| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 33,722,974 | 33,722,974 | 0 | 6.96 | 5.03 | -1.93 | hold |
| VANGUARD GROUP INC | 8,673,672 | 11,379,728 | +2,706,056 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 9,226,376 | 8,917,887 | -308,489 | 0.01 | 0.01 | -0.00 | sell |
| BlackRock, Inc. | 6,846,667 | 7,363,793 | +517,126 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 4,017,697 | 6,361,936 | +2,344,239 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,905,148 | 4,538,823 | +633,675 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,934,815 | 3,132,735 | +197,920 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 642,001 | 1,926,828 | +1,284,827 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 2,163,873 | 1,604,163 | -559,710 | 0.05 | 0.03 | -0.01 | sell |
| APEIRON CAPITAL Ltd | 1,200,941 | 1,310,941 | +110,000 | 21.87 | 12.87 | -9.00 | buy |
| UBS Group AG | 2,093,958 | 1,278,783 | -815,175 | 0.01 | 0.01 | -0.00 | sell |
| Aberdeen Group plc | 1,139,530 | 1,139,530 | 0 | 0.04 | 0.04 | -0.00 | hold |
| NOMURA HOLDINGS INC | 43,956 | 1,048,927 | +1,004,971 | 0.01 | 0.10 | +0.09 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,291,671 | 876,390 | -415,281 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (HK) LTD | 890,029 | 817,276 | -72,753 | 2.97 | 2.35 | -0.62 | sell |
| Fiera Capital Corp | 782,847 | 762,094 | -20,753 | 0.06 | 0.05 | -0.01 | sell |
| Polar Capital Holdings Plc | 1,000,000 | 746,393 | -253,607 | 0.11 | 0.07 | -0.04 | sell |
| Rock Springs Capital Management LP | 710,000 | 710,000 | 0 | 0.94 | 0.86 | -0.08 | hold |
| BANK OF AMERICA CORP /DE/ | 566,147 | 657,313 | +91,166 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 250,000 | 550,000 | +300,000 | 0.27 | 0.44 | +0.17 | buy |
| NORTHERN TRUST CORP | 531,628 | 546,262 | +14,634 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 484,010 | 537,530 | +53,520 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 513,763 | 513,763 | 0 | 0.06 | 0.06 | -0.01 | hold |
| GOLDMAN SACHS GROUP INC | 303,426 | 497,547 | +194,121 | 0.00 | 0.00 | +0.00 | buy |
| Capricorn Fund Managers Ltd | 0 | 496,266 | +496,266 | 0.00 | 3.44 | +3.44 | buy |
| BARCLAYS PLC | 313,824 | 475,777 | +161,953 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 424,027 | 426,075 | +2,048 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 380,004 | 374,583 | -5,421 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 343,524 | 367,126 | +23,602 | 0.00 | 0.00 | -0.00 | buy |
| QVT Financial LP | 360,524 | 360,524 | 0 | 1.07 | 0.83 | -0.24 | hold |
| TUDOR INVESTMENT CORP ET AL | 0 | 347,241 | +347,241 | 0.00 | 0.05 | +0.05 | buy |
| Rafferty Asset Management, LLC | 198,853 | 339,176 | +140,323 | 0.01 | 0.02 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 66,451 | 338,363 | +271,912 | 0.01 | 0.03 | +0.02 | buy |
| Sculptor Capital LP | 0 | 333,500 | +333,500 | 0.00 | 0.09 | +0.09 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 263,641 | 299,546 | +35,905 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 267,788 | 269,884 | +2,096 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 256,890 | 264,290 | +7,400 | 0.01 | 0.01 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 299,973 | 246,562 | -53,411 | 0.01 | 0.01 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 144,507 | 242,619 | +98,112 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 180,449 | 232,642 | +52,193 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 182,012 | 214,507 | +32,495 | 0.02 | 0.02 | +0.00 | buy |
| CITADEL ADVISORS LLC | 102,417 | 202,712 | +100,295 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 205,699 | 202,618 | -3,081 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 197,253 | +197,253 | 0.00 | 4.01 | +4.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 194,851 | +194,851 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 234,720 | 192,876 | -41,844 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 22,312 | 187,484 | +165,172 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 86,494 | 185,813 | +99,319 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 171,524 | +171,524 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 181,983 | 165,602 | -16,381 | 0.02 | 0.02 | -0.00 | sell |
| CITIGROUP INC | 113,338 | 159,873 | +46,535 | 0.00 | 0.00 | +0.00 | buy |
| GRIFFIN ASSET MANAGEMENT, INC. | 119,382 | 140,282 | +20,900 | 0.30 | 0.33 | +0.03 | buy |
| JPMORGAN CHASE & CO | 206,107 | 136,626 | -69,481 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 137,445 | 130,627 | -6,818 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 149,162 | 130,210 | -18,952 | 0.30 | 0.22 | -0.08 | sell |
| RHUMBLINE ADVISERS | 122,394 | 122,922 | +528 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 556,009 | 120,514 | -435,495 | 0.01 | 0.00 | -0.01 | sell |
| Cerity Partners LLC | 114,844 | 114,657 | -187 | 0.00 | 0.00 | -0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 112,199 | +112,199 | 0.00 | 0.06 | +0.06 | buy |
| Squarepoint Ops LLC | 291,222 | 109,826 | -181,396 | 0.01 | 0.00 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 12,000 | 102,969 | +90,969 | 0.04 | 0.21 | +0.17 | buy |
| Yong Rong (HK) Asset Management Ltd | 0 | 100,000 | +100,000 | 0.00 | 0.43 | +0.43 | buy |
| BANK OF MONTREAL /CAN/ | 100,520 | 98,018 | -2,502 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 97,502 | 96,009 | -1,493 | 0.00 | 0.00 | -0.00 | sell |
| Atle Fund Management AB | 92,737 | 92,737 | 0 | 0.84 | 0.75 | -0.09 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 94,550 | 92,538 | -2,012 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 91,835 | +91,835 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 86,440 | 88,419 | +1,979 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 106,943 | 80,284 | -26,659 | 0.03 | 0.01 | -0.02 | sell |
| TEMA ETFS LLC | 106,943 | 80,284 | -26,659 | 0.60 | 0.14 | -0.47 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 86,889 | 79,589 | -7,300 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 11,762 | 79,572 | +67,810 | 0.00 | 0.00 | +0.00 | buy |
| Polianta Ltd | 60,600 | 74,700 | +14,100 | 0.56 | 0.64 | +0.08 | buy |
| Wealth Management Partners, LLC | 75,612 | 74,570 | -1,042 | 0.60 | 0.49 | -0.11 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 74,153 | +74,153 | 0.00 | 0.02 | +0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 65,220 | 74,070 | +8,850 | 0.92 | 0.94 | +0.03 | buy |
| PROFUND ADVISORS LLC | 39,640 | 69,933 | +30,293 | 0.03 | 0.05 | +0.02 | buy |
| Illinois Municipal Retirement Fund | 31,062 | 68,673 | +37,611 | 0.01 | 0.02 | +0.01 | buy |
| WINTON GROUP Ltd | 0 | 64,900 | +64,900 | 0.00 | 0.05 | +0.05 | buy |
| Perseverance Asset Management International | 139,928 | 59,745 | -80,183 | 0.75 | 0.21 | -0.54 | sell |
| Russell Investments Group, Ltd. | 203,878 | 58,099 | -145,779 | 0.01 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 0 | 55,236 | +55,236 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 32,827 | 53,512 | +20,685 | 0.00 | 0.00 | +0.00 | buy |
| Treasurer of the State of North Carolina | 54,560 | 52,519 | -2,041 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 44,588 | 52,505 | +7,917 | 0.01 | 0.01 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 34,459 | 40,997 | +6,538 | 0.01 | 0.01 | +0.00 | buy |
| Verde Servicos Internacionais S.A. | 0 | 40,000 | +40,000 | 0.00 | 0.24 | +0.24 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 36,176 | 36,676 | +500 | 0.08 | 0.07 | -0.01 | buy |
| Vident Advisory, LLC | 39,156 | 36,646 | -2,510 | 0.01 | 0.01 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 36,265 | 36,492 | +227 | 0.00 | 0.00 | -0.00 | buy |
| Beacon Pointe Advisors, LLC | 0 | 35,726 | +35,726 | 0.00 | 0.01 | +0.01 | buy |
| Handelsbanken Fonder AB | 34,200 | 34,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DnB Asset Management AS | 32,277 | 30,923 | -1,354 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 30,548 | 30,588 | +40 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 30,250 | +30,250 | 0.00 | 0.02 | +0.02 | buy |
| ASSETMARK, INC | 31,084 | 29,866 | -1,218 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 40,407 | 29,550 | -10,857 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 29,844 | 29,176 | -668 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 267,255 | 28,264 | -238,991 | 0.52 | 0.03 | -0.49 | sell |
| SEI INVESTMENTS CO | 26,303 | 27,163 | +860 | 0.00 | 0.00 | -0.00 | buy |