| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 12,249,355 | 14,384,456 | +2,135,101 | 0.01 | 0.02 | +0.01 | buy |
| BlackRock, Inc. | 5,428,521 | 6,431,923 | +1,003,402 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,331,983 | 5,612,144 | +1,280,161 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 0 | 4,358,527 | +4,358,527 | 0.00 | 2.57 | +2.57 | buy |
| Fairmount Funds Management LLC | 3,459,913 | 3,914,458 | +454,545 | 6.72 | 9.27 | +2.55 | buy |
| VR Adviser, LLC | 3,882,709 | 3,882,709 | 0 | 4.72 | 5.97 | +1.25 | hold |
| STATE STREET CORP | 2,554,166 | 3,466,560 | +912,394 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,418,104 | 3,439,414 | +1,021,310 | 0.01 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 1,462,400 | 3,042,703 | +1,580,303 | 0.91 | 1.73 | +0.82 | buy |
| Deep Track Capital, LP | 5,380,449 | 2,524,833 | -2,855,616 | 3.24 | 1.79 | -1.45 | sell |
| Novo Holdings A/S | 2,380,000 | 2,380,000 | 0 | 3.31 | 5.75 | +2.44 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,766,187 | 1,992,174 | +225,987 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,744,406 | 1,971,678 | +227,272 | 0.27 | 0.36 | +0.09 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,122,532 | 1,971,411 | +848,879 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,842,925 | 1,792,626 | -1,050,299 | 2.36 | 2.76 | +0.39 | sell |
| Eversept Partners, LP | 1,924,306 | 1,782,235 | -142,071 | 3.18 | 3.11 | -0.07 | sell |
| Fisher Asset Management, LLC | 1,201,226 | 1,780,284 | +579,058 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 191,941 | 1,738,225 | +1,546,284 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.46 | +0.46 | buy |
| LOOMIS SAYLES & CO L P | 1,550,328 | 1,481,135 | -69,193 | 0.04 | 0.06 | +0.02 | sell |
| Kynam Capital Management, LP | 4,427,927 | 1,470,541 | -2,957,386 | 7.11 | 2.98 | -4.14 | sell |
| Paradigm Biocapital Advisors LP | 2,609,353 | 1,443,102 | -1,166,251 | 1.67 | 1.20 | -0.46 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,859,458 | 1,414,181 | -445,277 | 0.01 | 0.01 | +0.00 | sell |
| MARSHALL WACE, LLP | 869,188 | 1,375,739 | +506,551 | 0.02 | 0.04 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 764,562 | 1,264,047 | +499,485 | 0.00 | 0.01 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 1,154,080 | +1,154,080 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 815,485 | 1,115,929 | +300,444 | 0.08 | 0.13 | +0.05 | buy |
| JPMORGAN CHASE & CO | 309,133 | 1,010,260 | +701,127 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 1,000,717 | +1,000,717 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 245,759 | 990,117 | +744,358 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 982,576 | 982,576 | 0 | 1.71 | 1.98 | +0.27 | hold |
| Pictet Asset Management Holding SA | 1,049,385 | 922,767 | -126,618 | 0.02 | 0.03 | +0.01 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 851,663 | 884,532 | +32,869 | 1.00 | 1.52 | +0.51 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,220,128 | 790,018 | -430,110 | 0.04 | 0.04 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 1,154,487 | 788,076 | -366,411 | 2.74 | 2.33 | -0.40 | sell |
| Candriam S.C.A. | 860,232 | 785,098 | -75,134 | 0.10 | 0.12 | +0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 595,361 | 748,961 | +153,600 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 161,868 | 742,337 | +580,469 | 0.00 | 0.01 | +0.01 | buy |
| 5AM Venture Management, LLC | 736,595 | 736,595 | 0 | 5.82 | 7.21 | +1.38 | hold |
| First Turn Management, LLC | 0 | 690,528 | +690,528 | 0.00 | 2.46 | +2.46 | buy |
| CITADEL ADVISORS LLC | 77,373 | 679,694 | +602,321 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 620,862 | 668,417 | +47,555 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 638,777 | 555,594 | -83,183 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 242,307 | 517,398 | +275,091 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 202,821 | 503,868 | +301,047 | 0.01 | 0.03 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 937,467 | 479,758 | -457,709 | 0.01 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 136,280 | 460,125 | +323,845 | 0.00 | 0.01 | +0.01 | buy |
| Rosalind Advisors, Inc. | 600,000 | 450,000 | -150,000 | 4.58 | 5.10 | +0.53 | sell |
| ALGERT GLOBAL LLC | 0 | 425,039 | +425,039 | 0.00 | 0.21 | +0.21 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 423,272 | 423,272 | 0 | 0.71 | 1.17 | +0.46 | hold |
| FEDERATED HERMES, INC. | 132 | 416,358 | +416,226 | 0.00 | 0.02 | +0.02 | buy |
| HighVista Strategies LLC | 469,335 | 372,472 | -96,863 | 2.48 | 2.99 | +0.50 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 259,509 | 348,569 | +89,060 | 0.81 | 1.57 | +0.76 | buy |
| Voleon Capital Management LP | 0 | 345,713 | +345,713 | 0.00 | 0.23 | +0.23 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 341,258 | +341,258 | 0.00 | 0.01 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 377,711 | 324,746 | -52,965 | 0.03 | 0.04 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 312,759 | 303,774 | -8,985 | 0.00 | 0.00 | +0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 286,320 | +286,320 | 0.00 | 0.04 | +0.04 | buy |
| Propel Bio Management, LLC | 90,000 | 282,531 | +192,531 | 1.94 | 7.51 | +5.56 | buy |
| JANE STREET GROUP, LLC | 35,414 | 279,607 | +244,193 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 254,285 | +254,285 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 250,000 | 250,000 | 0 | 0.50 | 0.56 | +0.06 | hold |
| BARCLAYS PLC | 208,246 | 244,273 | +36,027 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 432,420 | 226,817 | -205,603 | 0.01 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 57,928 | 217,434 | +159,506 | 0.01 | 0.03 | +0.03 | buy |
| Bank of New York Mellon Corp | 197,170 | 215,866 | +18,696 | 0.00 | 0.00 | +0.00 | buy |
| Yiheng Capital Management, L.P. | 500,261 | 208,735 | -291,526 | 3.57 | 2.83 | -0.74 | sell |
| Russell Investments Group, Ltd. | 134,997 | 193,479 | +58,482 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 80,792 | 183,468 | +102,676 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 213,329 | 175,930 | -37,399 | 0.00 | 0.00 | +0.00 | sell |
| Privium Fund Management B.V. | 0 | 173,516 | +173,516 | 0.00 | 0.99 | +0.99 | buy |
| Kopp Family Office, LLC | 193,830 | 173,173 | -20,657 | 2.72 | 3.44 | +0.72 | sell |
| Hennion & Walsh Asset Management, Inc. | 154,338 | 169,167 | +14,829 | 0.12 | 0.18 | +0.06 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 344,084 | 167,934 | -176,150 | 0.05 | 0.04 | -0.02 | sell |
| UBS Group AG | 447,677 | 164,820 | -282,857 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 154,320 | +154,320 | 0.00 | 0.82 | +0.82 | buy |
| Hudson Bay Capital Management LP | 175,251 | 151,464 | -23,787 | 0.02 | 0.03 | +0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 150,000 | +150,000 | 0.00 | 0.10 | +0.10 | buy |
| WELLS FARGO & COMPANY/MN | 105,880 | 147,316 | +41,436 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 116,574 | 145,000 | +28,426 | 1.05 | 2.09 | +1.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 138,980 | 139,360 | +380 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 0 | 136,717 | +136,717 | 0.00 | 0.21 | +0.21 | buy |
| Qube Research & Technologies Ltd | 0 | 129,532 | +129,532 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 110,700 | 128,600 | +17,900 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 122,790 | +122,790 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 119,892 | +119,892 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37,640 | 116,524 | +78,884 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 78,800 | 114,002 | +35,202 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 83,500 | 112,682 | +29,182 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 50,000 | 103,531 | +53,531 | 0.02 | 0.05 | +0.03 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 101,083 | 101,083 | 0 | 0.09 | 0.11 | +0.02 | hold |
| SEVEN GRAND MANAGERS, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.24 | +0.24 | buy |
| Rafferty Asset Management, LLC | 68,065 | 99,750 | +31,685 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 104,360 | 97,451 | -6,909 | 0.00 | 0.00 | +0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 74,113 | 96,187 | +22,074 | 0.30 | 0.56 | +0.26 | buy |
| Merck & Co., Inc. | 93,414 | 93,414 | 0 | 0.88 | 1.05 | +0.17 | hold |
| ExodusPoint Capital Management, LP | 14,413 | 92,697 | +78,284 | 0.00 | 0.03 | +0.03 | buy |
| J. Safra Sarasin Holding AG | 51,703 | 88,271 | +36,568 | 0.02 | 0.04 | +0.03 | buy |
| Velan Capital Investment Management LP | 86,500 | 86,500 | 0 | 1.75 | 1.57 | -0.19 | hold |
| ADAR1 Capital Management, LLC | 101,704 | 77,198 | -24,506 | 0.22 | 0.18 | -0.04 | sell |