| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 2,375,000 | 2,375,000 | 0 | 2.60 | 1.54 | -1.06 | hold |
| ORBIMED ADVISORS LLC | 912,552 | 1,172,287 | +259,735 | 0.34 | 0.29 | -0.06 | buy |
| Octagon Capital Advisors LP | 1,115,000 | 1,115,000 | 0 | 3.68 | 2.24 | -1.44 | hold |
| BlackRock, Inc. | 802,721 | 873,374 | +70,653 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 645,650 | 659,202 | +13,552 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 528,937 | 528,937 | 0 | 0.02 | 0.01 | -0.01 | hold |
| MILLENNIUM MANAGEMENT LLC | 102,751 | 386,653 | +283,902 | 0.00 | 0.00 | +0.00 | buy |
| Altium Capital Management LLC | 195,000 | 385,000 | +190,000 | 1.20 | 1.41 | +0.22 | buy |
| Prosight Management, LP | 130,000 | 270,000 | +140,000 | 0.68 | 0.89 | +0.21 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 249,759 | 263,532 | +13,773 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 600,000 | 242,653 | -357,347 | 0.88 | 0.19 | -0.69 | sell |
| ARMISTICE CAPITAL, LLC | 0 | 236,000 | +236,000 | 0.00 | 0.06 | +0.06 | buy |
| STATE STREET CORP | 595,576 | 228,600 | -366,976 | 0.00 | 0.00 | -0.00 | sell |
| Vivo Capital, LLC | 166,794 | 166,794 | 0 | 0.28 | 0.22 | -0.06 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 325,668 | 164,735 | -160,933 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 172,630 | 162,962 | -9,668 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 16,000 | 139,100 | +123,100 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 42,970 | 134,175 | +91,205 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 91,864 | 103,264 | +11,400 | 0.00 | 0.00 | -0.00 | buy |
| Atle Fund Management AB | 69,573 | 98,304 | +28,731 | 0.67 | 0.56 | -0.11 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 93,643 | 97,882 | +4,239 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 24,215 | 89,377 | +65,162 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 75,292 | 75,292 | 0 | 0.54 | 0.33 | -0.21 | hold |
| GOLDMAN SACHS GROUP INC | 49,420 | 57,174 | +7,754 | 0.00 | 0.00 | -0.00 | buy |
| Velan Capital Investment Management LP | 50,000 | 56,700 | +6,700 | 1.12 | 0.58 | -0.54 | buy |
| Walleye Capital LLC | 36,963 | 55,236 | +18,273 | 0.01 | 0.01 | -0.00 | buy |
| Ikarian Capital, LLC | 284,715 | 51,431 | -233,284 | 1.82 | 0.17 | -1.65 | sell |
| WEXFORD CAPITAL LP | 68,556 | 45,021 | -23,535 | 0.34 | 0.14 | -0.20 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 36,647 | +36,647 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 0 | 34,132 | +34,132 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 5,408 | 31,640 | +26,232 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 24,268 | 31,475 | +7,207 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 31,295 | 31,295 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,810 | 29,814 | -996 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 28,709 | +28,709 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 27,383 | +27,383 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 26,894 | 26,894 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 23,801 | 24,679 | +878 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 11,383 | 24,566 | +13,183 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 41,800 | 24,200 | -17,600 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 24,760 | 24,190 | -570 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 24,276 | 23,207 | -1,069 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 14,886 | 23,037 | +8,151 | 0.01 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,731 | 22,924 | +193 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 38,462 | 18,156 | -20,306 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 16,075 | 16,075 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 14,691 | 15,114 | +423 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 11,027 | +11,027 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 82,618 | 10,534 | -72,084 | 0.05 | 0.00 | -0.05 | sell |
| HRT FINANCIAL LP | 24,564 | 10,314 | -14,250 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 7,484 | 9,210 | +1,726 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 8,555 | +8,555 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 5,590 | 8,206 | +2,616 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 8,158 | +8,158 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 4,249 | 6,444 | +2,195 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 5,951 | 5,951 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Corebridge Financial, Inc. | 5,527 | 5,792 | +265 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 5,507 | 5,277 | -230 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 12,852 | 4,726 | -8,126 | 0.01 | 0.00 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,100 | 4,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vestcor Inc | 3,100 | 3,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JTC Employer Solutions Trustee Ltd | 1,106 | 1,106 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,103 | 1,103 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 996 | 996 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 0 | 899 | +899 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 757 | 867 | +110 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 352 | 352 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Venturi Wealth Management, LLC | 89 | 317 | +228 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 10 | 206 | +196 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 185 | +185 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 10,028 | 152 | -9,876 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 19 | 144 | +125 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 11 | 97 | +86 | 0.00 | 0.00 | +0.00 | buy |
| Spire Wealth Management | 0 | 66 | +66 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,071 | 54 | -1,017 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 29 | 54 | +25 | 0.00 | 0.00 | -0.00 | buy |
| HighMark Wealth Management LLC | 41 | 41 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 76 | 20 | -56 | 0.00 | 0.00 | -0.00 | sell |
| Fortis Group Advisors, LLC | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STUDIO INVESTMENT MANAGEMENT LLC | 9 | 9 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 6,576 | 8 | -6,568 | 0.00 | 0.00 | -0.00 | sell |
| CIBC Private Wealth Group LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 9,920 | 0 | -9,920 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 64,366 | 0 | -64,366 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 39,516 | 0 | -39,516 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 26,000 | 0 | -26,000 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 7,331 | 0 | -7,331 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 19,073 | 0 | -19,073 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 34,039 | 0 | -34,039 | 0.00 | 0.00 | -0.00 | sell |
| Jaffetilchin Investment Partners, LLC | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 45,364 | 0 | -45,364 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 221,184 | 0 | -221,184 | 0.01 | 0.00 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 18,500 | 0 | -18,500 | 0.31 | 0.00 | -0.31 | sell |
| Squarepoint Ops LLC | 24,063 | 0 | -24,063 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 143,356 | 0 | -143,356 | 0.02 | 0.00 | -0.02 | sell |
| Qube Research & Technologies Ltd | 15,321 | 0 | -15,321 | 0.00 | 0.00 | -0.00 | sell |