| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 4,440,838 | 4,876,881 | +436,043 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 3,760,690 | 4,551,556 | +790,866 | 2.41 | 3.52 | +1.11 | buy |
| JPMORGAN CHASE & CO | 3,939,549 | 3,722,553 | -216,996 | 0.01 | 0.01 | -0.00 | sell |
| STATE STREET CORP | 2,631,220 | 3,122,639 | +491,419 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,820,382 | 1,339,838 | -480,544 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 0 | 1,300,064 | +1,300,064 | 0.00 | 0.97 | +0.97 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,226,957 | 1,197,073 | -29,884 | 0.01 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 929,672 | 950,551 | +20,879 | 0.00 | 0.00 | +0.00 | buy |
| Aquilo Capital Management, LLC | 802,424 | 906,248 | +103,824 | 10.10 | 14.31 | +4.21 | buy |
| Integral Health Asset Management, LLC | 325,000 | 760,000 | +435,000 | 0.84 | 1.57 | +0.73 | buy |
| GOLDMAN SACHS GROUP INC | 336,106 | 723,605 | +387,499 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 549,078 | 549,078 | 0 | 2.31 | 1.86 | -0.45 | hold |
| NORTHERN TRUST CORP | 446,773 | 431,785 | -14,988 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 196,073 | 426,955 | +230,882 | 0.01 | 0.02 | +0.01 | buy |
| WS MANAGEMENT LLLP | 431,200 | 379,059 | -52,141 | 0.76 | 0.73 | -0.03 | sell |
| RTW INVESTMENTS, LP | 0 | 350,000 | +350,000 | 0.00 | 0.11 | +0.11 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 327,451 | 343,615 | +16,164 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 337,773 | 310,668 | -27,105 | 0.00 | 0.00 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 222,363 | 300,114 | +77,751 | 0.02 | 0.03 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 695,184 | 292,341 | -402,843 | 0.06 | 0.03 | -0.04 | sell |
| AMERIPRISE FINANCIAL INC | 376,728 | 270,641 | -106,087 | 0.00 | 0.00 | -0.00 | sell |
| Artal Group S.A. | 0 | 250,000 | +250,000 | 0.00 | 0.14 | +0.14 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 37,720 | 235,962 | +198,242 | 0.00 | 0.02 | +0.02 | buy |
| Assenagon Asset Management S.A. | 106,682 | 227,611 | +120,929 | 0.01 | 0.01 | +0.01 | buy |
| ArchPoint Investors | 224,278 | 224,278 | 0 | 1.68 | 1.97 | +0.30 | hold |
| NORGES BANK | 220,524 | 220,524 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 236,023 | 216,211 | -19,812 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 72,211 | 186,753 | +114,542 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 183,795 | +183,795 | 0.00 | 0.03 | +0.03 | buy |
| Rafferty Asset Management, LLC | 120,833 | 179,868 | +59,035 | 0.01 | 0.01 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 94,418 | 170,218 | +75,800 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 55,323 | 165,821 | +110,498 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 165,073 | +165,073 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 132,748 | 162,699 | +29,951 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 18,154 | 158,179 | +140,025 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 157,640 | 156,160 | -1,480 | 0.00 | 0.00 | +0.00 | sell |
| MACQUARIE GROUP LTD | 149,000 | 149,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Woodline Partners LP | 0 | 146,334 | +146,334 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 146,220 | 142,044 | -4,176 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 148,229 | 141,420 | -6,809 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 110,178 | 111,840 | +1,662 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 110,000 | +110,000 | 0.00 | 0.38 | +0.38 | buy |
| RHUMBLINE ADVISERS | 111,331 | 109,539 | -1,792 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 34,267 | 108,580 | +74,313 | 0.01 | 0.03 | +0.02 | buy |
| CITADEL ADVISORS LLC | 212,044 | 108,497 | -103,547 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 73,700 | 106,284 | +32,584 | 0.08 | 0.12 | +0.04 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 103,065 | +103,065 | 0.00 | 0.10 | +0.10 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 100,000 | +100,000 | 0.00 | 0.04 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 19,600 | 97,500 | +77,900 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 67,949 | 90,595 | +22,646 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 115,071 | 89,984 | -25,087 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 0 | 84,470 | +84,470 | 0.00 | 1.52 | +1.52 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 83,993 | 83,993 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Swiss National Bank | 78,000 | 81,500 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 74,600 | 74,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 49,046 | 64,105 | +15,059 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 45,589 | 61,340 | +15,751 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 59,540 | 59,027 | -513 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 12,600 | 57,200 | +44,600 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 49,549 | 54,601 | +5,052 | 0.17 | 0.15 | -0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 67,760 | 51,476 | -16,284 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 70,114 | 50,643 | -19,471 | 0.03 | 0.02 | -0.01 | sell |
| PRUDENTIAL FINANCIAL INC | 47,144 | 50,024 | +2,880 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 112,004 | 49,452 | -62,552 | 0.00 | 0.00 | -0.00 | sell |
| LIBERTY ONE INVESTMENT MANAGEMENT, LLC | 33,842 | 48,060 | +14,218 | 0.07 | 0.11 | +0.04 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 45,131 | 45,131 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hudson Bay Capital Management LP | 90,000 | 44,900 | -45,100 | 0.01 | 0.01 | -0.01 | sell |
| Qube Research & Technologies Ltd | 18,938 | 42,972 | +24,034 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 42,704 | +42,704 | 0.00 | 0.06 | +0.06 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,981 | 41,255 | -726 | 0.00 | 0.00 | +0.00 | sell |
| Rockefeller Capital Management L.P. | 41,052 | 40,971 | -81 | 0.00 | 0.00 | +0.00 | sell |
| Ovata Capital Management Ltd | 0 | 40,000 | +40,000 | 0.00 | 0.44 | +0.44 | buy |
| Resolute Capital Asset Partners LLC | 0 | 40,000 | +40,000 | 0.00 | 0.44 | +0.44 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 38,544 | 38,544 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CANADA LIFE ASSURANCE Co | 33,135 | 37,211 | +4,076 | 0.00 | 0.00 | +0.00 | buy |
| TEXAS PERMANENT SCHOOL FUND CORP | 34,747 | 35,204 | +457 | 0.01 | 0.01 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 36,064 | 35,111 | -953 | 0.00 | 0.00 | +0.00 | sell |
| PDT Partners, LLC | 0 | 34,387 | +34,387 | 0.00 | 0.07 | +0.07 | buy |
| Campbell & CO Investment Adviser LLC | 15,805 | 34,041 | +18,236 | 0.03 | 0.06 | +0.04 | buy |
| Lion Point Capital, LP | 0 | 32,500 | +32,500 | 0.00 | 1.31 | +1.31 | buy |
| WELLS FARGO & COMPANY/MN | 25,742 | 29,635 | +3,893 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 21,650 | 29,500 | +7,850 | 0.02 | 0.02 | +0.01 | buy |
| Sigma Planning Corp | 12,430 | 27,575 | +15,145 | 0.02 | 0.02 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 66,447 | 27,093 | -39,354 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 38,535 | 26,849 | -11,686 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 24,966 | 24,967 | +1 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 24,899 | 24,656 | -243 | 0.01 | 0.01 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 22,744 | +22,744 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 22,326 | 22,128 | -198 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 21,565 | +21,565 | 0.00 | 0.03 | +0.03 | buy |
| MetLife Investment Management, LLC | 22,327 | 20,449 | -1,878 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 0 | 20,010 | +20,010 | 0.00 | 0.00 | +0.00 | buy |
| Louisiana State Employees Retirement System | 20,200 | 20,000 | -200 | 0.01 | 0.01 | +0.00 | sell |
| State of Tennessee, Department of Treasury | 21,974 | 19,371 | -2,603 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,739 | 18,177 | +1,438 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 17,425 | 17,731 | +306 | 0.00 | 0.00 | -0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 16,952 | +16,952 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,028 | 16,629 | -3,399 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,300 | 16,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11,615 | 15,485 | +3,870 | 0.00 | 0.00 | +0.00 | buy |