| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 0 | 30,750,000 | +30,750,000 | 0.39 | 0.43 | +0.04 | buy |
| SSI INVESTMENT MANAGEMENT LLC | 0 | 3,206,000 | +3,206,000 | 0.47 | 0.54 | +0.07 | buy |
| RTW INVESTMENTS, LP | 550,160 | 3,039,621 | +2,489,461 | 0.55 | 3.45 | +2.90 | buy |
| TORONTO DOMINION BANK | 0 | 882,758 | +882,758 | 0.00 | 0.19 | +0.19 | buy |
| Point72 Asset Management, L.P. | 0 | 280,324 | +280,324 | 0.00 | 0.06 | +0.06 | buy |
| Avoro Capital Advisors LLC | 3,111,111 | 3,375,000 | +263,889 | 3.05 | 3.79 | +0.74 | buy |
| LORD, ABBETT & CO. LLC | 181,485 | 439,221 | +257,736 | 0.06 | 0.16 | +0.11 | buy |
| First Turn Management, LLC | 0 | 210,578 | +210,578 | 0.00 | 2.69 | +2.69 | buy |
| BlackRock, Inc. | 2,540,377 | 2,711,532 | +171,155 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 81,571 | 220,163 | +138,592 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 119,048 | +119,048 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 652,827 | 764,975 | +112,148 | 0.01 | 0.01 | +0.00 | buy |
| Atle Fund Management AB | 41,831 | 141,296 | +99,465 | 1.33 | 1.66 | +0.33 | buy |
| CITADEL ADVISORS LLC | 47,037 | 131,906 | +84,869 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 0 | 75,182 | +75,182 | 0.00 | 0.02 | +0.02 | buy |
| Freestone Grove Partners LP | 0 | 70,536 | +70,536 | 0.00 | 0.06 | +0.06 | buy |
| Sofinnova Investments, Inc. | 299,417 | 366,175 | +66,758 | 1.29 | 2.09 | +0.81 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,504 | 64,419 | +60,915 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 830,684 | 891,070 | +60,386 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 8,055 | 66,228 | +58,173 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 371,139 | 428,952 | +57,813 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 142,203 | 191,999 | +49,796 | 0.01 | 0.01 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 3,249 | 53,023 | +49,774 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 46,337 | +46,337 | 0.00 | 0.16 | +0.16 | buy |
| Tidal Investments LLC | 0 | 45,725 | +45,725 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 11,757 | 52,070 | +40,313 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,240,281 | 1,279,816 | +39,535 | 0.01 | 0.02 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 34,610 | +34,610 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 287,746 | 318,766 | +31,020 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 29,198 | +29,198 | 0.00 | 0.11 | +0.11 | buy |
| Nan Fung Group Holdings Ltd | 0 | 28,300 | +28,300 | 0.00 | 2.66 | +2.66 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 104,986 | 133,191 | +28,205 | 0.01 | 0.02 | +0.01 | buy |
| NAN FUNG TRINITY (HK) Ltd | 80,775 | 103,775 | +23,000 | 0.64 | 1.30 | +0.66 | buy |
| Nicholas Investment Partners, LP | 0 | 22,243 | +22,243 | 0.00 | 0.18 | +0.18 | buy |
| MARSHALL WACE, LLP | 0 | 18,900 | +18,900 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 27,818 | 45,725 | +17,907 | 0.22 | 0.35 | +0.14 | buy |
| Swiss National Bank | 25,100 | 41,200 | +16,100 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15,278 | 30,795 | +15,517 | 0.00 | 0.00 | +0.00 | buy |
| MYDA Advisors LLC | 0 | 15,000 | +15,000 | 0.00 | 0.40 | +0.40 | buy |
| Creative Planning | 20,972 | 35,219 | +14,247 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 130,943 | 145,033 | +14,090 | 0.05 | 0.06 | +0.01 | buy |
| Kestra Advisory Services, LLC | 0 | 13,604 | +13,604 | 0.00 | 0.01 | +0.01 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 4,660 | 17,181 | +12,521 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,379 | 25,580 | +12,201 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 42,485 | 54,407 | +11,922 | 0.80 | 1.14 | +0.34 | buy |
| PRUDENTIAL FINANCIAL INC | 38,690 | 50,515 | +11,825 | 0.00 | 0.01 | +0.00 | buy |
| IMC-Chicago, LLC | 0 | 10,232 | +10,232 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 26,651 | 36,360 | +9,709 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 7,976 | +7,976 | 0.00 | 0.01 | +0.01 | buy |
| SummitTX Capital, L.P. | 13,449 | 20,812 | +7,363 | 0.04 | 0.08 | +0.04 | buy |
| Ellsworth Advisors, LLC | 0 | 7,217 | +7,217 | 0.00 | 0.15 | +0.15 | buy |
| INTEGRITY ALLIANCE, LLC. | 4,522 | 11,688 | +7,166 | 0.02 | 0.05 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,618 | 17,704 | +7,086 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 7,000 | +7,000 | 0.00 | 0.11 | +0.11 | buy |
| DEUTSCHE BANK AG\ | 23,525 | 30,316 | +6,791 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 85,773 | 92,228 | +6,455 | 0.01 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 25,000 | 31,000 | +6,000 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 5,670 | +5,670 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 88,623 | 94,015 | +5,392 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 5,314 | +5,314 | 0.00 | 0.25 | +0.25 | buy |
| OPPENHEIMER & CO INC | 0 | 5,131 | +5,131 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 38,104 | 43,090 | +4,986 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 4,510 | +4,510 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 12,827 | 17,333 | +4,506 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 3,792 | +3,792 | 0.00 | 0.04 | +0.04 | buy |
| Cinctive Capital Management LP | 0 | 3,637 | +3,637 | 0.00 | 0.03 | +0.03 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 3,482 | +3,482 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 6,200 | 9,600 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 3,136 | +3,136 | 0.00 | 0.00 | +0.00 | buy |
| OneDigital Investment Advisors LLC | 0 | 3,008 | +3,008 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 51,059 | 53,866 | +2,807 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,521 | 8,299 | +2,778 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 4,344 | 7,116 | +2,772 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 1,439 | 4,169 | +2,730 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 250 | 2,959 | +2,709 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,952 | 17,645 | +2,693 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 2,691 | +2,691 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 2,683 | +2,683 | 0.00 | 0.02 | +0.02 | buy |
| Artia Global Partners LP | 12,900 | 15,576 | +2,676 | 0.21 | 0.40 | +0.19 | buy |
| FRANKLIN RESOURCES INC | 14,368 | 17,034 | +2,666 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 2,468 | +2,468 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 2,121 | +2,121 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 3,604 | 5,719 | +2,115 | 0.00 | 0.00 | +0.00 | buy |
| Perbak Capital Partners LLP | 0 | 2,071 | +2,071 | 0.00 | 0.06 | +0.06 | buy |
| Abel Hall, LLC | 0 | 2,069 | +2,069 | 0.00 | 0.05 | +0.05 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 2,041 | +2,041 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 2,011 | +2,011 | 0.00 | 0.00 | +0.00 | buy |
| GABELLI FUNDS LLC | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Nilsine Partners, LLC | 0 | 1,981 | +1,981 | 0.00 | 0.02 | +0.02 | buy |
| STIFEL FINANCIAL CORP | 0 | 1,977 | +1,977 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 2,700 | 4,600 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Asset Management Inc | 0 | 1,861 | +1,861 | 0.00 | 0.00 | +0.00 | buy |
| TEALWOOD ASSET MANAGEMENT INC | 0 | 1,855 | +1,855 | 0.00 | 0.10 | +0.10 | buy |
| GREENLEAF TRUST | 0 | 1,803 | +1,803 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 87,032 | 88,833 | +1,801 | 0.37 | 0.49 | +0.12 | buy |
| Quantbot Technologies LP | 85 | 1,716 | +1,631 | 0.00 | 0.01 | +0.01 | buy |
| Quantinno Capital Management LP | 20,578 | 22,161 | +1,583 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 292,315 | 293,892 | +1,577 | 0.00 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 13,275 | 14,824 | +1,549 | 0.03 | 0.03 | -0.01 | buy |
| ABS Direct Equity Fund LLC | 0 | 1,500 | +1,500 | 0.00 | 0.17 | +0.17 | buy |