| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 1,390,000 | +1,390,000 | 0.00 | 0.47 | +0.47 | buy |
| BAKER BROS. ADVISORS LP | 535,478 | 1,552,478 | +1,017,000 | 0.09 | 0.42 | +0.33 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 881,934 | +881,934 | 0.00 | 0.05 | +0.05 | buy |
| PERCEPTIVE ADVISORS LLC | 1,481,300 | 2,362,279 | +880,979 | 0.48 | 0.90 | +0.42 | buy |
| SAMLYN CAPITAL, LLC | 0 | 689,763 | +689,763 | 0.00 | 0.26 | +0.26 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 658,000 | +658,000 | 0.00 | 0.03 | +0.03 | buy |
| Verition Fund Management LLC | 0 | 343,984 | +343,984 | 0.00 | 0.07 | +0.07 | buy |
| PFM Health Sciences, LP | 156,997 | 497,002 | +340,005 | 0.14 | 0.53 | +0.40 | buy |
| ExodusPoint Capital Management, LP | 0 | 328,064 | +328,064 | 0.00 | 0.09 | +0.09 | buy |
| BANK OF AMERICA CORP /DE/ | 19,685 | 240,504 | +220,819 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 164,100 | +164,100 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 2,195,179 | 2,349,345 | +154,166 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 126,067 | +126,067 | 0.00 | 0.03 | +0.03 | buy |
| MARSHALL WACE, LLP | 0 | 108,815 | +108,815 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 26,610 | 121,830 | +95,220 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 89,275 | +89,275 | 0.00 | 0.00 | +0.00 | buy |
| Cunning Capital Partners, LP | 0 | 52,465 | +52,465 | 0.00 | 1.30 | +1.30 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 26,056 | 74,856 | +48,800 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 44,221 | +44,221 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 17,046 | 59,114 | +42,068 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 296,657 | 336,540 | +39,883 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 37,493 | +37,493 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 36,493 | +36,493 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 30,986 | +30,986 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 323,428 | 349,722 | +26,294 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 25,221 | +25,221 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 282,844 | 302,863 | +20,019 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 15,200 | +15,200 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 15,124 | +15,124 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 11,582 | +11,582 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 820,776 | 828,597 | +7,821 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 183,188 | 189,758 | +6,570 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 4,409 | +4,409 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,007 | 8,937 | +3,930 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,353 | 6,941 | +2,588 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 23,401 | 25,415 | +2,014 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 5,342 | 6,425 | +1,083 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,490 | 3,424 | +934 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 810 | +810 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 19,837 | 20,430 | +593 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 8,672 | 9,003 | +331 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 8,500 | 8,812 | +312 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,260 | 1,336 | +76 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,277 | 45,313 | +36 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 3 | +3 | 0.00 | 0.00 | 0.00 | buy |
| Avior Wealth Management, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,423 | 1,423 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEA Management Company, LLC | 1,250,001 | 1,250,001 | 0 | 1.21 | 1.68 | +0.46 | hold |
| Accredited Investors Inc. | 29,115 | 29,115 | 0 | 0.03 | 0.04 | +0.01 | hold |
| MetLife Investment Management, LLC | 9,174 | 9,174 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JNBA Financial Advisors | 38,091 | 38,091 | 0 | 0.06 | 0.09 | +0.02 | hold |
| Cresset Asset Management, LLC | 18,510 | 18,510 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GAMMA Investing LLC | 99 | 99 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 17,903 | 17,903 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 548 | 548 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 951 | 951 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 1,493 | 1,493 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 17 | 17 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GAGNON SECURITIES LLC | 54,010 | 53,530 | -480 | 0.19 | 0.27 | +0.08 | sell |
| Tower Research Capital LLC (TRC) | 1,003 | 220 | -783 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,503 | 581 | -922 | 0.00 | 0.00 | -0.00 | sell |
| Trust Point Inc. | 20,395 | 19,395 | -1,000 | 0.02 | 0.03 | +0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,872 | 1,837 | -1,035 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 2,451 | 0 | -2,451 | 0.00 | 0.00 | -0.00 | sell |
| Tradition Wealth Management, LLC | 2,850 | 0 | -2,850 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 9,529 | 6,375 | -3,154 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 52,841 | 49,307 | -3,534 | 0.00 | 0.00 | +0.00 | sell |
| Pale Fire Capital SE | 14,409 | 10,269 | -4,140 | 0.03 | 0.03 | -0.00 | sell |
| Bank of New York Mellon Corp | 52,456 | 46,445 | -6,011 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 18,909 | 8,166 | -10,743 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 24,021 | 12,844 | -11,177 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 13,743 | 0 | -13,743 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 209,227 | 195,335 | -13,892 | 0.00 | 0.00 | +0.00 | sell |
| PUNCH & ASSOCIATES INVESTMENT MANAGEMENT, INC. | 60,000 | 0 | -60,000 | 0.05 | 0.00 | -0.05 | sell |
| CAPTRUST FINANCIAL ADVISORS | 544,835 | 467,245 | -77,590 | 0.03 | 0.04 | +0.01 | sell |
| J. Goldman & Co LP | 111,245 | 32,171 | -79,074 | 0.09 | 0.03 | -0.06 | sell |
| Commodore Capital LP | 1,754,704 | 1,555,954 | -198,750 | 2.23 | 2.25 | +0.01 | sell |
| Soleus Capital Management, L.P. | 2,179,481 | 1,731,338 | -448,143 | 3.52 | 3.28 | -0.24 | sell |
| VR Adviser, LLC | 1,885,538 | 970,000 | -915,538 | 1.88 | 1.00 | -0.89 | sell |