| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 6,995,861 | 6,145,861 | -850,000 | 0.55 | 0.63 | +0.08 | sell |
| FMR LLC | 5,350,659 | 5,779,029 | +428,370 | 0.00 | 0.00 | +0.00 | buy |
| BML Capital Management, LLC | 5,462,079 | 5,536,710 | +74,631 | 13.15 | 14.98 | +1.82 | buy |
| VANGUARD GROUP INC | 4,599,710 | 4,722,522 | +122,812 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,076,741 | 4,076,741 | 0 | 1.15 | 1.71 | +0.57 | hold |
| Bain Capital Life Sciences Investors, LLC | 2,485,638 | 2,485,638 | 0 | 0.73 | 0.81 | +0.08 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,807,912 | 1,882,480 | +74,568 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,630,037 | 1,678,383 | +48,346 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,496,303 | 1,123,400 | -372,903 | 0.01 | 0.01 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 962,458 | 962,458 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NORTHERN TRUST CORP | 711,513 | 687,269 | -24,244 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 550,537 | 672,984 | +122,447 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 584,326 | 612,319 | +27,993 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 319,100 | 577,400 | +258,300 | 0.00 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 595,692 | 571,359 | -24,333 | 0.00 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 407,656 | 404,639 | -3,017 | 0.00 | 0.00 | +0.00 | sell |
| Newtyn Management, LLC | 508,474 | 400,000 | -108,474 | 0.30 | 0.32 | +0.02 | sell |
| DIMENSIONAL FUND ADVISORS LP | 92,351 | 382,932 | +290,581 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 161,909 | 372,250 | +210,341 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 350,004 | +350,004 | 0.00 | 0.00 | +0.00 | buy |
| BANQUE PICTET & CIE SA | 345,077 | 345,077 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CM Management, LLC | 270,000 | 270,000 | 0 | 0.66 | 0.92 | +0.25 | hold |
| Acuitas Investments, LLC | 171,098 | 257,910 | +86,812 | 0.32 | 0.53 | +0.20 | buy |
| Bank of New York Mellon Corp | 255,288 | 239,557 | -15,731 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 15,600 | 212,763 | +197,163 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 185,177 | 207,759 | +22,582 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 228,840 | 207,069 | -21,771 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 221,565 | 196,264 | -25,301 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 173,014 | 196,000 | +22,986 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 185,411 | +185,411 | 0.00 | 0.00 | +0.00 | buy |
| Auour Investments LLC | 177,000 | 177,000 | 0 | 0.26 | 0.26 | -0.00 | hold |
| HSBC HOLDINGS PLC | 180,371 | 171,368 | -9,003 | 0.00 | 0.00 | -0.00 | sell |
| RBF Capital, LLC | 152,416 | 148,451 | -3,965 | 0.03 | 0.03 | +0.00 | sell |
| BARCLAYS PLC | 197,087 | 145,532 | -51,555 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 147,116 | 141,902 | -5,214 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 129,900 | 128,900 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 13,458 | 116,655 | +103,197 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 120,730 | 116,420 | -4,310 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 78,754 | 109,258 | +30,504 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 53,489 | 105,818 | +52,329 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 107,646 | 104,070 | -3,576 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 68,426 | 103,256 | +34,830 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 100,700 | 94,700 | -6,000 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 178,353 | 94,125 | -84,228 | 0.01 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 83,275 | 80,830 | -2,445 | 0.00 | 0.01 | +0.00 | sell |
| MACQUARIE GROUP LTD | 70,000 | 70,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 55,169 | 67,137 | +11,968 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 52,132 | 67,111 | +14,979 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 243,724 | 67,066 | -176,658 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 18,012 | 61,033 | +43,021 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 58,436 | 59,367 | +931 | 0.00 | 0.00 | +0.00 | buy |
| Marquette Asset Management, LLC | 47,166 | 47,166 | 0 | 0.03 | 0.03 | +0.01 | hold |
| DEUTSCHE BANK AG\ | 38,475 | 40,390 | +1,915 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 38,104 | 37,779 | -325 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 47,234 | 37,725 | -9,509 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 36,200 | 36,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LPL Financial LLC | 0 | 34,000 | +34,000 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,985 | 30,547 | -2,438 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 0 | 30,465 | +30,465 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 33,286 | 28,547 | -4,739 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 42,521 | 28,140 | -14,381 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 24,064 | 27,539 | +3,475 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 53,038 | 26,389 | -26,649 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 27,462 | 25,374 | -2,088 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 36,900 | 23,060 | -13,840 | 0.00 | 0.00 | -0.00 | sell |
| Numerai GP LLC | 0 | 22,580 | +22,580 | 0.00 | 0.04 | +0.04 | buy |
| Tidal Investments LLC | 0 | 21,472 | +21,472 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 13,874 | 21,163 | +7,289 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 25,717 | 20,809 | -4,908 | 0.01 | 0.01 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 20,153 | +20,153 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 18,020 | 19,671 | +1,651 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 149,878 | 19,071 | -130,807 | 0.04 | 0.01 | -0.03 | sell |
| Shay Capital LLC | 50,139 | 18,166 | -31,973 | 0.06 | 0.02 | -0.04 | sell |
| ExodusPoint Capital Management, LP | 16,762 | 17,560 | +798 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 16,828 | +16,828 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,345 | 16,292 | -53 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 9,653 | 16,179 | +6,526 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 12,493 | 14,777 | +2,284 | 0.00 | 0.00 | +0.00 | buy |
| Sunpointe, LLC | 11,943 | 11,943 | 0 | 0.05 | 0.05 | +0.01 | hold |
| Belvedere Trading LLC | 0 | 10,519 | +10,519 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 8,700 | 8,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Gladius Capital Management LP | 0 | 8,540 | +8,540 | 0.00 | 0.03 | +0.03 | buy |
| Quantbot Technologies LP | 7,222 | 8,522 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,618 | 7,707 | -4,911 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 7,514 | 7,514 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 6,044 | 6,044 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 5,500 | +5,500 | 0.00 | 0.01 | +0.01 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 3,400 | +3,400 | 0.00 | 0.01 | +0.01 | buy |
| ROTHSCHILD INVESTMENT LLC | 3,150 | 3,150 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 0 | 2,900 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 6,775 | 2,673 | -4,102 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,197 | 2,613 | +416 | 0.00 | 0.00 | +0.00 | buy |
| Capital Advisors, Ltd. LLC | 0 | 1,641 | +1,641 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 30,340 | 1,470 | -28,870 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 4,910 | 674 | -4,236 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 0 | 319 | +319 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 216 | 301 | +85 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 242 | 242 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Financial Advisors, LLC | 120 | 120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 0 | 99 | +99 | 0.00 | 0.00 | +0.00 | buy |