| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 33,722,974 | 36,391,063 | +2,668,089 | 5.03 | 3.73 | -1.31 | buy |
| FMR LLC | 8,917,887 | 13,360,807 | +4,442,920 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 11,379,728 | 11,177,220 | -202,508 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,538,823 | 9,371,415 | +4,832,592 | 0.01 | 0.02 | +0.01 | buy |
| BlackRock, Inc. | 7,363,793 | 9,361,921 | +1,998,128 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 6,361,936 | 6,636,361 | +274,425 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,132,735 | 3,147,480 | +14,745 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 202,712 | 2,475,708 | +2,272,996 | 0.00 | 0.03 | +0.03 | buy |
| Polymer Capital Management (HK) LTD | 817,276 | 1,421,155 | +603,879 | 2.35 | 3.87 | +1.52 | buy |
| Pictet Asset Management Holding SA | 1,604,163 | 1,383,775 | -220,388 | 0.03 | 0.02 | -0.01 | sell |
| NORGES BANK | 0 | 1,373,943 | +1,373,943 | 0.00 | 0.00 | +0.00 | buy |
| APEIRON CAPITAL Ltd | 1,310,941 | 1,309,241 | -1,700 | 12.87 | 26.48 | +13.61 | sell |
| TD ASSET MANAGEMENT INC | 537,530 | 1,205,272 | +667,742 | 0.01 | 0.02 | +0.01 | buy |
| Aberdeen Group plc | 1,139,530 | 927,171 | -212,359 | 0.04 | 0.03 | -0.01 | sell |
| MORGAN STANLEY | 1,926,828 | 926,579 | -1,000,249 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 876,390 | 892,629 | +16,239 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 1,278,783 | 870,719 | -408,064 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 109,826 | 715,410 | +605,584 | 0.00 | 0.03 | +0.02 | buy |
| Rock Springs Capital Management LP | 710,000 | 710,000 | 0 | 0.86 | 0.64 | -0.22 | hold |
| TWO SIGMA INVESTMENTS, LP | 25,030 | 578,248 | +553,218 | 0.00 | 0.02 | +0.01 | buy |
| NOMURA HOLDINGS INC | 1,048,927 | 542,234 | -506,693 | 0.10 | 0.03 | -0.07 | sell |
| Candriam S.C.A. | 513,763 | 540,662 | +26,899 | 0.06 | 0.05 | -0.01 | buy |
| NORTHERN TRUST CORP | 546,262 | 528,487 | -17,775 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 497,547 | 485,566 | -11,981 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 657,313 | 477,393 | -179,920 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 120,514 | 469,017 | +348,503 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 426,075 | 461,301 | +35,226 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 299,546 | 440,953 | +141,407 | 0.01 | 0.01 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 347,241 | 423,084 | +75,843 | 0.05 | 0.04 | -0.01 | buy |
| D. E. Shaw & Co., Inc. | 130,627 | 415,284 | +284,657 | 0.00 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 374,583 | 376,563 | +1,980 | 0.00 | 0.00 | -0.00 | buy |
| QVT Financial LP | 360,524 | 360,524 | 0 | 0.83 | 0.60 | -0.23 | hold |
| AQR CAPITAL MANAGEMENT LLC | 187,484 | 357,870 | +170,386 | 0.00 | 0.00 | +0.00 | buy |
| Sculptor Capital LP | 333,500 | 356,900 | +23,400 | 0.09 | 0.07 | -0.02 | buy |
| Bank of New York Mellon Corp | 367,126 | 353,756 | -13,370 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 475,777 | 338,390 | -137,387 | 0.00 | 0.00 | -0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 338,363 | 338,363 | 0 | 0.03 | 0.02 | -0.00 | hold |
| READYSTATE ASSET MANAGEMENT LP | 0 | 306,184 | +306,184 | 0.00 | 0.24 | +0.24 | buy |
| Rafferty Asset Management, LLC | 339,176 | 287,810 | -51,366 | 0.02 | 0.02 | -0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 242,619 | 251,391 | +8,772 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 269,884 | 237,788 | -32,096 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 232,642 | 232,642 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Verition Fund Management LLC | 165,602 | 228,990 | +63,388 | 0.02 | 0.02 | +0.00 | buy |
| Woodline Partners LP | 214,507 | 214,507 | 0 | 0.02 | 0.01 | -0.01 | hold |
| GRIFFIN ASSET MANAGEMENT, INC. | 140,282 | 195,547 | +55,265 | 0.33 | 0.37 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 192,876 | 130,886 | -61,990 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 159,873 | 129,926 | -29,947 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 122,922 | 121,341 | -1,581 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 130,210 | 121,307 | -8,903 | 0.22 | 0.16 | -0.06 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 74,153 | 113,391 | +39,238 | 0.02 | 0.02 | +0.00 | buy |
| Cerity Partners LLC | 114,657 | 112,878 | -1,779 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 202,618 | 112,437 | -90,181 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 69,933 | 103,761 | +33,828 | 0.05 | 0.06 | +0.01 | buy |
| Jefferies Financial Group Inc. | 15,000 | 100,000 | +85,000 | 0.00 | 0.01 | +0.01 | buy |
| Illinois Municipal Retirement Fund | 68,673 | 99,367 | +30,694 | 0.02 | 0.02 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 98,766 | +98,766 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 80,284 | 97,217 | +16,933 | 0.01 | 0.01 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 96,009 | 96,009 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TEMA ETFS LLC | 80,284 | 95,782 | +15,498 | 0.14 | 0.13 | -0.01 | buy |
| BANK OF MONTREAL /CAN/ | 98,018 | 95,371 | -2,647 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 91,835 | 92,882 | +1,047 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 102,969 | 91,869 | -11,100 | 0.21 | 0.12 | -0.09 | sell |
| Focus Partners Wealth | 88,419 | 88,448 | +29 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 112,199 | 87,069 | -25,130 | 0.06 | 0.07 | +0.01 | sell |
| AXQ CAPITAL, LP | 17,468 | 81,519 | +64,051 | 0.14 | 0.32 | +0.18 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 79,589 | 79,626 | +37 | 0.00 | 0.00 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 74,070 | 79,625 | +5,555 | 0.94 | 1.12 | +0.17 | buy |
| LMR Partners LLP | 0 | 75,200 | +75,200 | 0.00 | 0.01 | +0.01 | buy |
| Polianta Ltd | 74,700 | 74,700 | 0 | 0.64 | 0.17 | -0.46 | hold |
| Mariner, LLC | 79,572 | 73,497 | -6,075 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 136,626 | 67,422 | -69,204 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 30,923 | 61,061 | +30,138 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 59,945 | +59,945 | 0.00 | 0.03 | +0.03 | buy |
| Assenagon Asset Management S.A. | 0 | 59,621 | +59,621 | 0.00 | 0.00 | +0.00 | buy |
| Wealth Management Partners, LLC | 74,570 | 59,430 | -15,140 | 0.49 | 0.30 | -0.19 | sell |
| Farther Finance Advisors, LLC | 55,236 | 57,282 | +2,046 | 0.02 | 0.01 | -0.01 | buy |
| AMERIPRISE FINANCIAL INC | 53,512 | 54,012 | +500 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 264,290 | 53,777 | -210,513 | 0.01 | 0.00 | -0.01 | sell |
| Police & Firemen's Retirement System of New Jersey | 52,505 | 52,619 | +114 | 0.01 | 0.01 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 194,851 | 50,298 | -144,553 | 0.01 | 0.00 | -0.01 | sell |
| GUGGENHEIM CAPITAL LLC | 40,997 | 49,798 | +8,801 | 0.01 | 0.01 | +0.00 | buy |
| Treasurer of the State of North Carolina | 52,519 | 48,940 | -3,579 | 0.00 | 0.00 | -0.00 | sell |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 0 | 41,734 | +41,734 | 0.00 | 0.00 | +0.00 | buy |
| Beacon Pointe Advisors, LLC | 35,726 | 39,611 | +3,885 | 0.01 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 30,588 | 37,991 | +7,403 | 0.00 | 0.00 | -0.00 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 36,676 | 37,676 | +1,000 | 0.07 | 0.06 | -0.01 | buy |
| Handelsbanken Fonder AB | 34,200 | 37,600 | +3,400 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 29,176 | 37,084 | +7,908 | 0.00 | 0.00 | -0.00 | buy |
| Vident Advisory, LLC | 36,646 | 35,880 | -766 | 0.01 | 0.01 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 36,492 | 35,158 | -1,334 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 26,463 | 32,881 | +6,418 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 30,250 | 31,410 | +1,160 | 0.02 | 0.02 | -0.00 | buy |
| IMC-Chicago, LLC | 0 | 29,704 | +29,704 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 171,524 | 28,115 | -143,409 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 26,536 | 27,359 | +823 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 27,304 | +27,304 | 0.00 | 0.00 | +0.00 | buy |
| GREAT VALLEY ADVISOR GROUP, INC. | 25,673 | 25,640 | -33 | 0.01 | 0.01 | -0.00 | sell |
| Entropy Technologies, LP | 0 | 25,162 | +25,162 | 0.00 | 0.02 | +0.02 | buy |
| CIBC Asset Management Inc | 22,123 | 24,289 | +2,166 | 0.00 | 0.00 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 19,912 | 23,045 | +3,133 | 0.00 | 0.00 | -0.00 | buy |