| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 23,222,222 | 24,424,865 | +1,202,643 | 2.31 | 4.66 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,439,657 | 6,557,927 | +1,118,270 | 0.01 | 0.01 | -0.00 | buy |
| Twin Tree Management, LP | 223,826 | 495,782 | +271,956 | 0.12 | 0.23 | +0.11 | buy |
| Rafferty Asset Management, LLC | 108,315 | 311,692 | +203,377 | 0.01 | 0.02 | +0.01 | buy |
| Aberdeen Group plc | 1,136,286 | 1,290,425 | +154,139 | 0.05 | 0.04 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 694,722 | 837,954 | +143,232 | 0.01 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 64,094 | 170,594 | +106,500 | 0.02 | 0.06 | +0.04 | buy |
| GRIFFIN ASSET MANAGEMENT, INC. | 67,760 | 110,660 | +42,900 | 0.17 | 0.23 | +0.07 | buy |
| PROFUND ADVISORS LLC | 22,319 | 59,277 | +36,958 | 0.02 | 0.04 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 139,352 | 156,366 | +17,014 | 0.34 | 0.26 | -0.08 | buy |
| E Fund Management Co., Ltd. | 281,105 | 296,299 | +15,194 | 0.32 | 0.27 | -0.05 | buy |
| Atle Fund Management AB | 86,013 | 101,177 | +15,164 | 0.89 | 0.62 | -0.26 | buy |
| Rock Springs Capital Management LP | 1,040,000 | 1,054,000 | +14,000 | 0.74 | 0.72 | -0.02 | buy |
| WORLD EQUITY GROUP, INC. | 14,842 | 28,834 | +13,992 | 0.12 | 0.11 | -0.01 | buy |
| Wealth Management Partners, LLC | 88,383 | 97,383 | +9,000 | 0.90 | 0.75 | -0.15 | buy |
| Granahan Investment Management, LLC | 126,098 | 133,832 | +7,734 | 0.11 | 0.10 | -0.01 | buy |
| DnB Asset Management AS | 28,770 | 34,978 | +6,208 | 0.00 | 0.00 | -0.00 | buy |
| FULLCIRCLE WEALTH LLC | 11,250 | 16,365 | +5,115 | 0.11 | 0.15 | +0.03 | buy |
| TORNO CAPITAL, LLC | 3,639 | 8,308 | +4,669 | 0.10 | 0.03 | -0.07 | buy |
| SECTORAL ASSET MANAGEMENT INC | 26,700 | 30,000 | +3,300 | 0.35 | 0.36 | +0.01 | buy |
| ProShare Advisors LLC | 59,356 | 60,830 | +1,474 | 0.00 | 0.00 | 0.00 | buy |
| CIBC Asset Management Inc | 20,445 | 21,577 | +1,132 | 0.00 | 0.00 | 0.00 | buy |
| GREAT VALLEY ADVISOR GROUP, INC. | 25,000 | 25,101 | +101 | 0.01 | 0.01 | -0.00 | buy |
| Tortoise Investment Management, LLC | 1,380 | 1,460 | +80 | 0.00 | 0.00 | -0.00 | buy |
| VANCE WEALTH, LLC | 19,885 | 19,896 | +11 | 0.16 | 0.14 | -0.03 | buy |
| Polar Asset Management Partners Inc. | 31,300 | 27,100 | -4,200 | 0.01 | 0.01 | -0.01 | sell |
| VIRTUS ADVISERS, LLC | 11,390 | 3,979 | -7,411 | 0.12 | 0.03 | -0.09 | sell |
| Candriam S.C.A. | 850,403 | 842,551 | -7,852 | 0.11 | 0.09 | -0.02 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 26,287 | 15,344 | -10,943 | 0.27 | 0.12 | -0.15 | sell |
| Calamos Advisors LLC | 46,747 | 23,821 | -22,926 | 0.00 | 0.00 | -0.00 | sell |