| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 11,183,478 | 11,881,912 | +698,434 | 0.02 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 4,804,006 | 5,758,577 | +954,571 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 4,420,097 | 4,595,049 | +174,952 | 0.00 | 0.00 | -0.00 | buy |
| Deep Track Capital, LP | 3,750,945 | 4,522,741 | +771,796 | 2.72 | 3.25 | +0.53 | buy |
| VR Adviser, LLC | 3,882,709 | 3,882,709 | 0 | 4.63 | 5.11 | +0.48 | hold |
| STATE STREET CORP | 2,379,774 | 3,522,566 | +1,142,792 | 0.00 | 0.00 | +0.00 | buy |
| Fairmount Funds Management LLC | 3,445,813 | 3,445,813 | 0 | 6.36 | 6.57 | +0.21 | hold |
| Kynam Capital Management, LP | 2,511,295 | 3,326,262 | +814,967 | 4.43 | 4.21 | -0.22 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,242,925 | 2,492,925 | +250,000 | 3.65 | 3.16 | -0.48 | buy |
| Commodore Capital LP | 2,550,124 | 2,400,000 | -150,124 | 3.63 | 3.37 | -0.25 | sell |
| ALLIANCEBERNSTEIN L.P. | 2,202,739 | 2,286,994 | +84,255 | 0.02 | 0.01 | -0.00 | buy |
| Novo Holdings A/S | 2,385,000 | 2,250,000 | -135,000 | 2.69 | 2.61 | -0.08 | sell |
| MAVERICK CAPITAL LTD | 1,997,153 | 2,053,906 | +56,753 | 0.89 | 0.71 | -0.18 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,991,490 | 1,875,876 | -115,614 | 0.39 | 0.30 | -0.09 | sell |
| Paradigm Biocapital Advisors LP | 2,895,689 | 1,820,079 | -1,075,610 | 2.31 | 1.21 | -1.09 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,205,000 | 1,670,000 | +465,000 | 0.05 | 0.06 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,493,311 | 1,658,980 | +165,669 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,812,665 | 1,486,508 | -1,326,157 | 1.37 | 0.79 | -0.58 | sell |
| LOOMIS SAYLES & CO L P | 0 | 1,400,381 | +1,400,381 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 45,012 | 1,326,811 | +1,281,799 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,025,337 | 1,248,721 | +223,384 | 0.03 | 0.03 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 425,000 | 1,087,634 | +662,634 | 1.23 | 2.78 | +1.54 | buy |
| Vivo Capital, LLC | 1,678,207 | 982,576 | -695,631 | 3.16 | 2.11 | -1.05 | sell |
| GOLDMAN SACHS GROUP INC | 739,253 | 920,094 | +180,841 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 870,000 | 870,000 | 0 | 3.17 | 2.84 | -0.33 | hold |
| Woodline Partners LP | 818,995 | 813,647 | -5,348 | 0.16 | 0.11 | -0.05 | sell |
| Eversept Partners, LP | 691,232 | 779,998 | +88,766 | 1.21 | 1.54 | +0.34 | buy |
| Yiheng Capital Management, L.P. | 847,891 | 750,261 | -97,630 | 3.56 | 3.18 | -0.38 | sell |
| GREAT POINT PARTNERS LLC | 750,000 | 750,000 | 0 | 5.15 | 6.78 | +1.63 | hold |
| MORGAN STANLEY | 1,009,879 | 739,140 | -270,739 | 0.00 | 0.00 | -0.00 | sell |
| 5AM Venture Management, LLC | 736,595 | 736,595 | 0 | 3.46 | 3.37 | -0.09 | hold |
| Candriam S.C.A. | 749,804 | 731,221 | -18,583 | 0.10 | 0.08 | -0.02 | sell |
| NORTHERN TRUST CORP | 581,608 | 694,142 | +112,534 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 763,118 | 670,600 | -92,518 | 0.14 | 0.08 | -0.06 | sell |
| Cutter Capital Management, LP | 518,677 | 628,677 | +110,000 | 3.48 | 4.94 | +1.46 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 516,213 | 575,070 | +58,857 | 0.00 | 0.00 | -0.00 | buy |
| Fisher Asset Management, LLC | 494,924 | 518,027 | +23,103 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 84,733 | 512,071 | +427,338 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 560,007 | 481,639 | -78,368 | 0.14 | 0.09 | -0.05 | sell |
| Ikarian Capital, LLC | 499,977 | 469,949 | -30,028 | 3.53 | 2.57 | -0.96 | sell |
| LORD, ABBETT & CO. LLC | 391,958 | 459,588 | +67,630 | 0.03 | 0.03 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 138,067 | 442,070 | +304,003 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 482,136 | 424,537 | -57,599 | 0.02 | 0.02 | -0.01 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 633,090 | 423,272 | -209,818 | 2.00 | 0.98 | -1.02 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 410,440 | +410,440 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 379,547 | 402,874 | +23,327 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 442,334 | 379,596 | -62,738 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 59,600 | 371,200 | +311,600 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 668,036 | 365,972 | -302,064 | 0.01 | 0.01 | -0.01 | sell |
| CITADEL ADVISORS LLC | 241,267 | 358,358 | +117,091 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 444,800 | 335,569 | -109,231 | 0.02 | 0.01 | -0.01 | sell |
| JPMORGAN CHASE & CO | 400,351 | 304,334 | -96,017 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 84,146 | 285,954 | +201,808 | 0.18 | 0.48 | +0.30 | buy |
| PANAGORA ASSET MANAGEMENT INC | 168,433 | 253,022 | +84,589 | 0.02 | 0.02 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 180,969 | 247,107 | +66,138 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 235,987 | 224,484 | -11,503 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 197,401 | 210,899 | +13,498 | 0.21 | 0.18 | -0.03 | buy |
| Kopp Family Office, LLC | 205,737 | 205,407 | -330 | 2.98 | 2.50 | -0.49 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 203,853 | +203,853 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 152,542 | 200,857 | +48,315 | 0.20 | 0.13 | -0.06 | buy |
| Bank of New York Mellon Corp | 170,830 | 196,522 | +25,692 | 0.00 | 0.00 | -0.00 | buy |
| J. Goldman & Co LP | 0 | 179,496 | +179,496 | 0.00 | 0.12 | +0.12 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 172,810 | 178,444 | +5,634 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 90,651 | 172,960 | +82,309 | 0.01 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 525,000 | 159,614 | -365,386 | 1.85 | 0.48 | -1.38 | sell |
| BARCLAYS PLC | 125,397 | 157,860 | +32,463 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 185,240 | 154,563 | -30,677 | 1.45 | 1.10 | -0.35 | sell |
| MACQUARIE GROUP LTD | 143,395 | 142,393 | -1,002 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 146,749 | 137,918 | -8,831 | 0.10 | 0.08 | -0.02 | sell |
| CITIGROUP INC | 46,217 | 135,921 | +89,704 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 339,089 | 130,721 | -208,368 | 0.02 | 0.01 | -0.01 | sell |
| Trexquant Investment LP | 142,641 | 120,065 | -22,576 | 0.04 | 0.03 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 89,496 | 115,782 | +26,286 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 28,050 | 113,562 | +85,512 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 108,100 | 112,600 | +4,500 | 0.00 | 0.00 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.43 | +0.43 | buy |
| Artia Global Partners LP | 0 | 100,000 | +100,000 | 0.00 | 0.77 | +0.77 | buy |
| RHUMBLINE ADVISERS | 88,344 | 99,938 | +11,594 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 114,913 | 96,393 | -18,520 | 0.07 | 0.04 | -0.03 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,909 | 95,865 | +19,956 | 0.00 | 0.00 | -0.00 | buy |
| Concentric Capital Strategies, LP | 0 | 88,527 | +88,527 | 0.00 | 0.11 | +0.11 | buy |
| WELLS FARGO & COMPANY/MN | 49,004 | 64,447 | +15,443 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 46,825 | 64,057 | +17,232 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 49,069 | 60,202 | +11,133 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 58,688 | +58,688 | 0.00 | 0.21 | +0.21 | buy |
| Knights of Columbus Asset Advisors LLC | 57,565 | 57,711 | +146 | 0.09 | 0.07 | -0.01 | buy |
| Caption Management, LLC | 0 | 56,760 | +56,760 | 0.00 | 0.04 | +0.04 | buy |
| DIMENSIONAL FUND ADVISORS LP | 327,080 | 55,924 | -271,156 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,366 | 54,710 | +8,344 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 0 | 53,375 | +53,375 | 0.00 | 0.06 | +0.06 | buy |
| TD ASSET MANAGEMENT INC | 0 | 51,200 | +51,200 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,732 | 49,720 | +24,988 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 41,987 | 48,793 | +6,806 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 34,410 | 48,400 | +13,990 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 351,153 | 48,022 | -303,131 | 0.01 | 0.00 | -0.01 | sell |
| GROUP ONE TRADING LLC | 40,762 | 47,995 | +7,233 | 0.04 | 0.03 | -0.01 | buy |
| Soleus Capital Management, L.P. | 95,000 | 45,500 | -49,500 | 0.18 | 0.07 | -0.11 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 44,600 | +44,600 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 36,381 | 44,295 | +7,914 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 18,566 | 39,575 | +21,009 | 0.00 | 0.01 | +0.00 | buy |