| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 2,511,295 | 3,326,262 | +814,967 | 4.43 | 4.21 | -0.22 | buy |
| Deep Track Capital, LP | 3,750,945 | 4,522,741 | +771,796 | 2.72 | 3.25 | +0.53 | buy |
| Parkman Healthcare Partners LLC | 425,000 | 1,087,634 | +662,634 | 1.23 | 2.78 | +1.54 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,205,000 | 1,670,000 | +465,000 | 0.05 | 0.06 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,242,925 | 2,492,925 | +250,000 | 3.65 | 3.16 | -0.48 | buy |
| BIT Capital GmbH | 84,146 | 285,954 | +201,808 | 0.18 | 0.44 | +0.26 | buy |
| Cutter Capital Management, LP | 518,677 | 628,677 | +110,000 | 3.48 | 4.94 | +1.46 | buy |
| Eversept Partners, LP | 691,232 | 779,998 | +88,766 | 1.08 | 1.33 | +0.25 | buy |
| LORD, ABBETT & CO. LLC | 391,958 | 459,588 | +67,630 | 0.03 | 0.03 | -0.00 | buy |
| MAVERICK CAPITAL LTD | 1,997,153 | 2,053,906 | +56,753 | 0.89 | 0.71 | -0.18 | buy |
| Crestline Management, LP | 152,542 | 200,857 | +48,315 | 0.18 | 0.13 | -0.05 | buy |
| Fisher Asset Management, LLC | 494,924 | 518,027 | +23,103 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 46,825 | 64,057 | +17,232 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 9,206 | 26,000 | +16,794 | 0.04 | 0.10 | +0.07 | buy |
| DCF Advisers, LLC | 14,500 | 29,750 | +15,250 | 0.17 | 0.29 | +0.12 | buy |
| Hennion & Walsh Asset Management, Inc. | 197,401 | 210,899 | +13,498 | 0.21 | 0.18 | -0.03 | buy |
| Bayesian Capital Management, LP | 12,900 | 25,700 | +12,800 | 0.03 | 0.06 | +0.03 | buy |
| Mesirow Financial Investment Management, Inc. | 16,350 | 16,534 | +184 | 0.01 | 0.01 | -0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 57,565 | 57,711 | +146 | 0.09 | 0.07 | -0.01 | buy |
| J.Safra Asset Management Corp | 14 | 21 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Kopp Family Office, LLC | 205,737 | 205,407 | -330 | 2.98 | 2.50 | -0.49 | sell |
| StoneCrest Wealth Management, Inc. | 27,593 | 25,859 | -1,734 | 0.46 | 0.32 | -0.13 | sell |
| VIRTUS ADVISERS, LLC | 7,011 | 3,952 | -3,059 | 0.07 | 0.03 | -0.04 | sell |
| Corton Capital Inc. | 15,805 | 12,702 | -3,103 | 0.17 | 0.14 | -0.04 | sell |
| Woodline Partners LP | 818,995 | 813,647 | -5,348 | 0.16 | 0.11 | -0.05 | sell |
| Scientech Research LLC | 26,860 | 20,143 | -6,717 | 0.12 | 0.11 | -0.01 | sell |
| Candriam S.C.A. | 749,804 | 731,221 | -18,583 | 0.06 | 0.08 | +0.02 | sell |
| Ikarian Capital, LLC | 499,977 | 469,949 | -30,028 | 3.53 | 2.57 | -0.96 | sell |
| HighVista Strategies LLC | 185,240 | 154,563 | -30,677 | 1.45 | 1.10 | -0.35 | sell |
| Soleus Capital Management, L.P. | 95,000 | 45,500 | -49,500 | 0.18 | 0.07 | -0.11 | sell |
| Yiheng Capital Management, L.P. | 847,891 | 750,261 | -97,630 | 0.99 | 0.55 | -0.44 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,991,490 | 1,875,876 | -115,614 | 0.39 | 0.30 | -0.09 | sell |
| Novo Holdings A/S | 2,385,000 | 2,250,000 | -135,000 | 2.69 | 2.61 | -0.08 | sell |
| Commodore Capital LP | 2,550,124 | 2,400,000 | -150,124 | 3.63 | 3.37 | -0.25 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 633,090 | 423,272 | -209,818 | 2.00 | 0.98 | -1.02 | sell |
| Affinity Asset Advisors, LLC | 525,000 | 159,614 | -365,386 | 1.85 | 0.48 | -1.38 | sell |
| Vivo Capital, LLC | 1,678,207 | 982,576 | -695,631 | 3.16 | 2.11 | -1.05 | sell |
| Paradigm Biocapital Advisors LP | 2,895,689 | 1,820,079 | -1,075,610 | 2.31 | 1.21 | -1.09 | sell |
| PERCEPTIVE ADVISORS LLC | 2,812,665 | 1,486,508 | -1,326,157 | 1.35 | 0.79 | -0.57 | sell |