| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 7,915,792 | 7,915,792 | 0 | 5.19 | 4.15 | -1.04 | hold |
| Avoro Capital Advisors LLC | 3,375,000 | 3,400,000 | +25,000 | 3.79 | 3.19 | -0.60 | buy |
| RTW INVESTMENTS, LP | 3,039,621 | 3,304,903 | +265,282 | 3.45 | 2.95 | -0.50 | buy |
| PERCEPTIVE ADVISORS LLC | 3,127,200 | 3,197,200 | +70,000 | 7.05 | 5.19 | -1.86 | buy |
| BlackRock, Inc. | 2,711,532 | 3,018,785 | +307,253 | 0.01 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,518,705 | 1,955,304 | +436,599 | 0.01 | 0.01 | +0.00 | buy |
| NEA Management Company, LLC | 2,285,561 | 1,710,561 | -575,000 | 14.83 | 11.27 | -3.56 | sell |
| Soleus Capital Management, L.P. | 1,284,378 | 1,704,318 | +419,940 | 5.94 | 6.14 | +0.21 | buy |
| BANK OF AMERICA CORP /DE/ | 714,329 | 1,471,307 | +756,978 | 0.01 | 0.01 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,714,000 | 1,451,014 | -262,986 | 2.31 | 1.58 | -0.72 | sell |
| MORGAN STANLEY | 1,345,715 | 1,334,545 | -11,170 | 0.01 | 0.01 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,050,000 | 1,314,594 | +264,594 | 6.09 | 6.25 | +0.16 | buy |
| TORONTO DOMINION BANK | 882,758 | 1,258,758 | +376,000 | 0.19 | 0.22 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 891,070 | 1,111,662 | +220,592 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,279,816 | 1,025,837 | -253,979 | 0.02 | 0.01 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 428,952 | 906,595 | +477,643 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 764,975 | 870,449 | +105,474 | 0.01 | 0.01 | -0.00 | buy |
| Point72 Asset Management, L.P. | 280,324 | 650,916 | +370,592 | 0.06 | 0.10 | +0.05 | buy |
| Hood River Capital Management LLC | 0 | 628,411 | +628,411 | 0.00 | 0.48 | +0.48 | buy |
| FMR LLC | 36,360 | 548,983 | +512,623 | 0.00 | 0.00 | +0.00 | buy |
| APIS CAPITAL ADVISORS, LLC | 515,000 | 538,000 | +23,000 | 9.07 | 5.48 | -3.59 | buy |
| Holocene Advisors, LP | 369,979 | 533,147 | +163,168 | 0.10 | 0.13 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 464,328 | 530,922 | +66,594 | 0.01 | 0.02 | +0.01 | buy |
| UBS Group AG | 220,163 | 520,946 | +300,783 | 0.00 | 0.01 | +0.00 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 0 | 514,396 | +514,396 | 0.00 | 0.15 | +0.15 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 357,903 | 500,996 | +143,093 | 4.81 | 5.83 | +1.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 191,999 | 494,350 | +302,351 | 0.01 | 0.03 | +0.01 | buy |
| Artisan Partners Limited Partnership | 457,070 | 461,591 | +4,521 | 0.09 | 0.08 | -0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 444,909 | +444,909 | 0.00 | 0.02 | +0.02 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 417,816 | +417,816 | 0.00 | 0.14 | +0.14 | buy |
| Boxer Capital Management, LLC | 225,000 | 416,530 | +191,530 | 3.37 | 3.28 | -0.09 | buy |
| Saturn V Capital Management LP | 281,904 | 370,318 | +88,414 | 5.83 | 5.55 | -0.27 | buy |
| JENNISON ASSOCIATES LLC | 231,140 | 358,972 | +127,832 | 0.02 | 0.02 | +0.00 | buy |
| NORTHERN TRUST CORP | 318,766 | 356,919 | +38,153 | 0.00 | 0.00 | -0.00 | buy |
| LORD, ABBETT & CO. LLC | 439,221 | 352,372 | -86,849 | 0.16 | 0.11 | -0.06 | sell |
| First Turn Management, LLC | 210,578 | 329,101 | +118,523 | 2.69 | 3.68 | +1.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 320,893 | +320,893 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 293,892 | 320,893 | +27,001 | 0.01 | 0.00 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 241,549 | 303,860 | +62,311 | 0.20 | 0.18 | -0.02 | buy |
| FRANKLIN RESOURCES INC | 17,034 | 298,047 | +281,013 | 0.00 | 0.01 | +0.01 | buy |
| PFIZER INC | 295,652 | 295,652 | 0 | 13.13 | 17.35 | +4.22 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 133,191 | 278,827 | +145,636 | 0.02 | 0.03 | +0.01 | buy |
| Focus Partners Wealth | 233,390 | 232,559 | -831 | 0.03 | 0.02 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 243,899 | 196,770 | -47,129 | 0.46 | 0.28 | -0.19 | sell |
| Assenagon Asset Management S.A. | 0 | 188,141 | +188,141 | 0.00 | 0.03 | +0.03 | buy |
| MARSHALL WACE, LLP | 18,900 | 182,156 | +163,256 | 0.00 | 0.02 | +0.01 | buy |
| Granahan Investment Management, LLC | 88,833 | 179,053 | +90,220 | 0.49 | 0.67 | +0.18 | buy |
| Woodline Partners LP | 145,033 | 176,422 | +31,389 | 0.06 | 0.06 | -0.01 | buy |
| Alyeska Investment Group, L.P. | 75,182 | 170,846 | +95,664 | 0.02 | 0.05 | +0.02 | buy |
| Caption Management, LLC | 0 | 170,000 | +170,000 | 0.00 | 0.63 | +0.63 | buy |
| Fiera Capital Corp | 0 | 161,823 | +161,823 | 0.00 | 0.06 | +0.06 | buy |
| RAYMOND JAMES FINANCIAL INC | 117,457 | 158,231 | +40,774 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,497 | 155,378 | +142,881 | 0.00 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 0 | 127,931 | +127,931 | 0.00 | 0.73 | +0.73 | buy |
| Ensign Peak Advisors, Inc | 148,994 | 127,131 | -21,863 | 0.03 | 0.02 | -0.01 | sell |
| Bank of New York Mellon Corp | 94,015 | 116,370 | +22,355 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 92,228 | 111,832 | +19,604 | 0.01 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 19,661 | 110,542 | +90,881 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 193,843 | 110,022 | -83,821 | 3.19 | 1.97 | -1.22 | sell |
| FEDERATED HERMES, INC. | 119,048 | 107,981 | -11,067 | 0.02 | 0.02 | -0.01 | sell |
| NAN FUNG TRINITY (HK) Ltd | 103,775 | 103,775 | 0 | 1.30 | 1.07 | -0.23 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 49,498 | 102,746 | +53,248 | 0.01 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 66,228 | 100,994 | +34,766 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 182,601 | 100,368 | -82,233 | 0.70 | 0.30 | -0.40 | sell |
| STEMPOINT CAPITAL LP | 60,062 | 98,203 | +38,141 | 1.32 | 1.78 | +0.46 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 52,070 | 91,449 | +39,379 | 0.01 | 0.02 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 89,234 | +89,234 | 0.00 | 0.09 | +0.09 | buy |
| Nuveen, LLC | 76,654 | 84,306 | +7,652 | 0.00 | 0.00 | -0.00 | buy |
| Clearbridge Investments, LLC | 91,763 | 81,112 | -10,651 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 230,603 | 72,588 | -158,015 | 0.14 | 0.03 | -0.10 | sell |
| CAPTRUST FINANCIAL ADVISORS | 61,068 | 71,445 | +10,377 | 0.01 | 0.01 | -0.00 | buy |
| Freestone Grove Partners LP | 70,536 | 67,907 | -2,629 | 0.06 | 0.05 | -0.01 | sell |
| TFG Asset Management GP Ltd | 0 | 64,110 | +64,110 | 0.00 | 1.09 | +1.09 | buy |
| NOMURA HOLDINGS INC | 0 | 61,404 | +61,404 | 0.00 | 0.03 | +0.03 | buy |
| Harvest Investment Services, LLC | 54,407 | 59,747 | +5,340 | 1.14 | 0.97 | -0.17 | buy |
| Artia Global Partners LP | 15,576 | 59,316 | +43,740 | 0.40 | 1.18 | +0.78 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 64,419 | 57,698 | -6,721 | 0.01 | 0.01 | -0.00 | sell |
| Ghisallo Capital Management LLC | 0 | 55,000 | +55,000 | 0.00 | 0.11 | +0.11 | buy |
| GAGNON SECURITIES LLC | 53,342 | 53,240 | -102 | 1.41 | 1.07 | -0.33 | sell |
| PFM Health Sciences, LP | 0 | 52,155 | +52,155 | 0.00 | 0.47 | +0.47 | buy |
| SEI INVESTMENTS CO | 14,306 | 50,446 | +36,140 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 50,515 | 49,515 | -1,000 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 53,866 | 48,719 | -5,147 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 43,090 | 48,131 | +5,041 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 46,337 | 45,895 | -442 | 0.16 | 0.11 | -0.05 | sell |
| IMC-Chicago, LLC | 10,232 | 41,127 | +30,895 | 0.02 | 0.04 | +0.02 | buy |
| Tidal Investments LLC | 45,725 | 40,912 | -4,813 | 0.02 | 0.01 | -0.01 | sell |
| TEMA ETFS LLC | 45,725 | 40,912 | -4,813 | 0.35 | 0.14 | -0.21 | sell |
| DEUTSCHE BANK AG\ | 30,316 | 39,622 | +9,306 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 34,753 | 37,422 | +2,669 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 3,935 | 36,504 | +32,569 | 0.00 | 0.04 | +0.03 | buy |
| Quantinno Capital Management LP | 22,161 | 36,034 | +13,873 | 0.00 | 0.00 | +0.00 | buy |
| JNBA Financial Advisors | 35,753 | 35,753 | 0 | 0.34 | 0.28 | -0.06 | hold |
| Atom Investors LP | 76,321 | 34,488 | -41,833 | 0.62 | 0.32 | -0.30 | sell |
| Atle Fund Management AB | 141,296 | 33,313 | -107,983 | 1.66 | 0.94 | -0.72 | sell |
| Swiss National Bank | 41,200 | 31,500 | -9,700 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 38,963 | 31,284 | -7,679 | 0.02 | 0.01 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 30,795 | 31,092 | +297 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 28,537 | 30,700 | +2,163 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 35,219 | 30,469 | -4,750 | 0.00 | 0.00 | -0.00 | sell |