| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 36,391,063 | 32,786,348 | -3,604,715 | 3.96 | 2.39 | -1.57 | sell |
| FMR LLC | 10,853,199 | 10,043,947 | -809,252 | 0.01 | 0.01 | -0.00 | sell |
| STATE STREET CORP | 7,028,160 | 9,536,796 | +2,508,636 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 9,653,758 | 9,529,041 | -124,717 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 3,680,315 | 5,233,798 | +1,553,483 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 310,728 | 4,513,399 | +4,202,671 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,277,859 | 3,893,820 | -4,384,039 | 0.02 | 0.01 | -0.01 | sell |
| Point72 Asset Management, L.P. | 784,186 | 3,697,803 | +2,913,617 | 0.03 | 0.08 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,315,854 | 3,427,263 | +111,409 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 126,273 | 2,349,081 | +2,222,808 | 0.00 | 0.02 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,989,591 | +1,989,591 | 0.00 | 0.04 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 548,335 | 1,904,254 | +1,355,919 | 0.02 | 0.05 | +0.03 | buy |
| CITADEL ADVISORS LLC | 441,743 | 1,725,716 | +1,283,973 | 0.01 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 665,364 | 1,693,626 | +1,028,262 | 0.02 | 0.03 | +0.01 | buy |
| Squarepoint Ops LLC | 613,877 | 1,590,736 | +976,859 | 0.03 | 0.04 | +0.02 | buy |
| MORGAN STANLEY | 1,650,591 | 1,450,019 | -200,572 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 0 | 1,382,519 | +1,382,519 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 1,350,000 | +1,350,000 | 0.00 | 0.85 | +0.85 | buy |
| Octagon Capital Advisors LP | 0 | 1,250,000 | +1,250,000 | 0.00 | 1.67 | +1.67 | buy |
| D. E. Shaw & Co., Inc. | 2,242,229 | 1,243,556 | -998,673 | 0.03 | 0.01 | -0.02 | sell |
| Kynam Capital Management, LP | 0 | 1,200,000 | +1,200,000 | 0.00 | 0.97 | +0.97 | buy |
| Pictet Asset Management Holding SA | 1,323,179 | 1,134,299 | -188,880 | 0.03 | 0.02 | -0.01 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 976,851 | +976,851 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 960,867 | 976,851 | +15,984 | 0.00 | 0.00 | -0.00 | buy |
| APEIRON CAPITAL Ltd | 1,309,141 | 961,866 | -347,275 | 23.22 | 9.00 | -14.21 | sell |
| BANK OF AMERICA CORP /DE/ | 598,692 | 864,983 | +266,291 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 251,391 | 835,963 | +584,572 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 710,000 | 715,000 | +5,000 | 0.79 | 0.51 | -0.28 | buy |
| CITIGROUP INC | 199,133 | 714,000 | +514,867 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 981,185 | 696,714 | -284,471 | 0.02 | 0.01 | -0.01 | sell |
| NORTHERN TRUST CORP | 581,600 | 633,794 | +52,194 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 475,241 | 577,190 | +101,949 | 0.01 | 0.01 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 443,757 | 542,178 | +98,421 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 540,662 | 532,432 | -8,230 | 0.05 | 0.03 | -0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 603,933 | 521,339 | -82,594 | 0.01 | 0.01 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 362,858 | 441,934 | +79,076 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 404,679 | 431,299 | +26,620 | 0.00 | 0.00 | -0.00 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 58,272 | 431,028 | +372,756 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 956,894 | 426,084 | -530,810 | 0.01 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 526,103 | 416,847 | -109,256 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 115,738 | 389,618 | +273,880 | 0.03 | 0.05 | +0.02 | buy |
| QVT Financial LP | 360,524 | 360,524 | 0 | 0.54 | 0.34 | -0.20 | hold |
| Ghisallo Capital Management LLC | 0 | 350,000 | +350,000 | 0.00 | 0.10 | +0.10 | buy |
| HOHIMER WEALTH MANAGEMENT, LLC | 0 | 339,100 | +339,100 | 0.00 | 0.51 | +0.51 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 592,810 | 298,000 | -294,810 | 0.01 | 0.00 | -0.01 | sell |
| Nuveen, LLC | 243,992 | 294,867 | +50,875 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 49,040 | 274,894 | +225,854 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 80,780 | 243,607 | +162,827 | 0.14 | 0.23 | +0.09 | buy |
| DEUTSCHE BANK AG\ | 237,788 | 239,347 | +1,559 | 0.00 | 0.00 | -0.00 | buy |
| Polymer Capital Management (HK) LTD | 133,034 | 224,853 | +91,819 | 0.35 | 0.33 | -0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 69,615 | 220,180 | +150,565 | 1.16 | 2.24 | +1.08 | buy |
| Woodline Partners LP | 214,507 | 214,507 | 0 | 0.02 | 0.01 | -0.01 | hold |
| BARCLAYS PLC | 49,103 | 210,207 | +161,104 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 120,301 | 208,413 | +88,112 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 259,074 | 206,625 | -52,449 | 0.02 | 0.01 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 130,237 | 199,390 | +69,153 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 197,653 | +197,653 | 0.00 | 0.01 | +0.01 | buy |
| GRIFFIN ASSET MANAGEMENT, INC. | 191,872 | 193,582 | +1,710 | 0.41 | 0.30 | -0.11 | buy |
| ADAR1 Capital Management, LLC | 91,869 | 191,869 | +100,000 | 0.10 | 0.13 | +0.03 | buy |
| Trexquant Investment LP | 0 | 184,013 | +184,013 | 0.00 | 0.02 | +0.02 | buy |
| Focus Partners Wealth | 83,920 | 170,338 | +86,418 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 137,596 | 133,527 | -4,069 | 0.20 | 0.12 | -0.08 | sell |
| DIMENSIONAL FUND ADVISORS LP | 88,496 | 127,978 | +39,482 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 129,542 | 126,895 | -2,647 | 0.00 | 0.00 | -0.00 | sell |
| Tidal Investments LLC | 120,314 | 121,097 | +783 | 0.01 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 119,531 | 121,097 | +1,566 | 0.15 | 0.06 | -0.10 | buy |
| HSBC HOLDINGS PLC | 0 | 120,560 | +120,560 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 113,786 | 114,505 | +719 | 0.00 | 0.00 | -0.00 | buy |
| Quantinno Capital Management LP | 73,835 | 113,452 | +39,617 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA HOLDINGS INC | 313,981 | 112,359 | -201,622 | 0.05 | 0.01 | -0.04 | sell |
| BANK OF MONTREAL /CAN/ | 107,959 | 104,625 | -3,334 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 112,926 | 100,549 | -12,377 | 0.08 | 0.04 | -0.04 | sell |
| Caption Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.05 | +0.05 | buy |
| Beacon Pointe Advisors, LLC | 94,394 | 98,114 | +3,720 | 0.01 | 0.01 | -0.00 | buy |
| LMR Partners LLP | 34,122 | 96,177 | +62,055 | 0.01 | 0.01 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 96,009 | 94,229 | -1,780 | 0.00 | 0.00 | -0.00 | sell |
| AXQ CAPITAL, LP | 47,268 | 93,624 | +46,356 | 0.12 | 0.15 | +0.03 | buy |
| Schonfeld Strategic Advisors LLC | 22,505 | 91,557 | +69,052 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 79,696 | 90,338 | +10,642 | 0.00 | 0.00 | -0.00 | buy |
| Wealth Management Partners, LLC | 63,784 | 89,274 | +25,490 | 0.35 | 0.31 | -0.04 | buy |
| XTX Topco Ltd | 0 | 81,402 | +81,402 | 0.00 | 0.02 | +0.02 | buy |
| NICOLET BANKSHARES INC | 0 | 72,593 | +72,593 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 64,554 | 68,169 | +3,615 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 67,871 | +67,871 | 0.00 | 0.01 | +0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 66,402 | 67,835 | +1,433 | 0.01 | 0.01 | -0.00 | buy |
| Illinois Municipal Retirement Fund | 111,894 | 62,734 | -49,160 | 0.03 | 0.01 | -0.02 | sell |
| Bridgefront Capital, LLC | 0 | 60,416 | +60,416 | 0.00 | 0.23 | +0.23 | buy |
| Police & Firemen's Retirement System of New Jersey | 52,619 | 60,337 | +7,718 | 0.01 | 0.01 | -0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 60,000 | +60,000 | 0.00 | 0.31 | +0.31 | buy |
| Assenagon Asset Management S.A. | 59,621 | 59,621 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Treasurer of the State of North Carolina | 50,007 | 57,527 | +7,520 | 0.00 | 0.00 | -0.00 | buy |
| Entropy Technologies, LP | 21,783 | 57,017 | +35,234 | 0.02 | 0.03 | +0.01 | buy |
| Handelsbanken Fonder AB | 44,600 | 55,500 | +10,900 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 54,950 | +54,950 | 0.00 | 0.00 | +0.00 | buy |
| Machina Capital S.A.S. | 26,199 | 54,875 | +28,676 | 0.10 | 0.13 | +0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 53,777 | 53,777 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DnB Asset Management AS | 50,558 | 49,305 | -1,253 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 47,667 | 46,320 | -1,347 | 0.00 | 0.00 | -0.00 | sell |
| LEVIN CAPITAL STRATEGIES, L.P. | 37,676 | 46,176 | +8,500 | 0.05 | 0.05 | -0.01 | buy |
| Steward Partners Investment Advisory, LLC | 38,847 | 45,786 | +6,939 | 0.00 | 0.00 | -0.00 | buy |