| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 12,238,803 | 12,249,355 | +10,552 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 5,521,035 | 5,428,521 | -92,514 | 0.00 | 0.00 | +0.00 | sell |
| Deep Track Capital, LP | 5,380,449 | 5,380,449 | 0 | 2.42 | 3.24 | +0.82 | hold |
| Kynam Capital Management, LP | 4,427,927 | 4,427,927 | 0 | 6.66 | 7.11 | +0.45 | hold |
| VANGUARD GROUP INC | 4,508,508 | 4,331,983 | -176,525 | 0.00 | 0.00 | +0.00 | sell |
| VR Adviser, LLC | 3,882,709 | 3,882,709 | 0 | 4.07 | 4.72 | +0.65 | hold |
| Fairmount Funds Management LLC | 3,459,913 | 3,459,913 | 0 | 6.27 | 6.72 | +0.45 | hold |
| Commodore Capital LP | 4,875,000 | 3,200,000 | -1,675,000 | 4.81 | 3.37 | -1.44 | sell |
| TANG CAPITAL MANAGEMENT LLC | 2,842,925 | 2,842,925 | 0 | 2.01 | 2.36 | +0.35 | hold |
| Paradigm Biocapital Advisors LP | 2,741,576 | 2,609,353 | -132,223 | 1.64 | 1.67 | +0.03 | sell |
| STATE STREET CORP | 2,553,426 | 2,554,166 | +740 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,895,265 | 2,418,104 | -477,161 | 0.00 | 0.01 | +0.00 | sell |
| Novo Holdings A/S | 2,380,000 | 2,380,000 | 0 | 2.35 | 3.31 | +0.96 | hold |
| MAVERICK CAPITAL LTD | 2,257,010 | 2,212,701 | -44,309 | 0.48 | 0.64 | +0.15 | sell |
| Eversept Partners, LP | 1,902,539 | 1,924,306 | +21,767 | 2.68 | 3.18 | +0.50 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,944,020 | 1,859,458 | -84,562 | 0.01 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,740,614 | 1,766,187 | +25,573 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,744,406 | 1,744,406 | 0 | 0.24 | 0.27 | +0.04 | hold |
| LOOMIS SAYLES & CO L P | 1,338,472 | 1,550,328 | +211,856 | 0.02 | 0.04 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 447,507 | 1,462,400 | +1,014,893 | 0.23 | 0.91 | +0.68 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,108,586 | 1,220,128 | +111,542 | 0.03 | 0.04 | +0.02 | buy |
| Fisher Asset Management, LLC | 509,959 | 1,201,226 | +691,267 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 1,298,825 | 1,154,487 | -144,338 | 2.10 | 2.74 | +0.64 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 270,543 | 1,122,532 | +851,989 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,265,754 | 1,049,385 | -216,369 | 0.02 | 0.02 | +0.00 | sell |
| Vivo Capital, LLC | 982,576 | 982,576 | 0 | 1.41 | 1.71 | +0.30 | hold |
| DEUTSCHE BANK AG\ | 386,938 | 937,467 | +550,529 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 1,207,871 | 869,188 | -338,683 | 0.02 | 0.02 | +0.00 | sell |
| Candriam S.C.A. | 862,273 | 860,232 | -2,041 | 0.07 | 0.10 | +0.03 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 515,623 | 851,663 | +336,040 | 0.39 | 1.00 | +0.61 | buy |
| Woodline Partners LP | 815,485 | 815,485 | 0 | 0.06 | 0.08 | +0.02 | hold |
| GOLDMAN SACHS GROUP INC | 899,825 | 764,562 | -135,263 | 0.00 | 0.00 | +0.00 | sell |
| 5AM Venture Management, LLC | 736,595 | 736,595 | 0 | 3.96 | 5.82 | +1.86 | hold |
| DIMENSIONAL FUND ADVISORS LP | 485,698 | 638,777 | +153,079 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 596,883 | 620,862 | +23,979 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 700,000 | 600,000 | -100,000 | 4.74 | 4.58 | -0.16 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 574,021 | 595,361 | +21,340 | 0.00 | 0.00 | +0.00 | buy |
| Yiheng Capital Management, L.P. | 500,261 | 500,261 | 0 | 2.53 | 3.57 | +1.04 | hold |
| HighVista Strategies LLC | 484,559 | 469,335 | -15,224 | 2.49 | 2.48 | -0.01 | sell |
| UBS Group AG | 533,643 | 447,677 | -85,966 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 564,790 | 432,420 | -132,370 | 0.01 | 0.01 | +0.00 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 423,272 | 423,272 | 0 | 0.70 | 0.71 | +0.01 | hold |
| PANAGORA ASSET MANAGEMENT INC | 351,852 | 377,711 | +25,859 | 0.02 | 0.03 | +0.01 | buy |
| ROYAL BANK OF CANADA | 345,898 | 368,601 | +22,703 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 376,846 | 344,084 | -32,762 | 0.04 | 0.05 | +0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 332,089 | 312,759 | -19,330 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 415,989 | 309,133 | -106,856 | 0.00 | 0.00 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 259,509 | +259,509 | 0.00 | 0.81 | +0.81 | buy |
| Affinity Asset Advisors, LLC | 390,000 | 250,000 | -140,000 | 0.81 | 0.50 | -0.30 | sell |
| BANK OF AMERICA CORP /DE/ | 230,844 | 245,759 | +14,915 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 469,949 | 245,518 | -224,431 | 2.17 | 1.07 | -1.10 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 190,229 | 242,307 | +52,078 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 203,836 | 213,329 | +9,493 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 231,104 | 208,246 | -22,858 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 202,821 | +202,821 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 192,524 | 197,170 | +4,646 | 0.00 | 0.00 | +0.00 | buy |
| Kopp Family Office, LLC | 203,230 | 193,830 | -9,400 | 1.84 | 2.72 | +0.88 | sell |
| MORGAN STANLEY | 200,367 | 191,941 | -8,426 | 0.00 | 0.00 | +0.00 | sell |
| Hudson Bay Capital Management LP | 119,562 | 175,251 | +55,689 | 0.01 | 0.02 | +0.01 | buy |
| Nuveen, LLC | 223,235 | 161,868 | -61,367 | 0.00 | 0.00 | +0.00 | sell |
| MACQUARIE GROUP LTD | 157,167 | 154,739 | -2,428 | 0.00 | 0.00 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 168,324 | 154,338 | -13,986 | 0.10 | 0.12 | +0.03 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 190,104 | 138,980 | -51,124 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 59,436 | 136,280 | +76,844 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 87,885 | 134,997 | +47,112 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 91,483 | 116,574 | +25,091 | 0.58 | 1.05 | +0.47 | buy |
| Swiss National Bank | 108,900 | 110,700 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 79,781 | 105,880 | +26,099 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 107,385 | 104,360 | -3,025 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 170,598 | 101,704 | -68,894 | 0.39 | 0.22 | -0.17 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 111,545 | 101,083 | -10,462 | 0.04 | 0.09 | +0.04 | sell |
| Merck & Co., Inc. | 93,414 | 93,414 | 0 | 0.61 | 0.88 | +0.28 | hold |
| Propel Bio Management, LLC | 0 | 90,000 | +90,000 | 0.00 | 1.94 | +1.94 | buy |
| Velan Capital Investment Management LP | 86,500 | 86,500 | 0 | 1.21 | 1.75 | +0.54 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 182,452 | 83,594 | -98,858 | 0.08 | 0.05 | -0.03 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 78,515 | 83,500 | +4,985 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 62,217 | 80,792 | +18,575 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 89,600 | 78,800 | -10,800 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 649,543 | 77,373 | -572,170 | 0.01 | 0.00 | -0.01 | sell |
| MOODY ALDRICH PARTNERS LLC | 89,164 | 74,113 | -15,051 | 0.24 | 0.30 | +0.06 | sell |
| J. Goldman & Co LP | 100,777 | 70,026 | -30,751 | 0.04 | 0.06 | +0.01 | sell |
| Rafferty Asset Management, LLC | 76,412 | 68,065 | -8,347 | 0.00 | 0.00 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 12,180 | 64,594 | +52,414 | 0.00 | 0.03 | +0.03 | buy |
| SG Americas Securities, LLC | 12,137 | 62,118 | +49,981 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 62,029 | 62,029 | 0 | 0.42 | 0.51 | +0.09 | hold |
| Legal & General Group Plc | 59,983 | 59,983 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Knights of Columbus Asset Advisors LLC | 58,024 | 59,410 | +1,386 | 0.05 | 0.07 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 138,751 | 57,928 | -80,823 | 0.01 | 0.01 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,425 | 56,905 | +5,480 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,689 | 53,692 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 52,571 | 52,571 | 0 | 0.02 | 0.02 | +0.00 | hold |
| J. Safra Sarasin Holding AG | 171,119 | 51,703 | -119,416 | 0.04 | 0.02 | -0.02 | sell |
| AMERICAN CENTURY COMPANIES INC | 104,567 | 51,236 | -53,331 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 64,556 | 50,643 | -13,913 | 0.01 | 0.01 | +0.00 | sell |
| Simplify Asset Management Inc. | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 43,629 | 43,629 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALPS ADVISORS INC | 43,969 | 39,961 | -4,008 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 126,023 | 37,640 | -88,383 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 55,196 | 37,490 | -17,706 | 0.02 | 0.03 | +0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,798 | 35,862 | -5,936 | 0.00 | 0.00 | +0.00 | sell |