| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 0 | 4,322,747 | +4,322,747 | 0.00 | 1.12 | +1.12 | buy |
| FEDERATED HERMES, INC. | 1,351,275 | 5,371,775 | +4,020,500 | 0.01 | 0.03 | +0.03 | buy |
| Logos Global Management LP | 0 | 3,311,000 | +3,311,000 | 0.00 | 0.89 | +0.89 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 2,838,000 | +2,838,000 | 0.00 | 0.02 | +0.02 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 2,365,000 | +2,365,000 | 0.00 | 0.05 | +0.05 | buy |
| Ally Bridge Group (NY) LLC | 0 | 1,655,500 | +1,655,500 | 0.00 | 10.56 | +10.56 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 709,500 | +709,500 | 0.00 | 1.94 | +1.94 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 137,911 | +137,911 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 0 | 35,000 | +35,000 | 0.00 | 0.73 | +0.73 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 116,500 | 149,200 | +32,700 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 22,294 | +22,294 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 9,000 | +9,000 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 16,519 | 24,019 | +7,500 | 0.00 | 0.00 | +0.00 | buy |
| Apella Capital, LLC | 39,314 | 42,380 | +3,066 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 162 | 251 | +89 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 252,029 | 252,029 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 62 | 62 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BlackRock, Inc. | 72,669 | 72,669 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Groupe la Francaise | 337 | 0 | -337 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,341 | 501 | -840 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 75,625 | 69,919 | -5,706 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 17,416 | 10,579 | -6,837 | 0.00 | 0.00 | +0.00 | sell |
| Rangeley Capital, LLC | 10,000 | 0 | -10,000 | 0.02 | 0.00 | -0.02 | sell |
| ADAR1 Capital Management, LLC | 12,406 | 0 | -12,406 | 0.00 | 0.00 | -0.00 | sell |