| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 3,681,747 | 4,794,488 | +1,112,741 | 3.85 | 4.89 | +1.04 | buy |
| VR Adviser, LLC | 3,082,622 | 3,882,623 | +800,001 | 4.98 | 5.80 | +0.82 | buy |
| PERCEPTIVE ADVISORS LLC | 1,011,205 | 1,730,212 | +719,007 | 0.52 | 0.84 | +0.32 | buy |
| Deep Track Capital, LP | 2,963,267 | 3,631,728 | +668,461 | 1.76 | 2.77 | +1.01 | buy |
| 5AM Venture Management, LLC | 410,000 | 586,595 | +176,595 | 1.81 | 3.39 | +1.58 | buy |
| Knights of Columbus Asset Advisors LLC | 29,553 | 153,949 | +124,396 | 0.04 | 0.22 | +0.17 | buy |
| HighVista Strategies LLC | 104,756 | 198,484 | +93,728 | 0.74 | 1.57 | +0.83 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 224,339 | 281,500 | +57,161 | 2.31 | 3.45 | +1.14 | buy |
| Hennion & Walsh Asset Management, Inc. | 27,112 | 75,780 | +48,668 | 0.03 | 0.09 | +0.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 669,125 | 692,925 | +23,800 | 1.45 | 1.39 | -0.05 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 47,438 | 50,438 | +3,000 | 0.27 | 0.34 | +0.07 | buy |
| ALPS ADVISORS INC | 32,262 | 34,854 | +2,592 | 0.00 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,572 | 4,787 | +1,215 | 0.03 | 0.07 | +0.03 | buy |
| E Fund Management Co., Ltd. | 13,437 | 10,875 | -2,562 | 0.02 | 0.02 | -0.00 | sell |
| DCF Advisers, LLC | 13,500 | 9,500 | -4,000 | 0.14 | 0.14 | -0.00 | sell |
| Kopp Family Office, LLC | 214,290 | 205,600 | -8,690 | 2.08 | 2.60 | +0.52 | sell |
| Bellevue Group AG | 63,770 | 30,000 | -33,770 | 0.02 | 0.01 | -0.01 | sell |
| Kynam Capital Management, LP | 699,681 | 607,915 | -91,766 | 1.78 | 1.50 | -0.29 | sell |
| MPM BioImpact LLC | 255,323 | 100,000 | -155,323 | 1.05 | 0.51 | -0.54 | sell |
| Commodore Capital LP | 2,200,000 | 1,924,074 | -275,926 | 3.94 | 3.66 | -0.28 | sell |
| Eversept Partners, LP | 443,270 | 137,343 | -305,927 | 0.58 | 0.26 | -0.31 | sell |
| Octagon Capital Advisors LP | 1,067,143 | 620,000 | -447,143 | 2.88 | 2.16 | -0.72 | sell |
| Logos Global Management LP | 1,050,000 | 600,000 | -450,000 | 2.30 | 1.45 | -0.84 | sell |
| Polar Capital Holdings Plc | 1,600,000 | 979,917 | -620,083 | 0.18 | 0.13 | -0.05 | sell |
| BRAIDWELL LP | 1,735,182 | 323,102 | -1,412,080 | 0.84 | 0.26 | -0.58 | sell |