| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,039,621 | 3,304,903 | +265,282 | 3.45 | 2.95 | -0.50 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,050,000 | 1,314,594 | +264,594 | 6.09 | 6.25 | +0.16 | buy |
| Holocene Advisors, LP | 369,979 | 533,147 | +163,168 | 0.10 | 0.13 | +0.02 | buy |
| Alyeska Investment Group, L.P. | 75,182 | 170,846 | +95,664 | 0.02 | 0.05 | +0.02 | buy |
| Granahan Investment Management, LLC | 88,833 | 179,053 | +90,220 | 0.49 | 0.67 | +0.18 | buy |
| PERCEPTIVE ADVISORS LLC | 3,127,200 | 3,197,200 | +70,000 | 6.97 | 5.02 | -1.95 | buy |
| Avoro Capital Advisors LLC | 3,375,000 | 3,400,000 | +25,000 | 3.79 | 3.19 | -0.60 | buy |
| APIS CAPITAL ADVISORS, LLC | 515,000 | 538,000 | +23,000 | 9.07 | 5.48 | -3.59 | buy |
| Harvest Investment Services, LLC | 54,407 | 59,747 | +5,340 | 1.14 | 0.97 | -0.17 | buy |
| Artisan Partners Limited Partnership | 457,070 | 461,591 | +4,521 | 0.08 | 0.08 | -0.01 | buy |
| Red Door Wealth Management, LLC | 5,175 | 5,704 | +529 | 0.06 | 0.05 | -0.01 | buy |
| HighVista Strategies LLC | 13,105 | 13,472 | +367 | 0.41 | 0.32 | -0.09 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 125 | 170 | +45 | 0.01 | 0.01 | -0.00 | buy |
| Saxony Capital Management, LLC | 2,686 | 2,637 | -49 | 0.18 | 0.13 | -0.05 | sell |
| Nilsine Partners, LLC | 1,981 | 1,915 | -66 | 0.02 | 0.01 | -0.01 | sell |
| INTEGRITY ALLIANCE, LLC. | 11,688 | 11,618 | -70 | 0.05 | 0.04 | -0.01 | sell |
| GAGNON SECURITIES LLC | 53,342 | 53,240 | -102 | 1.41 | 1.07 | -0.33 | sell |
| NorthRock Partners, LLC | 4,853 | 4,354 | -499 | 0.01 | 0.01 | -0.00 | sell |
| PERKINS CAPITAL MANAGEMENT INC | 5,400 | 4,500 | -900 | 0.58 | 0.35 | -0.22 | sell |
| Focus Financial Network, Inc. | 8,828 | 7,702 | -1,126 | 0.04 | 0.02 | -0.01 | sell |
| Accredited Investors Inc. | 26,972 | 25,718 | -1,254 | 0.17 | 0.12 | -0.05 | sell |
| TEMA ETFS LLC | 45,725 | 40,912 | -4,813 | 0.35 | 0.14 | -0.21 | sell |
| Clearbridge Investments, LLC | 91,763 | 81,112 | -10,651 | 0.01 | 0.01 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 243,899 | 196,770 | -47,129 | 0.46 | 0.28 | -0.19 | sell |
| Hennion & Walsh Asset Management, Inc. | 182,601 | 100,368 | -82,233 | 0.70 | 0.30 | -0.40 | sell |
| Sio Capital Management, LLC | 193,843 | 110,022 | -83,821 | 3.17 | 1.90 | -1.27 | sell |
| Atle Fund Management AB | 141,296 | 33,313 | -107,983 | 1.66 | 0.94 | -0.72 | sell |
| Candriam S.C.A. | 230,603 | 72,588 | -158,015 | 0.14 | 0.03 | -0.10 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,714,000 | 1,451,014 | -262,986 | 2.31 | 1.58 | -0.72 | sell |
| NEA Management Company, LLC | 2,285,561 | 1,710,561 | -575,000 | 14.83 | 11.27 | -3.56 | sell |
| BAKER BROS. ADVISORS LP | 30,750,000 | 0 | -30,750,000 | 0.43 | 0.35 | -0.08 | sell |