| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 0 | 3,466,000 | +3,466,000 | 0.00 | 1.59 | +1.59 | buy |
| Saturn V Capital Management LP | 0 | 760,941 | +760,941 | 0.00 | 4.71 | +4.71 | buy |
| VANGUARD GROUP INC | 828,597 | 1,565,589 | +736,992 | 0.00 | 0.00 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 689,763 | 1,326,953 | +637,190 | 0.26 | 0.37 | +0.11 | buy |
| Vivo Capital, LLC | 0 | 610,500 | +610,500 | 0.00 | 0.92 | +0.92 | buy |
| BRAIDWELL LP | 0 | 516,643 | +516,643 | 0.00 | 0.27 | +0.27 | buy |
| MORGAN STANLEY | 2,349,345 | 2,835,465 | +486,120 | 0.00 | 0.00 | -0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 432,918 | +432,918 | 0.00 | 0.01 | +0.01 | buy |
| PFM Health Sciences, LP | 497,002 | 837,002 | +340,000 | 0.53 | 0.75 | +0.21 | buy |
| BAKER BROS. ADVISORS LP | 1,552,478 | 1,874,978 | +322,500 | 0.42 | 0.39 | -0.03 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,390,000 | 1,535,000 | +145,000 | 0.47 | 0.43 | -0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 349,722 | 493,851 | +144,129 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 336,540 | 439,097 | +102,557 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 328,064 | 429,934 | +101,870 | 0.09 | 0.08 | -0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 126,067 | 204,592 | +78,525 | 0.03 | 0.03 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 0 | 65,000 | +65,000 | 0.00 | 0.30 | +0.30 | buy |
| Point72 Asset Management, L.P. | 0 | 58,077 | +58,077 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 881,934 | 937,787 | +55,853 | 0.05 | 0.04 | -0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 54,217 | +54,217 | 0.00 | 0.05 | +0.05 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 45,000 | +45,000 | 0.00 | 0.62 | +0.62 | buy |
| MARSHALL WACE, LLP | 108,815 | 152,291 | +43,476 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 0 | 37,436 | +37,436 | 0.00 | 0.06 | +0.06 | buy |
| ALPS ADVISORS INC | 0 | 27,379 | +27,379 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 44,221 | 69,437 | +25,216 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,313 | 67,959 | +22,646 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 22,633 | +22,633 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 46,445 | 66,256 | +19,811 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 19,175 | +19,175 | 0.00 | 0.15 | +0.15 | buy |
| Cresset Asset Management, LLC | 18,510 | 37,494 | +18,984 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,941 | 24,709 | +17,768 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 16,260 | +16,260 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 14,517 | +14,517 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 189,758 | 200,477 | +10,719 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 10,600 | +10,600 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 25,415 | 32,464 | +7,049 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 5,901 | +5,901 | 0.00 | 0.05 | +0.05 | buy |
| MetLife Investment Management, LLC | 9,174 | 13,715 | +4,541 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 15,200 | 19,700 | +4,500 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 302,863 | 305,319 | +2,456 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 8,166 | 9,947 | +1,781 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 3,424 | 5,092 | +1,668 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 220 | 1,873 | +1,653 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 20,430 | 22,030 | +1,600 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 15,124 | 16,624 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 1,400 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 10,269 | 11,653 | +1,384 | 0.03 | 0.02 | -0.01 | buy |
| AlphaQuest LLC | 4,409 | 5,788 | +1,379 | 0.02 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,425 | 7,647 | +1,222 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 1,493 | 2,553 | +1,060 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 8,812 | 9,785 | +973 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,423 | 2,289 | +866 | 0.00 | 0.00 | +0.00 | buy |
| GPS Wealth Strategies Group, LLC | 0 | 658 | +658 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 104 | +104 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 17 | 44 | +27 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 3 | 11 | +8 | 0.00 | 0.00 | 0.00 | buy |
| FMR LLC | 1,336 | 1,342 | +6 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,362,279 | 2,362,279 | 0 | 0.90 | 0.93 | +0.03 | hold |
| CIBC Private Wealth Group LLC | 810 | 810 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 1,250,001 | 1,250,001 | 0 | 1.68 | 1.54 | -0.14 | hold |
| Accredited Investors Inc. | 29,115 | 29,115 | 0 | 0.04 | 0.03 | -0.01 | hold |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 164,100 | 164,100 | 0 | 0.01 | 0.01 | -0.00 | hold |
| JNBA Financial Advisors | 38,091 | 38,091 | 0 | 0.09 | 0.07 | -0.02 | hold |
| Cunning Capital Partners, LP | 52,465 | 52,465 | 0 | 1.30 | 1.68 | +0.38 | hold |
| Russell Investments Group, Ltd. | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 99 | 99 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 548 | 548 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| AMALGAMATED BANK | 581 | 581 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,837 | 1,693 | -144 | 0.00 | 0.00 | -0.00 | sell |
| GAGNON SECURITIES LLC | 53,530 | 53,192 | -338 | 0.27 | 0.20 | -0.08 | sell |
| Trust Point Inc. | 19,395 | 18,821 | -574 | 0.03 | 0.02 | -0.01 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 951 | 0 | -951 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 12,844 | 8,029 | -4,815 | 0.00 | 0.00 | -0.00 | sell |
| CAPTRUST FINANCIAL ADVISORS | 467,245 | 461,830 | -5,415 | 0.04 | 0.02 | -0.01 | sell |
| SG Americas Securities, LLC | 6,375 | 0 | -6,375 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 8,937 | 2,066 | -6,871 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 30,986 | 24,001 | -6,985 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 9,003 | 0 | -9,003 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 32,171 | 23,095 | -9,076 | 0.03 | 0.01 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 240,504 | 230,595 | -9,909 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 37,493 | 27,104 | -10,389 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 11,582 | 0 | -11,582 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 49,307 | 37,645 | -11,662 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 36,493 | 19,200 | -17,293 | 0.02 | 0.01 | -0.02 | sell |
| DIMENSIONAL FUND ADVISORS LP | 17,903 | 0 | -17,903 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 74,856 | 51,556 | -23,300 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 25,221 | 0 | -25,221 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 59,114 | 23,619 | -35,495 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 89,275 | 20,682 | -68,593 | 0.00 | 0.00 | -0.00 | sell |
| Commodore Capital LP | 1,555,954 | 1,464,105 | -91,849 | 2.25 | 1.64 | -0.61 | sell |
| CITADEL ADVISORS LLC | 121,830 | 12,231 | -109,599 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 343,984 | 165,675 | -178,309 | 0.07 | 0.02 | -0.05 | sell |
| Invesco Ltd. | 195,335 | 0 | -195,335 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 658,000 | 350,317 | -307,683 | 0.03 | 0.01 | -0.02 | sell |
| Soleus Capital Management, L.P. | 1,731,338 | 1,211,187 | -520,151 | 3.28 | 1.75 | -1.53 | sell |
| VR Adviser, LLC | 970,000 | 0 | -970,000 | 1.00 | 0.00 | -1.00 | sell |