| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,844,466 | 5,466,102 | -3,378,364 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 4,892,902 | 4,794,780 | -98,122 | 3.02 | 2.58 | -0.44 | sell |
| JPMORGAN CHASE & CO | 2,477,311 | 4,136,517 | +1,659,206 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,368,991 | 2,985,952 | -1,383,039 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 2,782,883 | 2,185,851 | -597,032 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,349,876 | 2,003,311 | +653,435 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 261,157 | 1,322,344 | +1,061,187 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,120,109 | 1,187,102 | +66,993 | 0.03 | 0.02 | -0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,150,188 | 1,171,422 | +21,234 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,088,651 | 1,094,225 | +5,574 | 0.00 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 1,275,000 | 900,000 | -375,000 | 1.57 | 0.62 | -0.96 | sell |
| Assenagon Asset Management S.A. | 559,872 | 856,572 | +296,700 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 743,387 | 756,238 | +12,851 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 203,231 | 585,408 | +382,177 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 1,132,564 | 532,000 | -600,564 | 0.61 | 0.41 | -0.20 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 500,000 | +500,000 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 487,987 | 465,261 | -22,726 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 0 | 449,400 | +449,400 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 125,933 | 389,428 | +263,495 | 0.00 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 233,999 | 363,403 | +129,404 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 361,313 | +361,313 | 0.00 | 0.05 | +0.05 | buy |
| Qube Research & Technologies Ltd | 194,074 | 353,993 | +159,919 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 350,000 | 350,000 | 0 | 0.05 | 0.04 | -0.01 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 417,739 | 349,730 | -68,009 | 0.00 | 0.00 | -0.00 | sell |
| Aquilo Capital Management, LLC | 930,708 | 346,302 | -584,406 | 10.99 | 4.58 | -6.40 | sell |
| Voss Capital, LP | 0 | 332,814 | +332,814 | 0.00 | 0.19 | +0.19 | buy |
| Hudson Bay Capital Management LP | 215,000 | 308,100 | +93,100 | 0.02 | 0.01 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 271,638 | 284,521 | +12,883 | 0.00 | 0.00 | -0.00 | buy |
| Siren, L.L.C. | 284,000 | 284,000 | 0 | 0.15 | 0.10 | -0.05 | hold |
| BANK OF AMERICA CORP /DE/ | 446,184 | 281,204 | -164,980 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 271,300 | +271,300 | 0.00 | 0.00 | +0.00 | buy |
| ArchPoint Investors | 224,278 | 221,528 | -2,750 | 0.79 | 0.56 | -0.22 | sell |
| PANAGORA ASSET MANAGEMENT INC | 209,422 | 208,029 | -1,393 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 184,653 | 200,375 | +15,722 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 111,485 | 193,303 | +81,818 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 78,703 | 192,708 | +114,005 | 0.02 | 0.03 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 149,280 | 188,844 | +39,564 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 68,000 | 180,000 | +112,000 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 569,008 | 170,129 | -398,879 | 1.00 | 0.27 | -0.73 | sell |
| JANE STREET GROUP, LLC | 38,776 | 164,911 | +126,135 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 151,715 | 164,729 | +13,014 | 0.07 | 0.06 | -0.02 | buy |
| Bank of New York Mellon Corp | 320,389 | 161,136 | -159,253 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 150,022 | +150,022 | 0.00 | 0.01 | +0.01 | buy |
| MACQUARIE GROUP LTD | 149,000 | 149,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Y-Intercept (Hong Kong) Ltd | 0 | 137,402 | +137,402 | 0.00 | 0.07 | +0.07 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 25,694 | 134,491 | +108,797 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 116,024 | 127,065 | +11,041 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 95,511 | 114,811 | +19,300 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,387 | 108,804 | +53,417 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 13,177 | 108,120 | +94,943 | 0.01 | 0.07 | +0.06 | buy |
| ExodusPoint Capital Management, LP | 189,099 | 105,668 | -83,431 | 0.02 | 0.01 | -0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 97,625 | 100,452 | +2,827 | 0.00 | 0.00 | -0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 100,000 | 100,000 | 0 | 0.03 | 0.01 | -0.02 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 20,441 | 96,093 | +75,652 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 87,368 | 95,026 | +7,658 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 76,641 | 93,821 | +17,180 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 0 | 88,148 | +88,148 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 36,507 | 84,817 | +48,310 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 81,500 | 81,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Opaleye Management Inc. | 0 | 80,000 | +80,000 | 0.00 | 0.11 | +0.11 | buy |
| DekaBank Deutsche Girozentrale | 74,600 | 74,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 115,025 | 74,269 | -40,756 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 66,078 | 72,183 | +6,105 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 55,106 | 63,377 | +8,271 | 0.00 | 0.00 | -0.00 | buy |
| PDT Partners, LLC | 0 | 63,015 | +63,015 | 0.00 | 0.04 | +0.04 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 57,841 | +57,841 | 0.00 | 0.12 | +0.12 | buy |
| Lion Point Capital, LP | 57,750 | 57,750 | 0 | 2.43 | 2.34 | -0.09 | hold |
| ALLIANCEBERNSTEIN L.P. | 59,027 | 53,900 | -5,127 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 136,164 | 52,128 | -84,036 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 36,152 | 48,437 | +12,285 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 45,689 | +45,689 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 117,728 | 44,823 | -72,905 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 40,478 | 43,502 | +3,024 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 41,160 | +41,160 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,884 | 39,554 | -330 | 0.00 | 0.00 | -0.00 | sell |
| Sigma Planning Corp | 38,210 | 37,310 | -900 | 0.01 | 0.01 | -0.00 | sell |
| Squarepoint Ops LLC | 39,705 | 37,230 | -2,475 | 0.00 | 0.00 | -0.00 | sell |
| Allianz Asset Management GmbH | 39,300 | 31,800 | -7,500 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 0 | 29,696 | +29,696 | 0.00 | 0.02 | +0.02 | buy |
| Graham Capital Management, L.P. | 17,865 | 28,542 | +10,677 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 27,189 | 27,189 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 40,972 | 27,108 | -13,864 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 36,257 | 26,434 | -9,823 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 41,146 | 25,869 | -15,277 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 36,082 | 25,607 | -10,475 | 0.02 | 0.01 | -0.01 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 17,163 | 25,430 | +8,267 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 24,761 | 24,761 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SHERBROOKE PARK ADVISERS LLC | 29,707 | 24,330 | -5,377 | 0.07 | 0.06 | -0.01 | sell |
| Aristides Capital LLC | 0 | 24,200 | +24,200 | 0.00 | 0.06 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,928 | 23,910 | +1,982 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 26,403 | 22,889 | -3,514 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 0 | 22,687 | +22,687 | 0.00 | 0.05 | +0.05 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 15,365 | 19,474 | +4,109 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 16,858 | 18,256 | +1,398 | 0.01 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,928 | 17,555 | -373 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 17,286 | +17,286 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,113 | 16,661 | +4,548 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 12,514 | 15,314 | +2,800 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 12,105 | 14,539 | +2,434 | 0.00 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 14,440 | 13,784 | -656 | 0.03 | 0.02 | -0.01 | sell |