| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 262,188 | 7,625,542 | +7,363,354 | 0.00 | 0.01 | +0.01 | buy |
| MAVERICK CAPITAL LTD | 0 | 2,325,841 | +2,325,841 | 0.00 | 1.04 | +1.04 | buy |
| Paradigm Biocapital Advisors LP | 3,681,747 | 4,794,488 | +1,112,741 | 3.85 | 4.89 | +1.04 | buy |
| VR Adviser, LLC | 3,082,622 | 3,882,623 | +800,001 | 4.98 | 5.80 | +0.82 | buy |
| CITADEL ADVISORS LLC | 102,431 | 886,641 | +784,210 | 0.00 | 0.02 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 1,011,205 | 1,730,212 | +719,007 | 0.52 | 0.84 | +0.32 | buy |
| Deep Track Capital, LP | 2,963,267 | 3,631,728 | +668,461 | 1.76 | 2.77 | +1.01 | buy |
| RTW INVESTMENTS, LP | 0 | 605,816 | +605,816 | 0.00 | 0.21 | +0.21 | buy |
| VANGUARD GROUP INC | 2,448,015 | 3,000,948 | +552,933 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 540,669 | +540,669 | 0.00 | 0.18 | +0.18 | buy |
| Walleye Capital LLC | 13,530 | 241,411 | +227,881 | 0.00 | 0.07 | +0.07 | buy |
| MORGAN STANLEY | 333,723 | 524,901 | +191,178 | 0.00 | 0.00 | +0.00 | buy |
| 5AM Venture Management, LLC | 410,000 | 586,595 | +176,595 | 1.81 | 3.39 | +1.58 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,890,998 | 2,059,464 | +168,466 | 0.01 | 0.02 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 138,000 | +138,000 | 0.00 | 0.33 | +0.33 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 859,095 | 994,468 | +135,373 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 29,553 | 153,949 | +124,396 | 0.04 | 0.22 | +0.17 | buy |
| Invesco Ltd. | 27,833 | 144,765 | +116,932 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 104,756 | 198,484 | +93,728 | 0.74 | 1.57 | +0.83 | buy |
| BARCLAYS PLC | 131,557 | 219,593 | +88,036 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 76,600 | 159,700 | +83,100 | 0.03 | 0.09 | +0.07 | buy |
| BANK OF AMERICA CORP /DE/ | 205,223 | 286,448 | +81,225 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 20,300 | 100,300 | +80,000 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 68,416 | 143,386 | +74,970 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 108,037 | 178,919 | +70,882 | 0.02 | 0.03 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 313,217 | 371,311 | +58,094 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 224,339 | 281,500 | +57,161 | 2.50 | 3.45 | +0.95 | buy |
| Affinity Asset Advisors, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.22 | +0.22 | buy |
| Hennion & Walsh Asset Management, Inc. | 27,112 | 75,780 | +48,668 | 0.03 | 0.09 | +0.07 | buy |
| Cinctive Capital Management LP | 0 | 41,168 | +41,168 | 0.00 | 0.06 | +0.06 | buy |
| Atika Capital Management LLC | 0 | 39,000 | +39,000 | 0.00 | 0.12 | +0.12 | buy |
| Hudson Bay Capital Management LP | 0 | 35,176 | +35,176 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 299,141 | 329,484 | +30,343 | 0.01 | 0.01 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 30,218 | +30,218 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 13,969 | 41,214 | +27,245 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 669,125 | 692,925 | +23,800 | 1.45 | 1.39 | -0.05 | buy |
| DEUTSCHE BANK AG\ | 22,023 | 42,791 | +20,768 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 19,456 | +19,456 | 0.00 | 0.03 | +0.03 | buy |
| NATIXIS | 0 | 19,317 | +19,317 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 18,509 | +18,509 | 0.00 | 0.13 | +0.13 | buy |
| Walleye Trading LLC | 0 | 16,602 | +16,602 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 401,666 | 413,641 | +11,975 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 138,177 | 149,811 | +11,634 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 9,533 | +9,533 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 59,636 | 67,968 | +8,332 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 5,868 | 13,110 | +7,242 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 27,360 | 34,566 | +7,206 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 6,593 | +6,593 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 50,922 | 56,938 | +6,016 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,759 | 8,369 | +4,610 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 47,438 | 50,438 | +3,000 | 0.27 | 0.34 | +0.07 | buy |
| ALPS ADVISORS INC | 32,262 | 34,854 | +2,592 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,950 | 17,495 | +1,545 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,996 | 37,394 | +1,398 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,572 | 4,787 | +1,215 | 0.03 | 0.07 | +0.03 | buy |
| SIMPLEX TRADING, LLC | 1,728 | 2,856 | +1,128 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 66,400 | 67,200 | +800 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 21,060 | 21,249 | +189 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 1 | 60 | +59 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 20 | 30 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,162 | 4,162 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Yiheng Capital Management, L.P. | 1,228,534 | 1,228,534 | 0 | 1.70 | 3.31 | +1.61 | hold |
| Ensign Peak Advisors, Inc | 89,185 | 89,185 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 22,271 | 22,271 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LMR Partners LLP | 10,000 | 10,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Vivo Capital, LLC | 1,678,207 | 1,678,207 | 0 | 2.82 | 2.99 | +0.17 | hold |
| Fairmount Funds Management LLC | 1,369,623 | 1,369,623 | 0 | 2.53 | 3.15 | +0.62 | hold |
| Orion Capital Management LLC | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Covestor Ltd | 5 | 5 | 0 | 0.00 | 0.00 | 0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 10,070 | 10,070 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,685 | 2,685 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15,161 | 15,161 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,080 | 12,080 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 14 | 0 | -14 | 0.00 | 0.00 | 0.00 | sell |
| JANUS HENDERSON GROUP PLC | 13,395 | 13,364 | -31 | 0.00 | 0.00 | +0.00 | sell |
| US BANCORP \DE\ | 37 | 0 | -37 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 60,497 | 60,434 | -63 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 11,056 | 10,857 | -199 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,411 | 16,055 | -356 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 17,052 | 16,682 | -370 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 5,835 | 5,429 | -406 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 26,525 | 25,940 | -585 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 29,227 | 27,687 | -1,540 | 0.00 | 0.00 | +0.00 | sell |
| E Fund Management Co., Ltd. | 13,437 | 10,875 | -2,562 | 0.02 | 0.02 | -0.00 | sell |
| GROUP ONE TRADING LLC | 2,645 | 17 | -2,628 | 0.00 | 0.00 | -0.00 | sell |
| DCF Advisers, LLC | 13,500 | 9,500 | -4,000 | 0.14 | 0.14 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,647 | 25,318 | -6,329 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 9,152 | 2,331 | -6,821 | 0.00 | 0.00 | -0.00 | sell |
| Kopp Family Office, LLC | 214,290 | 205,600 | -8,690 | 2.08 | 2.62 | +0.54 | sell |
| Squarepoint Ops LLC | 10,519 | 0 | -10,519 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 10,844 | 0 | -10,844 | 0.01 | 0.00 | -0.01 | sell |
| PROFUND ADVISORS LLC | 43,959 | 32,991 | -10,968 | 0.04 | 0.03 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 73,054 | 58,325 | -14,729 | 0.00 | 0.00 | +0.00 | sell |
| Pictet Asset Management Holding SA | 1,066,343 | 1,050,876 | -15,467 | 0.02 | 0.03 | +0.01 | sell |
| Engineers Gate Manager LP | 16,495 | 0 | -16,495 | 0.01 | 0.00 | -0.01 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 17,223 | 0 | -17,223 | 0.02 | 0.00 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 399,280 | 381,737 | -17,543 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 215,648 | 192,097 | -23,551 | 0.00 | 0.00 | +0.00 | sell |