| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 0 | 2,025,000 | +2,025,000 | 0.00 | 3.50 | +3.50 | buy |
| Point72 Asset Management, L.P. | 0 | 701,597 | +701,597 | 0.00 | 0.08 | +0.08 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 415,000 | +415,000 | 0.00 | 0.03 | +0.03 | buy |
| Octagon Capital Advisors LP | 0 | 405,000 | +405,000 | 0.00 | 1.93 | +1.93 | buy |
| CITADEL ADVISORS LLC | 0 | 369,167 | +369,167 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 195,899 | 559,271 | +363,372 | 0.32 | 5.97 | +5.65 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 339,074 | +339,074 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 324,902 | +324,902 | 0.00 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 0 | 259,456 | +259,456 | 0.00 | 0.03 | +0.03 | buy |
| VANGUARD GROUP INC | 179,456 | 437,264 | +257,808 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 192,495 | +192,495 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 185,148 | +185,148 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 171,976 | +171,976 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 132,584 | +132,584 | 0.00 | 0.06 | +0.06 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 124,273 | +124,273 | 0.00 | 0.04 | +0.04 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 41,615 | 156,013 | +114,398 | 0.01 | 0.17 | +0.16 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 106,378 | +106,378 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 0 | 100,617 | +100,617 | 0.00 | 1.10 | +1.10 | buy |
| Eversept Partners, LP | 0 | 88,934 | +88,934 | 0.00 | 0.26 | +0.26 | buy |
| Exome Asset Management LLC | 0 | 87,846 | +87,846 | 0.00 | 2.95 | +2.95 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 38,145 | 108,808 | +70,663 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 67,500 | +67,500 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 64,503 | +64,503 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 63,059 | +63,059 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 0 | 61,554 | +61,554 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 43,000 | +43,000 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 40,981 | +40,981 | 0.00 | 0.01 | +0.01 | buy |
| Atle Fund Management AB | 0 | 38,000 | +38,000 | 0.00 | 0.91 | +0.91 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 35,000 | +35,000 | 0.00 | 0.22 | +0.22 | buy |
| JANE STREET GROUP, LLC | 0 | 32,400 | +32,400 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 31,980 | +31,980 | 0.00 | 0.35 | +0.35 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 27,995 | +27,995 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 24,880 | +24,880 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 13,179 | 35,979 | +22,800 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 21,200 | +21,200 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 20,011 | +20,011 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 17,946 | +17,946 | 0.00 | 0.05 | +0.05 | buy |
| Man Group plc | 0 | 17,673 | +17,673 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 16,000 | +16,000 | 0.00 | 0.17 | +0.17 | buy |
| UBS Group AG | 0 | 15,465 | +15,465 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 15,304 | +15,304 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 14,943 | +14,943 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 566 | 15,307 | +14,741 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 12,314 | +12,314 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 11,984 | +11,984 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 0 | 11,100 | +11,100 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 10,527 | +10,527 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 10,290 | +10,290 | 0.00 | 0.05 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 10,123 | +10,123 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 9,652 | +9,652 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 9,182 | +9,182 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 7,500 | +7,500 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 3,353 | 9,154 | +5,801 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 5,143 | +5,143 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,990 | +1,990 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 1,081 | +1,081 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 700 | +700 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 1,190 | 1,726 | +536 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 507 | +507 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 3 | 23 | +20 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 41 | 41 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Scarborough Advisors, LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JTC Employer Solutions Trustee Ltd | 1,106 | 1,106 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STUDIO INVESTMENT MANAGEMENT LLC | 9 | 9 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| COMERICA BANK | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Keener Financial Planning LLC | 6 | 0 | -6 | 0.00 | 0.00 | 0.00 | sell |
| Fortis Group Advisors, LLC | 28 | 14 | -14 | 0.00 | 0.00 | +0.00 | sell |
| BFSG, LLC | 61 | 1 | -60 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 16,692 | 16,075 | -617 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 1,800 | 401 | -1,399 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 22,098 | 5,180 | -16,918 | 0.00 | 0.00 | +0.00 | sell |
| Sio Capital Management, LLC | 150,000 | 0 | -150,000 | 0.23 | 0.00 | -0.23 | sell |