| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 2,025,000 | 2,025,000 | 0 | 3.50 | 5.33 | +1.83 | hold |
| VANGUARD GROUP INC | 437,264 | 584,989 | +147,725 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 405,000 | 488,000 | +83,000 | 1.93 | 3.64 | +1.71 | buy |
| STATE STREET CORP | 35,979 | 442,333 | +406,354 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 415,000 | 400,000 | -15,000 | 0.03 | 0.03 | +0.00 | sell |
| CITADEL ADVISORS LLC | 369,167 | 332,761 | -36,406 | 0.01 | 0.01 | +0.00 | sell |
| Darwin Global Management, Ltd. | 0 | 325,140 | +325,140 | 0.00 | 1.66 | +1.66 | buy |
| Ikarian Capital, LLC | 559,271 | 309,540 | -249,731 | 5.97 | 4.37 | -1.60 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 192,495 | 302,186 | +109,691 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 171,976 | 257,635 | +85,659 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 40,981 | 249,259 | +208,278 | 0.01 | 0.11 | +0.09 | buy |
| MILLENNIUM MANAGEMENT LLC | 324,902 | 241,649 | -83,253 | 0.01 | 0.01 | -0.00 | sell |
| Assenagon Asset Management S.A. | 259,456 | 238,759 | -20,697 | 0.03 | 0.03 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 108,808 | 231,057 | +122,249 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 225,165 | +225,165 | 0.00 | 3.84 | +3.84 | buy |
| Point72 Asset Management, L.P. | 701,597 | 216,515 | -485,082 | 0.08 | 0.03 | -0.05 | sell |
| Avidity Partners Management LP | 0 | 215,600 | +215,600 | 0.00 | 0.41 | +0.41 | buy |
| JANUS HENDERSON GROUP PLC | 339,074 | 203,272 | -135,802 | 0.01 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 31,980 | 172,492 | +140,512 | 0.35 | 1.93 | +1.57 | buy |
| Vivo Capital, LLC | 0 | 166,794 | +166,794 | 0.00 | 0.70 | +0.70 | buy |
| Walleye Capital LLC | 132,584 | 150,391 | +17,807 | 0.06 | 0.07 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 124,273 | 140,300 | +16,027 | 0.04 | 0.05 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 116,271 | +116,271 | 0.00 | 0.06 | +0.06 | buy |
| STEMPOINT CAPITAL LP | 0 | 101,479 | +101,479 | 0.00 | 1.35 | +1.35 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.45 | +0.45 | buy |
| BARCLAYS PLC | 185,148 | 91,728 | -93,420 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 156,013 | 86,349 | -69,664 | 0.17 | 0.12 | -0.05 | sell |
| Exome Asset Management LLC | 87,846 | 84,790 | -3,056 | 2.95 | 3.42 | +0.46 | sell |
| Verition Fund Management LLC | 0 | 72,842 | +72,842 | 0.00 | 0.03 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 64,503 | 64,503 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 64,500 | +64,500 | 0.00 | 2.46 | +2.46 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 63,059 | 63,059 | 0 | 0.02 | 0.03 | +0.00 | hold |
| GOLDMAN SACHS GROUP INC | 106,378 | 60,528 | -45,850 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 56,468 | +56,468 | 0.00 | 3.22 | +3.22 | buy |
| BANK OF AMERICA CORP /DE/ | 27,995 | 53,087 | +25,092 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 49,013 | +49,013 | 0.00 | 0.12 | +0.12 | buy |
| Ensign Peak Advisors, Inc | 67,500 | 45,364 | -22,136 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 0 | 44,156 | +44,156 | 0.00 | 0.51 | +0.51 | buy |
| Hudson Bay Capital Management LP | 43,000 | 43,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 21,200 | 40,800 | +19,600 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 38,000 | 39,100 | +1,100 | 0.91 | 1.08 | +0.17 | buy |
| HighVista Strategies LLC | 0 | 38,793 | +38,793 | 0.00 | 0.64 | +0.64 | buy |
| NEOS Investment Management LLC | 0 | 36,455 | +36,455 | 0.00 | 0.07 | +0.07 | buy |
| Trexquant Investment LP | 11,984 | 33,164 | +21,180 | 0.01 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 0 | 30,236 | +30,236 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 28,843 | +28,843 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 20,011 | 25,775 | +5,764 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 23,212 | +23,212 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 15,465 | 21,649 | +6,184 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,527 | 21,131 | +10,604 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 0 | 20,600 | +20,600 | 0.00 | 0.02 | +0.02 | buy |
| Artia Global Partners LP | 0 | 20,000 | +20,000 | 0.00 | 0.23 | +0.23 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 19,060 | +19,060 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 16,075 | 16,075 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 15,854 | +15,854 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 11,100 | 15,000 | +3,900 | 0.01 | 0.01 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 17,946 | 14,446 | -3,500 | 0.05 | 0.05 | +0.01 | sell |
| RHUMBLINE ADVISERS | 0 | 14,103 | +14,103 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 12,609 | +12,609 | 0.00 | 0.09 | +0.09 | buy |
| Jump Financial, LLC | 0 | 12,272 | +12,272 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 16,000 | 12,000 | -4,000 | 0.17 | 0.11 | -0.06 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 11,414 | +11,414 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 11,328 | +11,328 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 32,400 | 10,292 | -22,108 | 0.00 | 0.00 | -0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 9,182 | 8,682 | -500 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 9,154 | 7,542 | -1,612 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 0 | 7,210 | +7,210 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 8 | 6,568 | +6,560 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 5,838 | +5,838 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 5,143 | 5,143 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 0 | 4,784 | +4,784 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 1,081 | 4,633 | +3,552 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 15,307 | 4,383 | -10,924 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 0 | 4,174 | +4,174 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 4,100 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 1,990 | 1,727 | -263 | 0.00 | 0.00 | +0.00 | sell |
| JTC Employer Solutions Trustee Ltd | 1,106 | 1,106 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 0 | 1,028 | +1,028 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 996 | +996 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 9,652 | 746 | -8,906 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 736 | +736 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,726 | 686 | -1,040 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 700 | 400 | -300 | 0.01 | 0.01 | -0.00 | sell |
| AMALGAMATED BANK | 0 | 352 | +352 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 132 | +132 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 41 | 41 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NBC SECURITIES, INC. | 33 | 33 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CoreCap Advisors, LLC | 25 | 25 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 23 | 23 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fortis Group Advisors, LLC | 14 | 14 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STUDIO INVESTMENT MANAGEMENT LLC | 9 | 9 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Scarborough Advisors, LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CIBC Private Wealth Group LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BFSG, LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROYAL BANK OF CANADA | 5,180 | 0 | -5,180 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 10,123 | 0 | -10,123 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 7,500 | 0 | -7,500 | 0.01 | 0.00 | -0.01 | sell |
| MACQUARIE GROUP LTD | 507 | 0 | -507 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 12,314 | 0 | -12,314 | 0.00 | 0.00 | -0.00 | sell |