| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,042,100 | 5,439,657 | +3,397,557 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 8,818,463 | 10,946,536 | +2,128,073 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 23,222,222 | 24,424,865 | +1,202,643 | 2.31 | 5.54 | +3.23 | buy |
| Aberdeen Group plc | 0 | 1,136,286 | +1,136,286 | 0.00 | 0.05 | +0.05 | buy |
| Darwin Global Management, Ltd. | 0 | 1,084,880 | +1,084,880 | 0.00 | 1.93 | +1.93 | buy |
| Rock Springs Capital Management LP | 0 | 1,040,000 | +1,040,000 | 0.00 | 0.74 | +0.74 | buy |
| Candriam S.C.A. | 0 | 850,403 | +850,403 | 0.00 | 0.11 | +0.11 | buy |
| FMR LLC | 7,565,427 | 8,303,119 | +737,692 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 650,833 | +650,833 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 934,729 | 1,432,713 | +497,984 | 0.00 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 266,800 | 694,722 | +427,922 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 29,700 | 402,167 | +372,467 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 47,693 | 397,678 | +349,985 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 285,000 | +285,000 | 0.00 | 0.52 | +0.52 | buy |
| E Fund Management Co., Ltd. | 10,076 | 281,105 | +271,029 | 0.00 | 0.32 | +0.31 | buy |
| MORGAN STANLEY | 337,117 | 577,298 | +240,181 | 0.00 | 0.00 | +0.00 | buy |
| Twin Tree Management, LP | 471 | 223,826 | +223,355 | 0.00 | 0.11 | +0.11 | buy |
| GROUP ONE TRADING LLC | 0 | 186,918 | +186,918 | 0.00 | 0.16 | +0.16 | buy |
| JANE STREET GROUP, LLC | 187,845 | 351,151 | +163,306 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,963,827 | 3,099,808 | +135,981 | 0.00 | 0.01 | +0.00 | buy |
| FORA Capital, LLC | 0 | 128,894 | +128,894 | 0.00 | 0.33 | +0.33 | buy |
| Granahan Investment Management, LLC | 0 | 126,098 | +126,098 | 0.00 | 0.11 | +0.11 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 253,801 | 366,395 | +112,594 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 0 | 103,276 | +103,276 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 99,442 | +99,442 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 97,575 | +97,575 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 16,745 | 109,934 | +93,189 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 206,057 | 295,629 | +89,572 | 0.00 | 0.01 | +0.00 | buy |
| Atle Fund Management AB | 0 | 86,013 | +86,013 | 0.00 | 0.89 | +0.89 | buy |
| Focus Partners Wealth | 0 | 84,466 | +84,466 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 7,056 | 90,141 | +83,085 | 0.00 | 0.00 | +0.00 | buy |
| GRIFFIN ASSET MANAGEMENT, INC. | 0 | 67,760 | +67,760 | 0.00 | 0.17 | +0.17 | buy |
| Bellevue Group AG | 0 | 64,094 | +64,094 | 0.00 | 0.02 | +0.02 | buy |
| WOLVERINE TRADING, LLC | 10,580 | 70,724 | +60,144 | 0.00 | 0.04 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 82,473 | 139,352 | +56,879 | 0.09 | 0.34 | +0.25 | buy |
| BANK OF AMERICA CORP /DE/ | 341,147 | 390,660 | +49,513 | 0.00 | 0.00 | +0.00 | buy |
| Calamos Advisors LLC | 0 | 46,747 | +46,747 | 0.00 | 0.00 | +0.00 | buy |
| Wealth Management Partners, LLC | 42,000 | 88,383 | +46,383 | 0.16 | 0.90 | +0.74 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 44,745 | +44,745 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 42,243 | +42,243 | 0.00 | 0.05 | +0.05 | buy |
| GOLDMAN SACHS GROUP INC | 453,944 | 495,355 | +41,411 | 0.00 | 0.00 | +0.00 | buy |
| Kestra Advisory Services, LLC | 0 | 39,218 | +39,218 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 19,953 | 58,737 | +38,784 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 21,919 | 56,024 | +34,105 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 32,756 | +32,756 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 31,680 | +31,680 | 0.00 | 0.01 | +0.01 | buy |
| Polar Asset Management Partners Inc. | 0 | 31,300 | +31,300 | 0.00 | 0.02 | +0.02 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 29,764 | +29,764 | 0.00 | 0.01 | +0.01 | buy |
| DnB Asset Management AS | 0 | 28,770 | +28,770 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 140,577 | 168,094 | +27,517 | 0.00 | 0.01 | +0.01 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 26,287 | +26,287 | 0.00 | 0.28 | +0.28 | buy |
| Handelsbanken Fonder AB | 63,900 | 88,000 | +24,100 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 36,133 | 58,147 | +22,014 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 34,082 | 53,375 | +19,293 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 18,967 | +18,967 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 18,677 | +18,677 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 0 | 17,080 | +17,080 | 0.00 | 0.73 | +0.73 | buy |
| LPL Financial LLC | 0 | 16,677 | +16,677 | 0.00 | 0.00 | +0.00 | buy |
| Q3 Asset Management | 0 | 16,473 | +16,473 | 0.00 | 0.08 | +0.08 | buy |
| EVOKE WEALTH, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.01 | +0.01 | buy |
| Artia Global Partners LP | 0 | 14,512 | +14,512 | 0.00 | 0.09 | +0.09 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 13,963 | +13,963 | 0.00 | 0.06 | +0.06 | buy |
| Scientech Research LLC | 0 | 12,567 | +12,567 | 0.00 | 0.05 | +0.05 | buy |
| CITIGROUP INC | 63,575 | 76,135 | +12,560 | 0.00 | 0.00 | +0.00 | buy |
| GTS SECURITIES LLC | 0 | 12,432 | +12,432 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 0 | 12,039 | +12,039 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 11,610 | +11,610 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 0 | 11,273 | +11,273 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 11,043 | +11,043 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 10,722 | +10,722 | 0.00 | 0.00 | +0.00 | buy |
| Willis Investment Counsel | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Equitable Holdings, Inc. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| CreativeOne Wealth, LLC | 11,600 | 20,195 | +8,595 | 0.00 | 0.02 | +0.01 | buy |
| Sargent Investment Group, LLC | 72,000 | 80,500 | +8,500 | 0.11 | 0.32 | +0.20 | buy |
| XTX Topco Ltd | 15,500 | 23,915 | +8,415 | 0.01 | 0.04 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 62,114 | 68,518 | +6,404 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 20,958 | 26,205 | +5,247 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 10,782 | 15,633 | +4,851 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 4,775 | +4,775 | 0.00 | 0.00 | +0.00 | buy |
| TORNO CAPITAL, LLC | 0 | 3,639 | +3,639 | 0.00 | 0.10 | +0.10 | buy |
| Invesco Ltd. | 71,677 | 74,495 | +2,818 | 0.00 | 0.00 | +0.00 | buy |
| WORLD EQUITY GROUP, INC. | 12,779 | 14,842 | +2,063 | 0.03 | 0.12 | +0.09 | buy |
| SECTORAL ASSET MANAGEMENT INC | 25,000 | 26,700 | +1,700 | 0.08 | 0.35 | +0.27 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 1,603 | +1,603 | 0.00 | 0.00 | +0.00 | buy |
| Belvedere Trading LLC | 0 | 1,548 | +1,548 | 0.00 | 0.00 | +0.00 | buy |
| Tortoise Investment Management, LLC | 0 | 1,380 | +1,380 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 43 | 1,233 | +1,190 | 0.00 | 0.02 | +0.02 | buy |
| Darwin Wealth Management, LLC | 0 | 1,150 | +1,150 | 0.00 | 0.01 | +0.01 | buy |
| FNY Investment Advisers, LLC | 0 | 1,100 | +1,100 | 0.00 | 0.01 | +0.01 | buy |
| Allworth Financial LP | 22 | 1,022 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Asset Management Inc | 19,705 | 20,445 | +740 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 58,857 | 59,356 | +499 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 257,046 | 257,531 | +485 | 0.00 | 0.01 | +0.00 | buy |
| GAMMA Investing LLC | 28 | 477 | +449 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| FOURPATH CAPITAL MANAGEMENT, LLC | 0 | 312 | +312 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 11,190 | 11,390 | +200 | 0.04 | 0.12 | +0.07 | buy |
| FIFTH THIRD BANCORP | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |