| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 0 | 1,481,300 | +1,481,300 | 0.00 | 0.48 | +0.48 | buy |
| MORGAN STANLEY | 1,967,776 | 2,195,179 | +227,403 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 209,227 | +209,227 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 2,056,484 | 2,179,481 | +122,997 | 1.89 | 3.52 | +1.63 | buy |
| Commodore Capital LP | 1,694,141 | 1,754,704 | +60,563 | 1.81 | 2.23 | +0.42 | buy |
| UBS Group AG | 13,018 | 52,841 | +39,823 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 791,595 | 820,776 | +29,181 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 275,424 | 296,657 | +21,233 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 3,191 | 24,021 | +20,830 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 19,685 | +19,685 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 307,764 | 323,428 | +15,664 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 14,848 | 26,610 | +11,762 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 9,529 | +9,529 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 47,191 | 52,456 | +5,265 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 11,840 | 17,046 | +5,206 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 10,409 | 14,409 | +4,000 | 0.01 | 0.03 | +0.02 | buy |
| RHUMBLINE ADVISERS | 20,473 | 23,401 | +2,928 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 280,026 | 282,844 | +2,818 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 8 | 2,490 | +2,482 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 2,451 | +2,451 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,579 | 5,007 | +2,428 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 181,153 | 183,188 | +2,035 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 16,889 | 18,909 | +2,020 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 4,281 | 5,342 | +1,061 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 412 | 1,260 | +848 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 8,215 | 8,500 | +285 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 19,834 | 19,837 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,423 | 1,423 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GAGNON SECURITIES LLC | 54,010 | 54,010 | 0 | 0.12 | 0.19 | +0.07 | hold |
| PUNCH & ASSOCIATES INVESTMENT MANAGEMENT, INC. | 60,000 | 60,000 | 0 | 0.04 | 0.05 | +0.02 | hold |
| BAKER BROS. ADVISORS LP | 535,478 | 535,478 | 0 | 0.03 | 0.09 | +0.06 | hold |
| NEA Management Company, LLC | 1,250,001 | 1,250,001 | 0 | 2.46 | 1.21 | -1.24 | hold |
| Accredited Investors Inc. | 29,115 | 29,115 | 0 | 0.02 | 0.03 | +0.01 | hold |
| MetLife Investment Management, LLC | 9,174 | 9,174 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JNBA Financial Advisors | 38,091 | 38,091 | 0 | 0.04 | 0.06 | +0.02 | hold |
| Cresset Asset Management, LLC | 18,510 | 18,510 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tradition Wealth Management, LLC | 2,850 | 2,850 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 17,903 | 17,903 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 548 | 548 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 951 | 951 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 17 | 17 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 8,707 | 8,672 | -35 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 75 | 0 | -75 | 0.00 | 0.00 | 0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 26,156 | 26,056 | -100 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 1,660 | 1,493 | -167 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 1,676 | 1,503 | -173 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 14,083 | 13,743 | -340 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,436 | 1,003 | -433 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,849 | 2,872 | -977 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 47,151 | 45,277 | -1,874 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,590 | 4,353 | -4,237 | 0.00 | 0.00 | -0.00 | sell |
| CAPTRUST FINANCIAL ADVISORS | 552,898 | 544,835 | -8,063 | 0.02 | 0.03 | +0.01 | sell |
| Murphy Pohlad Asset Management LLC | 11,200 | 0 | -11,200 | 0.04 | 0.00 | -0.04 | sell |
| J. Goldman & Co LP | 148,500 | 111,245 | -37,255 | 0.07 | 0.09 | +0.02 | sell |
| PFM Health Sciences, LP | 210,551 | 156,997 | -53,554 | 0.09 | 0.14 | +0.05 | sell |
| VR Adviser, LLC | 2,105,386 | 1,885,538 | -219,848 | 2.03 | 1.88 | -0.14 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,400,001 | 0 | -1,400,001 | 0.25 | 0.00 | -0.25 | sell |