| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 2,678,553 | 4,257,735 | +1,579,182 | 0.37 | 0.48 | +0.10 | buy |
| Commodore Capital LP | 400,000 | 695,650 | +295,650 | 0.38 | 0.52 | +0.13 | buy |
| Quantinno Capital Management LP | 0 | 201,286 | +201,286 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 447,171 | 602,472 | +155,301 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 648,118 | 796,981 | +148,863 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 836,023 | 948,429 | +112,406 | 0.01 | 0.01 | -0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 468,096 | 557,603 | +89,507 | 0.02 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 2,179,064 | 2,212,598 | +33,534 | 0.00 | 0.00 | -0.00 | buy |
| Saturn V Capital Management LP | 1,063,783 | 1,093,677 | +29,894 | 5.45 | 5.58 | +0.13 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 692,372 | 719,920 | +27,548 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 144,032 | 168,740 | +24,708 | 0.09 | 0.08 | -0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 62,776 | 84,825 | +22,049 | 0.00 | 0.00 | +0.00 | buy |
| Paloma Partners Management Co | 0 | 21,288 | +21,288 | 0.00 | 0.04 | +0.04 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 21,024 | +21,024 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,651,981 | 1,672,242 | +20,261 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 21,316 | 40,031 | +18,715 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 15,619 | +15,619 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 15,619 | +15,619 | 0.00 | 0.05 | +0.05 | buy |
| Trexquant Investment LP | 11,640 | 26,920 | +15,280 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 14,144 | +14,144 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 13,020 | +13,020 | 0.00 | 0.04 | +0.04 | buy |
| PERKINS CAPITAL MANAGEMENT INC | 0 | 11,350 | +11,350 | 0.00 | 0.12 | +0.12 | buy |
| Focus Financial Network, Inc. | 0 | 10,691 | +10,691 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 2,565,087 | 2,574,122 | +9,035 | 2.54 | 2.04 | -0.50 | buy |
| Bank of New York Mellon Corp | 64,125 | 68,766 | +4,641 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 20,847 | 24,687 | +3,840 | 0.11 | 0.11 | -0.00 | buy |
| RHUMBLINE ADVISERS | 38,755 | 42,194 | +3,439 | 0.00 | 0.00 | -0.00 | buy |
| GAGNON SECURITIES LLC | 52,479 | 54,310 | +1,831 | 0.14 | 0.12 | -0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,721 | 14,132 | +1,411 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 531 | 1,783 | +1,252 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 14,683 | 15,619 | +936 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,826 | 11,728 | +902 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 581 | 1,128 | +547 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 349 | +349 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 15,515 | 15,864 | +349 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 246 | +246 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 17,458 | 17,640 | +182 | 0.05 | 0.02 | -0.03 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 26,377 | 26,539 | +162 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 917 | 990 | +73 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 53 | +53 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 23 | 60 | +37 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 99 | 131 | +32 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 38 | 67 | +29 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 548 | 563 | +15 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 20 | +10 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 9 | 17 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,421 | 3,421 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 3,466,000 | 3,466,000 | 0 | 1.54 | 1.43 | -0.11 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,413 | 2,413 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 23,680 | 23,680 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 2,362,279 | 2,362,279 | 0 | 0.86 | 0.85 | -0.01 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,265,653 | 1,265,653 | 0 | 0.30 | 0.25 | -0.05 | hold |
| NEA Management Company, LLC | 1,250,001 | 1,250,001 | 0 | 0.92 | 0.97 | +0.05 | hold |
| Accredited Investors Inc. | 29,115 | 29,115 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Candriam S.C.A. | 263,590 | 263,590 | 0 | 0.02 | 0.02 | -0.00 | hold |
| JNBA Financial Advisors | 38,091 | 38,091 | 0 | 0.05 | 0.04 | -0.01 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivo Capital, LLC | 610,500 | 610,500 | 0 | 0.90 | 0.82 | -0.08 | hold |
| Russell Investments Group, Ltd. | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Shay Capital LLC | 14,300 | 14,300 | 0 | 0.05 | 0.04 | -0.00 | hold |
| Cresset Asset Management, LLC | 18,510 | 18,510 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRAIDWELL LP | 884,306 | 884,306 | 0 | 0.34 | 0.31 | -0.03 | hold |
| Police & Firemen's Retirement System of New Jersey | 6,451 | 6,451 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 3,490 | 3,490 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFIZER INC | 349,406 | 349,406 | 0 | 0.18 | 0.71 | +0.53 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,391 | 28,391 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GeoWealth Management, LLC | 148 | 0 | -148 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 184 | 0 | -184 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,495 | 1,300 | -195 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 16,256 | 16,019 | -237 | 0.00 | 0.00 | -0.00 | sell |
| BFSG, LLC | 300 | 0 | -300 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 19,725 | 19,361 | -364 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 20,384 | 19,872 | -512 | 0.00 | 0.00 | -0.00 | sell |
| Trust Point Inc. | 17,847 | 17,247 | -600 | 0.02 | 0.02 | -0.00 | sell |
| GPS Wealth Strategies Group, LLC | 658 | 0 | -658 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 9,219 | 8,012 | -1,207 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 30,028 | 28,798 | -1,230 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 1,670 | 0 | -1,670 | 0.02 | 0.00 | -0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 3,325 | 1,480 | -1,845 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 16,649 | 14,121 | -2,528 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 14,646 | 11,240 | -3,406 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 3,840 | 0 | -3,840 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 22,842 | 18,870 | -3,972 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 7,894 | 2,565 | -5,329 | 0.01 | 0.00 | -0.01 | sell |
| VIRTUS ADVISERS, LLC | 5,638 | 0 | -5,638 | 0.03 | 0.00 | -0.03 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 237,706 | 232,036 | -5,670 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 300,076 | 292,312 | -7,764 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 10,924 | 0 | -10,924 | 0.00 | 0.00 | -0.00 | sell |
| Bleakley Financial Group, LLC | 11,159 | 0 | -11,159 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 11,773 | 0 | -11,773 | 0.09 | 0.00 | -0.09 | sell |
| CITIGROUP INC | 38,808 | 23,247 | -15,561 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 83,914 | 68,239 | -15,675 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 19,235 | 0 | -19,235 | 0.02 | 0.00 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 39,660 | 20,351 | -19,309 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 20,122 | 0 | -20,122 | 0.01 | 0.00 | -0.01 | sell |
| BARCLAYS PLC | 57,199 | 35,376 | -21,823 | 0.00 | 0.00 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 25,000 | 0 | -25,000 | 0.33 | 0.00 | -0.33 | sell |
| Verition Fund Management LLC | 25,991 | 0 | -25,991 | 0.00 | 0.00 | -0.00 | sell |