| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 447,507 | 1,462,400 | +1,014,893 | 0.23 | 0.91 | +0.68 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 270,543 | 1,122,532 | +851,989 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 509,959 | 1,201,226 | +691,267 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 386,938 | 937,467 | +550,529 | 0.00 | 0.01 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 515,623 | 851,663 | +336,040 | 0.39 | 1.00 | +0.61 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 259,509 | +259,509 | 0.00 | 0.81 | +0.81 | buy |
| LOOMIS SAYLES & CO L P | 1,338,472 | 1,550,328 | +211,856 | 0.02 | 0.04 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 202,821 | +202,821 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 485,698 | 638,777 | +153,079 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,108,586 | 1,220,128 | +111,542 | 0.03 | 0.04 | +0.02 | buy |
| Propel Bio Management, LLC | 0 | 90,000 | +90,000 | 0.00 | 1.94 | +1.94 | buy |
| MILLENNIUM MANAGEMENT LLC | 59,436 | 136,280 | +76,844 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 119,562 | 175,251 | +55,689 | 0.01 | 0.02 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 12,180 | 64,594 | +52,414 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 190,229 | 242,307 | +52,078 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| SG Americas Securities, LLC | 12,137 | 62,118 | +49,981 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 87,885 | 134,997 | +47,112 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 26,315 | +26,315 | 0.00 | 0.04 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 79,781 | 105,880 | +26,099 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 351,852 | 377,711 | +25,859 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,740,614 | 1,766,187 | +25,573 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 91,483 | 116,574 | +25,091 | 0.58 | 1.05 | +0.47 | buy |
| JANE STREET GROUP, LLC | 10,737 | 35,414 | +24,677 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 596,883 | 620,862 | +23,979 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 345,898 | 368,601 | +22,703 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 1,902,539 | 1,924,306 | +21,767 | 2.68 | 3.18 | +0.50 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 574,021 | 595,361 | +21,340 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 62,217 | 80,792 | +18,575 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 983 | 17,645 | +16,662 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 230,844 | 245,759 | +14,915 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 14,413 | +14,413 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 12,238,803 | 12,249,355 | +10,552 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 203,836 | 213,329 | +9,493 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 8,956 | +8,956 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,425 | 56,905 | +5,480 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 78,515 | 83,500 | +4,985 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 126 | 5,000 | +4,874 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 192,524 | 197,170 | +4,646 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 15,757 | 19,221 | +3,464 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 2,756 | +2,756 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 3,533 | 6,005 | +2,472 | 0.00 | 0.01 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 2,407 | +2,407 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 199 | 2,085 | +1,886 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 108,900 | 110,700 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 1,632 | +1,632 | 0.00 | 0.02 | +0.02 | buy |
| Farther Finance Advisors, LLC | 449 | 1,940 | +1,491 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 58,024 | 59,410 | +1,386 | 0.05 | 0.07 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 6,001 | 7,262 | +1,261 | 0.03 | 0.04 | +0.02 | buy |
| SEI INVESTMENTS CO | 10,510 | 11,556 | +1,046 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 1,020 | +1,020 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 801 | +801 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,553,426 | 2,554,166 | +740 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 517 | 1,140 | +623 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 576 | +576 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 1,994 | 2,457 | +463 | 0.00 | 0.00 | +0.00 | buy |
| ALTFEST L J & CO INC | 13,210 | 13,550 | +340 | 0.02 | 0.03 | +0.01 | buy |
| Arizona State Retirement System | 16,635 | 16,864 | +229 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 115 | +115 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 12,808 | 12,918 | +110 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 427 | 501 | +74 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 49 | 92 | +43 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 119 | 132 | +13 | 0.00 | 0.00 | +0.00 | buy |
| MONTAG A & ASSOCIATES INC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 10 | +10 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 283 | 293 | +10 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,689 | 53,692 | +3 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 2,842,925 | 2,842,925 | 0 | 2.01 | 2.36 | +0.35 | hold |
| PRINCIPAL SECURITIES, INC. | 9 | 9 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,744,406 | 1,744,406 | 0 | 0.24 | 0.27 | +0.04 | hold |
| JANUS HENDERSON GROUP PLC | 27,472 | 27,472 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 26,968 | 26,968 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Novo Holdings A/S | 2,380,000 | 2,380,000 | 0 | 2.35 | 3.31 | +0.96 | hold |
| Yiheng Capital Management, L.P. | 500,261 | 500,261 | 0 | 2.53 | 3.57 | +1.04 | hold |
| Parkside Financial Bank & Trust | 70 | 70 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 19 | 19 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 43,629 | 43,629 | 0 | 0.00 | 0.00 | +0.00 | hold |
| J.Safra Asset Management Corp | 180 | 180 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 33 | 33 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VR Adviser, LLC | 3,882,709 | 3,882,709 | 0 | 4.07 | 4.72 | +0.65 | hold |
| Vivo Capital, LLC | 982,576 | 982,576 | 0 | 1.41 | 1.71 | +0.30 | hold |
| Parallel Advisors, LLC | 65 | 65 | 0 | 0.00 | 0.00 | +0.00 | hold |
| KLP KAPITALFORVALTNING AS | 11,400 | 11,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Capital Management, Inc | 134 | 134 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 13 | 13 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Woodline Partners LP | 815,485 | 815,485 | 0 | 0.06 | 0.08 | +0.02 | hold |
| 5AM Venture Management, LLC | 736,595 | 736,595 | 0 | 3.96 | 5.82 | +1.86 | hold |
| DCF Advisers, LLC | 62,029 | 62,029 | 0 | 0.42 | 0.51 | +0.09 | hold |
| Fairmount Funds Management LLC | 3,459,913 | 3,459,913 | 0 | 6.27 | 6.72 | +0.45 | hold |
| Velan Capital Investment Management LP | 86,500 | 86,500 | 0 | 1.21 | 1.75 | +0.54 | hold |
| Deep Track Capital, LP | 5,380,449 | 5,380,449 | 0 | 2.42 | 3.24 | +0.82 | hold |
| Kynam Capital Management, LP | 4,427,927 | 4,427,927 | 0 | 6.66 | 7.11 | +0.45 | hold |
| Covestor Ltd | 5 | 5 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 52,571 | 52,571 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 423,272 | 423,272 | 0 | 0.70 | 0.71 | +0.01 | hold |
| Merck & Co., Inc. | 93,414 | 93,414 | 0 | 0.61 | 0.88 | +0.28 | hold |
| Legal & General Group Plc | 59,983 | 59,983 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,719 | 19,719 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 2,531 | 2,531 | 0 | 0.00 | 0.00 | +0.00 | hold |