| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 36,391,063 | 36,391,063 | 0 | 3.73 | 3.96 | +0.24 | hold |
| FMR LLC | 13,360,807 | 10,853,199 | -2,507,608 | 0.01 | 0.01 | -0.00 | sell |
| BlackRock, Inc. | 9,361,921 | 9,653,758 | +291,837 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 9,371,415 | 8,277,859 | -1,093,556 | 0.02 | 0.02 | +0.00 | sell |
| STATE STREET CORP | 6,636,361 | 7,028,160 | +391,799 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 870,719 | 3,680,315 | +2,809,596 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,147,480 | 3,315,854 | +168,374 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 415,284 | 2,242,229 | +1,826,945 | 0.01 | 0.03 | +0.03 | buy |
| MORGAN STANLEY | 926,579 | 1,650,591 | +724,012 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,383,775 | 1,323,179 | -60,596 | 0.02 | 0.03 | +0.00 | sell |
| APEIRON CAPITAL Ltd | 1,309,241 | 1,309,141 | -100 | 26.48 | 23.22 | -3.27 | sell |
| TWO SIGMA INVESTMENTS, LP | 578,248 | 981,185 | +402,937 | 0.02 | 0.02 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 892,629 | 960,867 | +68,238 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 1,205,272 | 956,894 | -248,378 | 0.02 | 0.01 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 892,873 | +892,873 | 0.00 | 12.09 | +12.09 | buy |
| Point72 Asset Management, L.P. | 0 | 784,186 | +784,186 | 0.00 | 0.03 | +0.03 | buy |
| Rock Springs Capital Management LP | 710,000 | 710,000 | 0 | 0.64 | 0.79 | +0.16 | hold |
| Aberdeen Group plc | 927,171 | 665,364 | -261,807 | 0.03 | 0.02 | -0.00 | sell |
| Squarepoint Ops LLC | 715,410 | 613,877 | -101,533 | 0.03 | 0.03 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 603,933 | +603,933 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 477,393 | 598,692 | +121,299 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 440,953 | 592,810 | +151,857 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 528,487 | 581,600 | +53,113 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 50,298 | 548,335 | +498,037 | 0.00 | 0.02 | +0.02 | buy |
| Candriam S.C.A. | 540,662 | 540,662 | 0 | 0.05 | 0.05 | +0.01 | hold |
| Invesco Ltd. | 461,301 | 526,103 | +64,802 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 475,241 | +475,241 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 357,870 | 443,757 | +85,887 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,475,708 | 441,743 | -2,033,965 | 0.03 | 0.01 | -0.02 | sell |
| Bank of New York Mellon Corp | 353,756 | 404,679 | +50,923 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 423,084 | 384,988 | -38,096 | 0.04 | 0.04 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 362,858 | +362,858 | 0.00 | 0.00 | +0.00 | buy |
| QVT Financial LP | 360,524 | 360,524 | 0 | 0.60 | 0.54 | -0.06 | hold |
| NOMURA HOLDINGS INC | 542,234 | 313,981 | -228,253 | 0.03 | 0.05 | +0.02 | sell |
| E Fund Management Co., Ltd. | 22,196 | 311,825 | +289,629 | 0.02 | 0.18 | +0.15 | buy |
| GOLDMAN SACHS GROUP INC | 485,566 | 310,728 | -174,838 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 287,810 | 259,074 | -28,736 | 0.02 | 0.02 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 256,255 | +256,255 | 0.00 | 0.05 | +0.05 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 251,391 | 251,391 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nuveen, LLC | 232,642 | 243,992 | +11,350 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 237,788 | 237,788 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Woodline Partners LP | 214,507 | 214,507 | 0 | 0.01 | 0.02 | +0.00 | hold |
| CITIGROUP INC | 129,926 | 199,133 | +69,207 | 0.00 | 0.00 | +0.00 | buy |
| GRIFFIN ASSET MANAGEMENT, INC. | 195,547 | 191,872 | -3,675 | 0.37 | 0.41 | +0.04 | sell |
| China Universal Asset Management Co., Ltd. | 121,307 | 137,596 | +16,289 | 0.16 | 0.20 | +0.03 | buy |
| Polymer Capital Management (HK) LTD | 1,421,155 | 133,034 | -1,288,121 | 3.87 | 0.35 | -3.52 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 112,437 | 130,237 | +17,800 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 121,341 | 129,542 | +8,201 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 469,017 | 126,273 | -342,744 | 0.01 | 0.00 | -0.00 | sell |
| Tidal Investments LLC | 0 | 120,314 | +120,314 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 130,886 | 120,301 | -10,585 | 0.00 | 0.00 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 119,655 | +119,655 | 0.00 | 0.04 | +0.04 | buy |
| TEMA ETFS LLC | 95,782 | 119,531 | +23,749 | 0.13 | 0.15 | +0.02 | buy |
| Jump Financial, LLC | 0 | 115,738 | +115,738 | 0.00 | 0.03 | +0.03 | buy |
| Cerity Partners LLC | 112,878 | 113,786 | +908 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 103,761 | 112,926 | +9,165 | 0.06 | 0.08 | +0.02 | buy |
| Illinois Municipal Retirement Fund | 99,367 | 111,894 | +12,527 | 0.02 | 0.03 | +0.01 | buy |
| BANK OF MONTREAL /CAN/ | 95,371 | 107,959 | +12,588 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 100,000 | 100,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 96,009 | 96,009 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Beacon Pointe Advisors, LLC | 39,611 | 94,394 | +54,783 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 91,869 | 91,869 | 0 | 0.12 | 0.10 | -0.02 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 91,000 | +91,000 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 376,563 | 88,496 | -288,067 | 0.00 | 0.00 | -0.00 | sell |
| Focus Partners Wealth | 88,448 | 83,920 | -4,528 | 0.00 | 0.00 | +0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 87,069 | 80,780 | -6,289 | 0.07 | 0.14 | +0.07 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 79,626 | 79,696 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 14,323 | 73,835 | +59,512 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 79,625 | 69,615 | -10,010 | 1.12 | 1.16 | +0.04 | sell |
| GUGGENHEIM CAPITAL LLC | 49,798 | 66,402 | +16,604 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 67,422 | 64,554 | -2,868 | 0.00 | 0.00 | -0.00 | sell |
| Wealth Management Partners, LLC | 59,430 | 63,784 | +4,354 | 0.30 | 0.35 | +0.05 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 92,882 | 62,535 | -30,347 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 59,621 | 59,621 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 41,734 | 58,272 | +16,538 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 57,282 | +57,282 | 0.00 | 0.05 | +0.05 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 53,964 | +53,964 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 53,777 | 53,777 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 15,589 | 53,523 | +37,934 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 52,619 | 52,619 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DnB Asset Management AS | 61,061 | 50,558 | -10,503 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 57,282 | 50,316 | -6,966 | 0.01 | 0.01 | -0.00 | sell |
| Treasurer of the State of North Carolina | 48,940 | 50,007 | +1,067 | 0.00 | 0.00 | +0.00 | buy |
| Fieldview Capital Management, LLC | 0 | 49,204 | +49,204 | 0.00 | 0.27 | +0.27 | buy |
| BARCLAYS PLC | 338,390 | 49,103 | -289,287 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 37,084 | 49,040 | +11,956 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 54,012 | 47,667 | -6,345 | 0.00 | 0.00 | -0.00 | sell |
| AXQ CAPITAL, LP | 81,519 | 47,268 | -34,251 | 0.32 | 0.12 | -0.21 | sell |
| Handelsbanken Fonder AB | 37,600 | 44,600 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 31,410 | 42,781 | +11,371 | 0.02 | 0.03 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 37,991 | 42,383 | +4,392 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 23,045 | 38,847 | +15,802 | 0.00 | 0.00 | +0.00 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 37,676 | 37,676 | 0 | 0.06 | 0.05 | -0.00 | hold |
| Verition Fund Management LLC | 228,990 | 36,163 | -192,827 | 0.02 | 0.01 | -0.01 | sell |
| ProShare Advisors LLC | 32,881 | 34,686 | +1,805 | 0.00 | 0.00 | -0.00 | buy |
| LMR Partners LLP | 75,200 | 34,122 | -41,078 | 0.01 | 0.01 | -0.01 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 35,158 | 33,999 | -1,159 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 27,359 | 31,892 | +4,533 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 29,738 | +29,738 | 0.00 | 0.00 | +0.00 | buy |
| Machina Capital S.A.S. | 11,636 | 26,199 | +14,563 | 0.04 | 0.10 | +0.06 | buy |