| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 9,000 | 4,294,259 | +4,285,259 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 4,258,600 | +4,258,600 | 0.00 | 0.05 | +0.05 | buy |
| Foresite Capital Management VI LLC | 0 | 1,986,600 | +1,986,600 | 0.00 | 2.60 | +2.60 | buy |
| MILLENNIUM MANAGEMENT LLC | 137,911 | 708,291 | +570,380 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 72,669 | 624,857 | +552,188 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 69,919 | 338,735 | +268,816 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 218,759 | +218,759 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 119,131 | +119,131 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 93,308 | +93,308 | 0.00 | 0.00 | +0.00 | buy |
| Brendel Financial Advisors LLC | 0 | 41,799 | +41,799 | 0.00 | 0.12 | +0.12 | buy |
| STATE STREET CORP | 24,019 | 56,349 | +32,330 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 31,000 | +31,000 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 28,629 | +28,629 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 17,758 | +17,758 | 0.00 | 0.26 | +0.26 | buy |
| OMERS ADMINISTRATION Corp | 0 | 10,300 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 146 | +146 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 62 | 62 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 709,500 | 709,500 | 0 | 1.94 | 3.04 | +1.10 | hold |
| Vivo Capital, LLC | 4,322,747 | 4,322,747 | 0 | 1.12 | 2.17 | +1.04 | hold |
| Larson Financial Group LLC | 400 | 400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ally Bridge Group (NY) LLC | 1,655,500 | 1,655,500 | 0 | 10.56 | 9.91 | -0.65 | hold |
| SBI Securities Co., Ltd. | 251 | 251 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 2,365,000 | 2,365,000 | 0 | 0.05 | 0.08 | +0.04 | hold |
| Apella Capital, LLC | 42,380 | 42,250 | -130 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 501 | 0 | -501 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 22,294 | 21,394 | -900 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 1,500 | 0 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 10,579 | 4,767 | -5,812 | 0.00 | 0.00 | -0.00 | sell |
| Lion Point Capital, LP | 35,000 | 0 | -35,000 | 0.73 | 0.00 | -0.73 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 149,200 | 89,700 | -59,500 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 3,311,000 | 3,215,000 | -96,000 | 0.89 | 1.00 | +0.11 | sell |
| FEDERATED HERMES, INC. | 5,371,775 | 5,113,224 | -258,551 | 0.03 | 0.05 | +0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,838,000 | 1,419,000 | -1,419,000 | 0.02 | 0.01 | -0.00 | sell |