| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 12,231 | 774,928 | +762,697 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 439,097 | 1,107,415 | +668,318 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 516,643 | 884,306 | +367,663 | 0.27 | 0.37 | +0.11 | buy |
| ExodusPoint Capital Management, LP | 429,934 | 691,451 | +261,517 | 0.08 | 0.11 | +0.03 | buy |
| Saturn V Capital Management LP | 760,941 | 946,335 | +185,394 | 4.71 | 5.04 | +0.33 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 67,959 | 221,671 | +153,712 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 493,851 | 630,369 | +136,518 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 20,682 | 153,381 | +132,699 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 96,276 | +96,276 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 22,633 | 100,703 | +78,070 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 69,437 | 132,807 | +63,370 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,565,589 | 1,627,552 | +61,963 | 0.00 | 0.00 | -0.00 | buy |
| Commodore Capital LP | 1,464,105 | 1,522,332 | +58,227 | 1.64 | 1.42 | -0.22 | buy |
| Focus Partners Wealth | 0 | 58,000 | +58,000 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 200,477 | 257,890 | +57,413 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 56,587 | +56,587 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 51,611 | +51,611 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 230,595 | 277,352 | +46,757 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 8,029 | 53,605 | +45,576 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,066 | 45,110 | +43,044 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 37,645 | 73,283 | +35,638 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 19,700 | 55,000 | +35,300 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 1,211,187 | 1,245,387 | +34,200 | 1.75 | 1.54 | -0.21 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 30,600 | +30,600 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 27,973 | +27,973 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 21,150 | +21,150 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 20,577 | +20,577 | 0.00 | 0.02 | +0.02 | buy |
| Hennion & Walsh Asset Management, Inc. | 54,217 | 73,026 | +18,809 | 0.05 | 0.05 | +0.01 | buy |
| CITIGROUP INC | 5,092 | 19,435 | +14,343 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 13,722 | +13,722 | 0.00 | 0.01 | +0.01 | buy |
| AlphaQuest LLC | 5,788 | 18,962 | +13,174 | 0.01 | 0.03 | +0.01 | buy |
| Corton Capital Inc. | 0 | 11,782 | +11,782 | 0.00 | 0.09 | +0.09 | buy |
| PROFUND ADVISORS LLC | 0 | 11,267 | +11,267 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 19,200 | 29,872 | +10,672 | 0.01 | 0.01 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 10,366 | +10,366 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 7,995 | +7,995 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 16,260 | 23,680 | +7,420 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,762 | 16,969 | +7,207 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 37,436 | 44,162 | +6,726 | 0.06 | 0.07 | +0.01 | buy |
| Pale Fire Capital SE | 11,653 | 17,458 | +5,805 | 0.02 | 0.04 | +0.02 | buy |
| Values First Advisors, Inc. | 0 | 5,762 | +5,762 | 0.00 | 0.05 | +0.05 | buy |
| DEUTSCHE BANK AG\ | 9,785 | 13,668 | +3,883 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 27,379 | 30,093 | +2,714 | 0.00 | 0.00 | -0.00 | buy |
| FOURPATH CAPITAL MANAGEMENT, LLC | 0 | 2,350 | +2,350 | 0.00 | 0.01 | +0.01 | buy |
| nVerses Capital, LLC | 0 | 2,200 | +2,200 | 0.00 | 0.02 | +0.02 | buy |
| Corebridge Financial, Inc. | 12,568 | 14,398 | +1,830 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 19,175 | 20,875 | +1,700 | 0.15 | 0.18 | +0.03 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 45,000 | 46,600 | +1,600 | 0.62 | 0.56 | -0.06 | buy |
| ADAR1 Capital Management, LLC | 1,400 | 3,000 | +1,600 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 305,319 | 306,529 | +1,210 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 44 | 944 | +900 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 7,647 | 8,539 | +892 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 16,624 | 17,478 | +854 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 9,947 | 10,507 | +560 | 0.00 | 0.00 | -0.00 | buy |
| Venturi Wealth Management, LLC | 0 | 413 | +413 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,553 | 2,853 | +300 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,693 | 1,977 | +284 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,342 | 1,583 | +241 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,901 | 6,006 | +105 | 0.05 | 0.04 | -0.01 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 22,030 | 22,036 | +6 | 0.00 | 0.00 | -0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,289 | 2,289 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 3,466,000 | 3,466,000 | 0 | 1.59 | 1.51 | -0.08 | hold |
| PERCEPTIVE ADVISORS LLC | 2,362,279 | 2,362,279 | 0 | 0.93 | 0.76 | -0.18 | hold |
| BAKER BROS. ADVISORS LP | 1,874,978 | 1,874,978 | 0 | 0.39 | 0.29 | -0.10 | hold |
| CIBC Private Wealth Group LLC | 810 | 810 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,535,000 | 1,535,000 | 0 | 0.43 | 0.39 | -0.04 | hold |
| NEA Management Company, LLC | 1,250,001 | 1,250,001 | 0 | 1.54 | 1.02 | -0.53 | hold |
| Accredited Investors Inc. | 29,115 | 29,115 | 0 | 0.03 | 0.02 | -0.00 | hold |
| MetLife Investment Management, LLC | 13,715 | 13,715 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JNBA Financial Advisors | 38,091 | 38,091 | 0 | 0.07 | 0.06 | -0.01 | hold |
| Cunning Capital Partners, LP | 52,465 | 52,465 | 0 | 1.68 | 1.40 | -0.28 | hold |
| Arax Advisory Partners | 104 | 104 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivo Capital, LLC | 610,500 | 610,500 | 0 | 0.92 | 0.75 | -0.17 | hold |
| Russell Investments Group, Ltd. | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BFSG, LLC | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GPS Wealth Strategies Group, LLC | 658 | 658 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cresset Asset Management, LLC | 37,494 | 37,494 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 99 | 99 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 548 | 548 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,709 | 24,709 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 581 | 581 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 11 | 0 | -11 | 0.00 | 0.00 | 0.00 | sell |
| CAPTRUST FINANCIAL ADVISORS | 461,830 | 461,794 | -36 | 0.02 | 0.02 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,873 | 1,680 | -193 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 32,464 | 32,130 | -334 | 0.00 | 0.00 | -0.00 | sell |
| GAGNON SECURITIES LLC | 53,192 | 52,793 | -399 | 0.20 | 0.16 | -0.04 | sell |
| Trust Point Inc. | 18,821 | 18,395 | -426 | 0.02 | 0.02 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 27,104 | 20,951 | -6,153 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 10,600 | 0 | -10,600 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 23,619 | 12,007 | -11,612 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 66,256 | 53,297 | -12,959 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,517 | 0 | -14,517 | 0.00 | 0.00 | -0.00 | sell |
| Artisan Partners Limited Partnership | 432,918 | 415,677 | -17,241 | 0.01 | 0.01 | -0.00 | sell |
| J. Goldman & Co LP | 23,095 | 0 | -23,095 | 0.01 | 0.00 | -0.01 | sell |
| JANE STREET GROUP, LLC | 24,001 | 0 | -24,001 | 0.00 | 0.00 | -0.00 | sell |
| SAMLYN CAPITAL, LLC | 1,326,953 | 1,290,935 | -36,018 | 0.37 | 0.31 | -0.06 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 51,556 | 11,045 | -40,511 | 0.00 | 0.00 | -0.00 | sell |