| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 5,450,445 | 7,915,792 | +2,465,347 | 0.71 | 2.83 | +2.12 | buy |
| PERCEPTIVE ADVISORS LLC | 1,633,208 | 2,956,319 | +1,323,111 | 0.82 | 4.22 | +3.40 | buy |
| BlackRock, Inc. | 2,070,683 | 2,246,447 | +175,764 | 0.00 | 0.00 | +0.00 | buy |
| NEA Management Company, LLC | 2,294,261 | 2,144,261 | -150,000 | 2.31 | 5.81 | +3.51 | sell |
| VANGUARD GROUP INC | 1,667,785 | 2,059,047 | +391,262 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 784,079 | 1,512,852 | +728,773 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 3,011,818 | 1,178,860 | -1,832,958 | 2.78 | 3.11 | +0.34 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 1,150,000 | +1,150,000 | 0.00 | 2.19 | +2.19 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,389,427 | 1,088,799 | -300,628 | 0.32 | 0.88 | +0.56 | sell |
| UBS Group AG | 84,592 | 854,483 | +769,891 | 0.00 | 0.01 | +0.01 | buy |
| Sio Capital Management, LLC | 0 | 786,526 | +786,526 | 0.00 | 9.83 | +9.83 | buy |
| APIS CAPITAL ADVISORS, LLC | 0 | 776,000 | +776,000 | 0.00 | 8.47 | +8.47 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 677,229 | 766,471 | +89,242 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 733,530 | +733,530 | 0.00 | 0.56 | +0.56 | buy |
| STATE STREET CORP | 587,404 | 722,800 | +135,396 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 3,466,000 | 658,421 | -2,807,579 | 1.65 | 1.32 | -0.33 | sell |
| ALLIANCEBERNSTEIN L.P. | 28,270 | 652,649 | +624,379 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,186 | 598,156 | +582,970 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 401,678 | 585,892 | +184,214 | 0.01 | 0.04 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 262,874 | 539,527 | +276,653 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 89,049 | 526,615 | +437,566 | 0.00 | 0.02 | +0.02 | buy |
| Saturn V Capital Management LP | 1,185,520 | 473,828 | -711,692 | 6.41 | 5.13 | -1.28 | sell |
| GOLDMAN SACHS GROUP INC | 52,477 | 422,938 | +370,461 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 263,576 | 390,924 | +127,348 | 0.02 | 0.10 | +0.08 | buy |
| D. E. Shaw & Co., Inc. | 0 | 371,944 | +371,944 | 0.00 | 0.01 | +0.01 | buy |
| PFIZER INC | 349,406 | 349,406 | 0 | 0.81 | 3.95 | +3.14 | hold |
| Walleye Capital LLC | 0 | 298,901 | +298,901 | 0.00 | 0.12 | +0.12 | buy |
| ROYAL BANK OF CANADA | 59,276 | 279,102 | +219,826 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 261,415 | 276,161 | +14,746 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 233,059 | 268,749 | +35,690 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 253,375 | +253,375 | 0.00 | 0.77 | +0.77 | buy |
| LORD, ABBETT & CO. LLC | 0 | 247,874 | +247,874 | 0.00 | 0.04 | +0.04 | buy |
| JANE STREET GROUP, LLC | 0 | 244,714 | +244,714 | 0.00 | 0.01 | +0.01 | buy |
| Focus Partners Wealth | 0 | 234,843 | +234,843 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 13,100 | 194,800 | +181,700 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 55,917 | 191,323 | +135,406 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 191,068 | +191,068 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,647 | 178,851 | +176,204 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 174,493 | 171,354 | -3,139 | 0.09 | 0.31 | +0.21 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 162,256 | +162,256 | 0.00 | 0.06 | +0.06 | buy |
| Invesco Ltd. | 0 | 141,010 | +141,010 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 136,710 | +136,710 | 0.00 | 1.36 | +1.36 | buy |
| Clearbridge Investments, LLC | 0 | 134,220 | +134,220 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 120,884 | +120,884 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 99,379 | 111,281 | +11,902 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 193 | 108,020 | +107,827 | 0.00 | 0.01 | +0.01 | buy |
| J. Goldman & Co LP | 0 | 102,707 | +102,707 | 0.00 | 0.19 | +0.19 | buy |
| Patient Square Capital LP | 0 | 100,000 | +100,000 | 0.00 | 1.32 | +1.32 | buy |
| Boxer Capital Management, LLC | 0 | 90,000 | +90,000 | 0.00 | 1.42 | +1.42 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 88,686 | +88,686 | 0.00 | 0.63 | +0.63 | buy |
| Informed Momentum Co LLC | 0 | 87,292 | +87,292 | 0.00 | 0.49 | +0.49 | buy |
| Bank of New York Mellon Corp | 66,799 | 84,819 | +18,020 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 84,020 | +84,020 | 0.00 | 0.10 | +0.10 | buy |
| Verition Fund Management LLC | 0 | 81,223 | +81,223 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 0 | 72,796 | +72,796 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 68,780 | +68,780 | 0.00 | 0.06 | +0.06 | buy |
| CAPTRUST FINANCIAL ADVISORS | 570,441 | 67,535 | -502,906 | 0.02 | 0.01 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 62,779 | +62,779 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 61,800 | +61,800 | 0.00 | 0.05 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 768,796 | 61,418 | -707,378 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 58,827 | +58,827 | 0.00 | 0.04 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,519 | 56,955 | +45,436 | 0.00 | 0.00 | +0.00 | buy |
| GAGNON SECURITIES LLC | 53,990 | 53,955 | -35 | 0.15 | 0.53 | +0.39 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 52,179 | +52,179 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 13,711 | 52,045 | +38,334 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 78,076 | 51,801 | -26,275 | 0.00 | 0.00 | +0.00 | sell |
| Granahan Investment Management, LLC | 0 | 49,281 | +49,281 | 0.00 | 0.10 | +0.10 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,391 | 47,704 | +19,313 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 43,423 | +43,423 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 42,697 | 41,440 | -1,257 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 39,311 | +39,311 | 0.00 | 0.00 | +0.00 | buy |
| JNBA Financial Advisors | 38,091 | 37,753 | -338 | 0.05 | 0.17 | +0.12 | sell |
| Atle Fund Management AB | 0 | 37,157 | +37,157 | 0.00 | 0.72 | +0.72 | buy |
| Resolute Capital Asset Partners LLC | 0 | 34,000 | +34,000 | 0.00 | 0.88 | +0.88 | buy |
| Harvest Investment Services, LLC | 0 | 28,878 | +28,878 | 0.00 | 0.29 | +0.29 | buy |
| Burkehill Global Management, LP | 0 | 27,500 | +27,500 | 0.00 | 0.08 | +0.08 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 27,340 | +27,340 | 0.00 | 0.01 | +0.01 | buy |
| Accredited Investors Inc. | 29,115 | 27,115 | -2,000 | 0.02 | 0.07 | +0.05 | sell |
| NEOS Investment Management LLC | 17,011 | 25,790 | +8,779 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 17,011 | 25,790 | +8,779 | 0.06 | 0.11 | +0.05 | buy |
| SEI INVESTMENTS CO | 0 | 24,612 | +24,612 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 23,849 | +23,849 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 15,012 | 22,327 | +7,315 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 243,042 | 20,912 | -222,130 | 0.01 | 0.00 | -0.01 | sell |
| Quadrature Capital Ltd | 0 | 20,265 | +20,265 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 20,391 | 20,050 | -341 | 0.00 | 0.01 | +0.00 | sell |
| Quinn Opportunity Partners LLC | 0 | 19,500 | +19,500 | 0.00 | 0.07 | +0.07 | buy |
| Graham Capital Management, L.P. | 0 | 19,346 | +19,346 | 0.00 | 0.04 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 16,148 | 19,270 | +3,122 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 19,013 | +19,013 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 17,576 | +17,576 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 13,291 | 17,199 | +3,908 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 19,872 | 17,041 | -2,831 | 0.00 | 0.00 | +0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 26,269 | 15,793 | -10,476 | 0.00 | 0.00 | +0.00 | sell |
| Scientech Research LLC | 0 | 15,732 | +15,732 | 0.00 | 0.27 | +0.27 | buy |
| NISA INVESTMENT ADVISORS, LLC | 697 | 15,627 | +14,930 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 754,154 | 15,022 | -739,132 | 0.01 | 0.00 | -0.01 | sell |
| Aristides Capital LLC | 0 | 15,000 | +15,000 | 0.00 | 0.22 | +0.22 | buy |
| Virtu Financial LLC | 0 | 14,565 | +14,565 | 0.00 | 0.04 | +0.04 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,712 | 14,123 | -1,589 | 0.00 | 0.00 | +0.00 | sell |