| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,990,734 | 9,062,181 | +71,447 | 0.00 | 0.00 | -0.00 | buy |
| BML Capital Management, LLC | 6,650,000 | 7,608,312 | +958,312 | 13.11 | 15.83 | +2.73 | buy |
| FMR LLC | 6,618,297 | 6,425,225 | -193,072 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 4,607,060 | 4,788,912 | +181,852 | 1.10 | 1.06 | -0.04 | buy |
| VANGUARD GROUP INC | 4,851,218 | 4,666,854 | -184,364 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 5,441,896 | 3,341,653 | -2,100,243 | 0.62 | 0.45 | -0.18 | sell |
| Bain Capital Life Sciences Investors, LLC | 2,485,638 | 2,485,638 | 0 | 0.87 | 0.98 | +0.11 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,924,773 | 1,916,786 | -7,987 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,733,486 | 1,786,078 | +52,592 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,207,100 | 1,216,600 | +9,500 | 0.01 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 793,626 | 977,470 | +183,844 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 932,925 | 932,925 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Almitas Capital LLC | 1,384,529 | 752,003 | -632,526 | 1.64 | 0.55 | -1.09 | sell |
| NORTHERN TRUST CORP | 687,438 | 704,909 | +17,471 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 650,157 | 659,527 | +9,370 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 572,083 | 582,939 | +10,856 | 0.00 | 0.00 | +0.00 | buy |
| Newtyn Management, LLC | 380,000 | 580,000 | +200,000 | 0.20 | 0.34 | +0.14 | buy |
| MORGAN STANLEY | 488,899 | 567,040 | +78,141 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 582,400 | 493,600 | -88,800 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 95,244 | 409,259 | +314,015 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 509,471 | 390,899 | -118,572 | 0.01 | 0.00 | -0.00 | sell |
| BANQUE PICTET & CIE SA | 345,077 | 345,077 | 0 | 0.01 | 0.01 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 300,928 | 312,135 | +11,207 | 0.00 | 0.00 | +0.00 | buy |
| CM Management, LLC | 270,000 | 300,000 | +30,000 | 0.72 | 0.90 | +0.18 | buy |
| TWO SIGMA INVESTMENTS, LP | 341,761 | 285,921 | -55,840 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 193,578 | 256,083 | +62,505 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 595,249 | 218,788 | -376,461 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 221,562 | 218,509 | -3,053 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 212,690 | 212,030 | -660 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 177,077 | 200,113 | +23,036 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 194,529 | 196,702 | +2,173 | 0.00 | 0.00 | -0.00 | buy |
| Auour Investments LLC | 177,000 | 177,000 | 0 | 0.21 | 0.19 | -0.02 | hold |
| HSBC HOLDINGS PLC | 159,600 | 162,210 | +2,610 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 143,196 | 145,195 | +1,999 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 133,114 | 129,796 | -3,318 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 119,220 | 119,220 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 109,200 | 116,000 | +6,800 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 110,000 | +110,000 | 0.00 | 0.08 | +0.08 | buy |
| STRS OHIO | 105,500 | 105,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 96,433 | +96,433 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 98,069 | 86,169 | -11,900 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 77,581 | +77,581 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 44,157 | 76,352 | +32,195 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 70,001 | 73,883 | +3,882 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 70,000 | 70,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Verition Fund Management LLC | 56,909 | 67,304 | +10,395 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 57,833 | 60,934 | +3,101 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 148,451 | 54,929 | -93,522 | 0.03 | 0.01 | -0.02 | sell |
| Squarepoint Ops LLC | 15,697 | 50,750 | +35,053 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 0 | 50,087 | +50,087 | 0.00 | 0.00 | +0.00 | buy |
| Marquette Asset Management, LLC | 47,166 | 47,166 | 0 | 0.03 | 0.03 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 35,526 | 45,391 | +9,865 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,242 | 44,142 | +1,900 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 41,259 | 38,363 | -2,896 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 45,200 | 37,091 | -8,109 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 52,095 | 36,371 | -15,724 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 10,711 | 35,989 | +25,278 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 33,300 | +33,300 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 33,554 | 32,341 | -1,213 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 30,612 | 32,098 | +1,486 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 17,762 | 30,633 | +12,871 | 0.02 | 0.03 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 30,974 | 29,342 | -1,632 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 27,399 | 27,399 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ProShare Advisors LLC | 19,570 | 25,733 | +6,163 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 22,506 | +22,506 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 22,341 | +22,341 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 22,010 | 22,010 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 16,237 | 17,909 | +1,672 | 0.01 | 0.01 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,346 | 16,346 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ZACKS INVESTMENT MANAGEMENT | 23,940 | 13,966 | -9,974 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 15,743 | 13,817 | -1,926 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 0 | 12,511 | +12,511 | 0.00 | 0.00 | +0.00 | buy |
| Sunpointe, LLC | 11,943 | 11,943 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Blue Trust, Inc. | 8,700 | 8,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 7,514 | 7,514 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 7,216 | 7,216 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,591 | 5,591 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 11,734 | 3,617 | -8,117 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 19,031 | 3,426 | -15,605 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 3,053 | 2,815 | -238 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,673 | 2,673 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 245 | 2,472 | +2,227 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 1,281 | 1,584 | +303 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,102 | 504 | -598 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 242 | 242 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 216 | 216 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 207 | 207 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 12,756 | 177 | -12,579 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 0 | 150 | +150 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 95 | +95 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 66 | 67 | +1 | 0.00 | 0.00 | 0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 128 | 23 | -105 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 13,143 | 0 | -13,143 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 64,692 | 0 | -64,692 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 38,515 | 0 | -38,515 | 0.00 | 0.00 | -0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 10,912 | 0 | -10,912 | 0.03 | 0.00 | -0.03 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,168 | 0 | -53,168 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 13,868 | 0 | -13,868 | 0.00 | 0.00 | -0.00 | sell |
| Acuitas Investments, LLC | 323,542 | 0 | -323,542 | 0.48 | 0.00 | -0.48 | sell |
| Virtu Financial LLC | 29,491 | 0 | -29,491 | 0.01 | 0.00 | -0.01 | sell |