53,100 | 0.03 | 0.08 | +0.05 | buy |
| Commodore Capital LP | 2,528,032 | 2,550,124 | +22,092 | 2.25 | 3.63 | +1.38 | buy |
| Hennion & Walsh Asset Management, Inc. | 178,855 | 197,401 | +18,546 | 0.12 | 0.21 | +0.09 | buy |
| ADAR1 Capital Management, LLC | 8,000 | 9,206 | +1,206 | 0.02 | 0.04 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 6,884 | 7,011 | +127 | 0.04 | 0.07 | +0.03 | buy |
| StoneCrest Wealth Management, Inc. | 27,484 | 27,593 | +109 | 0.27 | 0.46 | +0.18 | buy |
| VR Adviser, LLC | 3,882,671 | 3,882,709 | +38 | 3.22 | 4.63 | +1.41 | buy |
| Paradigm Biocapital Advisors LP | 2,896,349 | 2,895,689 | -660 | 1.44 | 2.31 | +0.86 | sell |
| ALPS ADVISORS INC | 49,766 | 46,825 | -2,941 | 0.00 | 0.01 | +0.00 | sell |
| DCF Advisers, LLC | 17,750 | 14,500 | -3,250 | 0.12 | 0.17 | +0.05 | sell |
| HighVista Strategies LLC | 198,484 | 185,240 | -13,244 | 0.94 | 1.45 | +0.51 | sell |
| Bayesian Capital Management, LP | 28,682 | 12,900 | -15,782 | 0.04 | 0.03 | -0.01 | sell |
| Corton Capital Inc. | 31,732 | 15,805 | -15,927 | 0.22 | 0.17 | -0.04 | sell |
| Cinctive Capital Management LP | 47,248 | 26,541 | -20,707 | 0.03 | 0.03 | +0.00 | sell |
| Knights of Columbus Asset Advisors LLC | 79,974 | 57,565 | -22,409 | 0.07 | 0.09 | +0.02 | sell |
| BIT Capital GmbH | 145,556 | 84,146 | -61,410 | 0.15 | 0.18 | +0.03 | sell |
| Yiheng Capital Management, L.P. | 948,130 | 847,891 | -100,239 | 0.99 | 0.99 | -0.00 | sell |
| Deep Track Capital, LP | 3,923,849 | 3,750,945 | -172,904 | 1.52 | 2.72 | +1.20 | sell |
| Soleus Capital Management, L.P. | 340,000 | 95,000 | -245,000 | 0.39 | 0.18 | -0.21 | sell |
| MAVERICK CAPITAL LTD | 3,307,945 | 1,997,153 | -1,310,792 | 0.82 | 0.89 | +0.07 | sell |