| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 4,257,735 | 5,450,445 | +1,192,710 | 0.48 | 0.71 | +0.23 | buy |
| NEA Management Company, LLC | 1,250,001 | 2,294,261 | +1,044,260 | 0.97 | 2.31 | +1.33 | buy |
| Soleus Capital Management, L.P. | 2,574,122 | 3,011,818 | +437,696 | 2.04 | 2.78 | +0.74 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,265,653 | 1,389,427 | +123,774 | 0.25 | 0.32 | +0.07 | buy |
| Saturn V Capital Management LP | 1,093,677 | 1,185,520 | +91,843 | 5.58 | 6.41 | +0.83 | buy |
| Paloma Partners Management Co | 21,288 | 82,137 | +60,849 | 0.03 | 0.16 | +0.13 | buy |
| Quantinno Capital Management LP | 201,286 | 243,042 | +41,756 | 0.01 | 0.01 | 0.00 | buy |
| ALPS ADVISORS INC | 28,798 | 20,391 | +8,407 | 0.00 | 0.00 | 0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 168,740 | 174,493 | +5,753 | 0.08 | 0.09 | +0.02 | buy |
| NEOS Investment Management LLC | 15,619 | 17,011 | +1,392 | 0.00 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 15,619 | 17,011 | +1,392 | 0.05 | 0.06 | +0.01 | buy |
| PERKINS CAPITAL MANAGEMENT INC | 11,350 | 11,700 | +350 | 0.12 | 0.16 | +0.04 | buy |
| Candriam S.C.A. | 263,590 | 263,576 | -14 | 0.02 | 0.02 | +0.00 | sell |
| GAGNON SECURITIES LLC | 54,310 | 53,990 | -320 | 0.12 | 0.15 | +0.03 | sell |
| Pale Fire Capital SE | 17,640 | 15,940 | -1,700 | 0.02 | 0.02 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 13,020 | 7,487 | -5,533 | 0.04 | 0.03 | -0.00 | sell |
| Artisan Partners Limited Partnership | 454,646 | 401,678 | -52,968 | 0.01 | 0.01 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 2,362,279 | 1,633,208 | -729,071 | 0.84 | 0.81 | -0.04 | sell |