| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,779,029 | 6,436,123 | +657,094 | 0.00 | 0.00 | -0.00 | buy |
| BML Capital Management, LLC | 5,536,710 | 6,375,621 | +838,911 | 14.98 | 15.45 | +0.48 | buy |
| EcoR1 Capital, LLC | 6,145,861 | 5,441,896 | -703,965 | 0.63 | 0.55 | -0.08 | sell |
| VANGUARD GROUP INC | 4,722,522 | 4,724,405 | +1,883 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,076,741 | 4,476,741 | +400,000 | 1.71 | 1.51 | -0.21 | buy |
| Bain Capital Life Sciences Investors, LLC | 2,485,638 | 2,485,638 | 0 | 0.81 | 0.90 | +0.10 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,882,480 | 2,009,803 | +127,323 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,678,383 | 1,721,920 | +43,537 | 0.00 | 0.00 | -0.00 | buy |
| Almitas Capital LLC | 0 | 1,290,187 | +1,290,187 | 0.00 | 1.78 | +1.78 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,123,400 | 1,141,500 | +18,100 | 0.01 | 0.01 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 962,458 | 934,505 | -27,953 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 687,269 | 661,284 | -25,985 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 577,400 | 612,200 | +34,800 | 0.01 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 612,319 | 599,363 | -12,956 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 382,932 | 594,360 | +211,428 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 571,359 | 571,268 | -91 | 0.01 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 672,984 | 564,898 | -108,086 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 196,000 | 525,603 | +329,603 | 0.00 | 0.00 | +0.00 | buy |
| Newtyn Management, LLC | 400,000 | 380,000 | -20,000 | 0.32 | 0.24 | -0.09 | sell |
| TWO SIGMA INVESTMENTS, LP | 372,250 | 375,075 | +2,825 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 404,639 | 367,540 | -37,099 | 0.00 | 0.00 | -0.00 | sell |
| BANQUE PICTET & CIE SA | 345,077 | 345,077 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CM Management, LLC | 270,000 | 270,000 | 0 | 0.92 | 0.82 | -0.10 | hold |
| Bank of New York Mellon Corp | 239,557 | 266,184 | +26,627 | 0.00 | 0.00 | -0.00 | buy |
| Acuitas Investments, LLC | 257,910 | 259,289 | +1,379 | 0.53 | 0.46 | -0.07 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 350,004 | 255,166 | -94,838 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 207,069 | 221,342 | +14,273 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 196,264 | 195,037 | -1,227 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 182,326 | +182,326 | 0.00 | 0.00 | +0.00 | buy |
| Auour Investments LLC | 177,000 | 177,000 | 0 | 0.26 | 0.22 | -0.05 | hold |
| HSBC HOLDINGS PLC | 171,368 | 158,109 | -13,259 | 0.00 | 0.00 | -0.00 | sell |
| RBF Capital, LLC | 148,451 | 148,451 | 0 | 0.03 | 0.03 | -0.01 | hold |
| D. E. Shaw & Co., Inc. | 207,759 | 147,913 | -59,846 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 128,900 | 143,300 | +14,400 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 141,902 | 137,598 | -4,304 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 109,258 | 125,169 | +15,911 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 116,420 | 119,220 | +2,800 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 94,700 | 105,500 | +10,800 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 105,818 | 101,793 | -4,025 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 145,532 | 101,453 | -44,079 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 94,931 | +94,931 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 116,655 | 90,337 | -26,318 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 104,070 | 71,579 | -32,491 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 70,000 | 70,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 185,411 | 67,546 | -117,865 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 67,137 | 66,660 | -477 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 0 | 65,976 | +65,976 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 59,367 | 65,678 | +6,311 | 0.00 | 0.00 | -0.00 | buy |
| BERKSHIRE ASSET MANAGEMENT LLC/PA | 0 | 65,000 | +65,000 | 0.00 | 0.01 | +0.01 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 61,033 | 55,095 | -5,938 | 0.00 | 0.00 | -0.00 | sell |
| Marquette Asset Management, LLC | 47,166 | 47,166 | 0 | 0.03 | 0.03 | -0.01 | hold |
| MetLife Investment Management, LLC | 37,725 | 45,200 | +7,475 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 34,000 | 35,915 | +1,915 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 30,547 | 34,886 | +4,339 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 27,539 | 34,354 | +6,815 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 94,125 | 34,045 | -60,080 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 40,390 | 32,449 | -7,941 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 28,547 | 31,313 | +2,766 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 23,060 | 24,297 | +1,237 | 0.00 | 0.00 | -0.00 | buy |
| Shay Capital LLC | 18,166 | 24,186 | +6,020 | 0.02 | 0.02 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 22,010 | +22,010 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 14,777 | 19,197 | +4,420 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 16,828 | 18,691 | +1,863 | 0.00 | 0.00 | -0.00 | buy |
| Tidal Investments LLC | 21,472 | 18,419 | -3,053 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 17,560 | 17,560 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,292 | 16,346 | +54 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 19,671 | 15,466 | -4,205 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 20,153 | 14,640 | -5,513 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 28,140 | 14,051 | -14,089 | 0.00 | 0.00 | -0.00 | sell |
| Sunpointe, LLC | 11,943 | 11,943 | 0 | 0.05 | 0.03 | -0.03 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 25,374 | 11,425 | -13,949 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 16,179 | 9,894 | -6,285 | 0.01 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,470 | 9,482 | +8,012 | 0.00 | 0.00 | +0.00 | buy |
| Gladius Capital Management LP | 8,540 | 8,828 | +288 | 0.03 | 0.03 | -0.00 | buy |
| Blue Trust, Inc. | 8,700 | 8,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 26,389 | 8,235 | -18,154 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 7,514 | 7,514 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 6,044 | 6,044 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,707 | 5,591 | -2,116 | 0.00 | 0.00 | -0.00 | sell |
| Redwood Wealth Management Group, LLC | 0 | 5,000 | +5,000 | 0.00 | 0.01 | +0.01 | buy |
| ROTHSCHILD INVESTMENT LLC | 3,150 | 3,150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 Asia (Singapore) Pte. Ltd. | 5,500 | 3,028 | -2,472 | 0.01 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,673 | 2,673 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 30,465 | 2,515 | -27,950 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 674 | 504 | -170 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 242 | 242 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 301 | 233 | -68 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 0 | 207 | +207 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 23 | 182 | +159 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Financial Advisors, LLC | 120 | 120 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 0 | 118 | +118 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 118 | +118 | 0.00 | 0.00 | 0.00 | buy |
| Colonial Trust Advisors | 46 | 46 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Smartleaf Asset Management LLC | 0 | 46 | +46 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 20 | +20 | 0.00 | 0.00 | 0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 75 | 0 | -75 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 212,763 | 0 | -212,763 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 19,071 | 0 | -19,071 | 0.01 | 0.00 | -0.01 | sell |
| NORGES BANK | 36,200 | 0 | -36,200 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 99 | 0 | -99 | 0.00 | 0.00 | -0.00 | sell |