| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 1,462,400 | 3,042,703 | +1,580,303 | 0.91 | 1.69 | +0.78 | buy |
| Fairmount Funds Management LLC | 3,459,913 | 3,914,458 | +454,545 | 6.72 | 9.27 | +2.55 | buy |
| BAKER BROS. ADVISORS LP | 1,744,406 | 1,971,678 | +227,272 | 0.27 | 0.36 | +0.09 | buy |
| Propel Bio Management, LLC | 90,000 | 282,531 | +192,531 | 1.94 | 7.51 | +5.56 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 259,509 | 348,569 | +89,060 | 0.81 | 1.57 | +0.76 | buy |
| Simplify Asset Management Inc. | 50,000 | 103,531 | +53,531 | 0.02 | 0.05 | +0.03 | buy |
| J. Safra Sarasin Holding AG | 51,703 | 88,271 | +36,568 | 0.02 | 0.04 | +0.03 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 851,663 | 884,532 | +32,869 | 1.00 | 1.52 | +0.51 | buy |
| Knott David M Jr | 116,574 | 145,000 | +28,426 | 1.05 | 2.09 | +1.04 | buy |
| MOODY ALDRICH PARTNERS LLC | 74,113 | 96,187 | +22,074 | 0.30 | 0.56 | +0.26 | buy |
| Hennion & Walsh Asset Management, Inc. | 154,338 | 169,167 | +14,829 | 0.12 | 0.18 | +0.06 | buy |
| Virtus Investment Advisers, LLC | 7,262 | 8,233 | +971 | 0.04 | 0.07 | +0.02 | buy |
| J.Safra Asset Management Corp | 180 | 238 | +58 | 0.00 | 0.00 | +0.00 | buy |
| StoneCrest Wealth Management, Inc. | 24,977 | 24,920 | -57 | 0.24 | 0.31 | +0.08 | sell |
| Knights of Columbus Asset Advisors LLC | 59,410 | 58,026 | -1,384 | 0.07 | 0.10 | +0.03 | sell |
| J. Goldman & Co LP | 70,026 | 68,054 | -1,972 | 0.04 | 0.06 | +0.02 | sell |
| ALTFEST L J & CO INC | 13,550 | 9,767 | -3,783 | 0.03 | 0.03 | +0.00 | sell |
| DCF Advisers, LLC | 62,029 | 52,700 | -9,329 | 0.51 | 0.54 | +0.03 | sell |
| Kopp Family Office, LLC | 193,830 | 173,173 | -20,657 | 2.72 | 3.44 | +0.72 | sell |
| ADAR1 Capital Management, LLC | 101,704 | 77,198 | -24,506 | 0.22 | 0.18 | -0.04 | sell |
| LOOMIS SAYLES & CO L P | 1,550,328 | 1,481,135 | -69,193 | 0.04 | 0.06 | +0.02 | sell |
| Candriam S.C.A. | 860,232 | 785,098 | -75,134 | 0.10 | 0.12 | +0.02 | sell |
| HighVista Strategies LLC | 469,335 | 372,472 | -96,863 | 2.48 | 2.99 | +0.50 | sell |
| Eversept Partners, LP | 1,924,306 | 1,782,235 | -142,071 | 2.86 | 2.79 | -0.07 | sell |
| Rosalind Advisors, Inc. | 600,000 | 450,000 | -150,000 | 4.43 | 4.92 | +0.50 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 344,084 | 167,934 | -176,150 | 0.05 | 0.04 | -0.02 | sell |
| Yiheng Capital Management, L.P. | 500,261 | 208,735 | -291,526 | 1.59 | 1.31 | -0.28 | sell |
| Parkman Healthcare Partners LLC | 1,154,487 | 788,076 | -366,411 | 2.74 | 2.33 | -0.40 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,220,128 | 790,018 | -430,110 | 0.04 | 0.04 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 2,842,925 | 1,792,626 | -1,050,299 | 2.36 | 2.76 | +0.39 | sell |
| Paradigm Biocapital Advisors LP | 2,609,353 | 1,443,102 | -1,166,251 | 1.67 | 1.20 | -0.46 | sell |
| Deep Track Capital, LP | 5,380,449 | 2,524,833 | -2,855,616 | 3.24 | 1.79 | -1.45 | sell |
| Kynam Capital Management, LP | 4,427,927 | 1,470,541 | -2,957,386 | 7.11 | 2.98 | -4.14 | sell |