| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 2,344,971 | 2,344,971 | 0 | 1.11 | 1.13 | +0.02 | hold |
| ORBIMED ADVISORS LLC | 1,737,287 | 1,737,287 | 0 | 0.36 | 0.31 | -0.05 | hold |
| BlackRock, Inc. | 271,636 | 1,331,135 | +1,059,499 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 1,321,750 | 1,321,750 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Prosight Management, LP | 697,108 | 650,000 | -47,108 | 1.07 | 1.05 | -0.02 | sell |
| Stonepine Capital Management, LLC | 383,462 | 425,000 | +41,538 | 3.17 | 3.03 | -0.13 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 187,029 | 423,374 | +236,345 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 331,781 | 421,787 | +90,006 | 0.19 | 0.19 | -0.00 | buy |
| DIADEMA PARTNERS LP | 439,957 | 301,264 | -138,693 | 1.71 | 1.00 | -0.71 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 333,415 | 293,203 | -40,212 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 68,872 | 254,672 | +185,800 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 136,602 | 190,214 | +53,612 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 234,136 | 184,914 | -49,222 | 1.29 | 1.07 | -0.22 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 160,462 | 151,640 | -8,822 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 73,193 | 139,133 | +65,940 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 41,504 | 124,906 | +83,402 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 346,998 | 110,822 | -236,176 | 0.01 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 0 | 107,773 | +107,773 | 0.00 | 0.19 | +0.19 | buy |
| CITADEL ADVISORS LLC | 727,060 | 92,154 | -634,906 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 14 | 89,951 | +89,937 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 146,596 | 79,331 | -67,265 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 10,489 | 78,120 | +67,631 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 111,226 | 76,919 | -34,307 | 0.41 | 0.23 | -0.18 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 75,979 | +75,979 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 38,023 | 67,654 | +29,631 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 93,111 | 62,863 | -30,248 | 0.00 | 0.00 | -0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 55,455 | +55,455 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 55,455 | +55,455 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 55,224 | +55,224 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 45,282 | +45,282 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 44,840 | 44,000 | -840 | 0.45 | 0.38 | -0.07 | sell |
| CANTOR FITZGERALD, L. P. | 40,098 | 40,098 | 0 | 0.01 | 0.01 | -0.01 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 38,977 | +38,977 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 108,792 | 37,389 | -71,403 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 0 | 35,500 | +35,500 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 14,200 | 29,800 | +15,600 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 6,470 | 27,852 | +21,382 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,572 | 26,271 | +13,699 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 26,000 | 26,000 | 0 | 0.15 | 0.15 | -0.00 | hold |
| Jump Financial, LLC | 30,600 | 25,800 | -4,800 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 21,350 | 24,301 | +2,951 | 0.02 | 0.02 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 22,646 | +22,646 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 15,139 | 22,507 | +7,368 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 32,679 | 22,477 | -10,202 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 0 | 22,308 | +22,308 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 482 | 20,463 | +19,981 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 20,000 | +20,000 | 0.00 | 0.13 | +0.13 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 18,852 | +18,852 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 16,509 | +16,509 | 0.00 | 0.02 | +0.02 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 16,087 | +16,087 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 16,071 | +16,071 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 13,836 | +13,836 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 12,400 | 12,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quadrature Capital Ltd | 22,986 | 12,199 | -10,787 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 12,806 | 11,636 | -1,170 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 107,800 | 11,438 | -96,362 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 16,708 | 11,319 | -5,389 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 688 | 8,651 | +7,963 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 20,782 | 8,002 | -12,780 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 6,600 | +6,600 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 5,480 | +5,480 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 1,800 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 1,596 | +1,596 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,494 | +1,494 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,224 | 1,224 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JTC Employer Solutions Trustee Ltd | 1,106 | 1,106 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pinnacle Wealth Planning Services, Inc. | 949 | 949 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 684 | 934 | +250 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 601 | 601 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Atlantic Private Wealth, LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,013 | 355 | -658 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 336 | 336 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 0 | 332 | +332 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 287 | 287 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 208 | 73 | -135 | 0.00 | 0.00 | -0.00 | sell |
| Golden State Wealth Management, LLC | 73 | 73 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Spire Wealth Management | 66 | 66 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 52 | 55 | +3 | 0.00 | 0.00 | -0.00 | buy |
| HighMark Wealth Management LLC | 41 | 41 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Caitong International Asset Management Co., Ltd | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 33 | 33 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHILTON CAPITAL MANAGEMENT LLC | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Newbridge Financial Services Group, Inc. | 16 | 16 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VISION FINANCIAL MARKETS LLC | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fortis Group Advisors, LLC | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 13 | 13 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EASTERN BANK | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cassaday & Co Wealth Management LLC | 12 | 6 | -6 | 0.00 | 0.00 | -0.00 | sell |
| BFSG, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIFTH THIRD BANCORP | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROYAL BANK OF CANADA | 29,901 | 0 | -29,901 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 26,474 | 0 | -26,474 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 126 | 0 | -126 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 15,200 | 0 | -15,200 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 65,201 | 0 | -65,201 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 50,826 | 0 | -50,826 | 0.04 | 0.00 | -0.04 | sell |
| Laurion Capital Management LP | 19,600 | 0 | -19,600 | 0.02 | 0.00 | -0.02 | sell |
| Hudson Bay Capital Management LP | 29,578 | 0 | -29,578 | 0.00 | 0.00 | -0.00 | sell |