| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 4,257,735 | 5,450,445 | +1,192,710 | 0.48 | 0.71 | +0.23 | buy |
| BVF INC/IL | 3,466,000 | 3,466,000 | 0 | 1.43 | 1.65 | +0.22 | hold |
| Soleus Capital Management, L.P. | 2,574,122 | 3,011,818 | +437,696 | 2.04 | 2.78 | +0.74 | buy |
| NEA Management Company, LLC | 1,250,001 | 2,294,261 | +1,044,260 | 0.97 | 2.31 | +1.33 | buy |
| BlackRock, Inc. | 2,212,598 | 2,070,683 | -141,915 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 1,672,242 | 1,667,785 | -4,457 | 0.00 | 0.00 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 2,362,279 | 1,633,208 | -729,071 | 0.85 | 0.82 | -0.03 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,265,653 | 1,389,427 | +123,774 | 0.25 | 0.32 | +0.07 | buy |
| Saturn V Capital Management LP | 1,093,677 | 1,185,520 | +91,843 | 5.58 | 6.41 | +0.83 | buy |
| BRAIDWELL LP | 884,306 | 884,306 | 0 | 0.31 | 0.40 | +0.09 | hold |
| MORGAN STANLEY | 836,948 | 784,079 | -52,869 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 602,472 | 768,796 | +166,324 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 948,429 | 754,154 | -194,275 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 719,920 | 677,229 | -42,691 | 0.00 | 0.00 | +0.00 | sell |
| Vivo Capital, LLC | 610,500 | 610,500 | 0 | 0.82 | 0.83 | +0.02 | hold |
| STATE STREET CORP | 585,180 | 587,404 | +2,224 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 557,603 | 570,441 | +12,838 | 0.01 | 0.02 | +0.00 | buy |
| Artisan Partners Limited Partnership | 454,646 | 401,678 | -52,968 | 0.01 | 0.01 | +0.00 | sell |
| PFIZER INC | 349,406 | 349,406 | 0 | 0.71 | 0.81 | +0.10 | hold |
| Candriam S.C.A. | 263,590 | 263,576 | -14 | 0.02 | 0.02 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 251,729 | 262,874 | +11,145 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 292,312 | 261,415 | -30,897 | 0.00 | 0.00 | +0.00 | sell |
| Quantinno Capital Management LP | 201,286 | 243,042 | +41,756 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 239,504 | +239,504 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 232,036 | 233,059 | +1,023 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 168,740 | 174,493 | +5,753 | 0.08 | 0.09 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 84,825 | 99,379 | +14,554 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 20,351 | 89,049 | +68,698 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 68,239 | 84,592 | +16,353 | 0.00 | 0.00 | +0.00 | buy |
| Paloma Partners Management Co | 21,288 | 82,137 | +60,849 | 0.04 | 0.25 | +0.21 | buy |
| BARCLAYS PLC | 35,376 | 78,076 | +42,700 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 68,766 | 66,799 | -1,967 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,031 | 59,625 | +19,594 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 8,012 | 59,276 | +51,264 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 69,587 | 55,917 | -13,670 | 0.00 | 0.00 | -0.00 | sell |
| GAGNON SECURITIES LLC | 54,310 | 53,990 | -320 | 0.12 | 0.15 | +0.03 | sell |
| GOLDMAN SACHS GROUP INC | 89,073 | 52,477 | -36,596 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 42,194 | 42,697 | +503 | 0.00 | 0.00 | +0.00 | buy |
| JNBA Financial Advisors | 38,091 | 38,091 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Accredited Investors Inc. | 29,115 | 29,115 | 0 | 0.02 | 0.02 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,391 | 28,391 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 23,680 | 28,270 | +4,590 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 26,386 | +26,386 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 26,539 | 26,269 | -270 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 0 | 24,572 | +24,572 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 28,798 | 20,391 | -8,407 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 19,872 | 19,872 | 0 | 0.00 | 0.00 | +0.00 | hold |
| M Holdings Securities, Inc. | 0 | 17,848 | +17,848 | 0.00 | 0.04 | +0.04 | buy |
| NEOS Investment Management LLC | 15,619 | 17,011 | +1,392 | 0.00 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 15,619 | 17,011 | +1,392 | 0.05 | 0.06 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 16,642 | +16,642 | 0.00 | 0.01 | +0.01 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 21,024 | 16,415 | -4,609 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 18,870 | 16,148 | -2,722 | 0.00 | 0.00 | +0.00 | sell |
| Pale Fire Capital SE | 17,640 | 15,940 | -1,700 | 0.02 | 0.02 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 19,361 | 15,712 | -3,649 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,132 | 15,186 | +1,054 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 15,864 | 15,012 | -852 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 14,121 | 14,855 | +734 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 15,619 | 13,711 | -1,908 | 0.00 | 0.00 | +0.00 | sell |
| Creative Planning | 0 | 13,291 | +13,291 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 13,100 | +13,100 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 13,097 | +13,097 | 0.00 | 0.20 | +0.20 | buy |
| XTX Topco Ltd | 0 | 12,628 | +12,628 | 0.00 | 0.01 | +0.01 | buy |
| Kestra Advisory Services, LLC | 0 | 12,284 | +12,284 | 0.00 | 0.00 | +0.00 | buy |
| PERKINS CAPITAL MANAGEMENT INC | 11,350 | 11,700 | +350 | 0.12 | 0.16 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,728 | 11,519 | -209 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 23,247 | 10,802 | -12,445 | 0.00 | 0.00 | -0.00 | sell |
| Focus Financial Network, Inc. | 10,691 | 10,691 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Virtus Investment Advisers, LLC | 13,020 | 7,487 | -5,533 | 0.04 | 0.03 | -0.00 | sell |
| AlphaQuest LLC | 2,565 | 7,087 | +4,522 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 6,451 | 6,451 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 1,783 | 5,549 | +3,766 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 4,800 | +4,800 | 0.00 | 0.01 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 3,421 | 3,421 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 3,490 | 3,180 | -310 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 1,300 | 2,717 | +1,417 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,480 | 2,647 | +1,167 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,413 | 2,413 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,128 | 1,128 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Caitong International Asset Management Co., Ltd | 246 | 1,064 | +818 | 0.00 | 0.01 | +0.01 | buy |
| GAMMA Investing LLC | 131 | 906 | +775 | 0.00 | 0.00 | +0.00 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 0 | 904 | +904 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 990 | 697 | -293 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 563 | 563 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 60 | 290 | +230 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 349 | 224 | -125 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 14 | 193 | +179 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 124 | +124 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 14 | 115 | +101 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 67 | 106 | +39 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 20 | 65 | +45 | 0.00 | 0.00 | +0.00 | buy |
| GeoWealth Management, LLC | 0 | 43 | +43 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 17 | 17 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COLDSTREAM CAPITAL MANAGEMENT INC | 53 | 0 | -53 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 13,378 | 0 | -13,378 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 796,981 | 0 | -796,981 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 11,240 | 0 | -11,240 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 53,349 | 0 | -53,349 | 0.04 | 0.00 | -0.04 | sell |
| TWO SIGMA ADVISERS, LP | 21,900 | 0 | -21,900 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 26,920 | 0 | -26,920 | 0.00 | 0.00 | -0.00 | sell |